iodoacetic acid has been researched along with Disease Models, Animal in 167 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation." | 8.12 | Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022) |
| " The extract significantly and dose-dependently reduced cartilage erosion, bone loss, cartilage catabolic changes, serum osteoporotic-osteoarthritis biomarkers (procollagen-type-II-N-terminal-propeptide PIINP; procollagen-type-I-N-terminal-propeptide PINP; osteocalcin), inflammation (IL-1β) and mRNA expressions for nuclear-factor-kappa-beta NF-κβ, interleukin-1-beta IL-1β, cyclooxygenase-2; and matrix-metalloproteinase-13 MMP13 activities, in osteoporotic-osteoarthritis rats comparable to Diclofenac." | 7.96 | Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| "The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model." | 7.96 | Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. ( Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ, 2020) |
| "We investigated structural changes in the retina by using optical coherence tomography (OCT) in a feline model of retinal degeneration using iodoacetic acid (IAA)." | 7.91 | Analysis of Changes in Retinal Photoreceptors Using Optical Coherence Tomography in a Feline Model of Iodoacetic Acid-induced Retinal Degeneration. ( Lee, MS; Lee, SJ; Lee, SU; Lim, JW; Noh, GM, 2019) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 7.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| "After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin." | 7.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate." | 5.56 | Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 5.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| "Animal models with pharmacologically induced retinal degeneration including sodium iodate (NaIO3) and N-methyl-N-nitrosourea (MNU) have been extensively used in ophthalmic research to investigate retinal degeneration." | 4.95 | What Can Pharmacological Models of Retinal Degeneration Tell Us? ( Balmer, JM; Enzmann, V; Reisenhofer, MH, 2017) |
| " Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation." | 4.12 | Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022) |
| "The current work aimed to examine the properties of oral supplementation of niacinamide and undenatured type II collagen (UCII) on the inflammation and joint pain behavior of rats with osteoarthritis (OA)." | 4.02 | Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis. ( Durmus, AS; Juturu, V; Kucuk, O; Orhan, C; Ozercan, IH; Sahin, K; Sahin, N; Tuzcu, M, 2021) |
| " Osteoarthritis was induced in male adult control Wistar rats without any interventions and in Wisket rats after juvenile social isolation and ketamine treatment." | 3.96 | Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020) |
| " The extract significantly and dose-dependently reduced cartilage erosion, bone loss, cartilage catabolic changes, serum osteoporotic-osteoarthritis biomarkers (procollagen-type-II-N-terminal-propeptide PIINP; procollagen-type-I-N-terminal-propeptide PINP; osteocalcin), inflammation (IL-1β) and mRNA expressions for nuclear-factor-kappa-beta NF-κβ, interleukin-1-beta IL-1β, cyclooxygenase-2; and matrix-metalloproteinase-13 MMP13 activities, in osteoporotic-osteoarthritis rats comparable to Diclofenac." | 3.96 | Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| "The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model." | 3.96 | Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. ( Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ, 2020) |
| "We investigated structural changes in the retina by using optical coherence tomography (OCT) in a feline model of retinal degeneration using iodoacetic acid (IAA)." | 3.91 | Analysis of Changes in Retinal Photoreceptors Using Optical Coherence Tomography in a Feline Model of Iodoacetic Acid-induced Retinal Degeneration. ( Lee, MS; Lee, SJ; Lee, SU; Lim, JW; Noh, GM, 2019) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 3.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| " longa (PCL) against monosodium iodoacetate (MIA) induced osteoarthritis in rat and to compare with curcuminoids, which are contemporarily believed to be the only active phytochemicals of C." | 3.85 | Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats. ( Bethapudi, B; Chandrasekaran, PR; Murugan, S; Purusothaman, D; Velusami, CC, 2017) |
| "After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin." | 3.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Ebselen has tremendous pharmacological importance for some diseases due to its antioxidant, antiapoptotic, and anti-inflammatory features." | 1.91 | Ebselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritis. ( Kaçmaz, F; Kalacı, A; Karaboğa, İ; Okuyan, HM; Yurtal, Z, 2023) |
