Page last updated: 2024-10-18

iodine and Developmental Disabilities

iodine has been researched along with Developmental Disabilities in 25 studies

Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..

Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)

Research Excerpts

ExcerptRelevanceReference
"There are limited and inconsistent data suggesting that mild iodine deficiency in pregnancy might be associated with poorer developmental outcomes in children."7.91Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months. ( Anderson, PJ; Condo, D; Howell, S; Makrides, M; McPhee, AJ; Ryan, P; Skeaff, SA; Zhou, SJ, 2019)
" Dietary iodine and supplementation were measured through questionnaires twice during pregnancy."7.88Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study. ( Alvarez-Pedrerol, M; Basterrechea, M; Espada, M; González, L; Ibarluzea, J; Julvez, J; Llop, S; Lopez-Espinosa, MJ; Murcia, M; Rebagliato, M; Riaño, I; Tardón, A; Vioque, J, 2018)
"Iodine deficiency during pregnancy might be associated with reduced intelligence quotient (IQ) score in offspring."5.24Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. ( Galetti, V; Gowachirapant, S; Jaiswal, N; Mackenzie, I; Melse-Boonstra, A; Srinivasan, K; Stinca, S; Thomas, S; Thomas, T; Winichagoon, P; Zimmermann, MB, 2017)
"Cretinism, which is characterized by marked intellectual impairment and is associated with severe iodine deficiency, has been appreciated for many years."4.80Thyroid hormone and intellectual development: a clinician's view. ( Lazarus, JH, 1999)
"There are limited and inconsistent data suggesting that mild iodine deficiency in pregnancy might be associated with poorer developmental outcomes in children."3.91Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months. ( Anderson, PJ; Condo, D; Howell, S; Makrides, M; McPhee, AJ; Ryan, P; Skeaff, SA; Zhou, SJ, 2019)
" Dietary iodine and supplementation were measured through questionnaires twice during pregnancy."3.88Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study. ( Alvarez-Pedrerol, M; Basterrechea, M; Espada, M; González, L; Ibarluzea, J; Julvez, J; Llop, S; Lopez-Espinosa, MJ; Murcia, M; Rebagliato, M; Riaño, I; Tardón, A; Vioque, J, 2018)
"After 12 weeks of treatment (before pregnancy), iodine concentrations in urine and thyroid tissue and circulating thyroxine of adult females correlated with iodine intake."3.78Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring. ( Fan, C; Li, J; Liu, Y; Mao, J; Shan, Z; Teng, W; Wang, H; Zhang, H; Zhang, L, 2012)
"The frequency of SH in children with neurological disorders was of 7."1.32[Frequency of subclinical hypothyroidism among healthy children and those with neurological conditions in the state of Mérida, Venezuela]. ( Arata-Bellabarba, G; Arias-Ferreira, A; Bianchi, G; Jiménez-López, V; Mamán-Alvarado, D; Paoli-Valeri, M, 2003)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (24.00)18.2507
2000's4 (16.00)29.6817
2010's14 (56.00)24.3611
2020's1 (4.00)2.80

