iodoacetic acid has been researched along with Adjuvant Arthritis in 58 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diacerein (DIA) is a slow-acting drug for osteoarthritis (OA)." | 7.96 | A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. ( Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG, 2020) |
| "We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments." | 7.88 | Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018) |
| "The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model." | 7.83 | Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ( Kim, HJ; Kim, SE; Lee, JY; Park, JW; Park, K; Song, HR; Yun, YP, 2016) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 7.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis." | 5.56 | Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| " The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis." | 5.43 | Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. ( Britti, D; Cordaro, M; Cuzzocrea, S; Di Paola, R; Evangelista, M; Fusco, R; Impellizzeri, D; Morittu, VM, 2016) |
| " Monoiodoacetic acid (MIA) was injected intra-articularly to induce IFP fibrosis and persistent pain." | 4.02 | Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model. ( An, JS; Araya, N; Hino, J; Hoshino, T; Hosoda, H; Inomata, K; Isono, M; Kangawa, K; Katagiri, H; Koga, H; Miyatake, K; Miyazato, M; Muneta, T; Nakagawa, Y; Onuma, H; Sekiya, I; Tsuji, K, 2021) |
| "Diacerein (DIA) is a slow-acting drug for osteoarthritis (OA)." | 3.96 | A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. ( Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG, 2020) |
| "We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments." | 3.88 | Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018) |
| "The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model." | 3.83 | Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ( Kim, HJ; Kim, SE; Lee, JY; Park, JW; Park, K; Song, HR; Yun, YP, 2016) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 3.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| "Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis." | 1.56 | Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020) |
| " This study determined the drug dosage and the mechanisms of GMGHT for OA." | 1.56 | Gumiganghwal-tang ameliorates cartilage destruction via inhibition of matrix metalloproteinase. ( Ahn, KS; Choi, Y; Hahm, DH; Kim, MH; Lee, SG; Um, JY; Yang, WM, 2020) |
| "In contrast, we observed persistent joint pain after day 10 in the high-dose group." | 1.51 | Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. ( Akiyama, M; Hoshino, T; Inomata, K; Katagiri, H; Koga, H; Miyatake, K; Muneta, T; Nakagawa, Y; Onuma, H; Sekiya, I; Tsuji, K; Udo, M, 2019) |
| "Osteoarthritis was induced by injection of monoiodoacetate (MIA)." | 1.51 | Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis. ( Honjoh, K; Kokubo, Y; Matsumine, A; Miyazaki, T; Nakajima, H; Oki, H; Sakamoto, T; Takahashi, A; Watanabe, S, 2019) |
