intrinsic-factor and Stomach-Ulcer

Topics: Animals; Digestive System; Digestive System Physiological Phenomena; Duodenal Ulcer; Gastric Acid; Gastrins; Gastritis; Histamine; Histamine H2 Antagonists; Humans; Intrinsic Factor; Liver Circulation; Pepsinogens; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Regional Blood Flow; Stomach; Stomach Ulcer; Zollinger-Ellison Syndrome

Topics: Burimamide; Chemical Phenomena; Chemistry; Cimetidine; Duodenal Ulcer; Esophagitis, Peptic; Gastric Acid; Gastrins; Gastrointestinal Hemorrhage; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Hypersensitivity; Intrinsic Factor; Kinetics; Malabsorption Syndromes; Metiamide; Pancreas; Pepsin A; Ranitidine; Receptors, Histamine H2; Stomach Ulcer; Stress, Psychological; Zollinger-Ellison Syndrome

Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contrast to anticholinergic drugs, markedly inhibit food-stimulated acid secretion in duodenal ulcer patients. The relative roles of H2-receptor antagonists, anticholinergic drugs and antacids in the treatment of duodenal ulcer remain to be defined. Cimetidine currently is under investigation for the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, gastrointestinal bleeding and hypersecretory states. Although the long-term safety of cimetidine has not been established, in short-term clinical trials there have been no significant subjective or objective side-effects. Assuming that toxic effects do not develop, H2-receptor antagonists should improve the treatment of acid-peptic disease.

Topics: Cimetidine; Cyclic AMP; Duodenal Ulcer; Esophagitis, Peptic; Gastric Juice; Gastrins; Gastritis; Gastrointestinal Hemorrhage; Histamine; Histamine H2 Antagonists; Humans; Intrinsic Factor; Metiamide; Pepsin A; Stomach Ulcer

Cimetidine is a specific competitive histamine H2-receptor antagonist which effectively inhibits gastric acid secretion and is advocated for the treatment of chronic peptic ulceration, haemorrhage from erosive gastritis, and the control of gastric hypersecretion and peptic ulceration in the Zollinger-Ellison syndrome. Placebo-controlled trials in outpatients have demonstrated its efficacy in promoting the healing of endoscopically diagnosed duodenal ulceration, during a period of 4 to 6 weeks, but its role in the treatment of gastric ulcer is less clear. Preliminary evidence suggests that maintenance therapy with cimetidine reduces the rate of recurrence of duodenal ulcer, but further studies are required to clarify its role in this situation and in the treatment of oesophagitis and acute gastrointestinal haemorrhage. Cimetidine controls the peptic ulceration of Zollinger-Ellison syndrome in most patients when given continuously for up to 2 years. Side-effects have generally been trivial and have very seldom necessitated withdrawal of therapy except in the rare occurrence of gynaecomastia. The haematological abnormalities particularly agranulocytosis, which lead to the withdrawal from clinical use of metiamide, have not been reported with cimetidine, except for 1 case of transient neutropenia. The safety of long-term cimetidine administration has yet to be determined.

Topics: Acute Disease; Animals; Cimetidine; Duodenal Ulcer; Gastric Juice; Gastrins; Gastrointestinal Hemorrhage; Guanidines; Humans; Intrinsic Factor; Recurrence; Stomach Ulcer; Zollinger-Ellison Syndrome

Topics: Adrenal Cortex Hormones; Anemia, Pernicious; Animals; Antibodies; Autoantibodies; Biopsy; Chronic Disease; Gastric Juice; Gastric Mucosa; Gastrins; Gastritis; Humans; Intrinsic Factor; Schilling Test; Stomach; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12

Topics: Acetylcholine; Achlorhydria; Adenoma; Anemia, Pernicious; Atrophy; Duodenal Ulcer; Endocrine System Diseases; Gastrectomy; Gastric Juice; Gastric Mucins; Gastric Mucosa; Gastrins; Gastritis; Humans; Hyperplasia; Intrinsic Factor; Stomach Ulcer; Vagus Nerve; Zollinger-Ellison Syndrome

Topics: Anemia; Anemia, Pernicious; Blood Group Antigens; Duodenal Ulcer; Electrolytes; Gastric Acidity Determination; Gastritis; Humans; Hydrochloric Acid; Intrinsic Factor; L-Lactate Dehydrogenase; Pepsin A; Stomach Neoplasms; Stomach Ulcer; Zollinger-Ellison Syndrome

Human gastric mucosal cells were isolated from the resected fundic mucosa of peptic ulcer patients. The intracellular content and secretion of intrinsic factor were estimated by binding to cyano[57Co]cobalamin. The content was maximal in the enriched parietal cell fraction which also displayed the highest H+ production as measured by amino[14C] pyrine uptake. Secretagogues evoked full response after 15 min of incubation: pentagastrin (181% of basal secretion), carbachol (208%), histamine (250%) and dibutyryl cyclic adenosine monophosphate (304%). The phosphodiesterase inhibitor isobutylmethylxanthine was slightly more effective even than dibutyryl cAMP. The response to histamine was abolished by ranitidine, indicating activation of adenylate cyclase via histamine H2 receptors, but remained unaffected by atropine, which in turn blocked the carbachol effect, whereas ranitidine was ineffective. The mean formation rate was 8.4 fmol intrinsic factor/10(6) cells per h under basal conditions and 14.3 fmol in response to histamine.

Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Carbachol; Female; Gastric Mucosa; Histamine; Humans; In Vitro Techniques; Intrinsic Factor; Kinetics; Male; Middle Aged; Parietal Cells, Gastric; Pentagastrin; Protein Binding; Stomach Ulcer; Vitamin B 12

Topics: Anemia, Pernicious; Antibodies; Binding, Competitive; Gastritis; Humans; Intrinsic Factor; Reagent Kits, Diagnostic; Reference Values; Stomach Neoplasms; Stomach Ulcer

Topics: Anemia, Pernicious; Biopsy; Body Weight; Dumping Syndrome; Duodenal Ulcer; Dyspepsia; Female; Follow-Up Studies; Gastrectomy; Gastric Mucosa; Hemoglobins; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Male; Postgastrectomy Syndromes; Schilling Test; Stomach Ulcer; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Age Factors; Aged; Alcohol Drinking; Duodenal Ulcer; Erythrocytes; Follow-Up Studies; Gastrectomy; Gastric Juice; Humans; Intrinsic Factor; Leiomyoma; Methods; Middle Aged; Pepsin A; Postoperative Complications; Schilling Test; Stomach Neoplasms; Stomach Ulcer; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Duodenal Ulcer; False Negative Reactions; False Positive Reactions; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Gastritis; Histamine; Humans; Intrinsic Factor; Peptides; Stomach; Stomach Neoplasms; Stomach Ulcer; Time Factors; Vagotomy; Vagus Nerve; Zollinger-Ellison Syndrome

Topics: Adult; Antibodies; Biopsy; Diabetes Mellitus; Duodenal Ulcer; Fluorescent Antibody Technique; Gastritis; Gastrointestinal Diseases; Humans; Intrinsic Factor; Middle Aged; Stomach; Stomach Neoplasms; Stomach Ulcer

Topics: Anemia, Pernicious; Antibodies; Antibody Specificity; Antigen-Antibody Reactions; Atrophy; Autoimmune Diseases; Biopsy; Chronic Disease; Complement Fixation Tests; Fluorescent Antibody Technique; Gastric Mucosa; Gastritis; Humans; Immune Tolerance; Intrinsic Factor; Stomach Ulcer

Topics: Achlorhydria; Anemia, Pernicious; Duodenal Ulcer; Female; Gastric Juice; Gastric Mucosa; Histamine; Humans; Intrinsic Factor; Male; Radioimmunoassay; Stimulation, Chemical; Stomach; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer

Topics: Aged; Anemia, Pernicious; Autoantibodies; Body Height; Body Weight; Female; Fluorescent Antibody Technique; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Gastritis; Histamine; Humans; Intrinsic Factor; Iron; Ischemia; Male; Middle Aged; Peptic Ulcer; Polycythemia Vera; Stomach Ulcer; Vitamin B 12

Topics: Adult; Age Factors; Duodenal Ulcer; Female; Gastric Acidity Determination; Gastric Juice; Gastrins; Histamine; Humans; Injections, Subcutaneous; Intrinsic Factor; Male; Methods; Middle Aged; Radioimmunoassay; Stomach Ulcer; Time Factors; Vitamin B 12

Topics: Chromatography; Clinical Enzyme Tests; Enzyme Precursors; Gastric Acidity Determination; Gastric Juice; Gastritis; Humans; Intrinsic Factor; Peptide Hydrolases; Secretory Rate; Stomach Neoplasms; Stomach Ulcer

Topics: Anemia; Anemia, Pernicious; Corrinoids; Cortisone; Dogs; Duodenum; Hematinics; Hyperparathyroidism; Intrinsic Factor; Pathology; Research; Stomach Ulcer; Thyroidectomy; Vitamin B 12

Topics: Adult; Aged; Anemia, Pernicious; Antibodies; Cobalt Isotopes; Gastric Acidity Determination; Gastritis; Histamine; Humans; Immunoassay; Intrinsic Factor; Middle Aged; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12

Topics: Atrophy; Duodenal Ulcer; Gastritis; Gastritis, Atrophic; Humans; Intrinsic Factor; Polyps; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer; Vitamin B 12