involucrin and Hair-Diseases

involucrin has been researched along with Hair-Diseases* in 2 studies

Other Studies

2 other study(ies) available for involucrin and Hair-Diseases

ArticleYear
Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin.
    The British journal of dermatology, 1994, Volume: 131, Issue:4

    The expression of cytokeratins and involucrin varies greatly in different epithelia, and this raises the possibility that detailed analysis of these epidermal proteins might provide a means of identifying various skin tumours. The present study was conducted to determine the immunohistochemical distribution of cytokeratins and involucrin in calcifying epithelioma of Malherbe, in order to elucidate the nature and differentiation of this tumour. To correlate the immunohistochemical profile with the most frequent histological patterns, we categorized the basophilic, transitional, shadow, and squamoid cells, and the shreds of keratin. Comparative studies with normal skin showed that the shadow and transitional cells corresponded to hair cortex cells, the squamoid cells to the outer root sheath, the basophilic cells adjacent to the stroma to the outermost cell layer of the outer root sheath between the lower permanent portion and upper transient portion of the follicles, and the basophilic cells adjacent to the transitional cells to the hair matrix. The expression of cytokeratins in most shreds of keratin was similar to that in squamoid cells. Calcifying epithelioma was, therefore, shown to be composed of tumour cells differentiating into both the hair cortex and outer root sheath. These tumour cells were differentiated from basophilic cells, which showed the same staining patterns as the outermost cell layer of the outer root sheath between the lower permanent portion and upper transient portion of the hair follicles, supporting the hypothesis that the keratinocytes in the outermost cell layer can differentiate into the transitional portion of the follicle and anagen hair.

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Hair Diseases; Humans; Immunohistochemistry; Infant; Keratins; Middle Aged; Pilomatrixoma; Protein Precursors; Skin; Skin Neoplasms

1994
Involucrin expression in skin appendage tumours.
    The British journal of dermatology, 1987, Volume: 117, Issue:3

    The expression of involucrin was examined in 23 skin tumours of hair follicle origin, 17 tumours of sweat gland origin and three tumours of unknown origin, using an immunoperoxidase technique. All tumours from the hair follicle showed a positive reaction for involucrin. In particular keratoacanthoma and the squamous eddies in various tumours stained strongly. Trichofolliculoma, trichilemmoma and pilomatrixoma exhibited characteristic staining patterns which resembled those in the normal hair follicle. On the other hand the majority of the tumours of sweat gland origin did not stain, with restricted positive reactions in areas showing lumen formation or squamous metaplasia. In contrast to the lack of staining in syringoma, a positive reaction was observed in desmoplastic trichoepithelioma, which is histologically similar to syringoma. Clear cell acanthoma, the origin of which is still controversial, showed a staining pattern which indicated that its origin may not be in the sweat gland. These results suggest that testing for involucrin in skin appendage tumours may be very useful for understanding the kinetics of maturation as well as in determining the origin of the tumours.

    Topics: Carcinoma, Squamous Cell; Cystadenoma; Hair; Hair Diseases; Humans; Immunoenzyme Techniques; Keratoacanthoma; Protein Precursors; Skin Diseases; Skin Neoplasms; Sweat Gland Neoplasms; Sweat Glands

1987
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