intrinsic-factor and Iron-Metabolism-Disorders

Topics: Animals; Hematinics; Intrinsic Factor; Iron; Iron Metabolism Disorders; Rats; Vitamin B 12; Vitamin B Complex

The newer hematinics are merely refinements of preexisting forms of treatment, but they have aided particularly in a better understanding of the deficiency states. The intrinsic factor of Castle has not been isolated from the gastric juice, and the interrelationships of this substance with the extrinsic factor (vitamin B(12)) and folic acid have not been defined at this time. Vitamin B(12) appears to be the active principle of refined liver extract and alone is probably adequate treatment for pernicious anemia. The other varieties of megaloblastic anemia may result from deficiency of vitamin B(12) or folic acid, although generally treatment with the latter brings about complete and lasting remission. The use of multihematinics and multivitamin preparations containing folic acid is to be condemned, particularly because of the possibility of their obscuring anemia and thwarting diagnosis of pernicious anemia until neurologic complications have taken place. Saccharated oxide of iron is a relatively safe preparation for intravenous administration, but the indications for its use are few. Because the body has no mechanism for iron excretion, only the amount of iron necessary to make up a deficiency should be given, although there is no definite evidence that hemochromatosis results from overdosage.

Topics: Anemia; Anemia, Iron-Deficiency; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Hematinics; Humans; Intrinsic Factor; Iron; Iron Compounds; Iron Metabolism Disorders; Liver Extracts; Substance-Related Disorders; Vitamin B 12; Vitamins