| " Hits from this assay were tested in a plasma assay to assess inhibition of endogenous plasma autotaxin and subsequently tested for their ability to lower plasma LPA levels upon oral dosing of rats." | 1.46 | Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain. ( Bui, HH; Chambers, MG; Jones, SB; Lin, C; Mitchell, PG; Norman, BH; Oskins, JL; Pfeifer, LA; Swearingen, CA; Thirunavukkarasu, K, 2017) |
| "Preventive AR786 treatment inhibited pain behaviour development and therapeutic treatment attenuated established pain behaviour." | 1.43 | Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. ( Chapman, V; Mapp, PI; Nwosu, LN; Walsh, DA, 2016) |
| "The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects." | 1.43 | The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse. ( Malcangio, M; Pitcher, T; Sousa-Valente, J, 2016) |
| " The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis." | 1.43 | Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. ( Britti, D; Cordaro, M; Cuzzocrea, S; Di Paola, R; Evangelista, M; Fusco, R; Impellizzeri, D; Morittu, VM, 2016) |
| "Although analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear." | 1.42 | Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. ( Chapman, V; Nwosu, L; Sagar, DR; Walsh, DA, 2015) |
| "Inflammation and osteophyte scores were greater in MNX model compared to the MIA model." | 1.39 | Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. ( Ashraf, S; Burston, JJ; Chapman, V; Mapp, PI; Sagar, DR; Suri, S; Walsh, DA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.72) | 29.6817 |
| 2010's | 36 (62.07) | 24.3611 |
| 2020's | 21 (36.21) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, JI | 1 |
| Lee, HS | 1 |
| Jeon, YE | 1 |
| Kim, SM | 1 |
| Hong, SH | 1 |
| Moon, JM | 1 |
| Lim, CY | 1 |
| Kim, YH | 1 |
| Kim, EJ | 1 |
| Novikov, FN | 1 |
| Panova, MV | 1 |
| Titov, IY | 1 |
| Stroylov, VS | 1 |
| Stroganov, OV | 1 |
| Chilov, GG | 1 |
| Kwon, M | 1 |
| Nam, D | 1 |
| Kim, J | 2 |
| Ro, JY | 1 |
| Zhang, Y | 1 |
| Tricou, C | 1 |
| Yang, D | 1 |
| da Silva, JT | 1 |
| Zhang, R | 1 |
| Peng, KT | 1 |
| Liu, JF | 1 |
| Chiang, YC | 1 |
| Chen, PC | 1 |
| Chiang, MH | 1 |
| Shih, HN | 1 |
| Chang, PJ | 1 |
| Lee, CW | 1 |
| Chern, CM | 1 |
| Zhou, H | 1 |
| Wang, YH | 1 |
| Chang, CL | 1 |
| Chiou, WF | 1 |
| Chang, WT | 1 |
| Yao, CH | 1 |
| Liou, KT | 1 |
| Shen, YC | 1 |
| Hanafy, AS | 1 |
| El-Ganainy, SO | 1 |
| Piao, S | 1 |
| Du, W | 1 |
| Wei, Y | 1 |
| Yang, Y | 1 |
| Feng, X | 1 |
| Bai, L | 2 |
| Jung, JH | 1 |
| Kim, SE | 2 |
| Kim, HJ | 2 |
| Park, K | 3 |
| Song, GG | 1 |
| Choi, SJ | 1 |
| Artuzi, FE | 1 |
| Puricelli, E | 1 |
| Baraldi, CE | 1 |
| Quevedo, AS | 1 |
| Ponzoni, D | 1 |
| Na, HS | 2 |
| Park, JS | 2 |
| Cho, KH | 3 |
| Kwon, JY | 3 |
| Choi, J | 2 |
| Jhun, J | 3 |
| Kim, SJ | 3 |
| Park, SH | 4 |
| Cho, ML | 4 |
