Page last updated: 2024-10-29

iodixanol and Disease Models, Animal

iodixanol has been researched along with Disease Models, Animal in 31 studies

iodixanol: dimeric contrast media; structure given in first source
iodixanol : A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved."7.88Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury. ( Miao, D; Wang, Y; Yang, Z; Zhang, D; Zhang, H, 2018)
"In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved."3.88Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury. ( Miao, D; Wang, Y; Yang, Z; Zhang, D; Zhang, H, 2018)
"Rats received nitric oxide synthase inhibitor L-NAME (10 mg/kg) and cyclooxygenase inhibitor indomethacin (10 mg/kg) to induce the risk for developing iodinated contrast-induced acute kidney injury before receiving one of the interventions: NAC, furosemide, or placebo."3.80Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker. ( Franklin, T; Li, LP; Lu, J; Papadopoulou, MV; Prasad, PV; Solomon, R; Thacker, J; Zhou, Y, 2014)
"To experimentally evaluate gadolinium (Gd)-, carbon dioxide (CO(2))-, and iodixanol-enhanced digital subtraction angiography (DSA) versus histomorphometry in the assessment of renal artery stenosis."3.71Evaluation of renal arteries with use of gadoterate meglumine-, CO(2)-, and iodixanol-enhanced DSA measurements versus histomorphometry in renal artery restenosis in rabbits. ( Bazot, MJ; Bigot, JM; Bonneau, M; Boudghene, F; Farres, MT; Le Blanche, AF; Levy, B; Wassef, M, 2001)
"The overall lung injury score for the barium (60."1.46The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model. ( Belafsky, PC; Cheney, DM; Kuhn, MA; Litts, JK; Nativ-Zeltzer, N; Siddiqui, MT, 2017)
"Thrombosis was measured over a blood exposure period of 2 hours by gamma camera imaging of 111In-platelets and by gamma counting of deposited 125I-fibrin."1.31Antithrombotic effects of ionic and non-ionic contrast media in nonhuman primates. ( Chronos, NA; Hanson, SR; Markou, CP, 2001)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.23)18.2507
2000's6 (19.35)29.6817
2010's19 (61.29)24.3611
2020's5 (16.13)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Ran, F1
Yang, Y1
Yang, L1
Chen, S1
He, P1
Liu, Q1
Zou, Q1
Wang, D1
Hou, J1
Wang, P1
Sharma, A1
Kilari, S1
Cai, C1
Simeon, ML1
Misra, S1
Chen, W1
Sun, J1
Kappel, SS1
Gormsen, M1
Sangild, PT1
Aunsholt, L1
Ghaghada, KB3
Ren, P1
Devkota, L1
Starosolski, Z1
Zhang, C1
Vela, D2
Stupin, IV1
Tanifum, EA1
Annapragada, AV1
Shen, YH1
LeMaire, SA1
Wang, Y3
Zhang, H2
Yang, Z1
Miao, D1
Zhang, D1
Cheng, W1
Zhao, F1
Tang, CY1
Li, XW1
Luo, M1
Duan, SB1
Chen, YH1
Keiser, MS1
Davidson, BL1
Pop, R1
Kong, SH1
Langlois, A1
Marchegiani, F1
Shlomovitz, E1
Legnèr, A1
Bietiger, W1
Pinget, M1
Beaujeux, R1
Mutter, D1
Marescaux, J1
Diana, M1
Wang, Z1
Ren, K3
Zhang, X2
Hua, Z1
Xie, L1
Jiang, X1
Wang, R1
Gao, P1
Morales, H2
Lu, A2
Kurosawa, Y2
Clark, JF2
Leach, J1
Weiss, K1
Tomsick, T2
Li, LP2
Thacker, J1
Lu, J2
Franklin, T2
Zhou, Y2
Papadopoulou, MV1
Solomon, R2
Prasad, PV2
Wang, YC1
Tang, A1
Chang, D1
Zhang, SJ1
Ju, S1
Kee, P1
Bagalkot, V1
Johnson, E1
Danila, D1
Liu, TQ1
Luo, WL1
Tan, X1
Fang, Y1
Chen, J1
Yu, XF1
Cai, JR1
Ding, XQ1
Yao, L1
Dong, H1
Zhao, CX1
Gu, X1
Tan, TW1
Hamidian Jahromi, A1
Zhang, WW1
Siddiqui, MT1
Litts, JK1
Cheney, DM1
Kuhn, MA1
Nativ-Zeltzer, N1
Belafsky, PC1
Liu, Y1
Sun, WG1
Wang, JH1
Wu, CH1
Mahnken, AH1
Jost, G1
Bruners, P1
Sieber, M1
Seidensticker, PR1
Günther, RW1
Pietsch, H1
Chang, HJ1
George, RT3
Schuleri, KH3
Evers, K1
Kitagawa, K1
Lima, JA3
Lardo, AC3
Badea, CT1
Karumbaiah, L1
Fettig, N1
Bellamkonda, RV1
Johnson, GA2
Annapragada, A3
Centola, M1
Choi, SH1
Evers, KS1
Dawoud, F1
Bhavane, R1
Badea, C1
Clark, D1
Moturu, A1
Willerson, JT1
Cordeiro, MA1
Silva, C1
Amado, LC1
Saliaris, AP1
Fernandes, VR1
Zviman, M1
Nazarian, S1
Halperin, HR1
Wu, KC1
Hare, JM1
Kagadis, GC1
Spyridonos, P1
Karnabatidis, D1
Diamantopoulos, A1
Athanasiadis, E1
Daskalakis, A1
Katsanos, K1
Cavouras, D1
Mihailidis, D1
Siablis, D1
Nikiforidis, GC1
Leander, P1
Markou, CP1
Chronos, NA1
Hanson, SR1
Le Blanche, AF1
Bazot, MJ1
Bonneau, M1
Farres, MT1
Wassef, M1
Levy, B1
Bigot, JM1
Boudghene, F1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903): A Multicenter, Single-blind, Randomised Controlled Trial[NCT04028323]Phase 460 participants (Anticipated)Interventional2019-07-16Recruiting
Microvascular Obstruction by Contrast-enhanced MRI Following Percutaneous Coronary Interventions[NCT00692991]144 participants (Actual)Observational1999-10-31Completed
Multivariable Assessment of Coronary Artery Disease Using Cardiac CT Imaging[NCT00857792]120 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Ability to Detect Stress-induced Myocardial Perfusion Abnormalities by Analysis of MDCT Images Confirmed by Coronary Angiography and/or SPECT.

