iodine and Malnutrition studies

Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..

Malnutrition: An imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiological requirement.

Research Excerpts

Excerpt	Relevance	Reference
"Iodine supplementation during pregnancy in areas with mild-moderate deficiency is still a matter of debate."	9.41	Iodine status and supplementation in pregnancy: an overview of the evidence provided by meta-analyses. ( Chiovato, L; Croce, L; Magri, F; Moleti, M; Olivieri, A; Pearce, EN; Petrosino, E; Rotondi, M; Tanda, ML; Tonacchera, M, 2023)
" This review seeks to identify the risk of pre-eclampsia associated with insufficient iodine nutrition in pregnancy."	9.30	Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis. ( Businge, CB; Kengne, AP; Longo-Mbenza, B; Madini, N, 2019)
"Of 54 African countries, 23 had data on iodine nutrition in pregnancy mostly from subnational samples."	9.22	The prevalence of insufficient iodine intake in pregnancy in Africa: a systematic review and meta-analysis. ( Businge, CB; Kengne, AP; Longo-Mbenza, B; Musarurwa, HT, 2022)
"The present study suggests that mild maternal iodine deficiency is not associated with adverse pregnancy outcomes."	8.12	No Association Was Found Between Mild Iodine Deficiency During Pregnancy and Pregnancy Outcomes: a Follow-up Study Based on a Birth Registry. ( Cui, X; Guo, C; Jin, W; Shi, Z; Song, Q; Tang, H; Wang, H; Wang, Z; Yu, H; Zang, J, 2022)
"The relationship between iodine intake and depression is unknown."	8.12	Mild-to-moderate iodine deficiency and symptoms of emotional distress and depression in pregnancy and six months postpartum - Results from a large pregnancy cohort. ( Abel, MH; Brandlistuen, RE; Brantsæter, AL; Caspersen, IH; Garthus-Niegel, S; Meltzer, HM, 2022)
"Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function."	8.12	Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha. ( Quintos, JB; Sasidharan Pillai, S, 2022)
"Severe iodine deficiency during pregnancy has substantial hormonal consequences, such as fetal brain damage."	8.12	Can Mild-to-Moderate Iodine Deficiency during Pregnancy Alter Thyroid Function? Lessons from a Mother-Newborn Cohort. ( Almashanu, S; Anteby, EY; Avrahami-Benyounes, Y; Benbassat, C; Fytlovich, S; Gefel, D; Groisman, L; Ovadia, YS; Rorman, E; Rosen, SR; Shenhav, S; Zangen, S, 2022)
"We investigated the combined roles of a low-nutrition diet (low levels of protein, iodine, and selenium) and T-2 toxin in bone development and to establish an experimental animal model of Kashin-Beck disease (KBD) that reliably mimics the disease's pathological changes for further study of the pathogenesis and prevention of the disease."	7.79	An animal model of Kashin-Beck disease induced by a low-nutrition diet and exposure to T-2 toxin. ( Kang, P; Pei, F; Shen, B; Yang, J; Yao, Y; Zhou, Z, 2013)
"The pregnant women in this study had an absence of the usual free T(4) spike and a smaller than expected increment in total T(4), described during pregnancy in iodine-sufficient populations."	7.76	Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population. ( Ares, S; Costeira, MJ; de Escobar, GM; Oliveira, P; Palha, JA; Roque, S, 2010)
"Iodine is a necessary micronutrient for the production of thyroid hormones and normal human development."	6.66	Consequences of Severe Iodine Deficiency in Pregnancy: Evidence in Humans. ( Maraka, S; Motahari, H; Toloza, FJK, 2020)
"Iodine is an essential trace element for human and an antioxidant."	5.91	[Recognise of iodine effect on thyroid diseases and metabolism]. ( Shan, ZY; Teng, WP, 2023)
"Iodine deficiency is a common problem in pregnant women and may have implications for maternal and child health."	5.72	Iodine Supplementation in Pregnancy in an Iodine-Deficient Region: A Cross-Sectional Survey. ( Lemos, MC; Limbert, E; Lopes, CA; Martinez-de-Oliveira, J; Prazeres, S, 2022)
"Iodine supplementation during pregnancy in areas with mild-moderate deficiency is still a matter of debate."	5.41	Iodine status and supplementation in pregnancy: an overview of the evidence provided by meta-analyses. ( Chiovato, L; Croce, L; Magri, F; Moleti, M; Olivieri, A; Pearce, EN; Petrosino, E; Rotondi, M; Tanda, ML; Tonacchera, M, 2023)
"Despite growing success of salt iodization programs, a 2022 meta-analysis found that 53% of pregnant patients worldwide continue to have insufficient iodine intake during pregnancy."	5.41	An update: maternal iodine supplementation, thyroid function tests, and child neurodevelopmental outcomes. ( Nguyen, CT, 2023)
"Iodine deficiency is an important nutritional deficiency, with more than 2 billion people worldwide estimated to be at risk."	5.38	Teratology public affairs committee position paper: iodine deficiency in pregnancy. ( Jahnke, GD; Obican, SG; Scialli, AR; Soldin, OP, 2012)