| Lee, D | 1 |
| Ju, MK | 1 |
| Kim, H | 2 |
| Micheli, L | 1 |
| Di Cesare Mannelli, L | 1 |
| Mattoli, L | 1 |
| Tamimi, S | 1 |
| Flamini, E | 1 |
| Garetto, S | 1 |
| Lucci, J | 1 |
| Giovagnoni, E | 1 |
| Cinci, L | 1 |
| D'Ambrosio, M | 1 |
| Luceri, C | 1 |
| Ghelardini, C | 1 |
| Kim, MH | 1 |
| Choi, Y | 1 |
| Ahn, KS | 1 |
| Um, JY | 1 |
| Lee, SG | 1 |
| Hahm, DH | 1 |
| Yang, WM | 1 |
| Lee, H | 1 |
| Seo, J | 1 |
| Choi, K | 1 |
| Lee, Y | 1 |
| Kim, S | 1 |
| Mobasheri, A | 1 |
| Choi, H | 1 |
| Ju, L | 1 |
| Hu, P | 1 |
| Chen, P | 1 |
| Xue, X | 1 |
| Li, Z | 1 |
| He, F | 1 |
| Qiu, Z | 1 |
| Cheng, J | 1 |
| Huang, F | 1 |
| Park, H | 1 |
| Hong, J | 1 |
| Yin, Y | 1 |
| Joo, Y | 1 |
| Kim, Y | 1 |
| Shin, J | 1 |
| Kwon, HH | 1 |
| Shin, N | 1 |
| Shin, HJ | 1 |
| Beom, J | 1 |
| Kim, DW | 1 |
| An, JS | 1 |
| Tsuji, K | 2 |
| Onuma, H | 2 |
| Araya, N | 1 |
| Isono, M | 1 |
| Hoshino, T | 2 |
| Inomata, K | 2 |
| Hino, J | 1 |
| Miyazato, M | 1 |
| Hosoda, H | 1 |
| Kangawa, K | 1 |
| Nakagawa, Y | 2 |
| Katagiri, H | 2 |
| Miyatake, K | 2 |
| Sekiya, I | 2 |
| Muneta, T | 2 |
| Koga, H | 2 |
| Min, GY | 1 |
| Park, JM | 1 |
| Joo, IH | 1 |
| Kim, DH | 1 |
| Tian, Y | 2 |
| Gou, J | 1 |
| Zhang, H | 1 |
| Lu, J | 1 |
| Jin, Z | 1 |
| Jia, S | 1 |
| Onodera, T | 1 |
| Terkawi, MA | 1 |
| Iwasaki, K | 1 |
| Hishimura, R | 1 |
| Liang, D | 1 |
| Miyazaki, T | 2 |
| Iwasaki, N | 1 |
| Kwok, CHT | 1 |
| Kohro, Y | 1 |
| Mousseau, M | 1 |
| O'Brien, MS | 1 |
| Matyas, JR | 1 |
| McDougall, JJ | 2 |
| Trang, T | 1 |
| Allen, J | 1 |
| Imbert, I | 1 |
| Havelin, J | 1 |
| Henderson, T | 1 |
| Stevenson, G | 1 |
| Liaw, L | 1 |
| King, T | 1 |
| Hayashi, S | 1 |
| Kamei, N | 1 |
| Ikuta, Y | 1 |
| Shimizu, R | 1 |
| Ishikawa, M | 1 |
| Adachi, N | 1 |
| Ochi, M | 1 |
| Sousa-Valente, J | 2 |
| Calvo, L | 1 |
| Vacca, V | 1 |
| Simeoli, R | 1 |
| Arévalo, JC | 1 |
| Malcangio, M | 4 |
| Wang, W | 1 |
| Ha, C | 1 |
| Lin, T | 1 |
| Wang, D | 1 |
| Wang, Y | 1 |
| Gong, M | 1 |
| Shetty, YC | 1 |
| Godbharle, S | 1 |
| Brahma, S | 1 |
| Salgaonkar, S | 1 |
| Rege, NN | 1 |
| Korostynski, M | 1 |
| Malek, N | 1 |
| Piechota, M | 1 |
| Starowicz, K | 1 |
| Park, JG | 1 |
| Yi, YS | 1 |
| Hong, YH | 1 |
| Yoo, S | 1 |
| Han, SY | 1 |
| Kim, E | 1 |
| Jeong, SG | 1 |
| Aravinthan, A | 1 |
| Baik, KS | 1 |
| Choi, SY | 2 |
| Son, YJ | 1 |
| Kim, JH | 1 |
| Cho, JY | 1 |
| Lee, SH | 2 |
| Jung, K | 2 |
| Yang, CW | 1 |
| Hinata, M | 1 |
| Imai, S | 1 |
| Sanaki, T | 1 |
| Tsuchida, J | 1 |
| Yoshioka, T | 1 |
| Higashino, K | 1 |
| Yamamoto, M | 1 |
| Imai, M | 1 |
| Soga, M | 1 |
| Horita, N | 1 |
| Fukuda, I | 1 |
| Ikeda, M | 1 |
| Yamane, S | 1 |
| Morita, A | 1 |
| Kanemasa, T | 1 |
| Sakaguchi, G | 1 |
| Hasegawa, M | 1 |
| Minami, M | 1 |
| Morioka, Y | 1 |
| Kawarai, Y | 1 |
| Orita, S | 3 |
| Nakamura, J | 3 |
| Miyamoto, S | 2 |
| Suzuki, M | 3 |
| Inage, K | 2 |
| Hagiwara, S | 2 |