| "Eplerenone treatment produced a significant improvement in motor coordination and spontaneous locomotor activity in rats and modulated the key inflammatory mediators in OA (TNF-α, NF-κβ, and IL-6)." | 1.91 | Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis. ( Mostafa, RE; Salama, AAA, 2023) |
| "Chronic joint pain is common in patients with osteoarthritis (OA)." | 1.72 | Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis. ( Chao, D; Hogan, QH; Pan, B; Tran, H, 2022) |
| "Low back pain is one of the most common musculoskeletal disorders." | 1.72 | Development of a novel model of intervertebral disc degeneration by the intradiscal application of monosodium iodoacetate (MIA) in rat. ( Cho, HY; Han, HC; Suh, HR, 2022) |
| "Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom." | 1.72 | Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice. ( Elisei, L; Galdino, G; Malta, I; Moraes, T; Novaes, R, 2022) |
| "Clinically, chronic pain is the most common and disabling symptom of osteoarthritis (OA)." | 1.62 | Reduction of SIRT1 Mediates Monosodium Iodoacetate-Induced Osteoarthritic Pain by Upregulating p53 Expression in Rats. ( Chen, LM; Liu, CC; Wang, XP; Wu, GH; Xu, LJ, 2021) |
| "Knee osteoarthritis is a degenerative condition accompanied by chronic pain." | 1.56 | Laser irradiation activates spinal adenosine A1 receptor to alleviate osteoarthritis pain in monosodium iodoacetate injected rats. ( Lao, LX; Li, Y; Shen, XY; Wu, F, 2020) |
| " Further fine tuning of alginate formulation and effective dosage for might be required in order to improve therapeutic efficacy depending on the target disease." | 1.56 | MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study. ( Bernsen, M; Bos, PK; Haeck, J; Khatab, S; Kops, N; Leijs, MJ; Nieboer, M; van Buul, G; van Osch, GJVM; Verhaar, JAN, 2020) |
| "Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate." | 1.56 | Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| "Knee Osteoarthritis is a considerable public health concern, both in terms of life quality and treatment financial impacts." | 1.56 | Animal models of osteoarthritis: characterization of a model induced by Mono-Iodo-Acetate injected in rabbits. ( Abdelhedi, O; Charfi, S; Frikha, R; Keskes, H; Keskes, K; Rebai, MA; Sahnoun, N; Slimi, F, 2020) |
| "Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control." | 1.51 | Animal Models for the Study of Bone-Derived Pain. ( Largent-Milnes, TM; Thompson, AL; Vanderah, TW, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | 1.51 | Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "Osteoarthritis was induced through a single intra-articular injection of monosodium iodoacetate in both knee joints." | 1.48 | Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model. ( Hoso, M; Kuroki, H; Matsuzaki, T; Takahashi, I, 2018) |
| " However, it is unknown whether the antalgic gait caused by MIA is associated with severity of degeneration from the high dosage or the whole-joint degeneration associated with glycolysis inhibition." | 1.48 | Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis. ( Allen, KD; Lakes, EH, 2018) |
| "Two models of OA joint pain were used for the mechanistic studies." | 1.46 | Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. ( Ashraf, S; Barrett, DA; Bennett, AJ; Burston, JJ; Chapman, V; Huang, J; Li, L; Mapp, PI; Pousinis, P; Ravipati, S; Scammell, BE, 2017) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 1.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| "To assess neural correlates of mechanical hyperalgesia, hindpaws were stimulated with von Frey hairs (8 g: MIA; 15 g: control knee, based on behavioral withdrawal responses)." | 1.43 | Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. ( Abaei, M; Auer, DP; Chapman, V; Prior, M; Sagar, DR; Spicer, CH; Stockley, EG, 2016) |
| "The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects." | 1.43 | The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse. ( Malcangio, M; Pitcher, T; Sousa-Valente, J, 2016) |
| "Iodoacetic acid (IAA) has been applied to different species to acutely induce photoreceptor degeneration." | 1.39 | Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat. ( Gao, J; Huang, X; Li, X; Nan, Y; Pu, M; Ren, C; Zhang, Q, 2013) |
| "Inflammation and osteophyte scores were greater in MNX model compared to the MIA model." | 1.39 | Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. ( Ashraf, S; Burston, JJ; Chapman, V; Mapp, PI; Sagar, DR; Suri, S; Walsh, DA, 2013) |
| "Joint pain is a common clinical problem for which both inflammatory and degenerative joint diseases are major causes." | 1.39 | Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. ( Aracil-Fernández, A; Bura, SA; La Porta, C; Maldonado, R; Manzanares, J, 2013) |
