intrinsic-factor has been researched along with Liver-Cirrhosis* in 2 studies
2 other study(ies) available for intrinsic-factor and Liver-Cirrhosis
| Article | Year |
|---|---|
Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells.
The liver is the major site of pigment epithelium-derived factor (PEDF) synthesis. Recent evidence suggests a protective role of PEDF in liver cirrhosis. In the present study, immunohistochemical analyses revealed lower PEDF levels in liver tissues of patients with cirrhosis and in animals with chemically induced liver fibrosis. Delivery of the PEDF gene into liver cells produced local PEDF synthesis and ameliorated liver fibrosis in animals treated with either carbon tetrachloride or thioacetamide. In addition, suppression of peroxisome proliferator-activated receptor gamma expression, as well as nuclear translocation of nuclear factor-kappa B was found in hepatic stellate cells (HSCs) from fibrotic livers, and both changes were reversed by PEDF gene delivery. In culture-activated HSCs, PEDF, through the induction of peroxisome proliferator-activated receptor gamma, reduced the activity of nuclear factor-kappa B and prevented the nuclear localization of JunD. In conclusion, our observations that PEDF levels are reduced during liver cirrhosis and that PEDF gene delivery ameliorates cirrhosis suggest that PEDF is an intrinsic protector against liver cirrhosis. Direct inactivation of HSCs and the induction of apoptosis of activated HSCs may be two of the mechanisms by which PEDF suppresses liver cirrhosis. Topics: Animals; Apoptosis; Blotting, Western; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Eye Proteins; Fluorescent Antibody Technique; Hepatic Stellate Cells; Humans; Immunoenzyme Techniques; Immunoprecipitation; Intrinsic Factor; Liver; Liver Cirrhosis; Mice; Mice, Inbred BALB C; Nerve Growth Factors; NF-kappa B; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Serpins; Signal Transduction; Thioacetamide | 2010 |
A rapid quantitative method for measuring intestinal absorption of vitamin B 12 in man using a double label hepatic uptake test.
Topics: Anemia, Pernicious; Cobalt Isotopes; Humans; In Vitro Techniques; Injections, Intravenous; Intestinal Absorption; Intrinsic Factor; Liver; Liver Cirrhosis; Postgastrectomy Syndromes; Radiometry; Vitamin B 12 | 1966 |