intrinsic-factor and Neuroectodermal-Tumors--Primitive--Peripheral

intrinsic-factor has been researched along with Neuroectodermal-Tumors--Primitive--Peripheral* in 1 studies

Other Studies

1 other study(ies) available for intrinsic-factor and Neuroectodermal-Tumors--Primitive--Peripheral

Article	Year
Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma. Cancer research communications, 2023, Volume: 3, Issue:8 This study provides novel insights into the immunomodulatory functions of USP6, the only cancer cell-intrinsic factor demonstrated to regulate the immune TME in Ewing sarcoma. We demonstrate that USP6-mediated suppression of Ewing sarcoma tumorigenesis is dependent on NK cells. USP6 directly activates NK cell cytolytic function, inducing both intratumoral and systemic activation of NK cells in an Ewing sarcoma xenograft model. Topics: Animals; Apoptosis Inducing Factor; Bone Neoplasms; Humans; Intrinsic Factor; Ligands; Mice; Mice, Nude; Neuroectodermal Tumors, Primitive, Peripheral; Sarcoma, Ewing; Tumor Microenvironment; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases	2023

Article

Year

Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma.

Cancer research communications, 2023, Volume: 3, Issue:8

This study provides novel insights into the immunomodulatory functions of USP6, the only cancer cell-intrinsic factor demonstrated to regulate the immune TME in Ewing sarcoma. We demonstrate that USP6-mediated suppression of Ewing sarcoma tumorigenesis is dependent on NK cells. USP6 directly activates NK cell cytolytic function, inducing both intratumoral and systemic activation of NK cells in an Ewing sarcoma xenograft model.

Topics: Animals; Apoptosis Inducing Factor; Bone Neoplasms; Humans; Intrinsic Factor; Ligands; Mice; Mice, Nude; Neuroectodermal Tumors, Primitive, Peripheral; Sarcoma, Ewing; Tumor Microenvironment; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases

2023