intrinsic-factor and Nasal-Polyps

In the airway, IgE is traditionally regarded as a key mediator in allergic diseases, such as AR and allergic asthma. However, growing evidence demonstrates the importance of local IgE in airway inflammatory diseases, irrespective of the presence of allergy. In this review, we discuss the most recent evidence for IgE in chronic rhinosinusitis with nasal polyps(CRSwNP), including the local IgE's characteristics, the modulation of its synthesis, and its function. The levels of local IgE are significantly elevated in polyps independently of IgE serum levels and atopic status. Local IgE, which is correlated with type 2 inflammation, is polyclonal and functional. IgE is produced by active B cells and is dependent on the class switch recombination(CSR). In NPs, this process is triggered by not only allergens but also microbial colonization, especially the superantigen-

Topics: Cytokines; Humans; Immunity, Innate; Immunoglobulin E; Interleukin-13; Interleukin-2; Interleukin-4; Intrinsic Factor; Lymphocytes; Nasal Polyps; Superantigens; Transcription Factors; Transforming Growth Factor beta