iodoacetic acid has been researched along with Arthritis, Degenerative in 170 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation." | 8.12 | Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022) |
| "Diacerein (DIA) is a slow-acting drug for osteoarthritis (OA)." | 7.96 | A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. ( Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG, 2020) |
| "The anti-inflammatory and anti-catabolic actions of Diclofenac were compared with apigenin-C-glycosides rich Clinacanthus nutans (CN) leaf extract in osteoporotic-osteoarthritis rats." | 7.96 | Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| "The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model." | 7.96 | Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. ( Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ, 2020) |
| "We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments." | 7.88 | Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 7.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| "The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model." | 7.83 | Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ( Kim, HJ; Kim, SE; Lee, JY; Park, JW; Park, K; Song, HR; Yun, YP, 2016) |
| "After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin." | 7.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Our study demonstrated that atorvastatin attenuates MIA-induced osteoarthritic pain and protect cartilage degradation through inhibition of oxidative stress suggesting its importance in osteoarthritic pain management." | 7.81 | Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; Pathak, NN; Sharma, AK; Tandan, SK, 2015) |
| "Dexketoprofen and tramadol, alone or in combination, were evaluated after oral or intra-articular administration on knee osteoarthritis nociception induced by intra-articular (i." | 7.79 | Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats. ( Cialdai, C; Giuliani, S; Maggi, CA; Tramontana, M; Valenti, C, 2013) |
| " This study was carried out to investigate the effect of SMN, Celecoxib (CLX) individually and in combination on monoiodoacetate (MIA)-induced osteoarthritis (OA) in rat." | 7.78 | Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. ( Amniattalab, A; Ashkavand, Z; Malekinejad, H; Rezaei-Golmisheh, A; Vishwanath, BS, 2012) |
| "It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain unclear." | 5.91 | Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. ( Bai, X; Chen, J; Chen, L; Cheng, W; Hu, C; Liang, J; Liao, J; Liu, B; Liu, L; Liu, Q; Song, B; Wang, JD; Wang, Y; Xie, Q; Yang, K; Zhang, P; Zhao, N; Zheng, F, 2023) |
| "Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate." | 5.56 | Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| "Paw edema and thermal hyperalgesia were measured up to 6 h post-injection, when also myeloperoxidase activity and histological inflammation score were assessed." | 5.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| " The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis." | 5.43 | Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. ( Britti, D; Cordaro, M; Cuzzocrea, S; Di Paola, R; Evangelista, M; Fusco, R; Impellizzeri, D; Morittu, VM, 2016) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 5.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| " Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation." | 4.12 | Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022) |
| " Osteoarthritis was induced in male adult control Wistar rats without any interventions and in Wisket rats after juvenile social isolation and ketamine treatment." | 3.96 | Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020) |
| "Diacerein (DIA) is a slow-acting drug for osteoarthritis (OA)." | 3.96 | A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. ( Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG, 2020) |
| "The anti-inflammatory and anti-catabolic actions of Diclofenac were compared with apigenin-C-glycosides rich Clinacanthus nutans (CN) leaf extract in osteoporotic-osteoarthritis rats." | 3.96 | Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020) |
| "The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model." | 3.96 | Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. ( Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ, 2020) |
| "We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments." | 3.88 | Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018) |
| " longa (PCL) against monosodium iodoacetate (MIA) induced osteoarthritis in rat and to compare with curcuminoids, which are contemporarily believed to be the only active phytochemicals of C." | 3.85 | Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats. ( Bethapudi, B; Chandrasekaran, PR; Murugan, S; Purusothaman, D; Velusami, CC, 2017) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 3.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| "The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model." | 3.83 | Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ( Kim, HJ; Kim, SE; Lee, JY; Park, JW; Park, K; Song, HR; Yun, YP, 2016) |