" This review seeks to identify the risk of pre-eclampsia associated with insufficient iodine nutrition in pregnancy."	5.30	Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis. ( Businge, CB; Kengne, AP; Longo-Mbenza, B; Madini, N, 2019)
"Of 54 African countries, 23 had data on iodine nutrition in pregnancy mostly from subnational samples."	5.22	The prevalence of insufficient iodine intake in pregnancy in Africa: a systematic review and meta-analysis. ( Businge, CB; Kengne, AP; Longo-Mbenza, B; Musarurwa, HT, 2022)
"Articles on iodine-induced thyroid dysfunction from 2000 to 2022 were retrieved from the Web of Science Core Collection (WoSCC) using the following search terms: (((((TS=(hypothyroid)) OR TS=(hyperthyroid)) OR TS= ("TSH deficiency")) OR TS= ("thyroid stimulating hormone deficiency")) AND TS=(Iodine)) NOT TS=(radioiodine)."	4.31	Iodine-induced thyroid dysfunction: a scientometric study and visualization analysis. ( Gong, B; Lai, Y; Shan, Z; Wang, C; Wang, X; Yang, W, 2023)
"Iodine deficiency during pregnancy is a widespread public health concern, but indicators and methods for assessing iodine nutritional status are lacking."	4.31	Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China. ( Chen, Z; Gu, S; Li, X; Mo, Z; Tu, P; Wang, X; Wu, L; Xing, M, 2023)
"Iodine is a pivotal component of thyroid hormones, and its deficiency leads to negative pregnancy outcomes."	4.31	Iodine deficiency and real-life supplementation ineffectiveness in Polish pregnant women and its impact on thyroid metabolism. ( Filipowicz, D; Główka, FK; Karaźniewicz-Łada, M; Mikulska-Sauermann, AA; Ołtarzewski, M; Ruchała, M; Schomburg, L; Szczepanek-Parulska, E; Szymanowski, K, 2023)
"The present study suggests that mild maternal iodine deficiency is not associated with adverse pregnancy outcomes."	4.12	No Association Was Found Between Mild Iodine Deficiency During Pregnancy and Pregnancy Outcomes: a Follow-up Study Based on a Birth Registry. ( Cui, X; Guo, C; Jin, W; Shi, Z; Song, Q; Tang, H; Wang, H; Wang, Z; Yu, H; Zang, J, 2022)
"The article presents current data on the prevalence of thyroid diseases associated with iodine deficiency in Russia, focuses on the features of the comorbidity of iodine deficiency and autoimmune thyroid pathologies, methods for assessing the iodine supply of the population."	4.12	[Elimination of iodine deficiency is a concern for the health of the nation. An excursion into the history, scientific aspects and the current state of the legal regulation of the problem in Russia]. ( Troshina, EA, 2022)
"The relationship between iodine intake and depression is unknown."	4.12	Mild-to-moderate iodine deficiency and symptoms of emotional distress and depression in pregnancy and six months postpartum - Results from a large pregnancy cohort. ( Abel, MH; Brandlistuen, RE; Brantsæter, AL; Caspersen, IH; Garthus-Niegel, S; Meltzer, HM, 2022)
"Iodine deficiency goiter can develop in children on a restrictive diet and most have normal thyroid function."	4.12	Thyroid function tests of iodine deficiency goiter can mimic thyroid hormone resistance alpha. ( Quintos, JB; Sasidharan Pillai, S, 2022)
"Severe iodine deficiency during pregnancy has substantial hormonal consequences, such as fetal brain damage."	4.12	Can Mild-to-Moderate Iodine Deficiency during Pregnancy Alter Thyroid Function? Lessons from a Mother-Newborn Cohort. ( Almashanu, S; Anteby, EY; Avrahami-Benyounes, Y; Benbassat, C; Fytlovich, S; Gefel, D; Groisman, L; Ovadia, YS; Rorman, E; Rosen, SR; Shenhav, S; Zangen, S, 2022)
"Analysis of databases of neonatal screening for congenital hypothyroidism makes it possible to effectively, quickly and at minimal cost annually assess the iodine status in the population."	4.12	[Neonatal thyrotropin - indicatior of monitoring of iodine deficiency severity. What's level is considered a «cutoff point»?] ( Makarova, OB; Suplotova, LA; Troshina, A, 2022)
" DBM was defined as the co-occurrence of overweight/obesity and anemia (definition #1), overweight/obesity and anemia or vitamin A deficiency (definition #2), and overweight/obesity and anemia or vitamin A deficiency or iodine insufficiency (definition #3)."	4.02	Prevalence and Determinants of the Co-Occurrence of Overweight or Obesity and Micronutrient Deficiencies among Adults in the Philippines: Results from a National Representative Survey. ( de Juras, AR; Hsu, WC; Hu, SC, 2021)
"Antituberculosis drugs were effective in normalizing the serum zinc and selenium level, but the serum level of iron, vitamin d and iodine were not normalized by the anti-tuberculosis drugs."	3.91	Micronutrient levels of tuberculosis patients during the intensive phase, a prospective cohort study. ( Beyene, MB; Feleke, BE; Feleke, TE; Mekonnen, D, 2019)
