iodoacetic acid has been researched along with Ache in 62 studies
Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results showed that Chrysin not only attenuated synovial inflammation but also reduced the secretion of pain-related factors and increased the PWT and cold pain threshold in rats." | 7.96 | Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats. ( Ding, L; Li, X; Liao, T; Ma, Z; Wang, P; Wu, P; Xiao, Y; Xu, B; Zhang, H; Zhang, L, 2020) |
| "We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments." | 7.88 | Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 7.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| " After daily administration of atorvastatin (3, 10 and 30 mg/kg) for 20 days by oral gavage, pain was assessed on days 0, 1, 3, 7, 14 and 21." | 7.81 | Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; Pathak, NN; Sharma, AK; Tandan, SK, 2015) |
| "Acute oral toxicity of m-PGA resulted in LD50 values in excess of 2000 mg/kg." | 5.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 5.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| "The results showed that Chrysin not only attenuated synovial inflammation but also reduced the secretion of pain-related factors and increased the PWT and cold pain threshold in rats." | 3.96 | Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats. ( Ding, L; Li, X; Liao, T; Ma, Z; Wang, P; Wu, P; Xiao, Y; Xu, B; Zhang, H; Zhang, L, 2020) |
| "We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments." | 3.88 | Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018) |
| " Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain." | 3.85 | Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017) |
| " After daily administration of atorvastatin (3, 10 and 30 mg/kg) for 20 days by oral gavage, pain was assessed on days 0, 1, 3, 7, 14 and 21." | 3.81 | Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; Pathak, NN; Sharma, AK; Tandan, SK, 2015) |
| "Eplerenone treatment produced a significant improvement in motor coordination and spontaneous locomotor activity in rats and modulated the key inflammatory mediators in OA (TNF-α, NF-κβ, and IL-6)." | 1.91 | Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis. ( Mostafa, RE; Salama, AAA, 2023) |
| "Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom." | 1.72 | Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice. ( Elisei, L; Galdino, G; Malta, I; Moraes, T; Novaes, R, 2022) |
| "After osteoarthritis was induced by intra-articular injection of MIA, pain behavioral tests were performed." | 1.72 | Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis. ( Chao, D; Hogan, QH; Pan, B; Tran, H, 2022) |
| "Acute oral toxicity of m-PGA resulted in LD50 values in excess of 2000 mg/kg." | 1.51 | Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019) |
| "Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control." | 1.51 | Animal Models for the Study of Bone-Derived Pain. ( Largent-Milnes, TM; Thompson, AL; Vanderah, TW, 2019) |
| "Osteoarthritic pain is a chronic disabling condition lacking effective treatment." | 1.51 | Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019) |
| "Preventive AR786 treatment inhibited pain behaviour development and therapeutic treatment attenuated established pain behaviour." | 1.43 | Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. ( Chapman, V; Mapp, PI; Nwosu, LN; Walsh, DA, 2016) |
| " Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days." | 1.43 | Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016) |
| "To assess neural correlates of mechanical hyperalgesia, hindpaws were stimulated with von Frey hairs (8 g: MIA; 15 g: control knee, based on behavioral withdrawal responses)." | 1.43 | Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. ( Abaei, M; Auer, DP; Chapman, V; Prior, M; Sagar, DR; Spicer, CH; Stockley, EG, 2016) |
| "The current treatments for OA pain such as NSAIDS or opiates are neither sufficiently effective nor devoid of detrimental side effects." | 1.43 | The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse. ( Malcangio, M; Pitcher, T; Sousa-Valente, J, 2016) |
| "Although analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear." | 1.42 | Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. ( Chapman, V; Nwosu, L; Sagar, DR; Walsh, DA, 2015) |
| "Osteoarthritis was produced by single intra-articular injection of the MIA in the right knee joint on day 0." | 1.39 | Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Gupta, G; Kumar, D; Kumari, RR; Lingaraju, MC; More, AS; Pathak, NN; Sharma, AK; Tandan, SK, 2013) |
| "MIA injection produced thermal hyperalgesia (assessed by the plantar test) and tactile allodynia (measured with von Frey hairs)." | 1.35 | Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. ( Dolezal, T; Krsiak, M; Prochazkova, M; Prokesova, L; Zanvit, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.61) | 29.6817 |
| 2010's | 35 (56.45) | 24.3611 |
| 2020's | 26 (41.94) | 2.80 |
| Authors | Studies |
|---|---|
| Malta, I | 1 |
| Moraes, T | 1 |
| Elisei, L | 1 |
| Novaes, R | 1 |
| Galdino, G | 1 |
| Lee, M | 1 |
| Kim, GH | 1 |
| Kim, M | 1 |
| Seo, JM | 1 |
| Kim, YM | 1 |
| Seon, MR | 1 |
| Um, S | 1 |
| Choi, SJ | 1 |
| Oh, W | 1 |
| Song, BR | 1 |
| Jin, HJ | 1 |
| Zhang, X | 1 |
| Chen, R | 1 |
| Liao, Z | 1 |
| Zhu, Y | 1 |
| Chen, Y | 1 |
| Liu, J | 1 |
| Chen, X | 1 |
| Han, FY | 1 |
| Brockman, DA | 1 |
| Nicholson, JR | 1 |
| Corradini, L | 1 |
| Smith, MT | 1 |
| Lee, YM | 1 |
| Son, E | 1 |
| Kim, SH | 1 |
| Kim, DS | 1 |
| Chao, D | 1 |
| Tran, H | 1 |
| Hogan, QH | 1 |
| Pan, B | 1 |
| Na, HS | 3 |
| Lee, SY | 3 |
| Lee, DH | 1 |
| Woo, JS | 1 |
| Choi, SY | 2 |
| Cho, KH | 3 |
| Kim, SA | 2 |
| Go, EJ | 2 |
| Lee, AR | 1 |
| Choi, JW | 1 |
| Kim, SJ | 4 |
| Cho, ML | 7 |
| Arai, T | 1 |
| Suzuki-Narita, M | 1 |
| Takeuchi, J | 1 |
| Tajiri, I | 1 |
| Inage, K | 2 |
| Kawarai, Y | 1 |
| Eguchi, Y | 1 |
| Shiga, Y | 1 |
| Hozumi, T | 1 |
| Kim, G | 1 |
| Tsuchiya, R | 1 |
| Otagiri, T | 1 |
| Mukaihata, T | 1 |
| Hishiya, T | 1 |
| Toshi, N | 1 |
| Okuyama, K | 1 |
| Tokeshi, S | 1 |
| Furuya, T | 1 |
| Maki, S | 1 |
| Matsuura, Y | 1 |
| Suzuki, T | 3 |
| Nakamura, J | 3 |
| Hagiwara, S | 2 |
| Ohtori, S | 3 |
| Orita, S | 3 |
| Sriwatananukulkit, O | 2 |
| Desclaux, S | 2 |
| Tawonsawatruk, T | 2 |
| Srikuea, R | 2 |
| Himakhun, W | 2 |
| Likitnukul, S | 2 |
| Hemstapat, R | 2 |
| Jin, H | 1 |
| Yang, Y | 1 |
| Lei, G | 1 |
| Zeng, C | 1 |
| He, K | 1 |
| Wang, Y | 2 |
| Deng, C | 1 |
| Wei, J | 2 |
| Li, X | 3 |
