Page last updated: 2024-10-18

iodine and Renal Insufficiency

iodine has been researched along with Renal Insufficiency in 21 studies

Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..

Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Research Excerpts

ExcerptRelevanceReference
"In patients with renal failure, iodinated contrast agents may cause acute deterioration of the renal function and gadolinium-based contrast agents (GBCAs) may cause nephrogenic systemic fibrosis (NSF)."4.87[Kidney and iodinated and gadolinium-based contrast agents]. ( Clément, O; Faye, N; Fournier, L; Frija, G; Siauve, N, 2011)
" As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min."3.88[Treatment with metformin in type 2 diabetes mellitus - new routines when renal function is reduced and in connection with administration of iodine contrast media]. ( Frid, A; Sterner, G, 2018)
"We present a case study of a severe episode of iodine toxicity following povidone-iodine wash with clinical manifestations of cardiovascular collapse, metabolic acidosis, renal failure and seizures."3.77Cardiovascular collapse following povidone-iodine wash. ( Lavee, O; Linderman, R; Mackie, J; Nanavati, Z; Ramaswamykanive, H, 2011)
"Continuous mediastinal irrigation with povidone-iodine is used commonly for treating severe postoperative mediastinitis."3.72Iodine toxicity treated with hemodialysis and continuous venovenous hemodiafiltration. ( Albright, RC; De Chazal, I; Haugen, EN; Juncos, LA; Kanakiriya, S; Nath, KA, 2003)
"Patients with renal insufficiency or other contraindications to iodine-based contrast agents present a significant management dilemma when conventional arteriography is required."3.70Use of gadolinium as an intraarterial contrast agent in digital subtraction angiography of the cervical carotid arteries and intracranial circulation. Technical note. ( Casey, SO; Madison, MT; Nussbaum, ES; Sebring, LA, 2000)
" Their potential application are for renal insufficiency, allergic reaction to iodine contrast media and in cases of contra indication to ionised radiations."3.70[Upper urinary tract MRI]. ( Claudon, M; Lefèvre, F; Lemaître, L; Roy, C; Tuchmann, C, 2000)
"Half iodine-load SDCT lower limb CTA at 40 keV achieved higher VA than the control."3.30Halved contrast medium dose in lower limb dual-energy computed tomography angiography-a randomized controlled trial. ( Geitung, JT; Hykkerud, DL; Kristiansen, CH; Lauritzen, PM; Roy, S; Sanderud, A; Thomas, O; Tran, TT, 2023)
"However, wound infection occurred due to Pseudomonas aeruginosa."2.40Induction of a critical elevation of povidone-iodine absorption in the treatment of a burn patient: report of a case. ( Aiba, M; Arai, H; Asaumi, S; Furuya, K; Ishikawa, H; Morishita, Y; Ninomiya, J; Ohwada, S; Takagi, A, 1999)
"For patients with existing renal failure, this odds ratio was 0."2.38Metaanalysis of the relative nephrotoxicity of high- and low-osmolality iodinated contrast media. ( Barrett, BJ; Carlisle, EJ, 1993)
"Patients, >18 years old, without renal failure, presenting after blunt trauma, with serum creatinine measured at presentation, were retrospectively studied at a single center."1.46Is measurement of renal function necessary for all trauma patients before iodinated contrast administration? ( Hashim, J; Pantel, H; Rosenblatt, M; Stensland, KD, 2017)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's6 (28.57)18.2507
2000's4 (19.05)29.6817
2010's8 (38.10)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Kristiansen, CH1
Thomas, O1
Tran, TT1
Roy, S1
Hykkerud, DL1
Sanderud, A1
Geitung, JT1
Lauritzen, PM1
Park, JH1
Shin, HJ1
Choi, JY1
Lim, JS1
Park, MS1
Kim, MJ1
Oh, HJ1
Chung, YE1
Pantel, H1
Stensland, KD1
Hashim, J1
Rosenblatt, M1
Sterner, G3
Frid, A1
Oda, S1
Takaoka, H1
Katahira, K1
Honda, K1
Nakaura, T1
Nagayama, Y1
Taguchi, N1
Kidoh, M1
Utsunomiya, D1
Funama, Y1
Noda, K1
Oshima, S1
Yamashita, Y1
Vogt, B1
Burchardt, P1
Synowiec, T1
Jerzykowska, S1
Angerer, D1
Żurawski, J1
Ramaswamykanive, H1
Nanavati, Z1
Mackie, J1
Linderman, R1
Lavee, O1
Clément, O2
Faye, N1
Fournier, L1
Siauve, N1
Frija, G1
Stacul, F1
van der Molen, AJ1
Reimer, P1
Webb, JA1
Thomsen, HS1
Morcos, SK1
Almén, T3
Aspelin, P2
Bellin, MF1
Heinz-Peer, G1
Kanakiriya, S1
De Chazal, I1
Nath, KA1
Haugen, EN1
Albright, RC1
Juncos, LA1
KUHLBACK, B1
WAHLBERG, P1
Nyman, U1
Hellström, M1
Kristiansson, M1
Nossen, JO1
Jakobsen, JA1
Kjaersgaard, P1
Andrew, E1
Jacobsen, PB1
Berg, KJ1
Seeger, JM1
Self, S1
Harward, TR1
Flynn, TC1
Hawkins, IF1
Barrett, BJ1
Carlisle, EJ1
Frennby, B1
Hultberg, B1
Choyke, PL1
Cady, J1
DePollar, SL1
Austin, H1
Aiba, M1
Ninomiya, J1
Furuya, K1
Arai, H1
Ishikawa, H1
Asaumi, S1
Takagi, A1
Ohwada, S1
Morishita, Y1
Nussbaum, ES1
Casey, SO1
Sebring, LA1
Madison, MT1
Roy, C1
Lefèvre, F1
Lemaître, L1
Claudon, M1
Tuchmann, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Diagnostic Value of TOF-18F-FDG-PET/CT in Patients With Suspected Pancreatic Cancer[NCT03914950]174 participants (Actual)Interventional2014-02-07Completed
Automated Carbon Dioxide Angiography in Comparison to Iodinated Contrast Medium Angiography During Fenestrated/Branched Endovascular Abdominal Aortic Aneurysm Repair (F/B-EVAR)[NCT06103942]30 participants (Anticipated)Observational2023-11-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Lesion Size