| "Osteoarthritis was produced by single intra-articular injection of the MIA in the right knee joint on day 0." | 1.39 | Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Gupta, G; Kumar, D; Kumari, RR; Lingaraju, MC; More, AS; Pathak, NN; Sharma, AK; Tandan, SK, 2013) |
| "The effect of Nav1." | 1.38 | Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. ( McDougall, JJ; Schuelert, N, 2012) |
| "Osteoarthritis was induced by injection with a chemical (mono-iodoacetate), a surgical intervention (grooves applied in articular cartilage), and via exercise (strenuous running)." | 1.37 | Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models. ( Kops, N; Oei, EH; Piscaer, TM; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2011) |
| "The pain measures reached maximum on the fifht day, then remained relatively stable." | 1.35 | Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. ( Dolezal, T; Krsiak, M; Prochazkova, M; Prokesova, L; Zanvit, P, 2009) |
| " Furthermore, in an additional study animals were orally dosed vehicle (5 ml/kg), naproxen (0." | 1.34 | Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. ( Ball, AD; Heapy, CG; Ivanavicius, SP; Murray, F; Read, SJ; Westwood, RF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.80) | 18.7374 |
| 1990's | 6 (3.59) | 18.2507 |
| 2000's | 7 (4.19) | 29.6817 |
| 2010's | 82 (49.10) | 24.3611 |
| 2020's | 69 (41.32) | 2.80 |
| Authors | Studies |
|---|---|
| Malta, I | 1 |
| Moraes, T | 1 |
| Elisei, L | 1 |
| Novaes, R | 1 |
| Galdino, G | 1 |
| Lee, M | 2 |
| Kim, GH | 2 |
| Kim, M | 1 |
| Seo, JM | 1 |
| Kim, YM | 1 |
| Seon, MR | 1 |
| Um, S | 1 |
| Choi, SJ | 1 |
| Oh, W | 1 |
| Song, BR | 1 |
| Jin, HJ | 1 |
| Zhang, X | 1 |
| Chen, R | 1 |
| Liao, Z | 1 |
| Zhu, Y | 1 |
| Chen, Y | 1 |
| Liu, J | 1 |
| Chen, X | 1 |
| Xu, LJ | 1 |
| Liu, CC | 1 |
| Chen, LM | 1 |
| Wu, GH | 1 |
| Wang, XP | 1 |
| Kanno, K | 1 |
| Suzuki-Narita, M | 2 |
| Kawarai, Y | 4 |
| Hagiwara, S | 5 |
| Yoh, S | 2 |
| Nakamura, J | 7 |
| Orita, S | 9 |
| Inage, K | 4 |
| Suzuki, T | 7 |
| Ohtori, S | 10 |
| Zhang, H | 3 |
| Ding, L | 1 |
| Shi, X | 2 |
| Mei, W | 3 |
| Huang, Z | 2 |
| Zhang, L | 4 |
| Li, X | 5 |
| Xu, B | 2 |
| Wang, P | 3 |
| Novikov, FN | 1 |
| Panova, MV | 1 |
| Titov, IY | 1 |
| Stroylov, VS | 1 |
| Stroganov, OV | 1 |
| Chilov, GG | 1 |
| Sudo, T | 1 |
| Akeda, K | 1 |
| Kawaguchi, K | 1 |
| Hasegawa, T | 1 |
| Yamada, J | 1 |
| Inoue, N | 1 |
| Masuda, K | 1 |
| Sudo, A | 1 |
| Han, FY | 1 |
| Brockman, DA | 1 |
| Nicholson, JR | 1 |
| Corradini, L | 1 |
| Smith, MT | 1 |
| Aborehab, NM | 1 |
| El Bishbishy, MH | 1 |
| Orhan, C | 3 |
| Tuzcu, M | 2 |
| Durmus, AS | 2 |
| Sahin, N | 2 |
| Ozercan, IH | 2 |
| Deeh, PBD | 1 |
| Morde, A | 1 |
| Bhanuse, P | 1 |
| Acharya, M | 1 |
| Padigaru, M | 1 |
| Sahin, K | 3 |
| Miyamoto, S | 4 |
| Akazawa, T | 2 |
| Shiko, Y | 1 |
| Kawasaki, Y | 1 |
| Na, HS | 3 |
| Woo, JS | 2 |
| Kim, JH | 1 |
| Lee, JS | 1 |
| Um, IG | 1 |
| Cho, KH | 3 |
| Cho, ML | 5 |
| Chung, SJ | 1 |
| Park, SH | 3 |
| Chao, D | 1 |
| Tran, H | 1 |
| Hogan, QH | 1 |
| Pan, B | 1 |
| Lee, YS | 2 |
| Kim, SM | 2 |
| Park, EJ | 1 |
| Lee, HJ | 2 |
| Lee, SY | 2 |
| Lee, DH | 1 |
| Choi, SY | 2 |
| Kim, SA | 3 |
| Go, EJ | 3 |
| Lee, AR | 1 |
| Choi, JW | 1 |
| Kim, SJ | 4 |
| Lee, KS | 1 |
| Shetty, AA | 1 |
| Arai, T | 1 |
| Takeuchi, J | 1 |
| Tajiri, I | 1 |
| Eguchi, Y | 2 |
| Shiga, Y | 1 |
| Hozumi, T | 1 |
| Kim, G | 1 |
| Tsuchiya, R | 1 |
| Otagiri, T | 1 |
| Mukaihata, T | 1 |
| Hishiya, T | 1 |
| Toshi, N | 1 |
| Okuyama, K | 1 |
| Tokeshi, S | 1 |
| Furuya, T | 1 |
| Maki, S | 1 |
| Matsuura, Y | 1 |
| Okuyan, HM | 1 |
| Yurtal, Z | 1 |
| Karaboğa, İ | 1 |
| Kaçmaz, F | 1 |
| Kalacı, A | 1 |
| Chen, C | 3 |
| Zhou, H | 3 |
| Yin, Y | 5 |
| Hu, H | 3 |
| Jiang, B | 3 |
| Zhang, K | 3 |
| Wu, S | 3 |
| Shen, M | 3 |
| Wang, Z | 3 |
| Rabie, MA | 1 |
| Sayed, RH | 1 |
| Venkatesan, JK | 1 |
| Madry, H | 1 |
| Cucchiarini, M | 1 |
| El Sayed, NS | 1 |
| Mostafa, RE | 1 |
| Salama, AAA | 1 |
| Barry, F | 1 |
| Chai, F | 1 |
| Chijcheapaza-Flores, H | 1 |
| Garcia-Fernandez, MJ | 1 |
| Blanchemain, N | 1 |
| Nicot, R | 1 |
| Fang, Z | 1 |
| Lei, S | 1 |
| Feng, S | 1 |
| Zhou, C | 1 |
| Tong, X | 1 |
| Han, R | 1 |
| Jarecki, J | 1 |
| Polkowska, I | 1 |
| Kazimierczak, W | 1 |
| Wójciak, M | 1 |
| Sowa, I | 1 |
| Dresler, S | 1 |
| Blicharski, T | 1 |
| Elmounedi, N | 1 |
| Bahloul, W | 1 |
| Guidara, AR | 1 |
| Aoui, M | 1 |
| Trigui, M | 1 |
| Keskes, H | 2 |
| Ise, S | 1 |
| Ochiai, N | 2 |
| Hashimoto, E | 1 |
| Hirosawa, N | 1 |
| Kajiwara, D | 1 |
| Shimada, Y | 1 |
| Inagaki, K | 1 |
| Hiraoka, Y | 1 |
| Hattori, F | 1 |
| Sahin, E | 1 |
| Erten, F | 1 |
| Saiyed, Z | 1 |
| Azari, EK | 1 |
| Durkee, S | 1 |
| Wang, X | 1 |
| Song, J | 1 |