| Li, H | 2 |
| Mostafa, RE | 1 |
| Salama, AAA | 1 |
| Barry, F | 1 |
| Chai, F | 1 |
| Chijcheapaza-Flores, H | 1 |
| Garcia-Fernandez, MJ | 1 |
| Blanchemain, N | 1 |
| Nicot, R | 1 |
| Kwon, M | 1 |
| Nam, D | 1 |
| Kim, J | 2 |
| Wang, X | 1 |
| Song, J | 1 |
| Xia, P | 1 |
| Lin, Q | 1 |
| Chen, A | 1 |
| Cheng, K | 1 |
| Kong, F | 1 |
| Shi, Y | 1 |
| Yun, SY | 1 |
| Kim, Y | 2 |
| Kim, H | 2 |
| Lee, BK | 1 |
| Oh, DK | 1 |
| Jhun, JY | 2 |
| Lee, JS | 1 |
| Um, IG | 1 |
| Park, MS | 1 |
| Park, SH | 6 |
| Sun, J | 1 |
| Wang, XH | 1 |
| Song, FH | 1 |
| Li, DY | 1 |
| Gao, SJ | 1 |
| Zhang, LQ | 1 |
| Wu, JY | 1 |
| Liu, DQ | 1 |
| Wang, LW | 1 |
| Zhou, YQ | 1 |
| Mei, W | 1 |
| Cordaro, M | 1 |
| Siracusa, R | 1 |
| Impellizzeri, D | 1 |
| D' Amico, R | 1 |
| Peritore, AF | 1 |
| Crupi, R | 1 |
| Gugliandolo, E | 1 |
| Fusco, R | 1 |
| Di Paola, R | 1 |
| Schievano, C | 1 |
| Cuzzocrea, S | 1 |
| Li, Y | 1 |
| Wu, F | 1 |
| Lao, L | 1 |
| Shen, X | 1 |
| Sa, L | 1 |
| Wei, X | 1 |
| Huang, Q | 1 |
| Cai, Y | 1 |
| Lu, D | 1 |
| Mei, R | 1 |
| Hu, X | 1 |
| Lee, D | 1 |
| Ju, MK | 1 |
| Micheli, L | 2 |
| Di Cesare Mannelli, L | 2 |
| Mattoli, L | 1 |
| Tamimi, S | 1 |
| Flamini, E | 1 |
| Garetto, S | 1 |
| Lucci, J | 1 |
| Giovagnoni, E | 1 |
| Cinci, L | 1 |
| D'Ambrosio, M | 1 |
| Luceri, C | 1 |
| Ghelardini, C | 2 |
| Xu, J | 1 |
| Yan, L | 3 |
| Yan, B | 2 |
| Zhou, L | 3 |
| Tong, P | 3 |
| Shan, L | 3 |
| Liao, T | 1 |
| Ding, L | 1 |
| Wu, P | 1 |
| Zhang, L | 1 |
| Xu, B | 1 |
| Zhang, H | 1 |
| Ma, Z | 1 |
| Xiao, Y | 1 |
| Wang, P | 1 |
| Bryk, M | 1 |
| Chwastek, J | 1 |
| Kostrzewa, M | 1 |
| Mlost, J | 1 |
| Pędracka, A | 1 |
| Starowicz, K | 1 |
| da Silva Nascimento, FG | 1 |
| de Souza Ferreira Bringel, PH | 1 |
| Maia, FWS | 1 |
| Lima, CPC | 1 |
| Alves, RC | 1 |
| Feitosa, JPA | 1 |
| Mota, MRL | 1 |
| Assreuy, AMS | 1 |
| Castro, RR | 1 |
| Park, H | 1 |
| Hong, J | 1 |
| Yin, Y | 1 |
| Joo, Y | 1 |
| Shin, J | 1 |
| Kwon, HH | 1 |
| Shin, N | 1 |
| Shin, HJ | 1 |
| Beom, J | 1 |
| Kim, DW | 1 |
| Lucarini, E | 1 |
| Cialdai, F | 1 |
| Vignali, L | 1 |
| Monici, M | 1 |
| Park, YJ | 1 |
| Cho, YR | 1 |
| Oh, JS | 1 |
| Ahn, EK | 1 |
| Philpott, HT | 1 |
| O'Brien, M | 1 |
| McDougall, JJ | 1 |
| Wang, W | 1 |
| Ha, C | 1 |
| Lin, T | 1 |
| Wang, D | 1 |
| Gong, M | 1 |
| Shetty, YC | 1 |
| Godbharle, S | 1 |
| Brahma, S | 1 |
| Salgaonkar, S | 1 |
| Rege, NN | 1 |
| Ichiseki, T | 1 |
| Shimazaki, M | 1 |
| Ueda, Y | 1 |
| Ueda, S | 1 |
| Tsuchiya, M | 1 |
| Souma, D | 1 |
| Kaneuji, A | 1 |
| Kawahara, N | 1 |
| Kwon, JY | 3 |
| Lee, SH | 3 |
| Jhun, J | 3 |
| Choi, J | 1 |
| Jung, K | 3 |
| Yang, CW | 2 |
| Hinata, M | 1 |
| Imai, S | 1 |
| Sanaki, T | 2 |
| Tsuchida, J | 1 |
| Yoshioka, T | 2 |
| Higashino, K | 2 |
| Yamamoto, M | 1 |
| Imai, M | 1 |
| Soga, M | 1 |
| Horita, N | 1 |
| Fukuda, I | 1 |
| Ikeda, M | 1 |
| Yamane, S | 1 |
| Morita, A | 1 |
| Kanemasa, T | 1 |
| Sakaguchi, G | 1 |
| Hasegawa, M | 2 |
| Minami, M | 1 |
| Morioka, Y | 2 |
| Karlapudi, V | 1 |
| Prasad Mungara, AVV | 1 |
| Sengupta, K | 1 |
| Davis, BA | 1 |
| Raychaudhuri, SP | 1 |
| Haywood, AR | 1 |
| Hathway, GJ | 1 |
| Chapman, V | 4 |
| Cho, Y | 1 |
| Wang, C | 1 |
| Sun, W | 1 |
| Yu, L | 1 |
| Liu, F | 2 |
| Du, W | 2 |
