iodoacetic acid has been researched along with Arthralgia in 27 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
Arthralgia: Pain in the joint.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 7.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| " Monoiodoacetic acid (MIA) was injected intra-articularly to induce IFP fibrosis and persistent pain." | 4.02 | Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model. ( An, JS; Araya, N; Hino, J; Hoshino, T; Hosoda, H; Inomata, K; Isono, M; Kangawa, K; Katagiri, H; Koga, H; Miyatake, K; Miyazato, M; Muneta, T; Nakagawa, Y; Onuma, H; Sekiya, I; Tsuji, K, 2021) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 3.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| "In contrast, we observed persistent joint pain after day 10 in the high-dose group." | 1.51 | Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. ( Akiyama, M; Hoshino, T; Inomata, K; Katagiri, H; Koga, H; Miyatake, K; Muneta, T; Nakagawa, Y; Onuma, H; Sekiya, I; Tsuji, K; Udo, M, 2019) |
| "Osteoarthritis was induced by injection of monoiodoacetate (MIA)." | 1.51 | Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis. ( Honjoh, K; Kokubo, Y; Matsumine, A; Miyazaki, T; Nakajima, H; Oki, H; Sakamoto, T; Takahashi, A; Watanabe, S, 2019) |
| " Hits from this assay were tested in a plasma assay to assess inhibition of endogenous plasma autotaxin and subsequently tested for their ability to lower plasma LPA levels upon oral dosing of rats." | 1.46 | Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain. ( Bui, HH; Chambers, MG; Jones, SB; Lin, C; Mitchell, PG; Norman, BH; Oskins, JL; Pfeifer, LA; Swearingen, CA; Thirunavukkarasu, K, 2017) |
| "Two models of OA joint pain were used for the mechanistic studies." | 1.46 | Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. ( Ashraf, S; Barrett, DA; Bennett, AJ; Burston, JJ; Chapman, V; Huang, J; Li, L; Mapp, PI; Pousinis, P; Ravipati, S; Scammell, BE, 2017) |
| "Joint pain is a common clinical problem for which both inflammatory and degenerative joint diseases are major causes." | 1.39 | Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. ( Aracil-Fernández, A; Bura, SA; La Porta, C; Maldonado, R; Manzanares, J, 2013) |
| "The effect of Nav1." | 1.38 | Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. ( McDougall, JJ; Schuelert, N, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (70.37) | 24.3611 |
| 2020's | 8 (29.63) | 2.80 |
| Authors | Studies |
|---|---|
| Han, FY | 1 |
| Brockman, DA | 1 |
| Nicholson, JR | 1 |
| Corradini, L | 1 |
| Smith, MT | 1 |
| Barry, F | 1 |
| Chai, F | 1 |
| Chijcheapaza-Flores, H | 1 |
| Garcia-Fernandez, MJ | 1 |
| Blanchemain, N | 1 |
| Nicot, R | 1 |
| Sakamoto, J | 1 |
| Miyahara, S | 1 |
| Motokawa, S | 1 |
| Takahashi, A | 2 |
| Sasaki, R | 1 |
| Honda, Y | 1 |
| Okita, M | 1 |
| Na, HS | 1 |
| Park, JS | 1 |
| Cho, KH | 1 |
| Kwon, JY | 1 |
| Choi, J | 1 |
| Jhun, J | 1 |
| Kim, SJ | 1 |
| Park, SH | 1 |
| Cho, ML | 1 |
| Sun, L | 1 |
| Wang, G | 1 |
| He, M | 1 |
| Mei, Z | 1 |
| Zhang, F | 1 |
| Liu, P | 1 |
| An, JS | 1 |