" The survey assessed the prevalence of under and overnutrition, anemia, iron deficiency (ID), iron deficiency anemia (IDA), vitamin A deficiency (VAD), and urinary iodine concentration (UIC)."	3.91	Micronutrient Deficiencies, Nutritional Status and the Determinants of Anemia in Children 0-59 Months of Age and Non-Pregnant Women of Reproductive Age in The Gambia. ( Barrow, S; Ceesay, PO; Darboe, MK; Fofana, MN; Jallow, B; Petry, N; Phall, MC; Prentice, AM; Rohner, F; Sarr, A; Sawo, Y; Wegmüller, R; Wirth, JP, 2019)
" Folic acid taken in early pregnancy can prevent neural tube defects."	3.81	The epidemiology of global micronutrient deficiencies. ( Bailey, RL; Black, RE; West, KP, 2015)
"We investigated the combined roles of a low-nutrition diet (low levels of protein, iodine, and selenium) and T-2 toxin in bone development and to establish an experimental animal model of Kashin-Beck disease (KBD) that reliably mimics the disease's pathological changes for further study of the pathogenesis and prevention of the disease."	3.79	An animal model of Kashin-Beck disease induced by a low-nutrition diet and exposure to T-2 toxin. ( Kang, P; Pei, F; Shen, B; Yang, J; Yao, Y; Zhou, Z, 2013)
"Mild iodine deficiency during pregnancy can have significant effects on fetal development and future cognitive function."	3.79	The impact of iodine supplementation and bread fortification on urinary iodine concentrations in a mildly iodine deficient population of pregnant women in South Australia. ( Clifton, VL; Fogarty, PA; Hetzel, B; Hodyl, NA; Ma, G; Nettelbeck, T; Roberts, R; Torpy, DJ, 2013)
"The pregnant women in this study had an absence of the usual free T(4) spike and a smaller than expected increment in total T(4), described during pregnancy in iodine-sufficient populations."	3.76	Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population. ( Ares, S; Costeira, MJ; de Escobar, GM; Oliveira, P; Palha, JA; Roque, S, 2010)
"A sufficient amount of iodine in food is necessary for the thyroid gland to produce hormones during pregnancy."	3.73	Iodine excretion with urine and thyrotrophic hormone concentration in normal and complicated pregnancies in the industrial region of iodine deficiency. ( Bodzek, P; Olejek, A; Zamłyński, J, 2006)
"PROFILES was used to quantify the function consequences of malnutrition in term of protein energy malnutrition, iron deficiency and iodine deficiency."	3.72	Effects of malnutrition on economic productivity in China as estimated by PROFILES. ( Chen, CM; Chen, MX; Fu, G; Fu, ZY; He, W; Ross, J; Wang, YY, 2003)
"Iodine food intake was assessed using a 24-h dietary recall."	3.30	Iodine intake assessment in the staff of a Porto region university (Portugal): the iMC Salt trial. ( Bordalo, AA; Gonçalves, C; Machado, A; Moreira, P; Norton, P; Padrão, P; Pinho, O; Rodrigues, M; Silva-Santos, T, 2023)
"Iodine is an essential micronutrient and component of thyroid hormone."	3.01	Optimizing Growth: The Case for Iodine. ( Rigutto-Farebrother, J, 2023)
"Iodine is an essential component of the hormones produced by the thyroid gland and is, therefore, essential for mammalian life."	3.01	The Prevention of Iodine Deficiency: A History. ( Pearce, EN; Zimmermann, MB, 2023)
"Iodine deficiency has multiple adverse effects in humans due to inadequate thyroid hormone production that are termed the iodine deficiency disorders."	3.01	The remarkable impact of iodisation programmes on global public health. ( Zimmermann, MB, 2023)
"Iodine is a mineral nutrient essential for the regulation of a variety of key physiological functions including metabolism and brain development and function in children and adults."	2.82	Iodine and Iodine Deficiency: A Comprehensive Review of a Re-Emerging Issue. ( Hatch-McChesney, A; Lieberman, HR, 2022)
"Iodine deficiency is a global concern, and in recent years, there has been a significant improvement in the number of countries identified as being iodine-sufficient."	2.82	Improving Iodine Status in Lactating Women: What Works? ( Brough, L, 2022)
"Iodine is an essential element for growth and development of children."	2.82	Iodine Status of 6-12-Year-Old Children in Russia over the Past 10 Years: A Scoping Review. ( Aksenov, A; Grjibovski, AM; Korobitsyna, R; Sorokina, T; Trofimova, A, 2022)
"Iodine deficiency has been fought worldwide for decades, and substantial success has been achieved introducing the use of iodine-enriched salt."	2.82	The effect of sodium restriction on iodine prophylaxis: a review. ( Albertelli, M; Bagnasco, M; Boschetti, M; Ferone, D; Gatto, F; Musso, N; Nista, F; Vera, L, 2022)
"Iodine deficiency is a global issue and affects around 2 billion people worldwide, with pregnant women as a high-risk group."	2.72	Is There an Ideal Diet to Protect against Iodine Deficiency? ( Czarnywojtek, A; Dobrowolska, A; Krela-Kaźmierczak, I; Ratajczak, AE; Ruchała, M; Rychter, AM; Skoracka, K; Szymczak-Tomczak, A, 2021)
"Iodine deficiency has multiple adverse effects on growth and development."	2.72	GLOBAL ENDOCRINOLOGY: Global perspectives in endocrinology: coverage of iodized salt programs and iodine status in 2020. ( Andersson, M; Zimmermann, MB, 2021)