| Suzuki, T | 3 |
| Nakajima, T | 2 |
| Akazawa, T | 1 |
| Ohtori, S | 3 |
| Korotkyi, O | 1 |
| Vovk, A | 1 |
| Blokhina, O | 1 |
| Dvorshchenko, K | 1 |
| Falalyeyeva, T | 1 |
| Abenavoli, L | 1 |
| Ostapchenko, L | 1 |
| Udo, M | 1 |
| Akiyama, M | 1 |
| Lee, SY | 1 |
| Kim, GY | 1 |
| Kim, SA | 1 |
| Go, EJ | 1 |
| Park, MJ | 1 |
| Baek, JA | 1 |
| Sakamoto, T | 1 |
| Watanabe, S | 1 |
| Takahashi, A | 1 |
| Honjoh, K | 1 |
| Nakajima, H | 1 |
| Oki, H | 1 |
| Kokubo, Y | 1 |
| Matsumine, A | 1 |
| Thote, T | 1 |
| Lin, AS | 1 |
| Raji, Y | 1 |
| Moran, S | 1 |
| Stevens, HY | 1 |
| Hart, M | 1 |
| Kamath, RV | 1 |
| Guldberg, RE | 1 |
| Willett, NJ | 1 |
| Kelly, S | 1 |
| Dobson, KL | 1 |
| Harris, J | 1 |
| Mapp, PI | 2 |
| Sagar, DR | 2 |
| Ashraf, S | 1 |
| Burston, JJ | 1 |
| Suri, S | 1 |
| Chapman, V | 3 |
| Walsh, DA | 3 |
| Boudenot, A | 1 |
| Presle, N | 1 |
| Uzbekov, R | 1 |
| Toumi, H | 1 |
| Pallu, S | 1 |
| Lespessailles, E | 1 |
| Nwosu, L | 1 |
| Yassin, NZ | 1 |
| El-Shenawy, SM | 1 |
| Abdel-Rahman, RF | 1 |
| Yakoot, M | 1 |
| Hassan, M | 1 |
| Helmy, S | 1 |
| Ogbonna, AC | 2 |
| Clark, AK | 2 |
| Nwosu, LN | 1 |
| Moilanen, LJ | 1 |
| Hämäläinen, M | 1 |
| Nummenmaa, E | 1 |
| Ilmarinen, P | 1 |
| Vuolteenaho, K | 1 |
| Nieminen, RM | 1 |
| Lehtimäki, L | 1 |
| Moilanen, E | 1 |
| Taniguchi, A | 1 |
| Ishikawa, T | 1 |
| Miyagi, M | 1 |
| Kamoda, H | 1 |
| Sakuma, Y | 1 |
| Oikawa, Y | 1 |
| Kubota, G | 1 |
| Sainoh, T | 1 |
| Aoki, Y | 1 |
| Toyone, T | 1 |
| Inoue, G | 1 |
| Yamauchi, K | 1 |
| Takahashi, K | 2 |
| Pitcher, T | 1 |
| Otis, C | 1 |
| Gervais, J | 1 |
| Guillot, M | 1 |
| Gervais, JA | 1 |
| Gauvin, D | 1 |
| Péthel, C | 1 |
| Authier, S | 1 |
| Dansereau, MA | 1 |
| Sarret, P | 1 |
| Martel-Pelletier, J | 1 |
| Pelletier, JP | 1 |
| Beaudry, F | 1 |
| Troncy, E | 1 |
| Park, JW | 2 |
| Yun, YP | 1 |
| Lee, JY | 1 |
| Song, HR | 1 |
| Omae, T | 1 |
| Takazawa, M | 1 |
| Thirunavukkarasu, K | 1 |
| Swearingen, CA | 1 |
| Oskins, JL | 2 |
| Lin, C | 2 |
| Bui, HH | 2 |
| Jones, SB | 1 |
| Pfeifer, LA | 1 |
| Norman, BH | 1 |
| Mitchell, PG | 2 |
| Chambers, MG | 2 |
| Albacete, S | 1 |
| Schuelert, N | 1 |
| Choi, HS | 1 |
| Im, S | 1 |
| Suh, HJ | 1 |
| Di Paola, R | 1 |
| Fusco, R | 1 |
| Impellizzeri, D | 1 |
| Cordaro, M | 1 |
| Britti, D | 1 |
| Morittu, VM | 1 |
| Evangelista, M | 1 |
| Cuzzocrea, S | 1 |
| Nam, J | 1 |
| Perera, P | 1 |
| Liu, J | 1 |
| Wu, LC | 1 |
| Rath, B | 1 |
| Butterfield, TA | 1 |
| Agarwal, S | 1 |
| Gentry, C | 1 |
| Hobbs, C | 1 |
| Moon, SJ | 1 |
| Jeong, JH | 1 |
| Yang, EJ | 1 |
| Park, MK | 1 |
| Kim, EK | 1 |
| Kim, HY | 1 |
| Min, JK | 1 |
| Uryu, N | 1 |
| Okada, K | 1 |
| Kawakita, K | 1 |
58 other studies available for iodoacetic acid and Adjuvant Arthritis
| Article | Year |
|---|---|
Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats.
Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Respo | 2021 |
Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cartilage; | 2021 |
Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Inflammation; Iodoacetic Acid; Male; Osteoarthritis; Pain; Rats; X | 2023 |
Age and Sex Differences in Acute and Osteoarthritis-Like Pain Responses in Rats.
Topics: Aging; Animals; Arthritis, Experimental; Behavior, Animal; Capsaicin; Enzyme Inhibitors; Female; Hyp | 2020 |
Particulate matter exposure aggravates osteoarthritis severity.
Topics: Animals; Arthritis, Experimental; Biomarkers; Cytokines; Inhalation Exposure; Iodoacetic Acid; Knee | 2019 |
Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Basic Helix-Loop-Helix Transcription Factors | 2020 |
Thermoresponsive Hyalomer intra-articular hydrogels improve monoiodoacetate-induced osteoarthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Dic | 2020 |
Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model.
Topics: AMP-Activated Protein Kinases; Animals; Arthritis, Experimental; Cells, Cultured; Chondrocytes; Dise | 2020 |
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis.
Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Experimental; Ca | 2020 |
Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Chondroitin Sulfates; Disease Models, Animal | 2020 |
Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured; Chondrocytes; H | 2020 |
Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Arti | 2020 |
Intra-Articular Route for the System of Molecules 14G1862 from
Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper | 2020 |
Gumiganghwal-tang ameliorates cartilage destruction via inhibition of matrix metalloproteinase.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Cell Line, Tumor; Chondrocytes; Collagen Typ | 2020 |
TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement.
Topics: Animals; Arthritis, Experimental; Cell- and Tissue-Based Therapy; Chondrocytes; Genetic Therapy; Hum | 2020 |
Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Capsules; Cytokines; Drugs, Chinese Herbal; | 2020 |
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 3; Cartilage | 2020 |
Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model.
Topics: Adipose Tissue; Animals; Antifibrotic Agents; Arthralgia; Arthritis, Experimental; Behavior, Animal; | 2021 |
Inhibition effect of
Topics: Animals; Arthritis, Experimental; Caragana; Cells, Cultured; Chondrocytes; Humans; Inflammation Medi | 2021 |
The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Hydroxyeicosatetraenoic Acids; Inflammat | 2021 |
Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model.
Topics: Animals; Antibodies, Monoclonal, Humanized; Arthritis, Experimental; Cartilage, Articular; Dose-Resp | 2021 |
Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity.
Topics: Adenosine Triphosphate; Animals; Arthralgia; Arthritis, Experimental; Disease Models, Animal; Female | 2021 |
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats.