| "Although some evidence suggests that the prevalence of osteoarthritis (OA) is lower in smokers compared to nonsmokers, the mechanisms of nicotine-induced protection remain unclear." | 3.81 | Activation of α7 nicotinic acetylcholine receptors prevents monosodium iodoacetate-induced osteoarthritis in rats. ( Fan, W; Hu, J; Hui, Y; Liu, Y; Song, F; Wu, D; Wu, J; Zhu, C; Zhu, Q, 2015) |
| "After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin." | 3.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Our study demonstrated that atorvastatin attenuates MIA-induced osteoarthritic pain and protect cartilage degradation through inhibition of oxidative stress suggesting its importance in osteoarthritic pain management." | 3.81 | Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; Pathak, NN; Sharma, AK; Tandan, SK, 2015) |
| "Dexketoprofen and tramadol, alone or in combination, were evaluated after oral or intra-articular administration on knee osteoarthritis nociception induced by intra-articular (i." | 3.79 | Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats. ( Cialdai, C; Giuliani, S; Maggi, CA; Tramontana, M; Valenti, C, 2013) |
| " This study was carried out to investigate the effect of SMN, Celecoxib (CLX) individually and in combination on monoiodoacetate (MIA)-induced osteoarthritis (OA) in rat." | 3.78 | Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. ( Amniattalab, A; Ashkavand, Z; Malekinejad, H; Rezaei-Golmisheh, A; Vishwanath, BS, 2012) |
| "It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain unclear." | 1.91 | Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. ( Bai, X; Chen, J; Chen, L; Cheng, W; Hu, C; Liang, J; Liao, J; Liu, B; Liu, L; Liu, Q; Song, B; Wang, JD; Wang, Y; Xie, Q; Yang, K; Zhang, P; Zhao, N; Zheng, F, 2023) |
| "Chronic joint pain is common in patients with osteoarthritis (OA)." | 1.72 | Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis. ( Chao, D; Hogan, QH; Pan, B; Tran, H, 2022) |
| "Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom." | 1.72 | Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice. ( Elisei, L; Galdino, G; Malta, I; Moraes, T; Novaes, R, 2022) |
| " This study determined the drug dosage and the mechanisms of GMGHT for OA." | 1.56 | Gumiganghwal-tang ameliorates cartilage destruction via inhibition of matrix metalloproteinase. ( Ahn, KS; Choi, Y; Hahm, DH; Kim, MH; Lee, SG; Um, JY; Yang, WM, 2020) |
| " Further fine tuning of alginate formulation and effective dosage for might be required in order to improve therapeutic efficacy depending on the target disease." | 1.56 | MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study. ( Bernsen, M; Bos, PK; Haeck, J; Khatab, S; Kops, N; Leijs, MJ; Nieboer, M; van Buul, G; van Osch, GJVM; Verhaar, JAN, 2020) |
| "Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate." | 1.56 | Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| "In contrast, we observed persistent joint pain after day 10 in the high-dose group." | 1.51 | Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. ( Akiyama, M; Hoshino, T; Inomata, K; Katagiri, H; Koga, H; Miyatake, K; Muneta, T; Nakagawa, Y; Onuma, H; Sekiya, I; Tsuji, K; Udo, M, 2019) |
| "Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control." | 1.51 | Animal Models for the Study of Bone-Derived Pain. ( Largent-Milnes, TM; Thompson, AL; Vanderah, TW, 2019) |
| "Osteoarthritis was induced by injection of monoiodoacetate (MIA)." | 1.51 | Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis. ( Honjoh, K; Kokubo, Y; Matsumine, A; Miyazaki, T; Nakajima, H; Oki, H; Sakamoto, T; Takahashi, A; Watanabe, S, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | 1.51 | Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "Paw edema and thermal hyperalgesia were measured up to 6 h post-injection, when also myeloperoxidase activity and histological inflammation score were assessed." | 1.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| " However, it is unknown whether the antalgic gait caused by MIA is associated with severity of degeneration from the high dosage or the whole-joint degeneration associated with glycolysis inhibition." | 1.48 | Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis. ( Allen, KD; Lakes, EH, 2018) |
| "Osteoarthritis was induced through a single intra-articular injection of monosodium iodoacetate in both knee joints." | 1.48 | Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model. ( Hoso, M; Kuroki, H; Matsuzaki, T; Takahashi, I, 2018) |
| "Preventive AR786 treatment inhibited pain behaviour development and therapeutic treatment attenuated established pain behaviour." | 1.43 | Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. ( Chapman, V; Mapp, PI; Nwosu, LN; Walsh, DA, 2016) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 1.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| " The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis." | 1.43 | Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. ( Britti, D; Cordaro, M; Cuzzocrea, S; Di Paola, R; Evangelista, M; Fusco, R; Impellizzeri, D; Morittu, VM, 2016) |