"Iodine is a necessary micronutrient for the production of thyroid hormones and normal human development."	2.66	Consequences of Severe Iodine Deficiency in Pregnancy: Evidence in Humans. ( Maraka, S; Motahari, H; Toloza, FJK, 2020)
"The prevalence of thiamin and vitamin B12 deficiency was 10·5 % in Yunnan and 4·5 % in Chongqing provinces, respectively."	2.50	The phenomenon of micronutrient deficiency among children in China: a systematic review of the literature. ( Chan, EW; Chui, CS; Sutcliffe, AG; Wong, AY; Wong, IC, 2014)
"Childhood overweight is becoming an increasingly important contributor to adult obesity, diabetes, and non-communicable diseases."	2.49	Maternal and child undernutrition and overweight in low-income and middle-income countries. ( Bhutta, ZA; Black, RE; Christian, P; de Onis, M; Ezzati, M; Grantham-McGregor, S; Katz, J; Martorell, R; Uauy, R; Victora, CG; Walker, SP, 2013)
"Iodine deficiency is a public health problem in the US, with the iodine status of women of reproductive age decreasing in recent years."	1.91	Salt-Containing Recipes in Popular Magazines with the Highest Circulation in the United States Do Not Specify Iodized Salt in the Ingredient List. ( Cohen, E; Mico, K; Nieckula, E; Pachón, H; Rosas, AB; Uerling, J, 2023)
"Iodine deficiency is a global public health threat, affecting an estimated two billion people."	1.91	Factors associated with recent iodine intake level among household food handlers in Southwest Ethiopia: a cross-sectional study. ( Asefa, K; Asfaw, A; Behailu, M; Gebremariam, T; Oumer, A, 2023)
"Iodine is an essential trace element for human and an antioxidant."	1.91	[Recognise of iodine effect on thyroid diseases and metabolism]. ( Shan, ZY; Teng, WP, 2023)
"Nutritional deficiency is prevalent among the elderly, and it is associated with many adverse health consequences."	1.72	Temporal Trends in Incidence of Nutritional Deficiency among Older Adults in China: A Secondary Analysis of the Global Burden of Disease Study 1990-2019. ( Fu, J; Han, Y; Lin, L; Xiao, L, 2022)
"Iodine adequacy was also evident with a median 24 h UIE of 226 μg/day as a more robust metric of iodine status with an estimated average requirement (EAR) of 7."	1.72	The Prevalence and Risk Factors Associated with Iodine Deficiency in Canadian Adults. ( Britz-Mckibbin, P; Lear, SA; Mathiaparanam, S; Mente, A; Nori de Macedo, A; Poirier, P; Teo, KK; Wielgosz, A; Yusuf, S, 2022)
"Diagnosis of Hashimoto thyroiditis (HT) was based on elevated thyrotropin, presence of TPO-Abs, and ultrasound characteristics."	1.72	Increased Incidence of Hashimoto Thyroiditis in Selenium Deficiency: A Prospective 6-Year Cohort Study. ( Chen, P; Lv, H; Peng, X; Rijntjes, E; Schomburg, L; Shi, B; Wang, S; Wang, Y; Wei, J; Wu, Q; Wu, Y; Zhao, X, 2022)
"Iodine deficiency is a common problem in pregnant women and may have implications for maternal and child health."	1.72	Iodine Supplementation in Pregnancy in an Iodine-Deficient Region: A Cross-Sectional Survey. ( Lemos, MC; Limbert, E; Lopes, CA; Martinez-de-Oliveira, J; Prazeres, S, 2022)
"Iodine is a required nutrient for thyroid function."	1.48	IODINE NUTRITION IN THE REPUBLIC OF ARTSAKH (NAGORNO KARABAKH). ( Atayan, K; Baghdasaryan, S; Bilezikian, JP; Chiloyan, A; Hutchings, N; Manoukian, M; Qefoyan, M, 2018)
"Iodine excretion was measured in urine."	1.43	Species-Specific Associations Between Soil-Transmitted Helminths and Micronutrients in Vietnamese Schoolchildren. ( de Gier, B; Dijkhuizen, MA; Khan, NC; Nga, TT; Polman, K; Ponce, MC; van de Bor, M; Wieringa, FT; Winichagoon, P, 2016)
"Iodine deficiency is an important nutritional deficiency, with more than 2 billion people worldwide estimated to be at risk."	1.38	Teratology public affairs committee position paper: iodine deficiency in pregnancy. ( Jahnke, GD; Obican, SG; Scialli, AR; Soldin, OP, 2012)
"These conditions include intrauterine growth restriction (IUGR), low birth weight, protein-energy malnutrition, chronic energy deficit of women, and micronutrient deficiencies."	1.38	Global burden of maternal and child undernutrition and micronutrient deficiencies. ( Ahmed, T; Hossain, M; Sanin, KI, 2012)
"Iodine deficiency is a global public health problem, and estimates of the extent of the problem were last produced in 2003."	1.35	Iodine deficiency in 2007: global progress since 2003. ( Andersson, M; de Benoist, B; McLean, E; Rogers, L, 2008)
"The iodine intake was 189."	1.35	Adequate iodine intake of Slovenian adolescents is primarily attributed to excessive salt intake. ( Battelino, T; Fidler Mis, N; Kobe, H; Kotnik, P; Krzisnik, C; Sirca-Campa, A; Smole, K; Stimec, M; Zupancic, M, 2009)
"We found the relationship between stomach cancer and iodine deficiency to be significant."	1.32	Urinary iodine/creatinine ratio in patients with stomach cancer in Urmia, Islamic Republic of Iran. ( Aghdami, N; Behrouzian, R, 2004)

