Page last updated: 2024-10-18

iodine and Cognition Disorders

iodine has been researched along with Cognition Disorders in 34 studies

Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"The World Health Organization (WHO) recently increased their recommended iodine intake during pregnancy from 200 to 250 microg/d and suggested that a median urinary iodine (UI) concentration of 150-249 microg/L indicates adequate iodine intake in pregnant women."8.85Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. ( Zimmermann, MB, 2009)
"There are limited and inconsistent data suggesting that mild iodine deficiency in pregnancy might be associated with poorer developmental outcomes in children."7.91Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months. ( Anderson, PJ; Condo, D; Howell, S; Makrides, M; McPhee, AJ; Ryan, P; Skeaff, SA; Zhou, SJ, 2019)
" Dietary iodine and supplementation were measured through questionnaires twice during pregnancy."7.88Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study. ( Alvarez-Pedrerol, M; Basterrechea, M; Espada, M; González, L; Ibarluzea, J; Julvez, J; Llop, S; Lopez-Espinosa, MJ; Murcia, M; Rebagliato, M; Riaño, I; Tardón, A; Vioque, J, 2018)
"Reports from populations with an insufficient iodine intake suggest that children of mothers with mild iodine deficiency during pregnancy are at risk for cognitive impairments."7.80Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area. ( Ghassabian, A; Hofman, A; Jaddoe, VW; Peeters, RP; Ross, HA; Steenweg-de Graaff, J; Tiemeier, H; Verhulst, FC; White, T, 2014)
"The purpose of this study was to determine whether children born to mothers with urinary iodine concentrations (UICs) <150 μg/L during pregnancy have poorer educational outcomes in primary school than peers whose mothers did not have gestational ID (UIC ≥150 μg/L)."7.79Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort. ( Burgess, JR; Hay, I; Hynes, KL; Otahal, P, 2013)
" The potential adverse effects of mild iodine deficiency during pregnancy are uncertain."6.44The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. ( Zimmermann, MB, 2007)
"The World Health Organization (WHO) recently increased their recommended iodine intake during pregnancy from 200 to 250 microg/d and suggested that a median urinary iodine (UI) concentration of 150-249 microg/L indicates adequate iodine intake in pregnant women."4.85Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. ( Zimmermann, MB, 2009)
"While traditionally associated with cretinism and goiter, iodine deficiency has broad effects on central nervous system development that can occur in the absence of either condition."4.82Iodine deficiency: consequences and progress toward elimination. ( Haxton, DP; Maberly, GF; van der Haar, F, 2003)
"The fetus and the newborn are more sensitive than adults to a reduced environmental iodine supply, and in iodine-deficient areas, transient neonatal hypothyroidism is frequently observed."4.80[Transient congenital hypothyroidism: physiopathology and clinica]. ( Cavaliere, R; Chiovato, L; Montanelli, L; Pinchera, A; Santini, F; Vitti, P, 1998)
"There are limited and inconsistent data suggesting that mild iodine deficiency in pregnancy might be associated with poorer developmental outcomes in children."3.91Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months. ( Anderson, PJ; Condo, D; Howell, S; Makrides, M; McPhee, AJ; Ryan, P; Skeaff, SA; Zhou, SJ, 2019)
" Dietary iodine and supplementation were measured through questionnaires twice during pregnancy."3.88Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study. ( Alvarez-Pedrerol, M; Basterrechea, M; Espada, M; González, L; Ibarluzea, J; Julvez, J; Llop, S; Lopez-Espinosa, MJ; Murcia, M; Rebagliato, M; Riaño, I; Tardón, A; Vioque, J, 2018)
"The evidence regarding a potential link of low-to-moderate iodine deficiency, selenium status, and cadmium exposure during pregnancy with neurodevelopment is either contradicting or limited."3.83Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine. ( Bottai, M; Chalkiadaki, G; Chatzi, L; Fthenou, E; Georgiou, V; Kampouri, M; Kippler, M; Kogevinas, M; Koutra, K; Kyriklaki, A; Vafeiadi, M; Vahter, M; Vassilaki, M, 2016)
"Reports from populations with an insufficient iodine intake suggest that children of mothers with mild iodine deficiency during pregnancy are at risk for cognitive impairments."3.80Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area. ( Ghassabian, A; Hofman, A; Jaddoe, VW; Peeters, RP; Ross, HA; Steenweg-de Graaff, J; Tiemeier, H; Verhulst, FC; White, T, 2014)