| " Unexpectedly, vitamin C's effects did not strengthen with the increasing dosage, while the 100 mg/kg dosage was more efficient than the 200 or 300 mg/kg dosages." | 1.43 | Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways. ( Chang, KL; Cheng, HL; Chiu, PR; Hsieh, BS; Hu, YC; Huang, LW; Huang, TC; Yeh, JP, 2016) |
| "Although analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear." | 1.42 | Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. ( Chapman, V; Nwosu, L; Sagar, DR; Walsh, DA, 2015) |
| "25mg) into rats and orally treated with 2g/ml d-Fuzi at a dosage of 7 ml/kg body weight for 28 days." | 1.40 | Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate. ( Cao, G; Cheng, Y; Guo, Y; Jin, H; Jin, W; Shan, L; Tong, P; Xiao, L; Xu, S, 2014) |
| "Osteoarthritis was produced by single intra-articular injection of the MIA in the right knee joint on day 0." | 1.39 | Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Gupta, G; Kumar, D; Kumari, RR; Lingaraju, MC; More, AS; Pathak, NN; Sharma, AK; Tandan, SK, 2013) |
| "Osteoarthritis was induced by injection with a chemical (mono-iodoacetate), a surgical intervention (grooves applied in articular cartilage), and via exercise (strenuous running)." | 1.37 | Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models. ( Kops, N; Oei, EH; Piscaer, TM; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (3.53) | 18.7374 |
| 1990's | 10 (5.88) | 18.2507 |
| 2000's | 3 (1.76) | 29.6817 |
| 2010's | 81 (47.65) | 24.3611 |
| 2020's | 70 (41.18) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, JI | 1 |
| Lee, HS | 1 |
| Jeon, YE | 1 |
| Kim, SM | 3 |
| Hong, SH | 1 |
| Moon, JM | 1 |
| Lim, CY | 1 |
| Kim, YH | 1 |
| Kim, EJ | 1 |
| Wang, J | 1 |
| Wei, W | 1 |
| Zhang, X | 2 |
| Cao, S | 1 |
| Hu, B | 1 |
| Ye, Y | 1 |
| Jiang, M | 1 |
| Wang, T | 1 |
| Zuo, J | 1 |
| He, S | 1 |
| Yang, C | 1 |
| Malta, I | 1 |
| Moraes, T | 1 |
| Elisei, L | 1 |
| Novaes, R | 1 |
| Galdino, G | 1 |
| Lee, M | 2 |
| Kim, GH | 2 |
| Kim, M | 1 |
| Seo, JM | 1 |
| Kim, YM | 1 |
| Seon, MR | 1 |
| Um, S | 1 |
| Choi, SJ | 2 |
| Oh, W | 1 |
| Song, BR | 1 |
| Jin, HJ | 1 |
| Chen, R | 1 |
| Liao, Z | 1 |
| Zhu, Y | 1 |
| Chen, Y | 1 |
| Liu, J | 1 |
| Chen, X | 2 |
| Novikov, FN | 1 |
| Panova, MV | 1 |
| Titov, IY | 1 |
| Stroylov, VS | 1 |
| Stroganov, OV | 1 |
| Chilov, GG | 1 |
| Han, FY | 1 |
| Brockman, DA | 1 |
| Nicholson, JR | 1 |
| Corradini, L | 1 |
| Smith, MT | 1 |
| Aborehab, NM | 1 |
| El Bishbishy, MH | 1 |
| Lee, YM | 1 |
| Son, E | 1 |
| Kim, SH | 3 |
| Kim, DS | 1 |
| Liu, X | 4 |
| Zhao, J | 1 |
| Jiang, H | 3 |
| Li, H | 3 |
| Feng, Y | 1 |
| Ke, J | 1 |
| Long, X | 3 |
| Na, HS | 5 |
| Woo, JS | 2 |
| Kim, JH | 2 |
| Lee, JS | 2 |
| Um, IG | 2 |
| Cho, KH | 5 |
| Cho, ML | 9 |
| Chung, SJ | 1 |
| Park, SH | 9 |
| Chao, D | 1 |
| Tran, H | 1 |
| Hogan, QH | 1 |
| Pan, B | 1 |
| Lee, YS | 2 |
| Park, EJ | 1 |
| Lee, HJ | 2 |
| Lee, SY | 3 |
| Lee, DH | 1 |
| Choi, SY | 3 |
| Kim, SA | 2 |
| Go, EJ | 2 |
| Lee, AR | 1 |
| Choi, JW | 1 |
| Kim, SJ | 6 |
| Wang, Q | 1 |
| Peng, J | 1 |
| Liu, Y | 3 |
| Tian, Y | 3 |
| Li, J | 1 |
| Ren, YY | 1 |
| Gu, J | 1 |
| Tan, R | 1 |
| Yang, K | 4 |
| Xie, Q | 4 |
| Tang, T | 3 |
| Zhao, N | 4 |
| Liang, J | 4 |
| Shen, Y | 3 |
| Li, Z | 3 |
| Liu, B | 4 |
| Chen, J | 4 |
| Cheng, W | 4 |
| Bai, X | 4 |
| Zhang, P | 4 |
| Liu, Q | 5 |
| Song, B | 4 |
| Hu, C | 4 |
| Liu, L | 4 |
| Wang, Y | 8 |
| Chen, C | 3 |
| Zhou, H | 4 |
| Yin, Y | 5 |
| Hu, H | 3 |
| Jiang, B | 3 |
| Zhang, K | 3 |
| Wu, S | 3 |
| Shen, M | 3 |
| Wang, Z | 3 |
| Li, Y | 2 |
| Sun, H | 2 |
| Hu, Z | 3 |
| Guo, H | 2 |
| Sriwatananukulkit, O | 2 |
| Desclaux, S | 2 |
| Tawonsawatruk, T | 2 |
| Srikuea, R | 2 |
| Himakhun, W | 2 |
| Likitnukul, S | 2 |
| Hemstapat, R | 2 |
| Rabie, MA | 1 |
| Sayed, RH | 1 |
| Venkatesan, JK | 1 |
| Madry, H | 1 |
| Cucchiarini, M | 1 |
| El Sayed, NS | 1 |
| Jin, H | 2 |
| Yang, Y | 2 |
| Lei, G | 1 |
| Zeng, C | 1 |
| He, K | 1 |
| Deng, C | 1 |
| Wei, J | 1 |
| Li, X | 3 |
| Barry, F | 1 |
| Chai, F | 1 |
| Chijcheapaza-Flores, H | 1 |
| Garcia-Fernandez, MJ | 1 |
| Blanchemain, N | 1 |
| Nicot, R | 1 |
| Fang, Z | 1 |
| Lei, S | 1 |
| Feng, S | 1 |
| Zhou, C | 1 |
| Tong, X | 1 |
| Han, R | 1 |
| Kwon, M | 1 |
| Nam, D | 1 |
| Kim, J | 3 |
| Jarecki, J | 1 |
| Polkowska, I | 1 |
| Kazimierczak, W | 1 |
| Wójciak, M | 1 |
| Sowa, I | 1 |
| Dresler, S | 1 |
| Blicharski, T | 1 |
| Ise, S | 1 |
| Ochiai, N | 1 |
| Hashimoto, E | 1 |
| Hirosawa, N | 1 |
| Kajiwara, D | 1 |
| Shimada, Y | 1 |
| Inagaki, K | 1 |
| Hiraoka, Y | 1 |
| Hattori, F | 1 |
| Ohtori, S | 1 |
| Liao, J | 1 |
| Wang, JD | 1 |
| Zheng, F | 1 |
| Chen, L | 1 |
| Sahin, E | 1 |
| Orhan, C | 1 |
| Erten, F | 1 |
| Saiyed, Z | 1 |
| Azari, EK | 1 |
| Durkee, S | 1 |
| Sahin, K | 1 |
| Wang, X | 1 |
| Song, J | 1 |
| Xia, P | 1 |
| Lin, Q | 1 |
