intrinsic-factor has been researched along with Leukemia--Myeloid* in 7 studies
1 review(s) available for intrinsic-factor and Leukemia--Myeloid
Article | Year |
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The serum vitamin B12 level: its assay and significance.
1. Low serum B12 levels can be measured with considerable precision by microbiological assay with the Euglena gracilis assay and B12 deficiency can be recognised with a high level of consistency by either the Euglena or L. leichmannii assays. Either method is ideally suited for the assay of large numbers of specimens. The Lactobacillus leichmanii technique requires preliminary extraction of protein and it has been suggested that this may be a source of inaccuracy. 2. The radioisotope dilution assay should be the ideal method of measuring B12 levels in small or moderate numbers of specimens for it is a simple method that can be carried out in any laboratory with suitable counting equipment. After many false starts the conditions required for accurate assay are now understood. Each of 40 to 50 radioisotopic dilution techniques that have been introduced claims to be capable of differentiating B12 deficiency from control subjects but the reported correlations between the actual levels found in the two different assays are variable and the levels may be much higher with some radioisotopic methods. 3. The subnormal serum levels which are found in pernicious anaemia with all these techniques indicate severe reduction of the liver B12 level. A low serum B12 level in other conditions has, in the absence of associated folate or iron deficiency, the same significance. If the fall in the serum B12 level is associated with folate or iron deficiency, the tissue B12 levels are usually reduced but not to the low levels found in B12 deficiency states. 4. In practice, a subnormal B12 level is a valuable pointer not only to unsuspected pernicious anaemia but also to other gastrointestinal or nutritional disorders. The significance of a fall in the B12 level can only be understood if its cause is defined by a full clinical and gastroenterological investigation. 5. Falsely low serum B12 levels are found under certain iatrogenic conditions and B12 levels may be normal in spite of cellular deficiency of B12 under the rare circumstances of pernicious anaemia being associated with chronic myeloid leukaemia or when there is deficiency of TC 2. Topics: Anemia, Megaloblastic; Anemia, Pernicious; Ascorbic Acid; Biological Assay; Bone Marrow; Bone Marrow Cells; Carrier Proteins; Deoxyuridine; Euglena gracilis; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Lactobacillus; Leukemia, Myeloid; Male; Pregnancy; Pregnancy Complications; Radioisotope Dilution Technique; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 1976 |
6 other study(ies) available for intrinsic-factor and Leukemia--Myeloid
Article | Year |
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The use of chicken serum for measurement of serum vitamin B12 concentration by radioisotope dilution: discription of method and comparison with microbiological assay results.
Topics: Anemia, Pernicious; Animals; Biological Assay; Blood Proteins; Chickens; Cobalt Radioisotopes; Euglena gracilis; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Lactobacillus; Leukemia, Myeloid; Polycythemia Vera; Postgastrectomy Syndromes; Pregnancy; Protein Binding; Radioisotope Dilution Technique; Umbilical Cord; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
A comparison of the properties of chicken serum with other vitamin B12 binding proteins used in radioisotope dilution methods for measuring serum vitamin B12 concentrations.
Topics: Animals; Charcoal; Chickens; Chromatography, Gel; Cobalt Radioisotopes; Hemoglobins; Humans; Hydrogen-Ion Concentration; Intrinsic Factor; Leukemia, Myeloid; Methods; Protein Binding; Radioisotope Dilution Technique; Vitamin B 12 | 1973 |
Studies on the binding of vitamin B 12 by human saliva.
Topics: Anemia, Pernicious; Charcoal; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intrinsic Factor; Leukemia, Myeloid; Protein Binding; Saliva; Serum Albumin, Bovine; Vitamin B 12 | 1972 |
Blockade of vitamin B12-binding sites in gastric juice, serum and saliva by analogues and derivatives of vitamin B12 and by antibody to intrinsic factor.
Topics: Anemia, Pernicious; Anilides; Antigen-Antibody Reactions; Benzimidazoles; Binding Sites; Cellulose; Chromatography, Ion Exchange; Cobalt Isotopes; Gastric Juice; Humans; Intrinsic Factor; Leukemia, Myeloid; Saliva; Vitamin B 12 | 1967 |
THE DYNAMICS OF TRANSCOBALAMIN II. A VITAMIN B12 BINDING SUBSTANCE IN PLASMA.
Topics: Blood Proteins; Chemistry Techniques, Analytical; Chromatography; Cobalt Isotopes; Corrinoids; Humans; Intrinsic Factor; Leukemia; Leukemia, Myeloid; Metabolism; Schilling Test; Transcobalamins; Urine; Vascular Diseases; Vitamin B 12 | 1965 |
ACTIVITY OF COENZYME B12 IN MAN.
Topics: Absorption; Anemia; Anemia, Pernicious; Celiac Disease; Cobalt Isotopes; Cobamides; Coenzymes; Drug Therapy; Erythrocytes; Humans; Intestine, Small; Intestines; Intrinsic Factor; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Liver; Male; Metabolism; Reticulocytes; Schilling Test; Urine; Vitamin B 12 | 1964 |