"The purpose of this study was to determine whether children born to mothers with urinary iodine concentrations (UICs) <150 μg/L during pregnancy have poorer educational outcomes in primary school than peers whose mothers did not have gestational ID (UIC ≥150 μg/L)."3.79Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort. ( Burgess, JR; Hay, I; Hynes, KL; Otahal, P, 2013)
"After 12 weeks of treatment (before pregnancy), iodine concentrations in urine and thyroid tissue and circulating thyroxine of adult females correlated with iodine intake."3.78Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring. ( Fan, C; Li, J; Liu, Y; Mao, J; Shan, Z; Teng, W; Wang, H; Zhang, H; Zhang, L, 2012)
"Iodine deficiency is a leading cause of preventable brain damage worldwide and is associated with impaired cognitive function."2.49Iodine deficiency in the U.K.: an overlooked cause of impaired neurodevelopment? ( Bath, SC; Rayman, MP, 2013)
"Iodine deficiency has multiple adverse effects in humans, termed iodine deficiency disorders, due to inadequate thyroid hormone production."2.45Iodine deficiency. ( Zimmermann, MB, 2009)
"Iodine deficiency has multiple adverse effects on growth and development because of inadequate thyroid hormone production."2.45Iodine: it's important in patients that require parenteral nutrition. ( Zimmermann, MB, 2009)
" The potential adverse effects of mild iodine deficiency during pregnancy are uncertain."2.44The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review. ( Zimmermann, MB, 2007)
"Iodine is an essential component of the hormones produced by the thyroid gland."1.37The role of iodine in human growth and development. ( Zimmermann, MB, 2011)
"Iodine deficiency was a cause of clinically diagnosed borderline development delay only in 7% of children."1.34[Mental development disorders and attention-deficit syndrome caused by iodine deficiency: a clinical and epidemiological study]. ( Zhukov, AO, 2007)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's1 (2.94)18.2507
2000's10 (29.41)29.6817
2010's22 (64.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Murcia, M1
Espada, M1
Julvez, J1
Llop, S1
Lopez-Espinosa, MJ1
Vioque, J1
Basterrechea, M1
Riaño, I1
González, L1
Alvarez-Pedrerol, M1
Tardón, A1
Ibarluzea, J1
Rebagliato, M1
Zhou, SJ1
Condo, D1
Ryan, P1
Skeaff, SA1
Howell, S1
Anderson, PJ1
McPhee, AJ1
Makrides, M1
Bath, SC2
Rayman, MP2
Hynes, KL1
Otahal, P1
Hay, I1
Burgess, JR1
Loewenthal, L1
Stagnaro-Green, A1
Pearce, EN2
Steer, CD1
Golding, J1
Emmett, P1
Mitka, M1
Zimmermann, MB7
Taylor, PN1
Okosieme, OE1
Dayan, CM1
Lazarus, JH1
Leung, AM2
Brent, GA1
Graham-Evans, K1
Brown, N1
Ghassabian, A1
Steenweg-de Graaff, J1
Peeters, RP1
Ross, HA1
Jaddoe, VW1
Hofman, A1
Verhulst, FC1
White, T1
Tiemeier, H1
Caron, P1
Kippler, M1
Bottai, M1
Georgiou, V1
Koutra, K1
Chalkiadaki, G1
Kampouri, M1
Kyriklaki, A1
Vafeiadi, M1
Fthenou, E1
Vassilaki, M1
Kogevinas, M1
Vahter, M1
Chatzi, L1
Braverman, LE1
Suárez-Rodríguez, M1
Azcona-San Julián, C1
Alzina de Aguilar, V1
Zhang, L2
Teng, W2
Liu, Y2
Li, J2
Mao, J1
Fan, C1
Wang, H1
Zhang, H1
Shan, Z2
Trumpff, C1
De Schepper, J1
Tafforeau, J1
Van Oyen, H1
Vanderfaeillie, J1
Vandevijvere, S1
Gyurjyan, RH1
Lugovska, R1
Vevere, P1
van der Haar, F2
Maberly, GF2
Haxton, DP1
Wijaya-Erhardt, M1
Untoro, J1
Karyadi, E1
Wibowo, L1
Gross, R1
Zhukov, AO1
Muela Martínez, JA1
García León, A1
Torres Barahona, R1
Santiago Fernández, P1
Sóriguer Escofet, F1
Montanelli, L1
Pinchera, A1
Santini, F1
Cavaliere, R1
Vitti, P1
Chiovato, L1
Boyages, SC1
Collins, JK1
Jupp, JJ1
Morris, J1
Eastman, CJ1
Baltadzhieva, R1
Gurevich, T1
Korczyn, AD1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on Physiologic Requirement and Dietary Recommended Nutrient[NCT04419103]600 participants (Actual)Observational2019-07-01Completed
Iodine Nutrition During Pregnancy and Related Neonatal Physical Development[NCT02586220]250 participants (Actual)Observational2015-08-31Completed
Community Salt Testing and Relation of Iodine Intake to Visual Information Processing of Ethiopian Infants[NCT03889431]106 participants (Actual)Interventional2013-01-02Completed
The Effect of Iodine Intakes on Maternal and Infant Health and the Study of Iodine RNI for Different Stages of Pregnancy[NCT03710148]2,000 participants (Anticipated)Observational2014-01-01Recruiting
Study on the Displacement of Iodine Balance Value During Pregnancy and the Mechanism of Breast Iodine Homeostasis During Lactation Under Different Iodine Exposure[NCT05730803]1,200 participants (Anticipated)Observational2023-02-17Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for iodine and Cognition Disorders