| Yu, G | 1 |
| Hu, Z | 1 |
| Yuan, Q | 2 |
| Xiao, L | 1 |
| Zhang, J | 1 |
| Efferth, T | 2 |
| Sakurai, Y | 1 |
| Fujita, M | 1 |
| Kawasaki, S | 1 |
| Tofukuji, S | 1 |
| Yoneda, S | 1 |
| Takahashi, T | 1 |
| Koda, K | 1 |
| Asaki, T | 1 |
| Kim, GY | 1 |
| Park, MJ | 1 |
| Baek, JA | 1 |
| Thompson, AL | 1 |
| Largent-Milnes, TM | 1 |
| Vanderah, TW | 1 |
| Xie, D | 1 |
| Chen, F | 1 |
| Carcolé, M | 1 |
| Kummer, S | 1 |
| Gonçalves, L | 1 |
| Zamanillo, D | 1 |
| Merlos, M | 1 |
| Dickenson, AH | 1 |
| Fernández-Pastor, B | 1 |
| Cabañero, D | 1 |
| Maldonado, R | 1 |
| Lee, J | 1 |
| Hong, YS | 1 |
| Jeong, JH | 2 |
| Yang, EJ | 2 |
| Park, MK | 2 |
| Jung, YO | 1 |
| Min, JK | 2 |
| Kim, HY | 2 |
| Ishikawa, G | 1 |
| Nagakura, Y | 1 |
| Takeshita, N | 2 |
| Shimizu, Y | 2 |
| Sagar, DR | 2 |
| Nwosu, L | 1 |
| Walsh, DA | 2 |
| Pathak, NN | 2 |
| Balaganur, V | 2 |
| Lingaraju, MC | 2 |
| Kant, V | 1 |
| Kumar, D | 4 |
| Sharma, AK | 2 |
| Tandan, SK | 2 |
| Nwosu, LN | 1 |
| Mapp, PI | 1 |
| Taniguchi, A | 1 |
| Ishikawa, T | 1 |
| Miyagi, M | 1 |
| Kamoda, H | 1 |
| Sakuma, Y | 1 |
| Oikawa, Y | 1 |
| Kubota, G | 1 |
| Sainoh, T | 1 |
| Aoki, Y | 1 |
| Toyone, T | 1 |
| Inoue, G | 1 |
| Suzuki, M | 2 |
| Yamauchi, K | 1 |
| Takahashi, K | 2 |
| Frost, JM | 1 |
| DeGoey, DA | 1 |
| Shi, L | 1 |
| Gum, RJ | 1 |
| Fricano, MM | 1 |
| Lundgaard, GL | 1 |
| El-Kouhen, OF | 1 |
| Hsieh, GC | 1 |
| Neelands, T | 1 |
| Matulenko, MA | 1 |
| Daanen, JF | 1 |
| Pai, M | 1 |
| Ghoreishi-Haack, N | 1 |
| Zhan, C | 1 |
| Zhang, XF | 1 |
| Kort, ME | 1 |
| Abaei, M | 1 |
| Stockley, EG | 1 |
| Spicer, CH | 1 |
| Prior, M | 1 |
| Auer, DP | 1 |
| Pitcher, T | 1 |
| Sousa-Valente, J | 1 |
| Malcangio, M | 1 |
| Otis, C | 1 |
| Gervais, J | 1 |
| Guillot, M | 1 |
| Gervais, JA | 1 |
| Gauvin, D | 1 |
| Péthel, C | 1 |
| Authier, S | 1 |
| Dansereau, MA | 1 |
| Sarret, P | 1 |
| Martel-Pelletier, J | 1 |
| Pelletier, JP | 1 |
| Beaudry, F | 2 |
| Troncy, E | 1 |
| Miyamoto, S | 1 |
| Nakajima, T | 1 |
| Omae, T | 1 |
| Takazawa, M | 1 |
| Prochazkova, M | 1 |
| Zanvit, P | 1 |
| Dolezal, T | 1 |
| Prokesova, L | 1 |
| Krsiak, M | 1 |
| Yoshimi, E | 1 |
| Hatori, C | 1 |
| Kumakura, F | 1 |
| Seki, N | 1 |
| Ferland, CE | 1 |
| Pailleux, F | 1 |
| Vachon, P | 1 |
| Izumi, M | 1 |
| Ikeuchi, M | 1 |
| Ji, Q | 1 |
| Tani, T | 1 |
| More, AS | 1 |
| Kumari, RR | 1 |
| Gupta, G | 1 |
| Moon, SJ | 1 |
| Park, JS | 1 |
| Kim, EK | 1 |
| Shao, H | 1 |
| Han, G | 1 |
| Ling, P | 1 |
| Zhu, X | 1 |
| Wang, F | 1 |
| Zhao, L | 1 |
| Liu, X | 1 |
| Wang, G | 1 |
| Ying, Y | 1 |
| Zhang, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Cannabinoid Patch for Knee Osteoarthritis[NCT04412837] | Phase 2 | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to Inadequate funding) | ||
| Randomized Controlled Trial of Exercise Therapy in Combination With Central Nervous System-targeted Treatment Compared With Exercise Therapy Alone for Treatment of People With Knee Osteoarthritis[NCT03681613] | 104 participants (Anticipated) | Interventional | 2019-01-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for iodoacetic acid and Ache
| Article | Year |
|---|---|
Pain Intensity and Trajectory Following Intra-Articular Injection of Mono-Iodoacetate in Experimental Osteoarthritis: A Meta-Analysis of