Research

Studies (109)

Authors

Clinical Trials (36)

Trial Overview

Trial Outcomes

Adverse Events

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.92)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (13.76)	29.6817
2010's	36 (33.03)	24.3611
2020's	57 (52.29)	2.80

Authors	Studies
Xing, M	3
Gu, S	2
Wang, X	6
Mao, G	3
Mo, Z	4
Lou, X	3
Li, X	2
Huang, X	1
Wang, Y	5
Wang, Z	6
Candido, AC	1
Azevedo, FM	1
Macedo, MS	1
Priore, SE	1
Franceschini, SDCC	1
Shen, J	1
Song, Q	2
Cui, X	2
Shi, Z	2
Su, J	1
Zang, J	2
Yu, H	1
Wang, H	1
Jin, W	1
Guo, C	1
Tang, H	1
Nista, F	1
Bagnasco, M	2
Gatto, F	1
Albertelli, M	1
Vera, L	1
Boschetti, M	1
Musso, N	1
Ferone, D	1
Korobitsyna, R	1
Aksenov, A	1
Sorokina, T	1
Trofimova, A	1
Grjibovski, AM	1
Lopes, CA	1
Prazeres, S	1
Martinez-de-Oliveira, J	1
Limbert, E	1
Lemos, MC	1
Li, M	2
Wang, R	1
Lu, J	1
Li, W	1
Hu, Y	1
Chen, J	1
Ma, W	1
Yang, L	1
Wu, Q	1
Chen, P	1
Wei, J	1
Lv, H	1
Wang, S	2
Wu, Y	2
Zhao, X	1
Peng, X	1
Rijntjes, E	1
Schomburg, L	2
Shi, B	1
Mathiaparanam, S	1
Nori de Macedo, A	1
Mente, A	1
Poirier, P	1
Lear, SA	1
Wielgosz, A	1
Teo, KK	1
Yusuf, S	1
Britz-Mckibbin, P	1
Brough, L	1
Paśko, P	1
Okoń, K	1
Prochownik, E	1
Krośniak, M	1
Francik, R	1
Kryczyk-Kozioł, J	1
Grudzińska, M	1
Tyszka-Czochara, M	1
Malinowski, M	1
Sikora, J	1
Galanty, A	1
Zagrodzki, P	1
Asfaw, A	2
Tamiru, D	1
Belachew, T	1
Hatch-McChesney, A	1
Lieberman, HR	1
Brantsæter, AL	1
Garthus-Niegel, S	1
Brandlistuen, RE	1
Caspersen, IH	1
Meltzer, HM	1
Abel, MH	1
Sasidharan Pillai, S	1
Quintos, JB	1
Troshina, EA	2
Croce, L	1
Chiovato, L	1
Tonacchera, M	2
Petrosino, E	1
Tanda, ML	1
Moleti, M	2
Magri, F	1
Olivieri, A	2
Pearce, EN	2
Rotondi, M	1
Businge, CB	2
Musarurwa, HT	1
Longo-Mbenza, B	2
Kengne, AP	2
Zimmermann, MB	5
Xiao, L	2
Fu, J	2
Lin, L	3
Han, Y	2
Shenhav, S	1
Benbassat, C	1
Gefel, D	1
Zangen, S	1
Rosen, SR	1
Avrahami-Benyounes, Y	1
Almashanu, S	1
Groisman, L	1
Rorman, E	1
Fytlovich, S	1
Anteby, EY	1
Ovadia, YS	1
Milner, D	1
Boyle, F	1
McNulty, J	1
Knerr, I	1
Suplotova, LA	1
Makarova, OB	1
Troshina, A	1
Shan, ZY	1
Teng, WP	1
Rigutto-Farebrother, J	1
Lisco, G	1
De Tullio, A	1
Triggiani, D	1
Zupo, R	1
Giagulli, VA	1
De Pergola, G	1
Piazzolla, G	1
Guastamacchia, E	1
Sabbà, C	1
Triggiani, V	1
Bednarczuk, T	1
Kajdaniuk, D	1
Marek, B	1
Bolanowski, M	1
Dedecjus, M	1
Gilis-Januszewska, A	1
Hubalewska-Dydejczyk, A	1
Jarząb, B	1
Junik, R	1
Kamiński, G	1
Kos-Kudła, B	1
Kowalska, A	1
Lewiński, A	1
Matyjaszek-Matuszek, B	1
Ruchała, M	3
Siemińska, L	1
Sworczak, K	1
Syrenicz, A	1
Zgliczyński, W	1
Uerling, J	1
Nieckula, E	1
Mico, K	1
Rosas, AB	1
Cohen, E	1
Pachón, H	1
González-Martínez, S	1
Martínez-Morillo, E	1
Avello-Llano, N	1
Escudero-Gomis, AI	1
Delgado-Álvarez, E	1
Menéndez-Torre, EL	1
Machado, A	1
Gonçalves, C	1
Moreira, P	1
Pinho, O	1
Padrão, P	1
Silva-Santos, T	1
Rodrigues, M	1
Norton, P	1
Bordalo, AA	1
Schulz, CA	1
Weinhold, L	1
Schmid, M	1
Nöthen, MM	1
Nöthlings, U	1
Sleire, SN	1
Markhus, MW	1
Wan, S	1
Jin, B	1
Ren, B	1
Boah, M	1
Shen, H	1
Alzahrani, A	1
Ebel, R	1
Norton, G	1
Raab, A	1
Feldmann, J	1
Filipowicz, D	1
Szczepanek-Parulska, E	1
Mikulska-Sauermann, AA	1
Karaźniewicz-Łada, M	1
Główka, FK	1
Szymanowski, K	1
Ołtarzewski, M	1
Behailu, M	1
Oumer, A	1
Gebremariam, T	1
Asefa, K	1
Nguyen, CT	1
Chouraqui, JP	1
Yang, J	2
Su, Q	1
Gu, H	1
Qin, L	1
Wei, R	1
Zhang, X	1
Xu, Y	1
Li, Q	1
Rosendahl-Riise, H	1
Aksnes, S	1
Sabir, Z	1
Ulleberg, EK	1
Myklebust-Hansen, T	1
Aakre, I	1
Tu, P	1
Wu, L	1
Chen, Z	2
Makolina, NP	1
Platonova, NM	1
Isaeva, MP	1
Abdulkhabirova, FM	1
Nikankina, LV	1
Zuraeva, ZT	1
Isaeva, US	1
Atabaeva, KV	1
Fan, X	1
Zhao, L	1
Song, K	1
Wang, B	1
Xie, Y	1
Jiang, Y	1
Teng, W	1
Cai, C	1
Yao, Y	2
Gong, B	1
Wang, C	1
Yang, W	1
Shan, Z	1
Lai, Y	1
Terefe, B	1
Jembere, MM	1
Assimamaw, NT	1
Petry, N	1
Jallow, B	1
Sawo, Y	1
Darboe, MK	1
Barrow, S	1
Sarr, A	1
Ceesay, PO	1
Fofana, MN	1
Prentice, AM	1
Wegmüller, R	1
Rohner, F	1
Phall, MC	1
Wirth, JP	1
Zhu, W	2
Toloza, FJK	1
Motahari, H	1
Maraka, S	1
Codling, K	1
Laillou, A	1
Rudert, C	1
Borath, M	1
Gorstein, J	1
De Angelis, S	1
Regalbuto, C	1
Vermiglio, F	1
Medda, E	1
Rotondi, D	1
Di Cosmo, C	1
Dimida, A	1
Rago, T	1
Schiavo, M	1
Nazzari, E	1
Bossert, I	1
Sturniolo, G	1
Cesaretti, G	1
Krela-Kaźmierczak, I	1
Czarnywojtek, A	1
Skoracka, K	1
Rychter, AM	1
Ratajczak, AE	1
Szymczak-Tomczak, A	1
Dobrowolska, A	1
Cavanaugh, R	1
Andersson, M	3
Liu, L	2
Du, Y	1
Liu, P	2
Fan, L	1
Meng, F	1
de Juras, AR	1
Hsu, WC	1
Hu, SC	1
Leyvraz, M	1
David-Kigaru, DM	1
Macharia-Mutie, C	1
Aaron, GJ	1
Roefs, M	1
Tumilowicz, A	1
Hutchings, N	1
Baghdasaryan, S	1
Qefoyan, M	1
Chiloyan, A	1
Manoukian, M	1
Atayan, K	1
Bilezikian, JP	1
Xia, S	1
Fisher, J	1
Tran, T	1
Luchters, S	1
Tran, TD	1
Hipgrave, DB	1
Hanieh, S	1
Tran, H	1
Simpson, J	1
Nguyen, T	1
Le, M	1
Biggs, BA	1
Randremanana, RV	1
Bastaraud, A	1
Rabarijaona, LP	1
Piola, P	1
Rakotonirina, D	1