| Chen, A | 1 |
| Cheng, K | 1 |
| Kong, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Cannabinoid Patch for Knee Osteoarthritis[NCT04412837] | Phase 2 | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to Inadequate funding) | ||
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for iodoacetic acid and Arthritis, Degenerative
| Article | Year |
|---|---|
Pain Intensity and Trajectory Following Intra-Articular Injection of Mono-Iodoacetate in Experimental Osteoarthritis: A Meta-Analysis of
Topics: Animals; Injections, Intra-Articular; Iodoacetic Acid; Osteoarthritis; Pain; Pain Measurement; Rats | 2023 |
Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases.
Topics: Animals; Biological Products; Cartilage, Articular; Chondrocytes; Cytokines; Drug Evaluation, Precli | 2020 |
[Experimental arthrosis].
Topics: Adrenal Cortex Hormones; Animals; Disease Models, Animal; Enzyme Induction; Humans; Immobilization; | 1982 |
167 other studies available for iodoacetic acid and Arthritis, Degenerative
| Article | Year |
|---|---|
Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats.
Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Respo | 2021 |
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment.
Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Bone and Bones; Cartilage, Articular; Cell Differ | 2021 |
Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Male; Mice; Neuroglia; Nociception; Osteoarthritis | 2022 |
PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model.
Topics: Animals; C-Reactive Protein; Cytokines; Disease Models, Animal; Inflammation; Injections, Intra-Arti | 2021 |
The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium Iodoacetate Induced Osteoarthritis.
Topics: Animals; Cartilage, Articular; Cytokines; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; P | 2022 |
Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cartilage; | 2021 |
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat.
Topics: Animals; Arthralgia; Behavior Observation Techniques; Behavior, Animal; Behavioral Symptoms; Disease | 2022 |
Chondroprotection of fruit peels in a monosodium iodoacetate-induced osteoarthritis rat model via downregulation of Col1A1.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Fruit; Iodoacetic Acid; Osteoart | 2022 |
Anti-Inflammatory and Analgesic Effects of
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Iodoacetic Acid; Lipopolysaccharides; Mi | 2022 |
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.
Topics: Aggrecans; Animals; Cartilage, Articular; Chondrocytes; Cyclooxygenase 2; Humans; Iodoacetic Acid; M | 2022 |
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death.
Topics: Animals; Cartilage, Articular; Cell Death; Chondrocytes; Disease Models, Animal; Inflammation; Iodoa | 2022 |
Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ganglia, Spina | 2022 |
Anti-arthritic effects of Schisandra chinensis extract in monosodium iodoacetate-induced osteoarthritis rats.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Plant Extracts; Rats; Schisandra | 2022 |
Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Cartilage; Cartilage, Articular; Chemokine CCL2; Dis | 2022 |
[Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms].
Topics: Aconitine; Aconitum; Aggrecans; Alkaloids; Animals; Cells, Cultured; Cyclooxygenase 2; Fibroblast Gr | 2022 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats.
Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats; | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid.
Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop | 2023 |
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma | 2023 |
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma | 2023 |
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma | 2023 |
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Intra-articular injection of rAAV-hFGF-2 ameliorates monosodium iodoacetate-induced osteoarthritis in rats via inhibiting TLR-4 signaling and activating TIMP-1.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Fibroblast Growth Factor 2; Humans; Injection | 2023 |
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.
Topics: Animals; Arthralgia; Collagenases; Disease Models, Animal; Drug Delivery Systems; Injections, Intra- | 2023 |
Protective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Disease Models, Animal; Drugs, Chinese Herb | 2023 |
Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Inflammation; Iodoacetic Acid; Male; Osteoarthritis; Pain; Rats; X | 2023 |
Assessment of the Impact of Physical Activity on the Musculoskeletal System in Early Degenerative Knee Joint Lesions in an Animal Model.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Knee Joint; Male; Models, Animal; Muscular Atrophy | 2023 |
Evaluation of articular changes using a rat mono-iodoacetate-induced shoulder arthritis model by histology and radiology.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Radiology; R | 2023 |
Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling.
