intrinsic-factor and Hypothyroidism

Topics: Anemia, Pernicious; Animals; Antibodies; Autoantibodies; Gastric Juice; Humans; Hypothyroidism; Intrinsic Factor; Vitamin B 12

Autoimmune thyroid disease (AITD) is frequently accompanied by other organ-specific diseases. We investigated the frequency of the association AITD-Biermer's disease (BD) in patients with AITD by investigating the prevalence of intrinsic factor antibodies (IF-Ab).. Sera from 113 patients with AITD (hypo- or hyperthyroidism) were screened for the presence of type I IF-Ab with a competitive automated immunoassay based. Matched sera from 113 patients with dysthyroidism (not AITD) were tested.. Four IF-Ab positive patients suffered from AITD. BD was known for two of them and strongly suspected in the two others. All patients with no AITD tested IF-Ab negative. B12 levels were often low whatever the etiology.. The prevalence of IF-AbI is higher (3.5%) in patients with AITD. Prospective studies should investigate whether correcting thyroid dysfunction improves vitamin B12 levels, and establish whether routine screening for gastric autoimmunity is clinically useful or purely academic.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Autoantibodies; Child; Child, Preschool; Humans; Hyperthyroidism; Hypothyroidism; Infant; Intrinsic Factor; Middle Aged; Prevalence; Thyroiditis, Autoimmune; Thyroxine; Triiodothyronine; Vitamin B 12; Young Adult

To determine the prevalence of pernicious anaemia in patients with Type 1 diabetes mellitus and autoimmune thyroid disease.. A randomly selected asymptomatic group of 63 patients with Type 1 diabetes who also had autoimmune thyroid disease was studied. Blood samples were taken and assayed for serum B12. Those subjects with serum B12 concentrations below the reference range had a further blood sample taken for determination of intrinsic factor antibody.. One patient had been diagnosed previously to have pernicious anaemia. Three patients had low serum B12 concentration and positive intrinsic factor antibody, confirming the diagnosis of pernicious anaemia. The prevalence of pernicious anaemia in this population with Type 1 diabetes and concomitant autoimmune thyroid disease was 6.3%. In female patients the prevalence of pernicious anaemia was 8.5%.. Patients who have both Type 1 diabetes mellitus and autoimmune thyroid disease are at risk of developing pernicious anaemia.

Topics: Aged; Aged, 80 and over; Anemia, Pernicious; Autoantibodies; Diabetes Mellitus, Type 1; Female; Folic Acid; Graves Disease; Humans; Hypothyroidism; Intrinsic Factor; Middle Aged; Prevalence; Vitamin B 12

Topics: Aged; Aged, 80 and over; Autoantibodies; Autoimmune Diseases; Female; HLA-DR3 Antigen; HLA-DR4 Antigen; Humans; Hypothyroidism; Intrinsic Factor; Parietal Cells, Gastric; Sjogren's Syndrome; Syndrome; Thyroiditis, Autoimmune; Vitamin B 12 Deficiency; Xerostomia

Topics: Anemia, Pernicious; Antibodies; Humans; Hypothyroidism; Intrinsic Factor

Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.

Topics: Agammaglobulinemia; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Cell Migration Inhibition; Diabetes Mellitus; Female; Gastritis; Hematocrit; Humans; Hyperthyroidism; Hypothyroidism; Immunity, Cellular; Intestinal Absorption; Intrinsic Factor; Leukocytes; Lymphocyte Activation; Male; Vitamin B 12

Topics: Adolescent; Adult; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Female; Fluorescent Antibody Technique; Humans; Hypothyroidism; Intrinsic Factor; Male; Pedigree; Stomach; Thyroid Gland

Topics: Achlorhydria; Adult; Anemia, Pernicious; Female; Gastric Acidity Determination; Gastric Juice; Histamine; Humans; Hyperthyroidism; Hypothyroidism; Intrinsic Factor; Male; Middle Aged; Schilling Test; Stimulation, Chemical

Topics: Addison Disease; Adrenal Glands; Adult; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Cytoplasm; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypothyroidism; Intrinsic Factor; Middle Aged; Stomach; Thyroid Gland

A man presented with the sudden onset of pernicious anaemia at the age of 21. He had been treated for hypothyroidism since the age of 6. His father and only paternal aunt were also found to have pernicious anaemia. Gastric and thyroid antibody studies showed one or more antibodies to be present in all three subjects, as well as in the patient's mother.

Topics: Adult; Aged; Anemia, Pernicious; Autoantibodies; Female; Humans; Hypothyroidism; Intrinsic Factor; Male; Middle Aged; Myxedema; Stomach; Thyroglobulin; Thyroid Gland

Topics: Anemia, Pernicious; Antibodies; Antigen-Antibody Reactions; Autoantibodies; Fluorescent Antibody Technique; Gastric Mucosa; Gastritis; Humans; Hyperthyroidism; Hypothyroidism; Intrinsic Factor; Lupus Erythematosus, Systemic

Topics: Anemia, Pernicious; Antibodies; Autoantibodies; Duodenal Ulcer; Fluorescent Antibody Technique; Gastric Mucosa; Humans; Hypothyroidism; Immune Tolerance; In Vitro Techniques; Intrinsic Factor; Pneumomediastinum, Diagnostic; Tomography