Razafinimanana, JO	1
Ramangakoto, MH	1
Andriantsarafara, L	1
Randriamasiarijaona, H	1
Tucker-Brown, A	1
Harimanana, A	1
Namana, S	1
Feleke, BE	1
Feleke, TE	1
Mekonnen, D	1
Beyene, MB	1
Madini, N	1
Clifton, VL	1
Hodyl, NA	1
Fogarty, PA	1
Torpy, DJ	1
Roberts, R	1
Nettelbeck, T	1
Ma, G	1
Hetzel, B	1
Kang, P	1
Shen, B	1
Zhou, Z	1
Pei, F	1
Black, RE	4
Victora, CG	1
Walker, SP	1
Bhutta, ZA	4
Christian, P	1
de Onis, M	2
Ezzati, M	2
Grantham-McGregor, S	1
Katz, J	1
Martorell, R	1
Uauy, R	1
Das, JK	1
Rizvi, A	1
Gaffey, MF	1
Walker, N	1
Horton, S	1
Webb, P	1
Lartey, A	1
Kumar, MV	1
Nirmalan, PK	1
Erhardt, JG	1
Rahmathullah, L	1
Rajagopalan, S	1
Wong, AY	1
Chan, EW	1
Chui, CS	1
Sutcliffe, AG	1
Wong, IC	1
Imdad, A	1
Tulchinsky, TH	1
Bailey, RL	1
West, KP	1
Mogendi, JB	1
De Steur, H	1
Gellynck, X	1
Makokha, A	1
Hussein, I	1
Al Ghannami, S	1
El Badawi, S	1
Al Hamad, NM	1
Abbas Hajj, B	1
Al-Thani, M	1
Al-Thani, AA	1
Winichagoon, P	2
Pongcharoen, T	1
van der Haar, F	1
Qing-Zhen, J	1
Dold, S	1
Carriquiry, AL	1
de Gier, B	1
Nga, TT	1
Dijkhuizen, MA	1
Khan, NC	1
van de Bor, M	1
Ponce, MC	1
Polman, K	1
Wieringa, FT	1
de Benoist, B	1
McLean, E	1
Rogers, L	1
Lechtig, A	1
Cornale, G	1
Ugaz, ME	1
Arias, L	1
Suskind, DL	1
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Kotnik, P	1
Sirca-Campa, A	1
Zupancic, M	1
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Krzisnik, C	1
Fidler Mis, N	1
Teng, BJ	1
Zhang, SB	1
Su, XH	1
Yu, J	1
Liu, SJ	1
Costeira, MJ	1
Oliveira, P	1
Ares, S	1
Roque, S	1
de Escobar, GM	2
Palha, JA	1
Selamat, R	1
Mohamud, WN	1
Zainuddin, AA	1
Rahim, NS	1
Ghaffar, SA	1
Aris, T	1
Tukvadze, Sh	1
Kverenchkhiladze, R	1
Mansourian, AR	1
Roman Viñas, B	1
Ribas Barba, L	1
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Novakovic, R	1
Cavelaars, A	1
de Groot, LC	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Iodine Status of the Indigenous Peoples (Karen) Living in Laiwo Subdistrict, Sangkhlaburi District, Kanchanaburi Province, Thailand[NCT05920603]		600 participants (Actual)	Observational	2022-08-05	Completed
A Community-based Cluster Randomized Controlled Trial to Evaluate the Effectiveness of Different Bundles of Nutrition-specific Interventions in Improving Mean Length-for-age Z Score Among Children at 24 Months of Age in Rural Bangladesh[NCT02768181]		2,880 participants (Actual)	Interventional	2015-11-30	Completed
Evaluation of Integrated Agriculture and Nutrition Sensitive Interventions for the African Chicken Genetic Gains (ACGG) Program in Ethiopia[NCT03152227]		2,117 participants (Actual)	Interventional	2016-11-30	Completed
Bangladesh Multi-Sectoral Nutrition Project: Agricultural/Livelihood Mixed Methods Study[NCT04185597]		4,067 participants (Actual)	Interventional	2018-07-07	Completed
Association Between Prolactin Levels in Pregnant Women to- 2 Gether With Rates of Breastfeeding and the COVID-19 Virus. A 3 Randomised Trial[NCT05506280]		720 participants (Actual)	Observational	2022-04-13	Completed
Translating Adoption of Improved Varieties Into Nutritional Impact for Young Children: An RCT Exploring Strategies to Increase Consumption of Quality Protein Maize in Ethiopia[NCT02710760]		978 participants (Actual)	Interventional	2015-07-31	Completed
Ability of the Probiotic Vivomixx to Improve Environmental Enteropathy in Pregnant Women: a Proof of Concept Trial in Bangladesh, Pakistan, Senegal and Zambia[NCT05608928]	Phase 2	76 participants (Anticipated)	Interventional	2022-12-01	Not yet recruiting
Bangladesh Multisectoral Nutrition Project: Social Protection Mixed Methods Study[NCT04166370]		0 participants (Actual)	Interventional	2018-07-26	Withdrawn (stopped due to Stopped due to funding)
Nutritional Status and Iodized Salt Use Among School-aged Children Living in Phu Kut City, Xieng Khouang Province, Lao PDR[NCT05862376]		367 participants (Actual)	Observational	2021-04-01	Completed
Muscular Strength and Aerobic Capacity, a Symbiotic Relationship With Birth Weight and Metabolic Risk of Colombian Scholchildren: Study SIMAC[NCT03779737]		150 participants (Actual)	Interventional	2016-02-01	Completed
Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis in Rural South-central Côte d'Ivoire: Study Protocol of a Cluster Randomised Controlled Trial[NCT04250428]		720 participants (Anticipated)	Interventional	2020-02-29	Not yet recruiting
Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276]	Phase 2	81 participants (Actual)	Interventional	2016-04-01	Active, not recruiting
Scientific Foundations for Developing and Validating Food-based Dietary Guidelines and a Healthy Eating Index for Ethiopia[NCT03394963]		500 participants (Actual)	Observational	2019-11-01	Completed
Mobile Health Solutions to Help Community Providers Promote Maternal & Infant Nutrition & Health - A Community-based Cluster RCT in Rural India to Evaluate M-SAKHI for Use by ASHAs to Reduce Malnutrition in Infants up to 24 Months[NCT02457923]		2,728 participants (Anticipated)	Interventional	2017-02-01	Active, not recruiting