| Xia, P | 1 |
| Lin, Q | 1 |
| Chen, A | 1 |
| Cheng, K | 1 |
| Kong, F | 1 |
| Shi, Y | 1 |
| Yun, SY | 1 |
| Kim, Y | 3 |
| Kim, H | 2 |
| Lee, BK | 1 |
| Sun, J | 1 |
| Wang, XH | 1 |
| Song, FH | 1 |
| Li, DY | 1 |
| Gao, SJ | 1 |
| Zhang, LQ | 1 |
| Wu, JY | 1 |
| Liu, DQ | 1 |
| Wang, LW | 1 |
| Zhou, YQ | 1 |
| Zahid, A | 1 |
| Qamar, K | 1 |
| Tabassum, A | 1 |
| Abaid, M | 1 |
| Bashir Kiani, MR | 1 |
| Aslam, M | 1 |
| Sakamoto, J | 1 |
| Miyahara, S | 1 |
| Motokawa, S | 1 |
| Takahashi, A | 1 |
| Sasaki, R | 1 |
| Honda, Y | 1 |
| Okita, M | 1 |
| Saber, MM | 1 |
| Mahmoud, MM | 1 |
| Amin, HM | 1 |
| Essam, RM | 1 |
| Santiago, LÂM | 1 |
| Ataíde, ACS | 1 |
| de Araújo Morais, D | 1 |
| da Silva Lima, A | 1 |
| Dos Santos Martins, N | 1 |
| Dourado, AVCA | 1 |
| Ribeiro, RM | 1 |
| Lima-Neto, LG | 1 |
| de Sá Sousa, JC | 1 |
| da Rocha, CQ | 1 |
| de Sousa Cartágenes, MDS | 1 |
| Carvalho, RC | 1 |
| de Sousa, EM | 1 |
| Yu, Y | 1 |
| Park, K | 1 |
| Kim, HJ | 1 |
| Kim, JG | 1 |
| Kim, SE | 1 |
| Suzuki, M | 4 |
| Nakajima, T | 3 |
| Zavatti, M | 1 |
| Beretti, F | 1 |
| Casciaro, F | 1 |
| Bertucci, E | 1 |
| Maraldi, T | 1 |
| Banki, L | 1 |
| Büki, A | 1 |
| Horvath, G | 1 |
| Kekesi, G | 1 |
| Kis, G | 1 |
| Somogyvári, F | 1 |
| Jancsó, G | 1 |
| Vécsei, L | 1 |
| Varga, E | 1 |
| Tuboly, G | 1 |
| Tian, L | 1 |
| Su, Z | 1 |
| Ma, X | 1 |
| Wang, F | 2 |
| Guo, Y | 1 |
| Choi, DJ | 1 |
| Choi, SI | 1 |
| Choi, BR | 1 |
| Lee, DY | 1 |
| Kim, GS | 1 |
| Noh, GM | 1 |
| Lim, JW | 1 |
| Lee, MS | 1 |
| Lee, SU | 1 |
| Lee, SJ | 2 |
| Khotib, J | 1 |
| Utami, NW | 1 |
| Gani, MA | 1 |
| Ardianto, C | 1 |
| Li, Y | 2 |
| Wu, F | 2 |
| Wei, J | 1 |
| Lao, L | 1 |
| Shen, X | 1 |
| Barone, F | 1 |
| Muscatello, LV | 1 |
| Ventrella, D | 1 |
| Elmi, A | 1 |
| Romagnoli, N | 1 |
| Mandrioli, L | 1 |
| Maya-Vetencourt, JF | 1 |
| Bombardi, C | 1 |
| Mete, M | 1 |
| Sarli, G | 1 |
| Benfenati, F | 1 |
| Pertile, G | 1 |
| Bacci, ML | 1 |
| Lecocq, M | 1 |
| Linares, JM | 1 |
| Chaves-Jacob, J | 1 |
| Coyle, T | 1 |
| Roffino, S | 1 |
| Eyraud, M | 1 |
| Gigmes, D | 1 |
| Decherchi, P | 1 |
| Dousset, E | 1 |
| Rebai, MA | 1 |
| Sahnoun, N | 1 |
| Abdelhedi, O | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Cannabinoid Patch for Knee Osteoarthritis[NCT04412837] | Phase 2 | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to Inadequate funding) | ||
| Randomized Controlled Trial of Exercise Therapy in Combination With Central Nervous System-targeted Treatment Compared With Exercise Therapy Alone for Treatment of People With Knee Osteoarthritis[NCT03681613] | 104 participants (Anticipated) | Interventional | 2019-01-07 | Recruiting | |||
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis[NCT03479502] | Phase 4 | 1 participants (Actual) | Interventional | 2018-01-05 | Terminated (stopped due to Lack of personnel to help with recruiting) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for iodoacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
What Can Pharmacological Models of Retinal Degeneration Tell Us?
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug-Related Side Effects and Adverse Reacti | 2017 |
[Experimental arthrosis].
Topics: Adrenal Cortex Hormones; Animals; Disease Models, Animal; Enzyme Induction; Humans; Immobilization; | 1982 |
2 trials available for iodoacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
A Combination of Surgical and Chemical Induction in a Rabbit Model for Osteoarthritis of the Knee.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Iodoacetic Acid; | 2022 |
A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee.
Topics: Aged; Animals; Body Mass Index; Body Weight; Boswellia; Curcuma; Cytokines; Disease Models, Animal; | 2018 |
163 other studies available for iodoacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Male; Mice; Neuroglia; Nociception; Osteoarthritis | 2022 |
PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model.
Topics: Animals; C-Reactive Protein; Cytokines; Disease Models, Animal; Inflammation; Injections, Intra-Arti | 2021 |
The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium Iodoacetate Induced Osteoarthritis.
Topics: Animals; Cartilage, Articular; Cytokines; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; P | 2022 |
Reduction of SIRT1 Mediates Monosodium Iodoacetate-Induced Osteoarthritic Pain by Upregulating p53 Expression in Rats.
Topics: Animals; Chronic Pain; Disease Models, Animal; Iodoacetic Acid; Rats; Sirtuin 1; Spinal Cord Dorsal | 2021 |
Analgesic effects and arthritic changes following tramadol administration in a rat hip osteoarthritis model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Iodoacetic Acid; Male; | 2022 |
Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis.