Lesion or tumor size in cm in the pancreas measured in the diagnostic CT of the abdomen or upper abdomen. (NCT03914950)
Timeframe: 2 hours

Interventioncm (Mean)
Lesion Size in cm3.0

Participants With Increased Tracer Uptake Over the Pancreatic Lesion With and Without TOF

The number of participants with increased tracer uptake over the pancreatic lesion, i.e. the number of pancreatic lesions with increased tracer uptake with and without TOF. One pancreatic lesion per patient was measured. (NCT03914950)
Timeframe: 2 hours

InterventionParticipants (Count of Participants)
Participants With Increased Tracer Uptake With TOF116
Participants With Increased Tracer Uptake Without TOF101

SUVmax (Maximal Standard Uptake Value) Measurement 30 and 90 Min p.i. (Post Injection)

Quantitative measurement of regional tracer uptake by SUVmax in the TOF-PET/CT and standard PET/CT images over the FDG-accumulating lesions in the pancreas 30 and 90min p.i. The histopathological findings (malignant or benign) were assigned to the corresponding SUVmax values of the pancreatic lesions for the calculation of AUC values in ROC analysis. Then AUC values with and without TOF were compared with the DeLong-test to analyze if there is a significant difference in characterization of pancreatic lesions with TOF. (NCT03914950)
Timeframe: 2 hours

InterventionSUVmax (Number)
SUVmax TOF 30min p.i.0.77
SUVmax Without TOF 30min p.i.0.78
SUVmax TOF 90min p.i.0.81
SUVmax Without TOF 90min p.i.0.8

Reviews

4 reviews available for iodine and Renal Insufficiency

ArticleYear
[Kidney and iodinated and gadolinium-based contrast agents].
    Journal de radiologie, 2011, Volume: 92, Issue:4

    Topics: Aged; Contrast Media; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Fluid T

2011
Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines.
    European radiology, 2011, Volume: 21, Issue:12

    Topics: Contrast Media; Coronary Angiography; Europe; Female; Fluid Therapy; Gadolinium; Glomerular Filtrati

2011
Metaanalysis of the relative nephrotoxicity of high- and low-osmolality iodinated contrast media.
    Radiology, 1993, Volume: 188, Issue:1

    Topics: Contrast Media; Humans; Iodine; Osmolar Concentration; Renal Insufficiency

1993
Induction of a critical elevation of povidone-iodine absorption in the treatment of a burn patient: report of a case.
    Surgery today, 1999, Volume: 29, Issue:2

    Topics: Absorption; Acidosis; Aged; Anti-Infective Agents, Local; Bradycardia; Burns; Debridement; Fatal Out

1999

Trials

2 trials available for iodine and Renal Insufficiency

ArticleYear
Halved contrast medium dose in lower limb dual-energy computed tomography angiography-a randomized controlled trial.
    European radiology, 2023, Volume: 33, Issue:9

    Topics: Angiography; Computed Tomography Angiography; Humans; Iodine; Lower Extremity; Radiographic Image In

2023
Elimination of the non-ionic X-ray contrast media iodixanol and iohexol in patients with severely impaired renal function.
    Scandinavian journal of clinical and laboratory investigation, 1995, Volume: 55, Issue:4