| Tsuji, K | 3 |
| Onuma, H | 3 |
| Araya, N | 1 |
| Isono, M | 1 |
| Hoshino, T | 3 |
| Inomata, K | 2 |
| Hino, J | 1 |
| Miyazato, M | 1 |
| Hosoda, H | 1 |
| Kangawa, K | 1 |
| Nakagawa, Y | 2 |
| Katagiri, H | 3 |
| Miyatake, K | 3 |
| Sekiya, I | 3 |
| Muneta, T | 3 |
| Koga, H | 3 |
| Mlost, J | 1 |
| Kostrzewa, M | 1 |
| Borczyk, M | 1 |
| Bryk, M | 1 |
| Chwastek, J | 1 |
| Korostyński, M | 1 |
| Starowicz, K | 1 |
| Kwok, CHT | 1 |
| Kohro, Y | 1 |
| Mousseau, M | 1 |
| O'Brien, MS | 1 |
| Matyas, JR | 1 |
| McDougall, JJ | 5 |
| Trang, T | 1 |
| Allen, J | 1 |
| Imbert, I | 1 |
| Havelin, J | 1 |
| Henderson, T | 1 |
| Stevenson, G | 1 |
| Liaw, L | 1 |
| King, T | 1 |
| Philpott, HT | 1 |
| O'Brien, M | 1 |
| Miyagi, M | 2 |
| Ishikawa, T | 2 |
| Kamoda, H | 2 |
| Suzuki, M | 1 |
| Inoue, G | 2 |
| Sakuma, Y | 1 |
| Oikawa, Y | 1 |
| Orita, S | 2 |
| Uchida, K | 1 |
| Takahashi, K | 2 |
| Takaso, M | 1 |
| Ohtori, S | 2 |
| Aman, Y | 1 |
| Pitcher, T | 1 |
| Ballard, C | 1 |
| Malcangio, M | 1 |
| Udo, M | 2 |
| Ueki, H | 1 |
| Akiyama, M | 2 |
| Abula, K | 1 |
| Watanabe, T | 1 |
| Lockwood, SM | 1 |
| Lopes, DM | 1 |
| McMahon, SB | 1 |
| Dickenson, AH | 1 |
| Hahm, SC | 1 |
| Song, E | 1 |
| Jeon, H | 1 |
| Yoon, YW | 1 |
| Kim, J | 1 |
| Sakamoto, T | 1 |
| Miyazaki, T | 1 |
| Watanabe, S | 1 |
| Honjoh, K | 1 |
| Nakajima, H | 1 |
| Oki, H | 1 |
| Kokubo, Y | 1 |
| Matsumine, A | 1 |
| Sagar, DR | 1 |
| Ashraf, S | 2 |
| Xu, L | 1 |
| Burston, JJ | 2 |
| Menhinick, MR | 1 |
| Poulter, CL | 1 |
| Bennett, AJ | 2 |
| Walsh, DA | 1 |
| Chapman, V | 2 |
| van Buul, GM | 1 |
| Siebelt, M | 1 |
| Leijs, MJ | 1 |
| Bos, PK | 1 |
| Waarsing, JH | 1 |
| Kops, N | 1 |
| Weinans, H | 1 |
| Verhaar, JA | 1 |
| Bernsen, MR | 1 |
| van Osch, GJ | 1 |
| Moilanen, LJ | 1 |
| Hämäläinen, M | 1 |
| Nummenmaa, E | 1 |
| Ilmarinen, P | 1 |
| Vuolteenaho, K | 1 |
| Nieminen, RM | 1 |
| Lehtimäki, L | 1 |
| Moilanen, E | 1 |
| Thirunavukkarasu, K | 1 |
| Swearingen, CA | 1 |
| Oskins, JL | 3 |
| Lin, C | 2 |
| Bui, HH | 2 |
| Jones, SB | 1 |
| Pfeifer, LA | 1 |
| Norman, BH | 1 |
| Mitchell, PG | 2 |
| Chambers, MG | 3 |
| Albacete, S | 1 |
| Schuelert, N | 3 |
| Huang, J | 1 |
| Li, L | 1 |
| Mapp, PI | 1 |
| Ravipati, S | 1 |
| Pousinis, P | 1 |
| Barrett, DA | 1 |
| Scammell, BE | 1 |
| Johnson, MP | 1 |
| Jassal, K | 1 |
| Ochiai, N | 1 |
| Eguchi, Y | 1 |
| Arai, G | 1 |
| Toyone, T | 1 |
| Aoki, Y | 1 |
| Kubo, T | 1 |
| La Porta, C | 1 |
| Bura, SA | 1 |
| Aracil-Fernández, A | 1 |
| Manzanares, J | 1 |
| Maldonado, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Cannabinoid Patch for Knee Osteoarthritis[NCT04412837] | Phase 2 | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to Inadequate funding) | ||
| Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269] | Phase 2 | 30 participants (Anticipated) | Interventional | 2020-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
27 other studies available for iodoacetic acid and Arthralgia
| Article | Year |
|---|---|
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat.