Topics: Animals; Biomarkers; Disease Models, Animal; Down-Regulation; Fibroblasts; Fibrosis; Furocoumarins; | 2021 |
Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cartilage; | 2021 |
Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model.
Topics: Animals; Disease Models, Animal; Intervertebral Disc; Intervertebral Disc Degeneration; Iodoacetic A | 2021 |
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat.
Topics: Animals; Arthralgia; Behavior Observation Techniques; Behavior, Animal; Behavioral Symptoms; Disease | 2022 |
Chondroprotection of fruit peels in a monosodium iodoacetate-induced osteoarthritis rat model via downregulation of Col1A1.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Fruit; Iodoacetic Acid; Osteoart | 2022 |
Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Female; Iodoacetic Acid; Kn | 2022 |
Intra-articular injection of monoiodoacetate induces diverse hip osteoarthritis in rats, depending on its dose.
Topics: Animals; Disease Models, Animal; Humans; Injections, Intra-Articular; Iodoacetic Acid; Male; Osteoar | 2022 |
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death.
Topics: Animals; Cartilage, Articular; Cell Death; Chondrocytes; Disease Models, Animal; Inflammation; Iodoa | 2022 |
Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ganglia, Spina | 2022 |
Anti-arthritic effects of Schisandra chinensis extract in monosodium iodoacetate-induced osteoarthritis rats.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Plant Extracts; Rats; Schisandra | 2022 |
Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Cartilage; Cartilage, Articular; Chemokine CCL2; Dis | 2022 |
Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Diclofenac; Disease Models, Animal; Hyaluronic | 2022 |
Ebselen, an Active Seleno-Organic Compound, Alleviates Articular Cartilage Degeneration in a Rat Model of Knee Osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Morphogenetic Protein 2; Cartilage, Articular | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Intra-articular injection of rAAV-hFGF-2 ameliorates monosodium iodoacetate-induced osteoarthritis in rats via inhibiting TLR-4 signaling and activating TIMP-1.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Fibroblast Growth Factor 2; Humans; Injection | 2023 |
Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Eplerenone; Humans; Inflammation; Iodoacetic | 2023 |
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.
Topics: Animals; Arthralgia; Collagenases; Disease Models, Animal; Drug Delivery Systems; Injections, Intra- | 2023 |
Protective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Disease Models, Animal; Drugs, Chinese Herb | 2023 |
Assessment of the Impact of Physical Activity on the Musculoskeletal System in Early Degenerative Knee Joint Lesions in an Animal Model.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Knee Joint; Male; Models, Animal; Muscular Atrophy | 2023 |
Establishment of an Animal Model of Disk Degeneration by Intradiskal Injection of Monosodium Iodoacetate.
Topics: Animals; Disease Models, Animal; Injections; Intervertebral Disc Degeneration; Iodoacetic Acid; Rats | 2023 |
Evaluation of articular changes using a rat mono-iodoacetate-induced shoulder arthritis model by histology and radiology.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Radiology; R | 2023 |
The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats.
Topics: Administration, Oral; Animals; Cartilage, Articular; Collagen Type II; Disease Models, Animal; Iodoa | 2023 |
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; High-Intensity Interval Training; Hyperalgesia; Iodoacetic Acid; Os | 2023 |
Effective Technical Protocol for Producing a Mono-Iodoacetate-Induced Temporomandibular Joint Osteoarthritis in a Rat Model.
Topics: Animals; Bone Remodeling; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Pain; Rats; Tempo | 2023 |
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Hyperalgesia; Iodoacetic Acid; Neuroinflammat | 2023 |
Ameliorative Effects of Prolotherapy on Histomorphology of Tibial Articular Cartilage of Chemically Induced Osteoarthritic Knee Joint in a Rat Model.
Topics: Cartilage, Articular; Disease Models, Animal; Injections, Intra-Articular; Iodoacetic Acid; Osteoart | 2023 |
Regular walking exercise prior to knee osteoarthritis reduces joint pain in an animal model.
Topics: Animals; Arthralgia; Cartilage, Articular; Disease Models, Animal; Iodoacetic Acid; Knee Joint; Male | 2023 |
Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model.
Topics: Animals; Cartilage, Articular; Curcumin; Disease Models, Animal; Iodoacetic Acid; MicroRNAs; Osteoar | 2023 |
Bixa orellana ethyl acetate fraction and its isolated compound ellagic acid attenuate the progression of MIA-induced osteoarthritis in rat knees.
Topics: Animals; Bixaceae; Cartilage, Articular; Disease Models, Animal; Ellagic Acid; Iodoacetates; Iodoace | 2023 |
Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Disease Models, Animal; Interleukin-10; Int | 2023 |
Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Evaluation, Precl | 2020 |
Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate-induced animal model of osteoarthritis.
Topics: Amniotic Fluid; Animals; Disease Models, Animal; Exosomes; Humans; Iodoacetic Acid; Osteoarthritis; | 2020 |
Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia.
Topics: Analgesics, Opioid; Animals; Ankle Joint; Brain; Brain Stem; Chronic Pain; Diencephalon; Disease Mod | 2020 |
Inhibition of miR-203 Ameliorates Osteoarthritis Cartilage Degradation in the Postmenopausal Rat Model: Involvement of Estrogen Receptor α.
Topics: 3' Untranslated Regions; Aggrecans; Animals; Antagomirs; Cartilage; Collagen Type II; Disease Models | 2019 |
Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Astragalus propinquus; Cartilage, Articular; Cell Lin | 2019 |
Analysis of Changes in Retinal Photoreceptors Using Optical Coherence Tomography in a Feline Model of Iodoacetic Acid-induced Retinal Degeneration.