Authors

AuthorsStudies
Gowachirapant, S1
Jaiswal, N1
Melse-Boonstra, A1
Galetti, V1
Stinca, S1
Mackenzie, I1
Thomas, S1
Thomas, T1
Winichagoon, P1
Srinivasan, K1
Zimmermann, MB2
Murcia, M1
Espada, M1
Julvez, J1
Llop, S1
Lopez-Espinosa, MJ1
Vioque, J1
Basterrechea, M1
Riaño, I1
González, L1
Alvarez-Pedrerol, M1
Tardón, A1
Ibarluzea, J1
Rebagliato, M1
Zhou, SJ1
Condo, D1
Ryan, P1
Skeaff, SA1
Howell, S1
Anderson, PJ1
McPhee, AJ1
Makrides, M1
Walsh, V1
Brown, JVE1
McGuire, W2
Stagnaro-Green, A1
Pearce, EN1
Bath, SC1
Steer, CD1
Golding, J1
Emmett, P1
Rayman, MP1
Leung, AM1
Brent, GA1
Graham-Evans, K1
Brown, N1
Win, AZ1
Belcari, F1
Placidi, G1
Guzzetta, A1
Tonacchera, M1
Ciampi, M1
Bartoli, A1
Scaramuzzo, RT1
Frumento, P1
Cioni, G1
Pinchera, A1
Boldrini, A1
Ghirri, P1
Smyth, P1
O'Herlihy, C1
Suárez-Rodríguez, M1
Azcona-San Julián, C1
Alzina de Aguilar, V1
Zhang, L1
Teng, W1
Liu, Y2
Li, J2
Mao, J1
Fan, C1
Wang, H2
Zhang, H3
Shan, Z1
Hume, R1
Choudhury, N1
Gorman, KS1
Paoli-Valeri, M1
Mamán-Alvarado, D1
Jiménez-López, V1
Arias-Ferreira, A1
Bianchi, G1
Arata-Bellabarba, G1
Ibrahim, M1
Sinn, J1
Ferretti, G1
Grantham-McGregor, SM1
Fernald, LC1
Lazarus, JH1
Utiger, RD1
Hollowell, JG1
Garbe, PL1
Miller, DT1
Zagefka, H1
Huynh, HP1
Senger, AR1
Derington, CG1
Colantonio, LD1
Herrick, JS1
Cook, J1
King, JB1
Rosenson, RS1
Poudel, B1
Monda, KL1
Navar, AM1
Mues, KE1
Stevens, VW1
Nelson, RE1
Vanneman, ME1
Muntner, P1
Bress, AP1
Ma, B1
Ren, G1
Xu, J1
Yin, C1
Shi, Y1
Rahsepar, AA1
Bluemke, DA1
Habibi, M1
Liu, K1
Kawel-Boehm, N1
Ambale-Venkatesh, B1
Fernandes, VRS1
Rosen, BD1
Lima, JAC1
Carr, JC1
Freitag, TM1
Chen-Sankey, JC1
Duarte, DA1
Ramsey, MW1
Choi, K1
Winkler-Heil, R1
Hussain, M1
Hofmann, W1
Nicotera, AG1
Dicanio, D1
Pironti, E1
Bonsignore, M1
Cafeo, A1
Efthymiou, S1
Mondello, P1
Salpietro, V1
Houlden, H1
Di Rosa, G1
Hayes-Ryan, D1
O'Donoghue, K1
McCarthy, C1
Totorika, A1
Meaney, S1
Pang, RD1
Dormanesh, A1
Hoang, Y1
Chu, M1
Allem, JP1
Girón-Ortega, JA1
Márquez-Coello, M1
Gutiérrez-Saborido, D1
Arizcorreta, A1
Cuesta-Sancho, S1
Girón-González, JA1
Dovrat, G1
Pevzner, S1
Berthon, C1
Lerner, A1
Maimon, E1
Vainer, R1
Karpasas, M1
Ben-Elyiahu, Y1
Moisy, P1
Bettelheim, A1
Zilbermann, I1
Vanden Broeck, SMP1
Nelson, DJ1
Collado, A1
Falivene, L1
Cavallo, L1
Cordes, DB1
Slawin, AMZ1
Van Hecke, K1
Nahra, F1
Cazin, CSJ1
Nolan, SP1
Kranidiotis-Hisatomi, N1
Yi, H1
Oestreich, M1
Kwiezinski, C1
Weller, C1
van Pinxteren, D1
Brüggemann, M1
Mertes, S1
Stratmann, F1
Herrmann, H1
Treggiari, D1
Tridello, G1
Menin, L1
Borruso, A1
Pintani, E1
Iansa, P1
Cipolli, M1
Melotti, P1
Ren, L1
Liu, L3
Shu, X1
Lin, W1
Yang, P1
Chen, J1
Teo, KL1
Xiao, F1
Yao, T1
Zhao, X1
Yang, X1
Yu, DYW1
Rogach, AL1
Bordet, A1
Leitner, W1
Gao, S1
Xia, F1
Li, B2
Abdul Razak, IB1
Lu, K1
Brown, DE1
Wang, R1
Cheng, Y1
Ni, S1
Qu, H1
Xing, H1
Xu, Z1
Zhu, X1
Yuan, M1
Wang, L1
Yu, J1
Li, Y1
Yang, L1
Liu, H1
Cao, L1
Zhang, S1
Zhao, D1
Yan, T1
Yang, G1
Lin, Z1
Luo, M1
Ye, N1
Lee, SW1
Carnicelli, J1
Getya, D1
Gitsov, I1
Phillips, KS1
Ren, D1
Grützmacher, PG1
Suarez, S1
Tolosa, A1
Gachot, C1
Song, G1
Wang, B1
Presser, V1
Mücklich, F1
Anasori, B1
Rosenkranz, A1
Demireva, M1
Armentrout, PB1
Feng, D1
Cao, K1
He, ZZ1
Knibbs, LD1
Jalaludin, B1
Leskinen, A1
Roponen, M1
Komppula, M1
Jalava, P1
Guo, PY1
Xu, SL1
Yang, BY1
Hu, L1
Zeng, XW1
Chen, G1
Yu, HY1
Lin, L1
Dong, G1
Machulkin, AE1
Shafikov, RR1
Uspenskaya, AA1
Petrov, SA1
Ber, AP1
Skvortsov, DA1
Nimenko, EA1
Zyk, NU1
Smirnova, GB1
Pokrovsky, VS1
Abakumov, MA1
Saltykova, IV1
Akhmirov, RT1
Garanina, AS1
Polshakov, VI1
Saveliev, OY1
Ivanenkov, YA1
Aladinskaya, AV1
Finko, AV1
Yamansarov, EU1
Krasnovskaya, OO1
Erofeev, AS1
Gorelkin, PV1
Dontsova, OA1
Beloglazkina, EK1
Zyk, NV1
Khazanova, ES1
Majouga, AG1
Zheng, YK1
Su, BJ1
Wang, YQ1
Wang, HS1
Liao, HB1
Liang, D1
Shataer, D1
Duan, XM1
Xin, XL1
Aisa, HA1
Allu, SR1
Ravotto, L1
Troxler, T1
Vinogradov, SA1
Cheruku, RR1
Tracy, EC1
Tabaczynski, W1
Missert, JR1
Baumann, H1
Pandey, RK1
Rohde, JM1
Karavadhi, S1
Pragani, R1
Fang, Y1
Zhang, W1
McIver, A1
Zheng, H1
Liu, Q1
Davis, MI1
Urban, DJ1
Lee, TD1
Cheff, DM1
Hollingshead, M1
Henderson, MJ1
Martinez, NJ1
Brimacombe, KR1
Yasgar, A1
Zhao, W1
Klumpp-Thomas, C1
Michael, S1
Covey, J1
Moore, WJ1
Stott, GM1
Li, Z1
Simeonov, A1
Jadhav, A1
Frye, S1
Hall, MD1
Shen, M1
Wang, X1
Patnaik, S1
Boxer, MB1
Cheng, C1
Huang, B1
Chen, R1
Huang, Y1
Chen, H1
Pei, W1
Katahara, S1
Sugiyama, Y1
Yamane, M1
Komiya, Y1
Sato, T1
Chida, N1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Iodine Supplementation in Pregnant Women Living in Mild-to-moderately Iodine Deficient Areas in India and Thailand: Effects on Pregnancy Outcome and Infant Development[NCT00791466]829 participants (Actual)Interventional2008-09-30Completed
Study on Physiologic Requirement and Dietary Recommended Nutrient[NCT04419103]600 participants (Actual)Observational2019-07-01Completed
Iodine Nutrition During Pregnancy and Related Neonatal Physical Development[NCT02586220]250 participants (Actual)Observational2015-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for iodine and Developmental Disabilities