Topics: Animals; Cartilage, Articular; Chondrocytes; Iodoacetic Acid; Molecular Docking Simulation; Osteoart | 2023 |
The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats.
Topics: Administration, Oral; Animals; Cartilage, Articular; Collagen Type II; Disease Models, Animal; Iodoa | 2023 |
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; High-Intensity Interval Training; Hyperalgesia; Iodoacetic Acid; Os | 2023 |
Effective Technical Protocol for Producing a Mono-Iodoacetate-Induced Temporomandibular Joint Osteoarthritis in a Rat Model.
Topics: Animals; Bone Remodeling; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Pain; Rats; Tempo | 2023 |
Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Inflammation; Iodoacetic Acid; Osteoarthriti | 2023 |
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Hyperalgesia; Iodoacetic Acid; Neuroinflammat | 2023 |
Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model.
Topics: Animals; Cartilage, Articular; Curcumin; Disease Models, Animal; Iodoacetic Acid; MicroRNAs; Osteoar | 2023 |
Bixa orellana ethyl acetate fraction and its isolated compound ellagic acid attenuate the progression of MIA-induced osteoarthritis in rat knees.
Topics: Animals; Bixaceae; Cartilage, Articular; Disease Models, Animal; Ellagic Acid; Iodoacetates; Iodoace | 2023 |
Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Disease Models, Animal; Interleukin-10; Int | 2023 |
Transcranial Direct Current Stimulation Attenuates the Chronic Pain of Osteoarthritis in Rats via Reducing NMDAR2B Expressions in the Spinal Cord.
Topics: Analgesics; Animals; Chronic Pain; Hyperalgesia; Iodoacetic Acid; Osteoarthritis; Rats; Spinal Cord; | 2023 |
Development of an ultrathin sheet plastination technique in rat humeral joints with osteoarthritis induced by monosodium iodoacetate for neovascularization study.
Topics: Animals; Cartilage, Articular; Humerus; Injections, Intra-Articular; Iodoacetic Acid; Joints; Neovas | 2020 |
Comparative study of osteoarthritis induced by monoiodoacetate and papain in rabbit temporomandibular joints: macroscopic and microscopic analysis.
Topics: Animals; Cartilage, Articular; Iodoacetic Acid; Male; Osteoarthritis; Papain; Rabbits; Severity of I | 2020 |
Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate-induced animal model of osteoarthritis.
Topics: Amniotic Fluid; Animals; Disease Models, Animal; Exosomes; Humans; Iodoacetic Acid; Osteoarthritis; | 2020 |
Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia.
Topics: Analgesics, Opioid; Animals; Ankle Joint; Brain; Brain Stem; Chronic Pain; Diencephalon; Disease Mod | 2020 |
Inhibition of miR-203 Ameliorates Osteoarthritis Cartilage Degradation in the Postmenopausal Rat Model: Involvement of Estrogen Receptor α.
Topics: 3' Untranslated Regions; Aggrecans; Animals; Antagomirs; Cartilage; Collagen Type II; Disease Models | 2019 |
Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Astragalus propinquus; Cartilage, Articular; Cell Lin | 2019 |
Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Basic Helix-Loop-Helix Transcription Factors | 2020 |
Thermoresponsive Hyalomer intra-articular hydrogels improve monoiodoacetate-induced osteoarthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Dic | 2020 |
Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain.
Topics: Analgesics; Animals; Carrageenan; Female; Glucosamine; Hyperalgesia; Inflammation; Iodoacetic Acid; | 2019 |
Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model.
Topics: AMP-Activated Protein Kinases; Animals; Arthritis, Experimental; Cells, Cultured; Chondrocytes; Dise | 2020 |
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis.
Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Experimental; Ca | 2020 |
Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Chondroitin Sulfates; Disease Models, Animal | 2020 |
p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Humans; Iodoacetic A | 2020 |
Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cartilage, Articular; Chondrocytes; Cytokines; Fema | 2020 |
Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model.
Topics: Administration, Oral; Animals; Apigenin; Cytokines; Diclofenac; Disease Models, Animal; Dose-Respons | 2020 |
Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured; Chondrocytes; H | 2020 |
MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study.
Topics: Adult; Alginates; Animals; Cell Survival; Cell Tracking; Cells, Cultured; Disease Models, Animal; Fe | 2020 |
Intra-Articular Route for the System of Molecules 14G1862 from
Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper | 2020 |
Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Injections, Intra-Ar | 2020 |
Gumiganghwal-tang ameliorates cartilage destruction via inhibition of matrix metalloproteinase.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Cell Line, Tumor; Chondrocytes; Collagen Typ | 2020 |
Effect and mechanism of the CACNA2D1-CGRP pathway in osteoarthritis-induced ongoing pain.
Topics: Adenylyl Cyclases; Animals; Arthralgia; Calcitonin Gene-Related Peptide; Calcium Channels, L-Type; C | 2020 |
TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement.
