iodoacetic acid has been researched along with Innate Inflammatory Response in 33 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Cyasterone, a sterone derived from the roots of Cyathula officinalis Kuan, exerts protective effect against several inflammation-related diseases." | 8.31 | Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo. ( Fan, S; Fu, Q; Jian, X; Qu, Y; Shen, Y; Teng, L; Yang, L; Yang, Y; Zhang, L, 2023) |
| " Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation." | 8.12 | Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 7.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 7.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Acute oral toxicity of m-PGA resulted in LD50 values in excess of 2000 mg/kg." | 5.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| " Cyasterone, a sterone derived from the roots of Cyathula officinalis Kuan, exerts protective effect against several inflammation-related diseases." | 4.31 | Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo. ( Fan, S; Fu, Q; Jian, X; Qu, Y; Shen, Y; Teng, L; Yang, L; Yang, Y; Zhang, L, 2023) |
| " Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation." | 4.12 | Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022) |
| "The current work aimed to examine the properties of oral supplementation of niacinamide and undenatured type II collagen (UCII) on the inflammation and joint pain behavior of rats with osteoarthritis (OA)." | 4.02 | Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis. ( Durmus, AS; Juturu, V; Kucuk, O; Orhan, C; Ozercan, IH; Sahin, K; Sahin, N; Tuzcu, M, 2021) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 3.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 3.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Eplerenone treatment produced a significant improvement in motor coordination and spontaneous locomotor activity in rats and modulated the key inflammatory mediators in OA (TNF-α, NF-κβ, and IL-6)." | 1.91 | Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis. ( Mostafa, RE; Salama, AAA, 2023) |
| "Acute oral toxicity of m-PGA resulted in LD50 values in excess of 2000 mg/kg." | 1.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | 1.51 | Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects." | 1.43 | The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse. ( Malcangio, M; Pitcher, T; Sousa-Valente, J, 2016) |
| "Chronic inflammation is one of the major causes of cartilage destruction in osteoarthritis." | 1.37 | Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis. ( Agarwal, S; Butterfield, TA; Deschner, J; Gassner, R; Liu, J; Nam, J; Perera, P; Rath, B, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (45.45) | 24.3611 |
| 2020's | 16 (48.48) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, M | 1 |
| Kim, GH | 2 |
| Kim, M | 1 |
| Seo, JM | 1 |
| Kim, YM | 1 |
| Seon, MR | 1 |
| Um, S | 1 |
| Choi, SJ | 1 |
| Oh, W | 1 |
| Song, BR | 1 |
| Jin, HJ | 1 |
| Novikov, FN | 1 |
| Panova, MV | 1 |
| Titov, IY | 1 |
| Stroylov, VS | 1 |
| Stroganov, OV | 1 |
| Chilov, GG | 1 |
| Na, HS | 4 |
| Woo, JS | 2 |
| Kim, JH | 1 |
| Lee, JS | 2 |
| Um, IG | 2 |
| Cho, KH | 3 |
| Cho, ML | 5 |
| Chung, SJ | 1 |
| Park, SH | 4 |
| Lee, SY | 2 |
| Lee, DH | 1 |
| Choi, SY | 1 |
| Kim, SA | 1 |
| Go, EJ | 1 |
| Lee, AR | 1 |
| Choi, JW | 1 |
| Kim, SJ | 2 |
| Mostafa, RE | 1 |
| Salama, AAA | 1 |
| Kwon, M | 1 |
| Nam, D | 1 |
| Kim, J | 2 |