Topics: Animals; Axial Length, Eye; Blood Glucose; Body Weight; Cats; Disease Models, Animal; Enzyme Inhibit | 2019 |
The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2019 |
Laser Moxibustion Alleviates Knee Osteoarthritis Pain by Inhibiting Spinal Microglial Activation-Mediated Neuroinflammation in Rats.
Topics: Animals; Cytokines; Disease Models, Animal; Iodoacetic Acid; Low-Level Light Therapy; Male; Microgli | 2020 |
The porcine iodoacetic acid model of retinal degeneration: Morpho-functional characterization of the visual system.
Topics: Animals; Disease Models, Animal; Electroretinography; Enzyme Inhibitors; Female; Iodoacetic Acid; Ma | 2020 |
Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis.
Topics: Afferent Pathways; Alloys; Animals; Arthroplasty, Replacement, Knee; Benzophenones; Disease Models, | 2020 |
Animal models of osteoarthritis: characterization of a model induced by Mono-Iodo-Acetate injected in rabbits.
Topics: Animals; Bursa, Synovial; Canada; Cartilage; Chondrocytes; Disease Models, Animal; Enzyme Inhibitors | 2020 |
Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Chondroitin Sulfates; Disease Models, Animal | 2020 |
p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Humans; Iodoacetic A | 2020 |
Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model.
Topics: Administration, Oral; Animals; Apigenin; Cytokines; Diclofenac; Disease Models, Animal; Dose-Respons | 2020 |
Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Arti | 2020 |
MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study.
Topics: Adult; Alginates; Animals; Cell Survival; Cell Tracking; Cells, Cultured; Disease Models, Animal; Fe | 2020 |
Intra-Articular Route for the System of Molecules 14G1862 from
Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper | 2020 |
Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Injections, Intra-Ar | 2020 |
Effect and mechanism of the CACNA2D1-CGRP pathway in osteoarthritis-induced ongoing pain.
Topics: Adenylyl Cyclases; Animals; Arthralgia; Calcitonin Gene-Related Peptide; Calcium Channels, L-Type; C | 2020 |
A Mixture Containing Fermented
Topics: Achyranthes; Animals; Cartilage, Articular; Cytokines; Dietary Supplements; Disease Models, Animal; | 2020 |
Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Fibroblasts; Flavonoids; | 2020 |
Laser irradiation activates spinal adenosine A1 receptor to alleviate osteoarthritis pain in monosodium iodoacetate injected rats.
Topics: Alkylating Agents; Analgesia; Animals; Behavior, Animal; Disease Models, Animal; Gene Expression Reg | 2020 |
Topics: Animals; Cissus; Disease Models, Animal; Disease Progression; Female; India; Iodoacetic Acid; Knee J | 2020 |
Synthesis of
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Bone and Bones; C-Reactive Protein; COVID | 2021 |
Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Disease Progression; Endocannabinoids; Gene Expr | 2020 |
Galactomannan of Delonix regia seeds reduces nociception and morphological damage in the rat model of osteoarthritis induced by sodium monoiodoacetate.
Topics: Analgesics; Animals; Disease Models, Animal; Fabaceae; Foot Joints; Galactose; Iodoacetic Acid; Male | 2021 |
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 3; Cartilage | 2020 |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis.
Topics: Animals; Antarctic Regions; Cartilage, Articular; Cytokines; Disease Models, Animal; Euphausiacea; I | 2020 |
Herbal Composition LI73014F2 Alleviates Articular Cartilage Damage and Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cartilage, Articular; Cytokines; Disease Models, Anim | 2020 |
Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Chitosan; Disease Models, Animal; Electron Transport | 2020 |
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antirheumatic Agents; Apoptosis; Autophagy; Cells, Cultured; | 2021 |
CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development.
Topics: Analgesics; Animals; Arthralgia; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal | 2021 |
Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity.
Topics: Adenosine Triphosphate; Animals; Arthralgia; Arthritis, Experimental; Disease Models, Animal; Female | 2021 |
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 Alleviates Diabetes Mellitus-Osteoarthritis in Rats through Attenuating Synovial Inflammation and Cartilage Injury.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cartilage, Articular; Cytoskeletal Proteins; Diabetes | 2021 |
Biosynthesis of gold nanoparticles for the treatment of osteoarthritis alone or in combination with Diacerein
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Chenopodium; Disease Models, Animal; Drug Therapy | 2021 |
Development of a novel model of intervertebral disc degeneration by the intradiscal application of monosodium iodoacetate (MIA) in rat.
Topics: Animals; Disease Models, Animal; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Iodo | 2022 |
Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Collagen Type II; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Inflam | 2021 |
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.
Topics: Anesthetics, Local; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Models, | 2017 |
Spinal neuropeptide modulation, functional assessment and cartilage lesions in a monosodium iodoacetate rat model of osteoarthritis.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Cartilage Diseases; Disease Models, Animal; Fe | 2017 |
Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model.
Topics: Animals; Autophagy; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; C | 2017 |
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat.
Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Inflammation; Infrared Rays; Injections, Intra-A | 2017 |
Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats.
Topics: Administration, Oral; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Hyperalgesia; Injec | 2017 |
Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model.
Topics: Animals; Arthritis, Experimental; Cartilage Diseases; Cartilage, Articular; Cyclooxygenase 2; Diseas | 2018 |
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats.
Topics: Animals; Bone and Bones; Cartilage; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Female; Inf | 2017 |
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
Topics: Animals; Arthralgia; Cannabidiol; Disease Models, Animal; Inflammation; Iodoacetic Acid; Knee Joint; | 2017 |
Efficacy of nerve growth factor antibody in a knee osteoarthritis pain model in mice.
Topics: Animals; Antibodies; Arthralgia; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Evalu | 2017 |
A rat model of knee osteoarthritis suitable for electroacupuncture study.