ArticleYear
Iodine deficiency in the U.K.: an overlooked cause of impaired neurodevelopment?
    The Proceedings of the Nutrition Society, 2013, Volume: 72, Issue:2

    Topics: Brain; Child; Child Development; Cognition Disorders; Female; Humans; Iodine; Pregnancy; United King

2013
Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis.
    European journal of endocrinology, 2014, Volume: 170, Issue:1

    Topics: Adult; Child; Child Development; Cognition Disorders; Diet; Dietary Supplements; Evidence-Based Medi

2014
Neurocognitive outcomes of children secondary to mild iodine deficiency in pregnant women.
    Annales d'endocrinologie, 2015, Volume: 76, Issue:3

    Topics: Adult; Child; Child, Preschool; Cognition; Cognition Disorders; Congenital Hypothyroidism; Female; H

2015
Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review.
    The American journal of clinical nutrition, 2009, Volume: 89, Issue:2

    Topics: Adolescent; Adult; Biomarkers; Cognition Disorders; Dietary Supplements; Female; Growth Disorders; H

2009
Iodine deficiency.
    Endocrine reviews, 2009, Volume: 30, Issue:4

    Topics: Cognition Disorders; Growth Disorders; Humans; Iodine; Prevalence; Sodium Chloride, Dietary; Thyroid

2009
Iodine: it's important in patients that require parenteral nutrition.
    Gastroenterology, 2009, Volume: 137, Issue:5 Suppl

    Topics: Adult; Child; Cognition Disorders; Congenital Hypothyroidism; Deficiency Diseases; Dose-Response Rel

2009
Mild iodine deficiency in pregnancy in Europe and its consequences for cognitive and psychomotor development of children: a review.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2013, Volume: 27, Issue:3

    Topics: Child; Cognition Disorders; Europe; Female; Humans; Iodine; Pregnancy; Prenatal Exposure Delayed Eff