Topics: Animals; Arthritis, Experimental; Cell- and Tissue-Based Therapy; Chondrocytes; Genetic Therapy; Hum | 2020 |
Synthesis of
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Bone and Bones; C-Reactive Protein; COVID | 2021 |
Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Disease Progression; Endocannabinoids; Gene Expr | 2020 |
Galactomannan of Delonix regia seeds reduces nociception and morphological damage in the rat model of osteoarthritis induced by sodium monoiodoacetate.
Topics: Analgesics; Animals; Disease Models, Animal; Fabaceae; Foot Joints; Galactose; Iodoacetic Acid; Male | 2021 |
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 3; Cartilage | 2020 |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis.
Topics: Animals; Antarctic Regions; Cartilage, Articular; Cytokines; Disease Models, Animal; Euphausiacea; I | 2020 |
Herbal Composition LI73014F2 Alleviates Articular Cartilage Damage and Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cartilage, Articular; Cytokines; Disease Models, Anim | 2020 |
Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Chitosan; Disease Models, Animal; Electron Transport | 2020 |
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.
Topics: AMP-Activated Protein Kinases; Animals; Antirheumatic Agents; Apoptosis; Autophagy; Cells, Cultured; | 2021 |
Inhibition effect of
Topics: Animals; Arthritis, Experimental; Caragana; Cells, Cultured; Chondrocytes; Humans; Inflammation Medi | 2021 |
CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development.
Topics: Analgesics; Animals; Arthralgia; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal | 2021 |
The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Hydroxyeicosatetraenoic Acids; Inflammat | 2021 |
Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model.
Topics: Animals; Antibodies, Monoclonal, Humanized; Arthritis, Experimental; Cartilage, Articular; Dose-Resp | 2021 |
Biosynthesis of gold nanoparticles for the treatment of osteoarthritis alone or in combination with Diacerein
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Chenopodium; Disease Models, Animal; Drug Therapy | 2021 |
The active ingredients analysis of Herba Lysimachiae treating osteoarthritis based on the LC-MS/MS technology and public bioinformatics platforms.
Topics: Animals; Chromatography, Liquid; Computational Biology; Drugs, Chinese Herbal; Iodoacetic Acid; Male | 2021 |
Spinal neuropeptide modulation, functional assessment and cartilage lesions in a monosodium iodoacetate rat model of osteoarthritis.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Cartilage Diseases; Disease Models, Animal; Fe | 2017 |
Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model.
Topics: Animals; Autophagy; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; C | 2017 |
The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis.
Topics: Animals; Bone and Bones; Cartilage, Articular; Cell Differentiation; Cell Line; Cell Proliferation; | 2017 |
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat.
Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Inflammation; Infrared Rays; Injections, Intra-A | 2017 |
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats.
Topics: Animals; Bone and Bones; Cartilage; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Female; Inf | 2017 |
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
Topics: Animals; Arthralgia; Cannabidiol; Disease Models, Animal; Inflammation; Iodoacetic Acid; Knee Joint; | 2017 |
Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chemokine CXCL12; | 2018 |
Evaluation of oral multi-herbal preparation of Dashmoolarishta on mice model of osteoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Female; Hyaluronic Acid; Iodoacetic Acid; Male; | 2017 |
Low-intensity pulsed ultrasound stimulation for mandibular condyle osteoarthritis lesions in rats.
Topics: Animals; Bone Density; Chondrocytes; Iodoacetic Acid; Male; Mandibular Condyle; Matrix Metalloprotei | 2018 |
Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model.
Topics: Animals; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Gene Expression Regulation; Iodo | 2018 |
Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model.
Topics: ADAMTS5 Protein; Animals; Calcitonin Gene-Related Peptide; Cartilage, Articular; Cell Adhesion Molec | 2018 |
Tabetri™ (
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chondrocytes; Ethanol; Humans; Inflammat | 2017 |
The Combination of Probiotic Complex, Rosavin, and Zinc Improves Pain and Cartilage Destruction in an Osteoarthritis Rat Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Cyto | 2018 |
Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats.
Topics: Animals; Collagen Type II; Curcuma; Disease Models, Animal; Female; Humans; Iodoacetic Acid; Male; M | 2017 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic | 2018 |
In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum.
Topics: Animals; Anti-Inflammatory Agents; Chondrocytes; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dino | 2018 |
Development and characterization of various osteoarthritis models for tissue engineering.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Female; Guinea Pi | 2018 |
Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx.
Topics: Animals; Apoptosis; Calcium; Calcium Channels; Calcium Chelating Agents; Calmodulin; Cartilage, Arti | 2018 |
Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Fibrosis; Iodoacetic Acid; Male; Osteoarthrit | 2018 |
Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Enzyme Inhibitors; Gait; Iodoacetic Acid | 2018 |
Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expre | 2018 |
BST106 Protects against Cartilage Damage by Inhibition of Apoptosis and Enhancement of Autophagy in Osteoarthritic Rats.
Topics: Animals; Apoptosis; Autophagy; Cartilage, Articular; Chrysanthemum; Iodoacetic Acid; Knee Joint; Mal | 2018 |
Protective Effects of
Topics: Animals; Anti-Inflammatory Agents; Apiaceae; Caspase 3; Caspase 7; Cytochrome P-450 CYP2D6; Disease | 2018 |
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg | 2019 |
Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis.