Topics: Animals; Bone and Bones; Cartilage, Articular; Disease Models, Animal; Electroacupuncture; Injection | 2018 |
Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model.
Topics: ADAMTS5 Protein; Animals; Calcitonin Gene-Related Peptide; Cartilage, Articular; Cell Adhesion Molec | 2018 |
Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats.
Topics: Animals; Collagen Type II; Curcuma; Disease Models, Animal; Female; Humans; Iodoacetic Acid; Male; M | 2017 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic | 2018 |
Development and characterization of various osteoarthritis models for tissue engineering.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Female; Guinea Pi | 2018 |
Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx.
Topics: Animals; Apoptosis; Calcium; Calcium Channels; Calcium Chelating Agents; Calmodulin; Cartilage, Arti | 2018 |
Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Fibrosis; Iodoacetic Acid; Male; Osteoarthrit | 2018 |
Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Enzyme Inhibitors; Gait; Iodoacetic Acid | 2018 |
Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expre | 2018 |
Protective Effects of
Topics: Animals; Anti-Inflammatory Agents; Apiaceae; Caspase 3; Caspase 7; Cytochrome P-450 CYP2D6; Disease | 2018 |
The Open Source GAITOR Suite for Rodent Gait Analysis.
Topics: Animals; Artifacts; Contracture; Disease Models, Animal; Extremities; Gait Analysis; Iodoacetic Acid | 2018 |
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg | 2019 |
Clinical magnetic resonance-enabled characterization of mono-iodoacetate-induced osteoarthritis in a large animal species.
Topics: Animals; Body Size; Disease Models, Animal; Disease Progression; Humans; Injections, Intra-Articular | 2018 |
Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone.
Topics: Animals; Arthralgia; Avoidance Learning; Behavior, Animal; Calcitonin Gene-Related Peptide; Cartilag | 2018 |
Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model.
Topics: Animals; Ascorbic Acid; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Injections, Intr | 2019 |
Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Carrageenan; Chondroitin Sulfates; Cytokines; Disease Models, Anim | 2019 |
An investigation into the noradrenergic and serotonergic contributions of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Animals; Diffuse Noxious Inhibitory Cont | 2019 |
Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors.
Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease | 2019 |
Characterisation of peripheral and central components of the rat monoiodoacetate model of Osteoarthritis.
Topics: Animals; Arthralgia; Cartilage, Articular; Disease Models, Animal; Ganglia, Spinal; Immunohistochemi | 2019 |
The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Administration, Intravenous; Animals; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured | 2018 |
Animal Models for the Study of Bone-Derived Pain.
Topics: Animals; Behavior, Animal; Bone and Bones; Bone Neoplasms; Cell Culture Techniques; Cell Line, Tumor | 2019 |
Vitamin E ameliorates alterations to the articular cartilage of knee joints induced by monoiodoacetate and diabetes mellitus in rats.
Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Diabetes Mellitus; Disease Models, Animal | 2019 |
Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice.
Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Chondrocytes; Cytosol; Disease Models, Animal; Glycy | 2019 |
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2019 |
Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat.
Topics: Animals; Blindness; Cats; Disease Models, Animal; Electroretinography; Female; Injections, Intraveno | 2013 |
Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.
Topics: Animals; Arthralgia; Behavior, Animal; Bone Density Conservation Agents; Bone Remodeling; Diphosphon | 2014 |
Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Disease Progression; | 2013 |
Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines.
Topics: Analgesics; Animals; Cartilage; Cytokines; Disease Models, Animal; Gene Expression Regulation; Infla | 2013 |
Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Disease Models, Animal; Electric Stimulation; El | 2013 |
Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Disease Models, Animal; En | 2013 |
Histology, glycosaminoglycan level and cartilage stiffness in monoiodoacetate-induced osteoarthritis: comparative analysis with anterior cruciate ligament transection in rat model and human osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Glycosaminoglycan | 2014 |
Mesenchymal stem cells reduce pain but not degenerative changes in a mono-iodoacetate rat model of osteoarthritis.
Topics: Animals; Arthralgia; Cell- and Tissue-Based Therapy; Disease Models, Animal; Injections, Intra-Artic | 2014 |
Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model.
Topics: Absorptiometry, Photon; Animals; Arthritis, Experimental; Bone Density; Cartilage, Articular; Diseas | 2014 |
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxe | 2014 |
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A | 2015 |
Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate.
Topics: Animals; Body Weight; Cartilage, Articular; Cytokines; Disease Models, Animal; Enzyme-Linked Immunos | 2015 |
Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis.
Topics: Animals; Calcium Channel Blockers; Caveolin 2; Disease Models, Animal; Evoked Potentials; Functional | 2015 |
Asian Elm tree inner bark prevents articular cartilage deterioration in ovariectomized obese rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Iodoac | 2016 |
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Blotting, Western; Cells, Cultured; Chondrocytes; Dise | 2015 |
Decreased calcitonin gene-related peptide expression in the dorsal root ganglia of TNF-deficient mice in a monoiodoacetate-induced knee osteoarthritis model.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme In | 2015 |
Intra-articular injection of mono-iodoacetate induces osteoarthritis of the hip in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Hip Joint; Injections, Intra-Arterial; Iodoace | 2016 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Ev | 2016 |
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Capsaicin; Disease Models, Animal; Electric Stimula | 2016 |
Preliminary investigation of the effects of topical mixture of Lawsonia inermis L. and Ricinus communis L. leaves extract in treatment of osteoarthritis using MIA model in rats.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug | 2016 |
The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Chondrocytes; Disease Mode | 2016 |
Pain-related behavior and the characteristics of dorsal-root ganglia in a rat model of hip osteoarthritis induced by mono-iodoacetate.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, | 2017 |
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo | 2016 |
Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Arthralgia; Behavior, Animal; Cartilage, Articular; D | 2017 |
Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Hyperalgesia; Injections, Intra-Articular; Io | 2016 |
Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Biopsy, Needle; Disease Models, Animal; Gait; | 2017 |
Pulsed electromagnetic field at different stages of knee osteoarthritis in rats induced by low-dose monosodium iodoacetate: Effect on subchondral trabecular bone microarchitecture and cartilage degradation.