Topics: Anesthetics, Local; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Models, | 2017 |
Chondrocyte Cell-Sheet Transplantation for Treating Monoiodoacetate-Induced Arthritis in Rats.
Topics: Allografts; Animals; Arthritis, Experimental; Chondrocytes; Iodoacetic Acid; Rats; Rats, Sprague-Daw | 2017 |
Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model.
Topics: Animals; Arthritis, Experimental; Cartilage Diseases; Cartilage, Articular; Cyclooxygenase 2; Diseas | 2018 |
Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chemokine CXCL12; | 2018 |
Evaluation of oral multi-herbal preparation of Dashmoolarishta on mice model of osteoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Female; Hyaluronic Acid; Iodoacetic Acid; Male; | 2017 |
Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model.
Topics: Animals; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Gene Expression Regulation; Iodo | 2018 |
Tabetri™ (
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chondrocytes; Ethanol; Humans; Inflammat | 2017 |
The Combination of Probiotic Complex, Rosavin, and Zinc Improves Pain and Cartilage Destruction in an Osteoarthritis Rat Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Cyto | 2018 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic | 2018 |
Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Ganglia | 2018 |
Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Carrageenan; Chondroitin Sulfates; Cytokines; Disease Models, Anim | 2019 |
Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint.
Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Progression; | 2019 |
The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Administration, Intravenous; Animals; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured | 2018 |
Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis.
Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Fema | 2019 |
Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Disease Progression; | 2013 |
Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Disease Models, Animal; Electric Stimulation; El | 2013 |
Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Disease Models, Animal; En | 2013 |
Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model.
Topics: Absorptiometry, Photon; Animals; Arthritis, Experimental; Bone Density; Cartilage, Articular; Diseas | 2014 |
Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Injections, Intra-Articular; Iodoacetic Acid; Ma | 2015 |
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A | 2015 |
Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice.
Topics: Aging; Animals; Arthritis, Experimental; Behavior, Animal; Immunohistochemistry; Inflammation; Iodoa | 2015 |
Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.
Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Drug Evaluation, Preclinical; Iodoacetic | 2016 |
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.
Topics: Animals; Arthralgia; Arthritis, Experimental; Blotting, Western; Cells, Cultured; Chondrocytes; Dise | 2015 |
Decreased calcitonin gene-related peptide expression in the dorsal root ganglia of TNF-deficient mice in a monoiodoacetate-induced knee osteoarthritis model.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme In | 2015 |
The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Chondrocytes; Disease Mode | 2016 |
Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model.
Topics: Acclimatization; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Conditionin | 2016 |
Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Proliferation; Chond | 2016 |
Pain-related behavior and the characteristics of dorsal-root ganglia in a rat model of hip osteoarthritis induced by mono-iodoacetate.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, | 2017 |
Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.
Topics: Animals; Arthralgia; Arthritis, Experimental; Dogs; Humans; Iodoacetic Acid; Lysophosphatidylcholine | 2017 |
Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain.
Topics: Activating Transcription Factor 3; Adult; Aged; Aged, 80 and over; Animals; Arthralgia; Arthritis, E | 2017 |
Protective Effect of Deer Bone Oil on Cartilage Destruction in Rats with Monosodium Iodoacetate (MIA)-Induced Osteoarthritis.
Topics: Animals; Arthritis, Experimental; Bone and Bones; Cartilage, Articular; Cell Survival; Cells, Cultur | 2016 |
Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dicarboxylic Acids; Hyaluron | 2016 |
Transcriptome-wide gene regulation by gentle treadmill walking during the progression of monoiodoacetate-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage; Disease Progression; Exercise Test; Exercise Therapy; F | 2011 |
Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Hyperalgesia; I | 2013 |
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis.
Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco | 2013 |
Analgesic effects of indirect moxibustion on an experimental rat model of osteoarthritis in the knee.
Topics: Acupuncture Analgesia; Animals; Arthritis, Experimental; Disease Models, Animal; Iodoacetic Acid; Ma | 2007 |