Topics: Animals; Cartilage; Chondrocytes; Iodoacetic Acid; Lactobacillus acidophilus; Male; Osteoarthritis; | 2018 |
Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone.
Topics: Animals; Arthralgia; Avoidance Learning; Behavior, Animal; Calcitonin Gene-Related Peptide; Cartilag | 2018 |
Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model.
Topics: Animals; Ascorbic Acid; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Injections, Intr | 2019 |
Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Carrageenan; Chondroitin Sulfates; Cytokines; Disease Models, Anim | 2019 |
An investigation into the noradrenergic and serotonergic contributions of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Animals; Diffuse Noxious Inhibitory Cont | 2019 |
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis.
Topics: Agkistrodon; Analgesics; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Complex Mixtures; H | 2019 |
Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint.
Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Progression; | 2019 |
The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Administration, Intravenous; Animals; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured | 2018 |
Animal Models for the Study of Bone-Derived Pain.
Topics: Animals; Behavior, Animal; Bone and Bones; Bone Neoplasms; Cell Culture Techniques; Cell Line, Tumor | 2019 |
Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation.
Topics: Animals; Carbolines; Cell Line, Tumor; Female; Freund's Adjuvant; Humans; Hyperalgesia; Iodoacetic A | 2019 |
Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound.
Topics: Amides; Analgesics; Animals; Cannabinoids; Dronabinol; Ethanolamines; Iodoacetic Acid; Male; Motor A | 2019 |
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-α-induced activation of NF-ĸB pathway in chondrocytes.
Topics: Analgesics; Animals; Arthritis; Blood Platelets; Cell Survival; Chondrocytes; Gene Expression Regula | 2019 |
Vitamin E ameliorates alterations to the articular cartilage of knee joints induced by monoiodoacetate and diabetes mellitus in rats.
Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Diabetes Mellitus; Disease Models, Animal | 2019 |
Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice.
Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Chondrocytes; Cytosol; Disease Models, Animal; Glycy | 2019 |
Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis.
Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Fema | 2019 |
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2019 |
Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.
Topics: Animals; Arthralgia; Behavior, Animal; Bone Density Conservation Agents; Bone Remodeling; Diphosphon | 2014 |
Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats.
Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Iodo | 2013 |
Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines.
Topics: Analgesics; Animals; Cartilage; Cytokines; Disease Models, Animal; Gene Expression Regulation; Infla | 2013 |
Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis.
Topics: Animals; Apoptosis; Cartilage, Articular; Caspase 3; Caspase 8; Chondrocytes; Estradiol; Fas Ligand | 2013 |
Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate.
Topics: Animals; Diterpenes; Drugs, Chinese Herbal; Iodoacetic Acid; Male; Osteoarthritis; Plant Extracts; R | 2014 |
Histology, glycosaminoglycan level and cartilage stiffness in monoiodoacetate-induced osteoarthritis: comparative analysis with anterior cruciate ligament transection in rat model and human osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Glycosaminoglycan | 2014 |
Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model.
Topics: Absorptiometry, Photon; Animals; Arthritis, Experimental; Bone Density; Cartilage, Articular; Diseas | 2014 |
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxe | 2014 |
Near infrared spectroscopy for rapid determination of Mankin score components: a potential tool for quantitative characterization of articular cartilage at surgery.
Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Cartilage Diseases; Cartil | 2014 |
Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats.
Topics: Animals; Body Weight; Bone and Bones; Cartilage, Articular; Cytokines; Deer; Eating; Gene Expression | 2014 |
Activation of α7 nicotinic acetylcholine receptors prevents monosodium iodoacetate-induced osteoarthritis in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Chondrocytes; Iodoacetic Acid; Ma | 2015 |
Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Injections, Intra-Articular; Iodoacetic Acid; Ma | 2015 |
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A | 2015 |
Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy.
Topics: Animals; Atorvastatin; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibit | 2015 |
Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate.
Topics: Animals; Body Weight; Cartilage, Articular; Cytokines; Disease Models, Animal; Enzyme-Linked Immunos | 2015 |
Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis.
Topics: Animals; Calcium Channel Blockers; Caveolin 2; Disease Models, Animal; Evoked Potentials; Functional | 2015 |
Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.
Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Drug Evaluation, Preclinical; Iodoacetic | 2016 |
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Blotting, Western; Cells, Cultured; Chondrocytes; Dise | 2015 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Ev | 2016 |
Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model.
Topics: Acclimatization; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Conditionin | 2016 |
Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Proliferation; Chond | 2016 |
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo | 2016 |
Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain.
Topics: Activating Transcription Factor 3; Adult; Aged; Aged, 80 and over; Animals; Arthralgia; Arthritis, E | 2017 |
Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage.
Topics: Animals; Cartilage, Articular; Cell Differentiation; Cells, Cultured; DNA Transposable Elements; Ext | 2017 |
Protective Effect of Deer Bone Oil on Cartilage Destruction in Rats with Monosodium Iodoacetate (MIA)-Induced Osteoarthritis.
