Page last updated: 2024-10-29

iodixanol and Chronic Disease

iodixanol has been researched along with Chronic Disease in 11 studies

iodixanol: dimeric contrast media; structure given in first source
iodixanol : A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"The combined prophylactic strategy of sodium bicarbonate plus N-acetylsyteine (NAC) seems to be effective in preventing contrast induced acute kidney injury (CI-AKI) in patients at low-to-medium risk."6.25Renal insufficiency following contrast media administration trial II (REMEDIAL II): RenalGuard system in high-risk patients for contrast-induced acute kidney injury: rationale and design. ( Briguori, C; Condorelli, G; Ricciardelli, B; Visconti, G, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, Y1
Zhao, HW1
Zhang, XJ1
Chen, BJ1
Yu, GN1
Hou, AJ1
Luan, B1
Stojanovska, J1
Cronin, P1
Gross, BH1
Kazerooni, EA1
Tsodikov, A1
Frank, L1
Oral, H1
Solomon, R1
Matejka, J1
Varvarovsky, I1
Vojtisek, P1
Herman, A1
Rozsival, V1
Borkova, V1
Kvasnicka, J1
Hu, S1
Akhlaghi, F1
Chitnis, S1
Chiu, R1
Go, S1
Rout, P1
Steffes, M1
Abbott, JD1
Dworkin, L1
Bostom, A1
Briguori, C1
Visconti, G1
Ricciardelli, B1
Condorelli, G1
Lardo, AC1
Cordeiro, MA1
Silva, C1
Amado, LC1
George, RT1
Saliaris, AP1
Schuleri, KH1
Fernandes, VR1
Zviman, M1
Nazarian, S1
Halperin, HR1
Wu, KC1
Hare, JM1
Lima, JA1
Deray, G1
Barrett, BJ1
Katzberg, RW1
Thomsen, HS1
Chen, N1
Sahani, D1
Soulez, G1
Heiken, JP1
Lepanto, L1
Ni, ZH2
Nelson, R1
Solomon, RJ1
Natarajan, MK1
Doucet, S1
Sharma, SK1
Staniloae, CS1
Katholi, RE1
Gelormini, JL1
Labinaz, M1
Moreyra, AE1
Reed, PS1
Dixon, SR1
Boura, JA1
O'Neill, WW1
Kahn, JK1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Renal Insufficiency Following Contrast Media Administration Trial II (Remedial II): The RenalGuard System in High-Risk Patients for Contrast-Induced Acute Kidney Injury[NCT01098032]Phase 3294 participants (Actual)Interventional2009-01-31Completed
Microvascular Obstruction by Contrast-enhanced MRI Following Percutaneous Coronary Interventions[NCT00692991]144 participants (Actual)Observational1999-10-31Completed
Multivariable Assessment of Coronary Artery Disease Using Cardiac CT Imaging[NCT00857792]120 participants (Actual)Interventional2009-03-31Completed
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer[NCT03943966]73 participants (Actual)Interventional2019-11-11Completed
The Effect of Administration on N-Acetylcysteine on Serum Creatinine Levels in Patients With Chronic Kidney Disease[NCT00498342]0 participants Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Contrast-induced Acute Kidney Injury

The primary outcome measure will be the rate of development of CI-AKI in the 2 study arms (number of participants). CI-AKI is defined as an increase in the serum creatinine concentration >=0.3 mg/dL from the baseline value at 48 hours after administration of the contrast media or the need for dialysis. (NCT01098032)
Timeframe: at 48 hours following contrast exposure

Interventionparticipants (Number)
Systemic Alone Therapy Group146
RenalGuard System Group146

Ability to Detect Stress-induced Myocardial Perfusion Abnormalities by Analysis of MDCT Images Confirmed by Coronary Angiography and/or SPECT.

(NCT00857792)
Timeframe: 3 months

Intervention% accurately detected perfusion defects (Number)
Open Label78

Reviews

1 review available for iodixanol and Chronic Disease

ArticleYear
Renal insufficiency following contrast media administration trial II (REMEDIAL II): RenalGuard system in high-risk patients for contrast-induced acute kidney injury: rationale and design.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2011, Volume: 6, Issue:9

    Topics: Acetylcysteine; Acute Kidney Injury; Biomarkers; Chi-Square Distribution; Chronic Disease; Contrast

2011

Trials

4 trials available for iodixanol and Chronic Disease

ArticleYear
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease.
    Heart and vessels, 2010, Volume: 25, Issue:6

    Topics: Acute Kidney Injury; Age Factors; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Biomarker

2010
Renal insufficiency following contrast media administration trial II (REMEDIAL II): RenalGuard system in high-risk patients for contrast-induced acute kidney injury: rationale and design.
    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2011, Volume: 6, Issue:9

    Topics: Acetylcysteine; Acute Kidney Injury; Biomarkers; Chi-Square Distribution; Chronic Disease; Contrast

2011
Contrast-induced nephropathy in patients with chronic kidney disease undergoing computed tomography: a double-blind comparison of iodixanol and iopamidol.
    Investigative radiology, 2006, Volume: 41, Issue:11

    Topics: Adult; Aged; Chronic Disease; Contrast Media; Double-Blind Method; Female; Humans; Iopamidol; Kidney

2006
Cardiac Angiography in Renally Impaired Patients (CARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with chronic kidney disease.
    Circulation, 2007, Jun-26, Volume: 115, Issue:25

    Topics: Aged; Aged, 80 and over; Cardiac Catheterization; Chronic Disease; Contrast Media; Creatinine; Doubl

2007

Other Studies

7 other studies available for iodixanol and Chronic Disease

ArticleYear
CHA2DS2-VASC score as a preprocedural predictor of contrast-induced nephropathy among patients with chronic total occlusion undergoing percutaneous coronary intervention: a single-center experience.
    BMC cardiovascular disorders, 2019, 03-29, Volume: 19, Issue:1

    Topics: Aged; Biomarkers; Blood Pressure; China; Chronic Disease; Contrast Media; Coronary Angiography; Coro

2019
Left atrial function and maximum volume as determined by MDCT are independently associated with atrial fibrillation.
    Academic radiology, 2014, Volume: 21, Issue:9

    Topics: Adult; Aged; Atrial Fibrillation; Atrial Function, Left; Chronic Disease; Cohort Studies; Contrast M

2014
Nephrotoxicity of iodixanol versus iopamidol inpatients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic procedures.
    American heart journal, 2010, Volume: 159, Issue:2

    Topics: Chronic Disease; Contrast Media; Coronary Angiography; Diabetic Nephropathies; Humans; Inpatients; I

2010
Comparison of plasma clearance of iodixanol during versus after angiography.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 56, Issue:6

    Topics: Adult; Aged; Chronic Disease; Contrast Media; Coronary Angiography; Female; Glomerular Filtration Ra

2010
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar.
    Circulation, 2006, Jan-24, Volume: 113, Issue:3

    Topics: Acute Disease; Animals; Cell Death; Chronic Disease; Cicatrix; Contrast Media; Coronary Angiography;

2006
Iodixanol and chronic kidney disease.
    The Journal of invasive cardiology, 2006, Volume: 18, Issue:2

    Topics: Chronic Disease; Contrast Media; Diabetic Nephropathies; Humans; Kidney Diseases; Triiodobenzoic Aci

2006
Comparison of the usefulness of gadodiamide and iodine mixture versus iodinated contrast alone for prevention of contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angiography.
    The American journal of cardiology, 2007, Oct-01, Volume: 100, Issue:7

    Topics: Aged; Aged, 80 and over; Chronic Disease; Contrast Media; Coronary Angiography; Female; Gadolinium D

2007