(NCT00857792)
Timeframe: 3 months

Intervention% accurately detected perfusion defects (Number)
Open Label78

Other Studies

31 other studies available for iodixanol and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Capsaicin Prevents Contrast-Associated Acute Kidney Injury through Activation of Nrf2 in Mice.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Acute Kidney Injury; Animals; Capsaicin; Contrast Media; Disease Models, Animal; Kidney; Malondialde

2022
Increased fibrotic signaling in a murine model for intra-arterial contrast-induced acute kidney injury.
    American journal of physiology. Renal physiology, 2020, 05-01, Volume: 318, Issue:5

    Topics: Acute Kidney Injury; Animals; Apoptosis; Carotid Arteries; Cell Hypoxia; Cell Proliferation; Collage

2020
Gut transit time, using radiological contrast imaging, to predict early signs of necrotizing enterocolitis.
    Pediatric research, 2021, Volume: 89, Issue:1

    Topics: Animals; Animals, Newborn; Contrast Media; Disease Models, Animal; Enterocolitis, Necrotizing; Femal

2021
Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography.
    Arteriosclerosis, thrombosis, and vascular biology, 2021, Volume: 41, Issue:4

    Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm; Aortic Dissection; Aortic Rupture; Aortography; Com

2021
Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Apoptosis; Biomarkers;

2018
Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model.
    Archives of toxicology, 2018, Volume: 92, Issue:7

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Iohexol; Kidney Function Tests

2018
Adeno-Associated Virus Production, Purification, and Titering.
    Current protocols in mouse biology, 2018, Volume: 8, Issue:4

    Topics: Animals; Centrifugation, Density Gradient; Contrast Media; Dependovirus; Disease Models, Animal; HEK

2018
Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization.
    Surgical innovation, 2019, Volume: 26, Issue:3

    Topics: Angiography, Digital Subtraction; Animals; Contrast Media; Disease Models, Animal; Duodenum; Emboliz

2019
Evaluation of iodine contrast-induced acute kidney injury via different injection routes using BOLD-MRI.
    Renal failure, 2019, Volume: 41, Issue:1

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Ear Auricle; Femoral Artery; H

2019
Blood Oxygen Level-Dependent Imaging and Intravoxel Incoherent Motion MRI of Early Contrast-Induced Acute Kidney Injury in a Rabbit Model.
    Kidney & blood pressure research, 2019, Volume: 44, Issue:4

    Topics: Acute Kidney Injury; Animals; Contrast Media; Diffusion Magnetic Resonance Imaging; Disease Models,

2019
Decreased infarct volume and intracranial hemorrhage associated with intra-arterial nonionic iso-osmolar contrast material in an MCA occlusion/reperfusion model.
    AJNR. American journal of neuroradiology, 2014, Volume: 35, Issue:10

    Topics: Animals; Cerebral Hemorrhage; Cerebral Infarction; Contrast Media; Disease Models, Animal; Infusions

2014
Efficacy of preventive interventions for iodinated contrast-induced acute kidney injury evaluated by intrarenal oxygenation as an early marker.
    Investigative radiology, 2014, Volume: 49, Issue:10

    Topics: Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Contrast Media; Dise

2014
Significant perturbation in renal functional magnetic resonance imaging parameters and contrast retention for iodixanol compared with iopromide: an experimental study using blood-oxygen-level-dependent/diffusion-weighted magnetic resonance imaging and com
    Investigative radiology, 2014, Volume: 49, Issue:11

    Topics: Acute Kidney Injury; Analysis of Variance; Animals; Contrast Media; Diffusion Magnetic Resonance Ima