Topics: Animals; Arthritis, Experimental; Bone and Bones; Cartilage, Articular; Cell Survival; Cells, Cultur | 2016 |
Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dicarboxylic Acids; Hyaluron | 2016 |
Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways.
Topics: Animals; Apoptosis; Ascorbic Acid; Cell Line, Tumor; Chondrocytes; Cytokines; Humans; Iodoacetic Aci | 2016 |
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Topics: Animals; Cartilage, Articular; Cattle; Disease Models, Animal; Dose-Response Relationship, Drug; Enz | 2009 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Dicl | 2011 |
Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models.
Topics: Animals; Apoptosis; Arthrography; Cartilage, Articular; Chondrocytes; Cumulative Trauma Disorders; D | 2011 |
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, Liquid; Disease Models, Animal; Dynorphins | 2011 |
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis.
Topics: Acid Sensing Ion Channels; Animals; Behavior, Animal; Cnidarian Venoms; Gene Expression Regulation; | 2012 |
Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia.
Topics: Animals; Anthraquinones; Chondrocytes; Disease Models, Animal; Hyperalgesia; Iodoacetic Acid; Osteoa | 2013 |
Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats.
Topics: Animals; Antioxidants; Cartilage, Articular; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Evaluation | 2012 |
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Clove Oil; Disease Models, Animal; Dynorphins; | 2012 |
Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Hyperalgesia; I | 2013 |
Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intra-Articular; Iodo | 2013 |
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis.
Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco | 2013 |
Intra-articular injection of xanthan gum reduces pain and cartilage damage in a rat osteoarthritis model.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Injections, Intra-Articular; Iodoacetic Acid; | 2013 |
Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis.
Topics: Animals; Cartilage, Articular; Cyclooxygenase 2; Enzyme Inhibitors; Gelatinases; Gene Expression; Im | 2004 |
Chemical arthrodesis of the distal tarsal joints using sodium monoiodoacetate in 104 horses.
Topics: Animals; Arthrodesis; Enzyme Inhibitors; Horse Diseases; Horses; Injections, Intra-Articular; Iodoac | 2004 |
Immobilization ameliorates chemically-induced articular cartilage damage.
Topics: Animals; Cartilage, Articular; Femur; Guinea Pigs; Histocytochemistry; Immobilization; Injections, I | 1984 |
Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase.
Topics: Animals; Cartilage, Articular; Collagenases; Iodoacetates; Iodoacetic Acid; Knee Joint; Male; Mice; | 1994 |
Histomorphological studies on the effect of recombinant human superoxide dismutase in biochemically induced osteoarthritis.
Topics: Animals; Cartilage, Articular; Chickens; Female; Humans; Injections, Intra-Articular; Iodoacetates; | 1993 |
Prolonged effect of iodoacetate on articular cartilage and its modification by an anti-rheumatic drug.
Topics: Animals; Cartilage, Articular; Diclofenac; Iodoacetates; Iodoacetic Acid; Knee Joint; Male; Osteoart | 1993 |
In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint.
Topics: Animals; Autoradiography; Cartilage, Articular; Disease Models, Animal; Iodoacetates; Iodoacetic Aci | 1993 |
Use of sodium monoiodoacetate to fuse the distal hock joints in horses.
Topics: Animals; Arthrodesis; Female; Hindlimb; Horse Diseases; Horses; Injections, Intra-Articular; Iodoace | 1995 |
In vitro magnetic resonance microimaging of experimental osteoarthritis in the rat knee joint.
Topics: Animals; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; Knee Joint; Magnetic Resonance | 1997 |
Cross-relaxation times of normal and biochemically induced osteoarthritic rabbit knee cartilages.
Topics: Animals; Body Water; Cartilage, Articular; Iodoacetates; Iodoacetic Acid; Knee Joint; Magnetic Reson | 1997 |
Gait analysis in a rat model of osteoarthrosis.
Topics: Animals; Disease Models, Animal; Gait; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; K | 1997 |
Evaluation of intra-articularly administered sodium monoiodoacetate-induced chemical injury to articular cartilage of horses.
Topics: Animals; Carpus, Animal; Cartilage, Articular; Disease Models, Animal; Histocytochemistry; Horse Dis | 1992 |
Fusion of the distal intertarsal and tarsometatarsal joints in the horse using intraarticular sodium monoiodoacetate.
Topics: Animals; Arthrodesis; Cartilage, Articular; Horse Diseases; Horses; Iodoacetates; Iodoacetic Acid; L | 1991 |
Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints.
Topics: Animals; Biomechanical Phenomena; Glycosaminoglycans; Injections, Intra-Articular; Iodoacetates; Iod | 1989 |
[Monoiodoacetic acid-induced arthropathy of the rabbit knee--a contribution to the pathogenesis of arthrosis].
Topics: Animals; Disease Models, Animal; Glycolysis; Injections, Intra-Articular; Iodoacetates; Iodoacetic A | 1989 |
Chemical model of osteoarthritis--a pharmacological evaluation.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Disease Models, | 1987 |
Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage.
Topics: Animals; Cartilage Diseases; Cartilage, Articular; Guinea Pigs; Histocytochemistry; Iodoacetates; Io | 1985 |