First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition[NCT03174236]	Phase 3	2,000 participants (Anticipated)	Interventional	2017-09-04	Active, not recruiting
Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae[NCT05519254]	Phase 3	150 participants (Anticipated)	Interventional	2023-03-10	Recruiting
Bioavailability of Essential Amino Acids From the Common Bean (Phaseolus Vulgaris) in Young Healthy Jamaican Adults Consuming a Typical Meal[NCT04118517]		10 participants (Actual)	Interventional	2019-05-29	Completed
Study on Dietary Intake Levels of Iodine for 3-6 Years Old Pre-school Children[NCT06074770]		2,650 participants (Anticipated)	Observational	2023-05-05	Recruiting
Impact Evaluation of the DFID Programme to Accelerate Improved Nutrition of the Extreme Poor in Bangladesh[NCT02597608]		11,340 participants (Actual)	Interventional	2013-07-31	Completed
Evaluation of the Effectiveness and Impact of Community Case Management of Severe Acute Malnutrition Through Lady Health Workers As Compared To a Facility Based Program: A Cluster Randomized Controlled Trial[NCT03043352]		762 participants (Actual)	Interventional	2015-04-20	Completed
Supplementation With WellnessPack Mama During Pregnancy and Lactation - a Randomized Double-blind, Placebo-controlled Study[NCT02190565]		0 participants (Actual)	Interventional	2018-04-07	Withdrawn (stopped due to Business decision - strategy changes and budget limitations)
Evaluation of the Effectiveness of Nutrition Education Intervention Among Rural Mothers on Pulse and Cereal Mix Complementary Food and Nutritional Status of Children Age 6-24 Months in Sidama Zone, Southern Ethiopia[NCT02638571]		772 participants (Actual)	Interventional	2016-01-19	Completed
Effects of Video-based Health Education on Health Status of Pregnant Mothers and Their Infants (From 0 to 6 Months) in Dirashe District Southern Ethiopia - a Cluster Randomized Controlled Trial.[NCT04414527]		675 participants (Actual)	Interventional	2020-03-13	Completed
Vitamin D Deficiency, Iodine Deficiency and Lead Levels in Haitian Infants and Children.[NCT02301520]		299 participants (Actual)	Observational	2015-01-31	Completed
Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism Requiring High Levothyroxine Dosage; a Randomized Control Trial[NCT05733078]	Phase 2	40 participants (Anticipated)	Interventional	2023-04-30	Not yet recruiting
Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation[NCT01079923]		40 participants (Actual)	Interventional	2010-02-28	Completed
Weight Patterns in the Month After Birth: Relationship With Dietary Intake[NCT04025827]		741 participants (Actual)	Observational	2019-04-22	Completed
Promotion of Complimentary Feeding Practices Through Health Messages: a Community-based Clustered Randomized Trial in Rural Bangladesh[NCT03024710]		360 participants (Actual)	Interventional	2011-01-31	Completed
Multidimensional Evaluation of the Early Emergence of Executive Function and Emotional Regulation in Young Children in Bangladesh Using Nutritional and Psychosocial Intervention: A Pilot Study[NCT05629624]		280 participants (Anticipated)	Interventional	2022-02-07	Recruiting
Use of Low-level Laser Therapy on Children Aged One to Five Years With Energy-protein Malnutrition[NCT03355313]		50 participants (Actual)	Interventional	2017-09-01	Enrolling by invitation
Milk Matters in Malnutrition, is it the Lactose or Dairy Protein?[NCT04216043]		1,102 participants (Actual)	Interventional	2020-09-16	Completed
Chronic Malnutrition and Oral Health Status in Children Aged One to Five Years[NCT03529500]		82 participants (Actual)	Observational	2017-02-02	Completed
Community Based Management of Severe Malnutrition in Under 5 Children in Tribal Area of Melghat, Maharashtra- Cluster Randomized Control Field Trial[NCT02671786]		824 participants (Actual)	Interventional	2011-05-31	Completed
Assessing the Feasibility of Integrating a Package of Maternal Nutrition Interventions Into Antenatal Care Services in Burkina Faso: A Cluster-Randomized Evaluation[NCT04155437]		8,110 participants (Actual)	Interventional	2019-11-06	Completed
Comparison of a Novel Ready-to-use Supplementary Food (RUSF) With Whey Permeate to Standard Peanut/Soy RUSF for the Treatment of Moderate Acute Malnutrition in Rural Malawian Children: a Randomised, Double-blinded, Clinical Effectiveness Trial[NCT01790048]		2,259 participants (Actual)	Interventional	2013-02-28	Completed
A Nutrition/Hygiene Education Program for the Prevention of Child Malnutrition in Rural Kenya[NCT01679535]		246 participants (Actual)	Interventional	2011-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Any adverse events from the supplementary foods reported in the 3 month time frame. (NCT01790048)
Timeframe: 3 months