| Teng, L | 1 |
| Shen, Y | 2 |
| Qu, Y | 1 |
| Yang, L | 1 |
| Yang, Y | 1 |
| Jian, X | 1 |
| Fan, S | 1 |
| Zhang, L | 1 |
| Fu, Q | 1 |
| Oh, DK | 1 |
| Jhun, JY | 2 |
| Park, MS | 1 |
| Cordaro, M | 1 |
| Siracusa, R | 1 |
| Impellizzeri, D | 1 |
| D' Amico, R | 1 |
| Peritore, AF | 1 |
| Crupi, R | 1 |
| Gugliandolo, E | 1 |
| Fusco, R | 1 |
| Di Paola, R | 1 |
| Schievano, C | 1 |
| Cuzzocrea, S | 1 |
| Sa, L | 1 |
| Wei, X | 1 |
| Huang, Q | 1 |
| Cai, Y | 1 |
| Lu, D | 1 |
| Mei, R | 1 |
| Hu, X | 1 |
| Park, JS | 1 |
| Kwon, JY | 1 |
| Choi, J | 1 |
| Jhun, J | 1 |
| Lee, H | 1 |
| Kim, H | 1 |
| Seo, J | 1 |
| Choi, K | 1 |
| Lee, Y | 1 |
| Park, K | 1 |
| Kim, S | 1 |
| Mobasheri, A | 1 |
| Choi, H | 1 |
| Park, H | 1 |
| Hong, J | 1 |
| Yin, Y | 1 |
| Joo, Y | 1 |
| Kim, Y | 1 |
| Shin, J | 1 |
| Kwon, HH | 1 |
| Shin, N | 1 |
| Shin, HJ | 1 |
| Beom, J | 1 |
| Kim, DW | 1 |
| Tian, Y | 1 |
| Gou, J | 1 |
| Zhang, H | 1 |
| Lu, J | 1 |
| Jin, Z | 1 |
| Jia, S | 1 |
| Bai, L | 1 |
| Li, M | 1 |
| Xiao, YB | 1 |
| Wang, XT | 1 |
| Zhuang, JP | 1 |
| Zhou, CL | 1 |
| Sahin, K | 1 |
| Kucuk, O | 1 |
| Orhan, C | 1 |
| Tuzcu, M | 1 |
| Durmus, AS | 1 |
| Ozercan, IH | 1 |
| Sahin, N | 1 |
| Juturu, V | 1 |
| Pan, L | 1 |
| Ding, W | 1 |
| Li, J | 1 |
| Gan, K | 1 |
| Xu, J | 1 |
| Zheng, M | 1 |
| Micheli, L | 1 |
| Di Cesare Mannelli, L | 1 |
| Lucarini, E | 1 |
| Cialdai, F | 1 |
| Vignali, L | 1 |
| Ghelardini, C | 1 |
| Monici, M | 1 |
| Park, YJ | 1 |
| Cho, YR | 1 |
| Oh, JS | 1 |
| Ahn, EK | 1 |
| Philpott, HT | 1 |
| O'Brien, M | 1 |
| McDougall, JJ | 1 |
| Wenzhao, L | 1 |
| Jiangdong, N | 1 |
| Deye, S | 1 |
| Muliang, D | 1 |
| Junjie, W | 1 |
| Xianzhe, H | 1 |
| Mingming, Y | 1 |
| Jun, H | 1 |
| Carcolé, M | 1 |
| Kummer, S | 1 |
| Gonçalves, L | 1 |
| Zamanillo, D | 1 |
| Merlos, M | 1 |
| Dickenson, AH | 1 |
| Fernández-Pastor, B | 1 |
| Cabañero, D | 1 |
| Maldonado, R | 1 |
| Lee, J | 1 |
| Hong, YS | 1 |
| Jeong, JH | 1 |
| Yang, EJ | 1 |
| Park, MK | 1 |
| Jung, YO | 1 |
| Min, JK | 1 |
| Kim, HY | 1 |
| Yassin, NZ | 1 |
| El-Shenawy, SM | 1 |
| Abdel-Rahman, RF | 1 |
| Yakoot, M | 1 |
| Hassan, M | 1 |
| Helmy, S | 1 |
| Ogbonna, AC | 1 |
| Clark, AK | 1 |
| Malcangio, M | 2 |
| Moilanen, LJ | 1 |
| Hämäläinen, M | 1 |
| Nummenmaa, E | 1 |
| Ilmarinen, P | 1 |
| Vuolteenaho, K | 1 |
| Nieminen, RM | 1 |
| Lehtimäki, L | 1 |
| Moilanen, E | 1 |
| Pitcher, T | 1 |
| Sousa-Valente, J | 1 |
| Meesawatsom, P | 1 |
| Burston, J | 1 |
| Hathway, G | 1 |
| Bennett, A | 1 |
| Chapman, V | 1 |
| Orita, S | 1 |
| Ishikawa, T | 1 |
| Miyagi, M | 1 |
| Ochiai, N | 1 |
| Inoue, G | 1 |
| Eguchi, Y | 1 |
| Kamoda, H | 1 |
| Arai, G | 1 |
| Toyone, T | 1 |
| Aoki, Y | 1 |
| Kubo, T | 1 |
| Takahashi, K | 1 |
| Ohtori, S | 1 |
| Nam, J | 1 |
| Perera, P | 1 |
| Liu, J | 1 |
| Rath, B | 1 |
| Deschner, J | 1 |
| Gassner, R | 1 |
| Butterfield, TA | 1 |
| Agarwal, S | 1 |
| Izumi, M | 1 |
| Ikeuchi, M | 1 |
| Ji, Q | 1 |
| Tani, T | 1 |
| STENGER, EG | 1 |
| KOHLER, V | 1 |
| SCHARF, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Cannabinoid Patch for Knee Osteoarthritis[NCT04412837] | Phase 2 | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to Inadequate funding) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
33 other studies available for iodoacetic acid and Innate Inflammatory Response
| Article | Year |
|---|---|
PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model.