ArticleYear
Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants.
    The Cochrane database of systematic reviews, 2019, 02-26, Volume: 2

    Topics: Developmental Disabilities; Dietary Supplements; Enteral Nutrition; Humans; Infant; Infant Mortality

2019
Neurodisability: metabolic and hormonal aspects.
    Developmental medicine and child neurology. Supplement, 2003, Volume: 95

    Topics: Child; Developmental Disabilities; Female; Humans; Hypothyroidism; Iodine; Nervous System Diseases;

2003
Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants.
    The Cochrane database of systematic reviews, 2006, Apr-19, Issue:2

    Topics: Developmental Disabilities; Dietary Supplements; Enteral Nutrition; Humans; Infant Mortality; Infant

2006
Nutritional deficiencies and subsequent effects on mental and behavioral development in children.
    The Southeast Asian journal of tropical medicine and public health, 1997, Volume: 28 Suppl 2

    Topics: Achievement; Adolescent; Anemia, Iron-Deficiency; Child; Child Development; Child Nutrition Disorder

1997
Thyroid hormone and intellectual development: a clinician's view.
    Thyroid : official journal of the American Thyroid Association, 1999, Volume: 9, Issue:7

    Topics: Brain; Congenital Hypothyroidism; Developmental Disabilities; Female; Humans; Infant, Newborn; Intel

1999
Another reason for iodine prophylaxis.
    Lancet (London, England), 1990, Jun-16, Volume: 335, Issue:8703

    Topics: Adult; Child; Child, Preschool; Congenital Hypothyroidism; Developmental Disabilities; Female; Fetal

