Page last updated: 2024-10-18

iodine and Bipolar Disorder

iodine has been researched along with Bipolar Disorder in 24 studies

Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..

Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Research Excerpts

ExcerptRelevanceReference
"Lithium is especially taken as a maintenance medication for Bipolar Disorder."4.02Lithium from breast-milk inhibits thyroid iodine uptake and hormone production, which are remedied by maternal iodine supplementation. ( Ahmed, I; Ahmed, R; Alda, M; Ali, A; Amjad, N; Barman, I; Bergink, V; Cho, WCS; Khan, MS; Lau, C; Law, AWL; Liu, Y; Liu, Z; Ma, V; Manno, FAM; Manno, SHC; Paidi, SK; Raza, F; Zhang, C; Zhang, Y, 2021)
" The following effects were noted with lithium treatment: (a) thyroid weight increased concomitant with a slowing of thyroidal iodine release; (b) the ability to concentrate iodide was increased only after goiters were established; (c) on the LID, (131)I uptake was elevated throughout all phases of treatment, even when the release rate was normal; (d) iodine organification was unaffected but the proportion of (131)I present as iodothyronines was decreased; (e) the thyroidal (127)I content was increased; (f) despite these changes, the serum PBI remained normal as did the thyroxine turnover rate; and (g) thyrotropin (TSH) levels in serum were the same as controls except for a slight elevation early in the course of treatment; TSH levels did not correlate with goitrogenesis."3.65Antithyroid effects of lithium. ( Berens, SC; Bernstein, RS; Robbins, J; Wolff, J, 1970)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199021 (87.50)18.7374
1990's1 (4.17)18.2507
2000's1 (4.17)29.6817
2010's0 (0.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Ahmed, I1
Ma, V1
Liu, Y1
Khan, MS1
Liu, Z1
Zhang, C1
Paidi, SK1
Manno, FAM1
Amjad, N1
Manno, SHC1
Ahmed, R1
Law, AWL1
Ali, A1
Raza, F1
Zhang, Y1
Cho, WCS1
Barman, I1
Alda, M1
Bergink, V1
Lau, C1
Arlt, S1
Burkhardt, D1
Wiedemann, K1
Schou, M1
Amdisen, A1
Eskjaer Jensen, S1
Olsen, T1
Parkhon-Shtefanesku, K1
Nikolau, G1
Aurora, A1
Kuku, I1
Vianu, I1
Abuzzahab, FS1
Dahlman, HC1
Zimmermann, RL1
Gerdes, H1
Dewhurst, KE1
Kabir, DJ1
Exley, D1
Harris, GW1
Mandelbrote, BM1
Berens, SC1
Bernstein, RS1
Robbins, J1
Wolff, J1
Klempel, K1
Shopsin, B1
Shenkman, L1
Blum, M1
Hollander, CS1
Bora, SS1
Radichevich, I1
Werner, SC1
Davis, JM1
Fann, WE1
Snively, WD1
Becker, B1
Fieve, RR1
Platman, SR1
Aref, MA1
El-Badramany, M1
Hannora, N1
Sharaf, Z1
El-Awadi, A1
Skutsch, GM3
Paschlis, C1
Jenner, FA1
Lee, CR1
Hill, SE1
Jennings Triccas, G1
Hullin, RP1
Lee, MR1
Levell, MJ1
Saran, BM1
Miller, EB1
Pain, RW1
Skripal, PJ1
Turkel, SB1
Cafaro, DR1
Reid, HE1

Reviews

2 reviews available for iodine and Bipolar Disorder

ArticleYear
[Side-effects and effects of lithium therapy on the endocrinium in man].
    Der Internist, 1973, Volume: 14, Issue:4

    Topics: Animals; Bipolar Disorder; Catecholamines; Diabetes Insipidus; Female; Gastrins; Glucagon; Goiter; H

1973
Lithium.
    Annual review of pharmacology, 1971, Volume: 11

    Topics: Adjustment Disorders; Amines; Animals; Bipolar Disorder; Body Temperature; Diuretics; Electroencepha

1971

Trials

2 trials available for iodine and Bipolar Disorder

ArticleYear
A three year double blind investigation of the effects of lithium carbonate on serum protein-bound iodine in manic depressive patients.
    Neuropsychobiology, 1975, Volume: 1, Issue:5

    Topics: Aged; Bipolar Disorder; Blood Proteins; Clinical Trials as Topic; Female; Humans; Iodine; Lithium; M

1975
Artifactual elevation of PBI from an iodinated dye used to stain medicinal capsules pink.
    The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:9

    Topics: Bipolar Disorder; Blood Proteins; Capsules; Carbonates; Chromatography, Paper; Clinical Trials as To

1969

Other Studies

20 other studies available for iodine and Bipolar Disorder

ArticleYear
Lithium from breast-milk inhibits thyroid iodine uptake and hormone production, which are remedied by maternal iodine supplementation.
    Bipolar disorders, 2021, Volume: 23, Issue:6