Topics: Animals; Injections, Intra-Articular; Iodoacetic Acid; Osteoarthritis; Pain; Pain Measurement; Rats | 2023 |
1 trial available for iodoacetic acid and Ache
| Article | Year |
|---|---|
A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee.
Topics: Aged; Animals; Body Mass Index; Body Weight; Boswellia; Curcuma; Cytokines; Disease Models, Animal; | 2018 |
60 other studies available for iodoacetic acid and Ache
| Article | Year |
|---|---|
Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice.
Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Male; Mice; Neuroglia; Nociception; Osteoarthritis | 2022 |
PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model.
Topics: Animals; C-Reactive Protein; Cytokines; Disease Models, Animal; Inflammation; Injections, Intra-Arti | 2021 |
The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium Iodoacetate Induced Osteoarthritis.
Topics: Animals; Cartilage, Articular; Cytokines; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; P | 2022 |
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat.
Topics: Animals; Arthralgia; Behavior Observation Techniques; Behavior, Animal; Behavioral Symptoms; Disease | 2022 |
Anti-Inflammatory and Analgesic Effects of
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Iodoacetic Acid; Lipopolysaccharides; Mi | 2022 |
Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ganglia, Spina | 2022 |
Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Cartilage; Cartilage, Articular; Chemokine CCL2; Dis | 2022 |
Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Diclofenac; Disease Models, Animal; Hyaluronic | 2022 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain.
Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta | 2023 |
Eplerenone modulates the inflammatory response in monosodium iodoacetate-induced knee osteoarthritis in rats: Involvement of RANKL/OPG axis.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Eplerenone; Humans; Inflammation; Iodoacetic | 2023 |
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.
Topics: Animals; Arthralgia; Collagenases; Disease Models, Animal; Drug Delivery Systems; Injections, Intra- | 2023 |
Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Topics: Animals; Arthritis, Experimental; Inflammation; Iodoacetic Acid; Male; Osteoarthritis; Pain; Rats; X | 2023 |
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; High-Intensity Interval Training; Hyperalgesia; Iodoacetic Acid; Os | 2023 |
Effective Technical Protocol for Producing a Mono-Iodoacetate-Induced Temporomandibular Joint Osteoarthritis in a Rat Model.
Topics: Animals; Bone Remodeling; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Pain; Rats; Tempo | 2023 |
Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Inflammation; Iodoacetic Acid; Osteoarthriti | 2023 |
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Hyperalgesia; Iodoacetic Acid; Neuroinflammat | 2023 |
Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain.
Topics: Analgesics; Animals; Carrageenan; Female; Glucosamine; Hyperalgesia; Inflammation; Iodoacetic Acid; | 2019 |
Laser Moxibustion Alleviates Knee Osteoarthritis Pain by Inhibiting Spinal Microglial Activation-Mediated Neuroinflammation in Rats.