Topics: Animals; C-Reactive Protein; Cytokines; Disease Models, Animal; Inflammation; Injections, Intra-Arti | 2021 |
Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cartilage; | 2021 |
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death.
Topics: Animals; Cartilage, Articular; Cell Death; Chondrocytes; Disease Models, Animal; Inflammation; Iodoa | 2022 |
Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Cartilage; Cartilage, Articular; Chemokine CCL2; Dis | 2022 |
Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Eplerenone; Humans; Inflammation; Iodoacetic | 2023 |
Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Inflammation; Iodoacetic Acid; Male; Osteoarthritis; Pain; Rats; X | 2023 |
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Topics: Animals; Apoptosis; Chondrocytes; Inflammation; Iodoacetic Acid; MAP Kinase Signaling System; NF-kap | 2023 |
Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Inflammation; Iodoacetic Acid; Osteoarthriti | 2023 |
Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain.
Topics: Analgesics; Animals; Carrageenan; Female; Glucosamine; Hyperalgesia; Inflammation; Iodoacetic Acid; | 2019 |
Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cartilage, Articular; Chondrocytes; Cytokines; Fema | 2020 |
Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured; Chondrocytes; H | 2020 |
TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement.
Topics: Animals; Arthritis, Experimental; Cell- and Tissue-Based Therapy; Chondrocytes; Genetic Therapy; Hum | 2020 |
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 3; Cartilage | 2020 |
The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Hydroxyeicosatetraenoic Acids; Inflammat | 2021 |
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 Alleviates Diabetes Mellitus-Osteoarthritis in Rats through Attenuating Synovial Inflammation and Cartilage Injury.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cartilage, Articular; Cytoskeletal Proteins; Diabetes | 2021 |
Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Collagen Type II; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Inflam | 2021 |
Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression.
Topics: Aged; Aldehyde Dehydrogenase, Mitochondrial; Apoptosis; Aquaporin 4; Chondrocytes; Humans; Inflammat | 2021 |
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat.
Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Inflammation; Infrared Rays; Injections, Intra-A | 2017 |
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats.
Topics: Animals; Bone and Bones; Cartilage; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Female; Inf | 2017 |
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
Topics: Animals; Arthralgia; Cannabidiol; Disease Models, Animal; Inflammation; Iodoacetic Acid; Knee Joint; | 2017 |
Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice.
Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Chondrocytes; Cytosol; Disease Models, Animal; Glycy | 2019 |
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2019 |
Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines.
Topics: Analgesics; Animals; Cartilage; Cytokines; Disease Models, Animal; Gene Expression Regulation; Infla | 2013 |
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A | 2015 |
Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice.
Topics: Aging; Animals; Arthritis, Experimental; Behavior, Animal; Immunohistochemistry; Inflammation; Iodoa | 2015 |
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Blotting, Western; Cells, Cultured; Chondrocytes; Dise | 2015 |
The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Chondrocytes; Disease Mode | 2016 |
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo | 2016 |
Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.
Topics: Animals; Arthralgia; Chronic Disease; Disease Models, Animal; Disease Progression; Female; Inflammat | 2011 |
Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis.
Topics: Animals; Arthritis; Bone and Bones; Cartilage, Articular; Cell Proliferation; Cluster Analysis; Dise | 2011 |
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis.
Topics: Acid Sensing Ion Channels; Animals; Behavior, Animal; Cnidarian Venoms; Gene Expression Regulation; | 2012 |
[Antiphlogistic effect of phenylbutazone in calcium cyanide-, monoiodo-acetic acid- and sodium fluoride-induced edema of rat paw].
Topics: Animals; Calcium; Cyanides; Edema; Inflammation; Iodoacetic Acid; Phenylbutazone; Rats; Sodium Fluor | 1958 |
[Importance of metabolic processes sensitive to mono-iodoacetic acid for tissue inflammation].
Topics: Humans; Inflammation; Iodoacetic Acid | 1951 |