2013
Iodine deficiency: consequences and progress toward elimination.
    Food and nutrition bulletin, 2003, Volume: 24, Issue:4 Suppl

    Topics: Adolescent; Adult; Child; Child, Preschool; Cognition Disorders; Congenital Hypothyroidism; Developi

2003
The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.
    Thyroid : official journal of the American Thyroid Association, 2007, Volume: 17, Issue:9

    Topics: Child; Cognition Disorders; Deficiency Diseases; Female; Growth Disorders; Humans; Infant, Newborn;

2007
The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.
    Thyroid : official journal of the American Thyroid Association, 2007, Volume: 17, Issue:9

    Topics: Child; Cognition Disorders; Deficiency Diseases; Female; Growth Disorders; Humans; Infant, Newborn;

2007
The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.
    Thyroid : official journal of the American Thyroid Association, 2007, Volume: 17, Issue:9

    Topics: Child; Cognition Disorders; Deficiency Diseases; Female; Growth Disorders; Humans; Infant, Newborn;

2007
The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.
    Thyroid : official journal of the American Thyroid Association, 2007, Volume: 17, Issue:9

    Topics: Child; Cognition Disorders; Deficiency Diseases; Female; Growth Disorders; Humans; Infant, Newborn;

2007
[Transient congenital hypothyroidism: physiopathology and clinica].
    Annali dell'Istituto superiore di sanita, 1998, Volume: 34, Issue:3

    Topics: Adult; Age Factors; Cognition Disorders; Congenital Hypothyroidism; Fetal Diseases; Humans; Hypothyr

1998
Autonomic impairment in amyotrophic lateral sclerosis.
    Current opinion in neurology, 2005, Volume: 18, Issue:5

    Topics: Amyotrophic Lateral Sclerosis; Animals; Autonomic Nervous System Diseases; Cognition Disorders; Dige

2005

Trials

1 trial available for iodine and Cognition Disorders

ArticleYear
Efficacy of daily and weekly multiple micronutrient food-like tablets for the correction of iodine deficiency in Indonesian males aged 6-12 mo.
    The American journal of clinical nutrition, 2007, Volume: 85, Issue:1

    Topics: Cognition Disorders; Dietary Supplements; Double-Blind Method; Drug Administration Schedule; Growth;

2007

Other Studies

22 other studies available for iodine and Cognition Disorders

ArticleYear
Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study.
    Journal of epidemiology and community health, 2018, Volume: 72, Issue:3

    Topics: Adult; Child, Preschool; Cognition; Cognition Disorders; Creatinine; Cross-Sectional Studies; Develo

2018
Association Between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months.
    American journal of epidemiology, 2019, 02-01, Volume: 188, Issue:2

    Topics: Adult; Child Development; Cognition Disorders; Developmental Disabilities; Dietary Supplements; Fema

2019
Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:5

    Topics: Child; Cognition Disorders; Cohort Studies; Educational Measurement; Female; Follow-Up Studies; Food

2013
Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:5

    Topics: Child; Cognition Disorders; Cohort Studies; Educational Measurement; Female; Follow-Up Studies; Food

2013
Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:5

    Topics: Child; Cognition Disorders; Cohort Studies; Educational Measurement; Female; Follow-Up Studies; Food

2013
Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:5

    Topics: Child; Cognition Disorders; Cohort Studies; Educational Measurement; Female; Follow-Up Studies; Food

2013
Study links iodine deficiency in pregnancy with poor cognitive outcomes in children.
    BMJ (Clinical research ed.), 2013, May-23, Volume: 346

    Topics: Cognition Disorders; Cohort Studies; Educational Measurement; Female; Health Promotion; Humans; Infa

2013
Iodine and pregnancy: a call to action.
    Lancet (London, England), 2013, Jul-27, Volume: 382, Issue:9889

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Pregnancy; Pregnancy Compli

2013
Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC).
    Lancet (London, England), 2013, Jul-27, Volume: 382, Issue:9889