Topics: Animals; Cytokines; Disease Models, Animal; Iodoacetic Acid; Low-Level Light Therapy; Male; Microgli | 2020 |
Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cartilage, Articular; Chondrocytes; Cytokines; Fema | 2020 |
Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Arti | 2020 |
Intra-Articular Route for the System of Molecules 14G1862 from
Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper | 2020 |
Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats.
Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Injections, Intra-Ar | 2020 |
Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats.
Topics: Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Flavonoids; Inflammasomes; Iodoacetic Acid | 2020 |
Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Disease Progression; Endocannabinoids; Gene Expr | 2020 |
Galactomannan of Delonix regia seeds reduces nociception and morphological damage in the rat model of osteoarthritis induced by sodium monoiodoacetate.
Topics: Analgesics; Animals; Disease Models, Animal; Fabaceae; Foot Joints; Galactose; Iodoacetic Acid; Male | 2021 |
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 3; Cartilage | 2020 |
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat.
Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Inflammation; Infrared Rays; Injections, Intra-A | 2017 |
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats.
Topics: Animals; Bone and Bones; Cartilage; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Female; Inf | 2017 |
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.
Topics: Animals; Arthralgia; Cannabidiol; Disease Models, Animal; Inflammation; Iodoacetic Acid; Knee Joint; | 2017 |
Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chemokine CXCL12; | 2018 |
Evaluation of oral multi-herbal preparation of Dashmoolarishta on mice model of osteoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Female; Hyaluronic Acid; Iodoacetic Acid; Male; | 2017 |
Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model.
Topics: ADAMTS5 Protein; Animals; Calcitonin Gene-Related Peptide; Cartilage, Articular; Cell Adhesion Molec | 2018 |
The Combination of Probiotic Complex, Rosavin, and Zinc Improves Pain and Cartilage Destruction in an Osteoarthritis Rat Model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Cyto | 2018 |
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic | 2018 |
Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expre | 2018 |
Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis.
Topics: Animals; Cartilage; Chondrocytes; Iodoacetic Acid; Lactobacillus acidophilus; Male; Osteoarthritis; | 2018 |
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis.
Topics: Agkistrodon; Analgesics; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Complex Mixtures; H | 2019 |
Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors.
Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease | 2019 |
The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.
Topics: Administration, Intravenous; Animals; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured | 2018 |
Animal Models for the Study of Bone-Derived Pain.
Topics: Animals; Behavior, Animal; Bone and Bones; Bone Neoplasms; Cell Culture Techniques; Cell Line, Tumor | 2019 |
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-α-induced activation of NF-ĸB pathway in chondrocytes.
Topics: Analgesics; Animals; Arthritis; Blood Platelets; Cell Survival; Chondrocytes; Gene Expression Regula | 2019 |
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2019 |
Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines.
Topics: Analgesics; Animals; Cartilage; Cytokines; Disease Models, Animal; Gene Expression Regulation; Infla | 2013 |
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxe | 2014 |
Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Injections, Intra-Articular; Iodoacetic Acid; Ma | 2015 |
Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy.
Topics: Animals; Atorvastatin; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibit | 2015 |
Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.
Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Drug Evaluation, Preclinical; Iodoacetic | 2016 |
Decreased calcitonin gene-related peptide expression in the dorsal root ganglia of TNF-deficient mice in a monoiodoacetate-induced knee osteoarthritis model.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme In | 2015 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Ev | 2016 |
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.
Topics: Animals; Behavior, Animal; Brain; Brain Mapping; Capsaicin; Disease Models, Animal; Electric Stimula | 2016 |
The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Cartilage, Articular; Chondrocytes; Disease Mode | 2016 |
Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model.
Topics: Acclimatization; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Conditionin | 2016 |
Pain-related behavior and the characteristics of dorsal-root ganglia in a rat model of hip osteoarthritis induced by mono-iodoacetate.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, | 2017 |
Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Hyperalgesia; | 2009 |
Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cell Line; Chondrocytes; Din | 2011 |
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry.
Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, Liquid; Disease Models, Animal; Dynorphins | 2011 |
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis.
Topics: Acid Sensing Ion Channels; Animals; Behavior, Animal; Cnidarian Venoms; Gene Expression Regulation; | 2012 |
Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intra-Articular; Iodo | 2013 |
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis.
Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco | 2013 |
Intra-articular injection of xanthan gum reduces pain and cartilage damage in a rat osteoarthritis model.
Topics: Animals; Cartilage, Articular; Disease Models, Animal; Injections, Intra-Articular; Iodoacetic Acid; | 2013 |