Topics: Animals; Cancellous Bone; Cartilage, Articular; Collagen Type I; Collagen Type II; Disease Models, A | 2017 |
Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Hyperalgesia; | 2009 |
Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis.
Topics: Animals; Cartilage, Articular; Cell Proliferation; Cells, Cultured; Chondrocytes; Dinoprostone; Dise | 2008 |
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Topics: Animals; Cartilage, Articular; Cattle; Disease Models, Animal; Dose-Response Relationship, Drug; Enz | 2009 |
Correlation between high-resolution optical coherence tomography (OCT) images and histopathology in an iodoacetic acid-induced model of retinal degeneration in rabbits.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Iodoacetic Acid; Photoreceptor Cells, Vertebrate | 2011 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Dicl | 2011 |
Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Chondrocytes; Din | 2011 |
Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models.
Topics: Animals; Apoptosis; Arthrography; Cartilage, Articular; Chondrocytes; Cumulative Trauma Disorders; D | 2011 |
Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.
Topics: Animals; Arthralgia; Chronic Disease; Disease Models, Animal; Disease Progression; Female; Inflammat | 2011 |
Anatomical evidence of photoreceptor degeneration induced by iodoacetic acid in the porcine eye.
Topics: Animals; Biomarkers; Calbindins; Cell Count; Disease Models, Animal; Dose-Response Relationship, Dru | 2011 |
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, Liquid; Disease Models, Animal; Dynorphins | 2011 |
Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of Swine retinal degeneration.
Topics: Animals; Cell Count; Cell Survival; Chromosome Pairing; Disease Models, Animal; Dose-Response Relati | 2011 |
Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.
Topics: Analysis of Variance; Aniline Compounds; Animals; Arthralgia; Disease Models, Animal; Exploratory Be | 2012 |
Iodoacetic acid, but not sodium iodate, creates an inducible swine model of photoreceptor damage.
Topics: Animals; Blood Glucose; Dark Adaptation; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2012 |
Dose-dependent expression of neuronal injury markers during experimental osteoarthritis induced by monoiodoacetate in the rat.
Topics: Activating Transcription Factor 3; Animals; Behavior, Animal; Biomarkers; Disease Models, Animal; Ga | 2012 |
Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia.
Topics: Animals; Anthraquinones; Chondrocytes; Disease Models, Animal; Hyperalgesia; Iodoacetic Acid; Osteoa | 2013 |
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Clove Oil; Disease Models, Animal; Dynorphins; | 2012 |
Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.
Topics: Animals; Arthralgia; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalges | 2013 |
Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intra-Articular; Iodo | 2013 |
Intra-articular injection of xanthan gum reduces pain and cartilage damage in a rat osteoarthritis model.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Injections, Intra-Articular; Iodoacetic Acid; | 2013 |
The influence of doxycycline on articular cartilage in experimental osteoarthrosis induced by iodoacetate.
Topics: Animals; Anti-Bacterial Agents; Cartilage, Articular; Disease Models, Animal; Doxycycline; Female; G | 2004 |
Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation.
Topics: Activating Transcription Factor 3; Animals; Disease Models, Animal; Gene Expression; Humans; Hyperal | 2007 |
A novel approach to screening for new neuroprotective compounds for the treatment of stroke.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Cell Line, Transformed; Cell Survival; Disease Mo | 2007 |
Analgesic effects of indirect moxibustion on an experimental rat model of osteoarthritis in the knee.
Topics: Acupuncture Analgesia; Animals; Arthritis, Experimental; Disease Models, Animal; Iodoacetic Acid; Ma | 2007 |
In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint.
Topics: Animals; Autoradiography; Cartilage, Articular; Disease Models, Animal; Iodoacetates; Iodoacetic Aci | 1993 |
Gait analysis in a rat model of osteoarthrosis.
Topics: Animals; Disease Models, Animal; Gait; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; K | 1997 |
[Changes in the total calcium content and in the activity of alkaline phosphatase and gamma-glutamyltransferase in the blood serum of rats with Mönckeberg's experimental arteriosclerosis].
Topics: Acute Disease; Alkaline Phosphatase; Animals; Arteriosclerosis; Calcinosis; Calcium; Disease Models, | 1998 |
Evaluation of intra-articularly administered sodium monoiodoacetate-induced chemical injury to articular cartilage of horses.
Topics: Animals; Carpus, Animal; Cartilage, Articular; Disease Models, Animal; Histocytochemistry; Horse Dis | 1992 |
[A biochemical study of an animal model with defective muscle glycolysis, induced by iodoacetate administration].
Topics: Animals; Disease Models, Animal; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycogen Storage Disease | 1992 |
A pharmacological model of ischemia in the hippocampal slice.
Topics: Animals; Brain Ischemia; Cyanides; Disease Models, Animal; Hippocampus; In Vitro Techniques; Iodoace | 1990 |
[Monoiodoacetic acid-induced arthropathy of the rabbit knee--a contribution to the pathogenesis of arthrosis].
Topics: Animals; Disease Models, Animal; Glycolysis; Injections, Intra-Articular; Iodoacetates; Iodoacetic A | 1989 |
Chemical model of osteoarthritis--a pharmacological evaluation.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Disease Models, | 1987 |