    Topics: Adult; Child; Cognition Disorders; Creatinine; Developmental Disabilities; Dyslexia; Female; Humans;

2013
Even mild iodine deficiency during gestation may impair brain function in children.
    JAMA, 2013, Jun-19, Volume: 309, Issue:23

    Topics: Brain; Child; Child Development; Cognition Disorders; Cohort Studies; Deficiency Diseases; Dyslexia;

2013
Nutrition: Are mild maternal iodine deficiency and child IQ linked?
    Nature reviews. Endocrinology, 2013, Volume: 9, Issue:9

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Learning Disabilities; Male

2013
Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8-9 years of age.
    Evidence-based nursing, 2014, Volume: 17, Issue:3

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Pregnancy; Pregnancy Compli

2014
Maternal first-trimester iodine deficiency predicts poor cognitive outcome in English children.
    Archives of disease in childhood. Education and practice edition, 2014, Volume: 99, Issue:6

    Topics: Cognition Disorders; Developmental Disabilities; Female; Humans; Iodine; Pregnancy; Pregnancy Compli

2014
Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area.
    BMJ open, 2014, Jun-12, Volume: 4, Issue:6

    Topics: Adult; Child; Cognition; Cognition Disorders; Female; Humans; Iodine; Male; Netherlands; Pregnancy;

2014
Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine.
    European journal of epidemiology, 2016, Volume: 31, Issue:11

    Topics: Adult; Cadmium; Child Development; Child, Preschool; Cognition Disorders; Female; Greece; Humans; Io

2016
Iodine deficiency in industrialized countries.
    Clinical endocrinology, 2011, Volume: 75, Issue:3

    Topics: Cognition Disorders; Developed Countries; Growth Disorders; Humans; Iodine; Malnutrition; Nutritiona

2011
The role of iodine in human growth and development.
    Seminars in cell & developmental biology, 2011, Volume: 22, Issue:6

    Topics: Abortion, Spontaneous; Adult; Birth Weight; Cell Differentiation; Cell Movement; Child; Cognition Di

2011
Iodine nutrition in pregnancy and lactation.
    Endocrinology and metabolism clinics of North America, 2011, Volume: 40, Issue:4

    Topics: Cognition Disorders; Diet; Dietary Supplements; Female; Fetal Development; Humans; Hypothyroidism; I

2011
Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012, Volume: 30, Issue:6

    Topics: Child, Preschool; Cognition Disorders; Developmental Disabilities; Female; Humans; Hypothyroidism; I

2012
Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring.
    BMC neuroscience, 2012, Oct-08, Volume: 13

    Topics: Age Factors; Animals; Animals, Newborn; Anti-Infective Agents, Local; Brain-Derived Neurotrophic Fac

2012
Maternal marginal iodine deficiency affects the expression of relative proteins during brain development in rat offspring.
    The Journal of endocrinology, 2013, Volume: 217, Issue:1

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Congenital Hypothyroidism; Disease

2013
Newborn thyrotropin screening confirms iodine deficiency in Latvia.
    European journal of clinical nutrition, 2006, Volume: 60, Issue:5

    Topics: Biomarkers; Cognition Disorders; Female; Humans; Infant Nutrition Disorders; Infant, Newborn; Iodine

2006
[Mental development disorders and attention-deficit syndrome caused by iodine deficiency: a clinical and epidemiological study].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007, Volume: 107, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Catchment Area, Health; Child; Cognition Disorders; D

2007
[Effects of the iodine deficiency on intellectual variables among children].
    Psicothema, 2008, Volume: 20, Issue:2

    Topics: Adolescent; Catchment Area, Health; Child; Cognition Disorders; Female; Humans; Intellectual Disabil

2008
Iodine deficiency impairs intellectual and neuromotor development in apparently-normal persons. A study of rural inhabitants of north-central China.
    The Medical journal of Australia, 1989, Jun-19, Volume: 150, Issue:12

    Topics: Adolescent; Adult; Audiometry; Child; China; Cognition Disorders; Cohort Studies; Congenital Hypothy

1989