    Topics: Aged; Body Weight; Contrast Media; Creatinine; Double-Blind Method; Feces; Glomerular Filtration Rat

1995

Other Studies

15 other studies available for iodine and Renal Insufficiency

ArticleYear
Is there association between statin usage and contrast-associated acute kidney injury after intravenous administration of iodine-based contrast media in enhanced computed tomography?
    European radiology, 2020, Volume: 30, Issue:10

    Topics: Acute Kidney Injury; Administration, Intravenous; Aged; Contrast Media; Female; Glomerular Filtratio

2020
Is measurement of renal function necessary for all trauma patients before iodinated contrast administration?
    Emergency radiology, 2017, Volume: 24, Issue:5

    Topics: Adolescent; Adult; Aged; Contrast Media; Female; Humans; Injury Severity Score; Iodine; Kidney Funct

2017
[Treatment with metformin in type 2 diabetes mellitus - new routines when renal function is reduced and in connection with administration of iodine contrast media].
    Lakartidningen, 2018, 04-03, Volume: 115

    Topics: Acidosis, Lactic; Body Size; Contrast Media; Diabetes Mellitus, Type 2; Female; Glomerular Filtratio

2018
Low contrast material dose coronary computed tomographic angiography using a dual-layer spectral detector system in patients at risk for contrast-induced nephropathy.
    The British journal of radiology, 2019, Volume: 92, Issue:1094

    Topics: Acute Kidney Injury; Computed Tomography Angiography; Contrast Media; Humans; Image Processing, Comp

2019
Patient safety in vascular access patients on hemodialysis: contrast agents and renal function.
    Contributions to nephrology, 2015, Volume: 184

    Topics: Contrast Media; Creatinine; Gadolinium; Glomerular Filtration Rate; Humans; Iodine; Kidney; Magnetic

2015
Early renal dysfunction after iodine contrast administration: new insight into the actual problem.
    Kardiologia polska, 2015, Volume: 73, Issue:3

    Topics: Angioplasty; Contrast Media; Coronary Angiography; Humans; Iodine; Renal Insufficiency

2015
Cardiovascular collapse following povidone-iodine wash.
    Anaesthesia and intensive care, 2011, Volume: 39, Issue:1

    Topics: Acidosis; Aged; Anti-Infective Agents, Local; Anticonvulsants; Diuretics; Fluid Therapy; Follow-Up S

2011
Iodine toxicity treated with hemodialysis and continuous venovenous hemodiafiltration.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 41, Issue:3

    Topics: Hemodiafiltration; Humans; Iodine; Liver Failure; Male; Mediastinitis; Mediastinum; Middle Aged; Poi

2003
The radioactive iodine excretion test in renal failure.
    Scandinavian journal of clinical and laboratory investigation, 1958, Volume: 10, Issue:1

    Topics: Humans; Iodine; Iodine Radioisotopes; Kidney Function Tests; Radioisotopes; Renal Insufficiency

1958
Contrast-medium-Induced nephropathy correlated to the ratio between dose in gram iodine and estimated GFR in ml/min.
    Acta radiologica (Stockholm, Sweden : 1987), 2005, Volume: 46, Issue:8

    Topics: Adult; Age Factors; Aged; Algorithms; Body Size; Contrast Media; Coronary Angiography; Creatinine; F

2005
Carbon dioxide gas as an arterial contrast agent.
    Annals of surgery, 1993, Volume: 217, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aneurysm; Angiography; Arterial Occlusive Diseases; Carbon Dioxide;

1993
Iohexol clearance for GFR-determination in renal failure--single or multiple plasma sampling?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:3

    Topics: Adult; Aged; Contrast Media; Female; Glomerular Filtration Rate; Humans; Iodine; Iohexol; Kidney; Ma

1996
Determination of serum creatinine prior to iodinated contrast media: is it necessary in all patients?
    Techniques in urology, 1998, Volume: 4, Issue:2

    Topics: Adult; Aged; Contrast Media; Cost-Benefit Analysis; Creatinine; Female; Humans; Iodine; Kidney Disea

1998
Use of gadolinium as an intraarterial contrast agent in digital subtraction angiography of the cervical carotid arteries and intracranial circulation. Technical note.
    Journal of neurosurgery, 2000, Volume: 92, Issue:5

    Topics: Angiography, Digital Subtraction; Arteriosclerosis; Basilar Artery; Carotid Arteries; Carotid Artery

2000
[Upper urinary tract MRI].
    Journal de radiologie, 2000, Volume: 81, Issue:9 Suppl

    Topics: Contraindications; Contrast Media; Dilatation, Pathologic; Humans; Hydronephrosis; Image Processing,

2000