1990

Trials

1 trial available for iodine and Developmental Disabilities

ArticleYear
Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial.
    The lancet. Diabetes & endocrinology, 2017, Volume: 5, Issue:11

    Topics: Adult; Child; Child, Preschool; Developmental Disabilities; Dietary Supplements; Double-Blind Method

2017

Other Studies

18 other studies available for iodine and Developmental Disabilities

ArticleYear
Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study.
    Journal of epidemiology and community health, 2018, Volume: 72, Issue:3

    Topics: Adult; Child, Preschool; Cognition; Cognition Disorders; Creatinine; Cross-Sectional Studies; Develo

2018
Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months.
    American journal of epidemiology, 2019, 02-01, Volume: 188, Issue:2

    Topics: Adult; Child Development; Cognition Disorders; Developmental Disabilities; Dietary Supplements; Fema

2019
Iodine and pregnancy: a call to action.
    Lancet (London, England), 2013, Jul-27, Volume: 382, Issue:9889

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Pregnancy; Pregnancy Compli

2013
Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC).
    Lancet (London, England), 2013, Jul-27, Volume: 382, Issue:9889

    Topics: Adult; Child; Cognition Disorders; Creatinine; Developmental Disabilities; Dyslexia; Female; Humans;

2013
Nutrition: Are mild maternal iodine deficiency and child IQ linked?
    Nature reviews. Endocrinology, 2013, Volume: 9, Issue:9

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Learning Disabilities; Male

2013
Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8-9 years of age.
    Evidence-based nursing, 2014, Volume: 17, Issue:3

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Pregnancy; Pregnancy Compli

2014
Maternal first-trimester iodine deficiency predicts poor cognitive outcome in English children.
    Archives of disease in childhood. Education and practice edition, 2014, Volume: 99, Issue:6

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Pregnancy; Pregnancy Compli

2014
Micronutrient deficiencies in early childhood can lower a country's GDP: The Myanmar example.
    Nutrition (Burbank, Los Angeles County, Calif.), 2016, Volume: 32, Issue:1

    Topics: Anemia, Iron-Deficiency; Child Nutrition Disorders; Child, Preschool; Deficiency Diseases; Developin

2016
Thyroid-stimulating hormone levels in the first days of life and perinatal factors associated with sub-optimal neuromotor outcome in pre-term infants.
    Journal of endocrinological investigation, 2011, Volume: 34, Issue:10

    Topics: Developmental Disabilities; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Infant, Newb

2011
Dietary iodine intake in pregnancy: an update.
    Irish medical journal, 2012, Volume: 105, Issue:1

    Topics: Developmental Disabilities; Female; Humans; Iodine; Ireland; Pregnancy; Pregnancy Complications; Ris

2012
Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012, Volume: 30, Issue:6

    Topics: Child, Preschool; Cognition Disorders; Developmental Disabilities; Female; Humans; Hypothyroidism; I

2012
Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring.
    BMC neuroscience, 2012, Oct-08, Volume: 13

    Topics: Age Factors; Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain-Derived Neurotrophic Fac

2012
Subclinical prenatal iodine deficiency negatively affects infant development in Northern China.
    The Journal of nutrition, 2003, Volume: 133, Issue:10

    Topics: China; Cognition; Developmental Disabilities; Educational Status; Female; Fetal Blood; Humans; Infan

2003
[Frequency of subclinical hypothyroidism among healthy children and those with neurological conditions in the state of Mérida, Venezuela].
    Investigacion clinica, 2003, Volume: 44, Issue:3

    Topics: Autoantibodies; Child, Preschool; Comorbidity; Developmental Disabilities; Female; Humans; Hypothyro

2003
[The prevention of disorders due to iodine deficiency: the experience of neuropsychological screening].
    Annali dell'Istituto superiore di sanita, 1994, Volume: 30, Issue:3

    Topics: Child; Developmental Disabilities; Humans; Infant, Newborn; Iodine; Italy; Mass Screening; Neuropsyc

1994
Maternal hypothyroidism and fetal development.
    The New England journal of medicine, 1999, Aug-19, Volume: 341, Issue:8

    Topics: Child; Developmental Disabilities; Embryonic and Fetal Development; Female; Humans; Hypothyroidism;

1999
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
    The New England journal of medicine, 1999, Dec-23, Volume: 341, Issue:26

    Topics: Child; Developmental Disabilities; Female; Humans; Hypothyroidism; Intelligence; Iodine; Pregnancy;

1999
    Journal of applied social psychology, 2021, Volume: 51, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Animals; Anti-Bacterial Agents; Anti-

2021