2014
Noninvasive detection of macrophages in atheroma using a radiocontrast-loaded phosphatidylserine-containing liposomal contrast agent for computed tomography.
    Molecular imaging and biology, 2015, Volume: 17, Issue:3

    Topics: Animals; Aorta; Apoptosis; Contrast Media; Disease Models, Animal; Inflammation; Liposomes; Macropha

2015
A novel contrast-induced acute kidney injury model based on the 5/6-nephrectomy rat and nephrotoxicological evaluation of iohexol and iodixanol in vivo.
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Acute Kidney Injury; Animals; Contrast Media; Disease Models, Animal; Iohexol; Kidney; Male; Nephrec

2014
Effect of iodinated contrast medium in diabetic rat kidneys as evaluated by blood-oxygenation-level-dependent magnetic resonance imaging and urinary neutrophil gelatinase-associated lipocalin.
    Investigative radiology, 2015, Volume: 50, Issue:6

    Topics: Acute-Phase Proteins; Animals; Contrast Media; Diabetes Mellitus, Experimental; Disease Models, Anim

2015
Evaluation of urine fibrinogen level in a murine model of contrast-induced nephropathy.
    Vascular, 2016, Volume: 24, Issue:3

    Topics: Acute Kidney Injury; Animals; Biomarkers; Creatinine; Disease Models, Animal; Early Diagnosis; Fibri

2016
Variable MR and pathologic patterns of hemorrhage after iodinated contrast infusion in MCA occlusion/reperfusion model.
    Journal of neurointerventional surgery, 2017, Volume: 9, Issue:12

    Topics: Animals; Brain; Cerebral Hemorrhage; Contrast Media; Disease Models, Animal; Infarction, Middle Cere

2017
The effect of aspirated barium sulfate, iodixanol, and diatrizoic acid on survival and lung injury in a lagomorph model.
    The Laryngoscope, 2017, Volume: 127, Issue:5

    Topics: Animals; Barium Sulfate; Contrast Media; Diatrizoate; Disease Models, Animal; Lung Injury; Male; Rab

2017
Application of BOLD MRI and DTI for the evaluation of renal effect related to viscosity of iodinated contrast agent in a rat model.
    Journal of magnetic resonance imaging : JMRI, 2017, Volume: 46, Issue:5

    Topics: Animals; Contrast Media; Diffusion Tensor Imaging; Disease Models, Animal; Hypoxia-Inducible Factor

2017
Multidetector computed tomography (MDCT) evaluation of myocardial viability: intraindividual comparison of monomeric vs. dimeric contrast media in a rabbit model.
    European radiology, 2009, Volume: 19, Issue:2

    Topics: Animals; Contrast Media; Disease Models, Animal; Heart; Iohexol; Male; Myocardial Contraction; Myoca

2009
Prospective electrocardiogram-gated delayed enhanced multidetector computed tomography accurately quantifies infarct size and reduces radiation exposure.
    JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:4

    Topics: Algorithms; Animals; Contrast Media; Disease Models, Animal; Electrocardiography; Microvessels; Myoc

2009
Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging.
    Academic radiology, 2011, Volume: 18, Issue:1

    Topics: Animals; Contrast Media; Disease Models, Animal; Female; Imaging, Three-Dimensional; Mammary Neoplas

2011
CT for evaluation of myocardial cell therapy in heart failure: a comparison with CMR imaging.
    JACC. Cardiovascular imaging, 2011, Volume: 4, Issue:12

    Topics: Animals; Contrast Media; Disease Models, Animal; Female; Gadolinium DTPA; Heart Failure; Linear Mode

2011
Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent.
    Circulation. Cardiovascular imaging, 2013, Mar-01, Volume: 6, Issue:2

    Topics: Animals; Aorta; Aortic Diseases; Aortography; Apolipoproteins E; Atherosclerosis; Cell Line; Contras

2013
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Computerized analysis of digital subtraction angiography: a tool for quantitative in-vivo vascular imaging.
    Journal of digital imaging, 2008, Volume: 21, Issue:4

    Topics: Angiography, Digital Subtraction; Animals; Contrast Media; Disease Models, Animal; False Negative Re

2008
A new liposomal contrast medium for CT of the liver. An imaging study in a rabbit tumour model.
    Acta radiologica (Stockholm, Sweden : 1987), 1996, Volume: 37, Issue:1

    Topics: Animals; Contrast Media; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Liposo

1996
Antithrombotic effects of ionic and non-ionic contrast media in nonhuman primates.
    Thrombosis and haemostasis, 2001, Volume: 85, Issue:3

    Topics: Animals; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Contrast Media; Disease Models, Animal;

2001
Evaluation of renal arteries with use of gadoterate meglumine-, CO(2)-, and iodixanol-enhanced DSA measurements versus histomorphometry in renal artery restenosis in rabbits.
    Journal of vascular and interventional radiology : JVIR, 2001, Volume: 12, Issue:6

    Topics: Angiography, Digital Subtraction; Animals; Carbon Dioxide; Contrast Media; Disease Models, Animal; H

2001