Topics: Animals; Arthralgia; Behavior Observation Techniques; Behavior, Animal; Behavioral Symptoms; Disease | 2022 |
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.
Topics: Animals; Arthralgia; Collagenases; Disease Models, Animal; Drug Delivery Systems; Injections, Intra- | 2023 |
Regular walking exercise prior to knee osteoarthritis reduces joint pain in an animal model.
Topics: Animals; Arthralgia; Cartilage, Articular; Disease Models, Animal; Iodoacetic Acid; Knee Joint; Male | 2023 |
Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured; Chondrocytes; H | 2020 |
Effect and mechanism of the CACNA2D1-CGRP pathway in osteoarthritis-induced ongoing pain.
Topics: Adenylyl Cyclases; Animals; Arthralgia; Calcitonin Gene-Related Peptide; Calcium Channels, L-Type; C | 2020 |
Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model.
Topics: Adipose Tissue; Animals; Antifibrotic Agents; Arthralgia; Arthritis, Experimental; Behavior, Animal; | 2021 |
CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development.
Topics: Analgesics; Animals; Arthralgia; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal | 2021 |
Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity.
Topics: Adenosine Triphosphate; Animals; Arthralgia; Arthritis, Experimental; Disease Models, Animal; Female | 2021 |
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.
Topics: Anesthetics, Local; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Models, | 2017 |
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
Topics: Animals; Arthralgia; Cannabidiol; Disease Models, Animal; Inflammation; Iodoacetic Acid; Knee Joint; | 2017 |
Efficacy of nerve growth factor antibody in a knee osteoarthritis pain model in mice.
Topics: Animals; Antibodies; Arthralgia; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Evalu | 2017 |
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg | 2019 |
Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone.
Topics: Animals; Arthralgia; Avoidance Learning; Behavior, Animal; Calcitonin Gene-Related Peptide; Cartilag | 2018 |
Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint.
Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Progression; | 2019 |
Characterisation of peripheral and central components of the rat monoiodoacetate model of Osteoarthritis.
Topics: Animals; Arthralgia; Cartilage, Articular; Disease Models, Animal; Ganglia, Spinal; Immunohistochemi | 2019 |
Transcutaneous Electrical Nerve Stimulation Reduces Knee Osteoarthritic Pain by Inhibiting Spinal Glial Cells in Rats.
Topics: Animals; Arthralgia; Astrocytes; Cell Count; Hyperalgesia; Iodoacetic Acid; Knee Joint; Male; Neurog | 2019 |
Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis.
Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Fema | 2019 |
Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.
Topics: Animals; Arthralgia; Behavior, Animal; Bone Density Conservation Agents; Bone Remodeling; Diphosphon | 2014 |
Mesenchymal stem cells reduce pain but not degenerative changes in a mono-iodoacetate rat model of osteoarthritis.
Topics: Animals; Arthralgia; Cell- and Tissue-Based Therapy; Disease Models, Animal; Injections, Intra-Artic | 2014 |
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Blotting, Western; Cells, Cultured; Chondrocytes; Dise | 2015 |
Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.
Topics: Animals; Arthralgia; Arthritis, Experimental; Dogs; Humans; Iodoacetic Acid; Lysophosphatidylcholine | 2017 |
Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain.
Topics: Activating Transcription Factor 3; Adult; Aged; Aged, 80 and over; Animals; Arthralgia; Arthritis, E | 2017 |
Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Arthralgia; Behavior, Animal; Cartilage, Articular; D | 2017 |
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Dicl | 2011 |
Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.
Topics: Animals; Arthralgia; Chronic Disease; Disease Models, Animal; Disease Progression; Female; Inflammat | 2011 |
Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.
Topics: Analysis of Variance; Aniline Compounds; Animals; Arthralgia; Disease Models, Animal; Exploratory Be | 2012 |
Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.
Topics: Animals; Arthralgia; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalges | 2013 |