Height

Intervention	Participants (Count of Participants)
Whey Permeate RUSF	0
Soy Protein RUSF	0

Amount of height gained over the intervention period. (NCT01790048)
Timeframe: 3 months

Mid-Upper-Arm Circumference (MUAC) Gain

Recovery From Moderate Acute Malnutrition (MAM)

Intervention	mm/d (Mean)
Whey Permeate RUSF	0.30
Soy Protein RUSF	0.29

Intervention	mm/d (Mean)
Whey Permeate RUSF	0.26
Soy Protein RUSF	0.22

The primary outcome measures will be recovery from MAM (achieving MUAC ≥ 12.5 cm by 12 weeks) or failure (death, development of severe acute malnutrition, transfer to hospital for inpatient care, failure to recover from MAM by 12 weeks, default). (NCT01790048)
Timeframe: 3 months

Time to Graduation

Intervention	Participants (Count of Participants)
Whey Permeate RUSF	960
Soy Protein RUSF	874

The amount of time required for a patient to reach recovery (NCT01790048)
Timeframe: 3 months

Weight

Intervention	days (Mean)
Whey Permeate RUSF	29.3
Soy Protein RUSF	30.4

Amount of weight gained over the course of treatment (NCT01790048)
Timeframe: 3 months

iodine and Malnutrition