    Topics: Animals; Bipolar Disorder; Dietary Supplements; Female; Humans; Iodine; Lithium; Milk, Human; Rats;

2021
Thyrotoxicosis after iodine contrast medium administration: rapid mood swing to mania and subsequent psychotic depression in a patient with bipolar disorder during lithium therapy.
    Pharmacopsychiatry, 2008, Volume: 41, Issue:4

    Topics: Antimanic Agents; Bipolar Disorder; Contrast Media; Depression; Female; Humans; Iodine; Lithium Chlo

2008
Occurrence of goitre during lithium treatment.
    British medical journal, 1968, Sep-21, Volume: 3, Issue:5620

    Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Female; Goiter; Humans; Incidence; Iodine; Li

1968
[Blood iodine levels in depressive states].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1966, Volume: 66, Issue:4

    Topics: Adjustment Disorders; Bipolar Disorder; Depression; Depressive Disorder, Major; Humans; Iodine

1966
Blood-levels of thyrotrophic hormone, protein-bound iodine, and cortisol in schizophrenia and affective states.
    Lancet (London, England), 1968, Nov-30, Volume: 2, Issue:7579

    Topics: Adolescent; Adult; Aged; Bipolar Disorder; Blood Proteins; Depression; Female; Humans; Hydrocortison

1968
Antithyroid effects of lithium.
    The Journal of clinical investigation, 1970, Volume: 49, Issue:7

    Topics: Animals; Bipolar Disorder; Goiter; Humans; Hypophysectomy; Iodine; Lithium; Male; Organ Size; Rats;

1970
[Orientational study on the plasma tyrosine circadian rhythm in depressive syndromes of various etiology].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1972, Volume: 216, Issue:2

    Topics: 17-Hydroxycorticosteroids; Adult; Aged; Bipolar Disorder; Catecholamines; Circadian Rhythm; Depressi

1972
Iodine and lithium-induced hypothyroidism. Documentation of synergism.
    The American journal of medicine, 1973, Volume: 55, Issue:5

    Topics: Adult; Bipolar Disorder; Drug Synergism; Humans; Hypothyroidism; Iodine; Lithium; Male; Middle Aged;

1973
Minerals, macro and micro: dynamic nutrients. II. The micro-minerals.
    Annals of allergy, 1968, Volume: 26, Issue:5

    Topics: Animals; Bipolar Disorder; Chromium; Cobalt; Copper; Deficiency Diseases; Diet; Fluorine; Food Analy

1968
Lithium and thyroid function. Reply.
    The American journal of psychiatry, 1969, Volume: 125, Issue:8

    Topics: Bipolar Disorder; Drug Compounding; Female; Goiter; Humans; Iodine; Lithium; Male; New York; Thyroid

1969
Lithium loss in sweat.
    Psychosomatics, 1982, Volume: 23, Issue:4

    Topics: Adult; Bipolar Disorder; Female; Humans; Lithium; Male; Middle Aged; Sweat

1982
Manic depression--a disorder of central dopaminergic rhythm.
    Medical hypotheses, 1981, Volume: 7, Issue:6

    Topics: Acetylcholine; Aldosterone; Bipolar Disorder; Circadian Rhythm; Climate; Depressive Disorder; Dopami

1981
Sweat electrolytes in manic-depressive illness.
    Lancet (London, England), 1977, Sep-03, Volume: 2, Issue:8036

    Topics: Bipolar Disorder; Humans; Potassium; Sweat

1977
Aldosterone and sweat potassium in manic-depression.
    Lancet (London, England), 1977, Sep-17, Volume: 2, Issue:8038

    Topics: Aldosterone; Bipolar Disorder; Humans; Potassium; Sweat

1977
Sweat-electrolytes in manic-depressive illness.
    Lancet (London, England), 1977, Oct-22, Volume: 2, Issue:8043

    Topics: Bipolar Disorder; Circadian Rhythm; Humans; Potassium; Sodium; Sweat

1977
Sweat lithium in manic-depression.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Bipolar Disorder; Female; Humans; Lithium; Middle Aged; Sodium; Sweat

1979
Endocrine possibilities in manic depressive illness.
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 135

    Topics: Aldosterone; Bipolar Disorder; Humans; Hydrocortisone; Periodicity; Potassium; Sodium; Sweat; Vasopr

1979
Sweat lithium in manic-depression.
    The British journal of psychiatry : the journal of mental science, 1978, Volume: 133

    Topics: Bipolar Disorder; Humans; Lithium; Pilocarpine; Sweat; Sweating

1978
Lithium treatment of a bipolar patient with cystic fibrosis.
    The American journal of psychiatry, 1992, Volume: 149, Issue:4

    Topics: Adult; Bipolar Disorder; Chlorides; Cystic Fibrosis; Female; Humans; Lithium Carbonate; Sweat

1992
Letter: The brass-ring sign.
    Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864

    Topics: Adult; Bipolar Disorder; Diabetes Mellitus; Female; Humans; Premenstrual Syndrome; Skin Manifestatio

1974