intrinsic-factor and Hyperthyroidism

Autoimmune thyroid disease (AITD) is frequently accompanied by other organ-specific diseases. We investigated the frequency of the association AITD-Biermer's disease (BD) in patients with AITD by investigating the prevalence of intrinsic factor antibodies (IF-Ab).. Sera from 113 patients with AITD (hypo- or hyperthyroidism) were screened for the presence of type I IF-Ab with a competitive automated immunoassay based. Matched sera from 113 patients with dysthyroidism (not AITD) were tested.. Four IF-Ab positive patients suffered from AITD. BD was known for two of them and strongly suspected in the two others. All patients with no AITD tested IF-Ab negative. B12 levels were often low whatever the etiology.. The prevalence of IF-AbI is higher (3.5%) in patients with AITD. Prospective studies should investigate whether correcting thyroid dysfunction improves vitamin B12 levels, and establish whether routine screening for gastric autoimmunity is clinically useful or purely academic.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Autoantibodies; Child; Child, Preschool; Humans; Hyperthyroidism; Hypothyroidism; Infant; Intrinsic Factor; Middle Aged; Prevalence; Thyroiditis, Autoimmune; Thyroxine; Triiodothyronine; Vitamin B 12; Young Adult

Topics: Antibodies; Humans; Hyperthyroidism; Intrinsic Factor

Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.

Topics: Agammaglobulinemia; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Cell Migration Inhibition; Diabetes Mellitus; Female; Gastritis; Hematocrit; Humans; Hyperthyroidism; Hypothyroidism; Immunity, Cellular; Intestinal Absorption; Intrinsic Factor; Leukocytes; Lymphocyte Activation; Male; Vitamin B 12

Topics: Adult; Aged; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Cell Movement; Female; Follow-Up Studies; Gastric Juice; Gastritis; Graves Disease; Humans; Hyperthyroidism; Intestinal Absorption; Intrinsic Factor; Leukocytes; Male; Middle Aged; Myxedema; Thyroid Diseases; Thyroiditis, Autoimmune; Vitamin B 12

Topics: Anemia, Pernicious; Autoantibodies; Humans; Hyperthyroidism; Intrinsic Factor; Long-Acting Thyroid Stimulator; Middle Aged

Topics: Anemia, Pernicious; Animals; Antibody Formation; Antigen-Antibody Reactions; Autoantibodies; Autoimmune Diseases; Basement Membrane; Complement System Proteins; Erythrocytes; gamma-Globulins; Glomerulonephritis; Guinea Pigs; Humans; Hyperthyroidism; Intrinsic Factor; Iodine Isotopes; Long-Acting Thyroid Stimulator; Myasthenia Gravis; Organ Specificity; Thyrotropin; Vitamin B 12

Topics: Achlorhydria; Adult; Anemia, Pernicious; Female; Gastric Acidity Determination; Gastric Juice; Histamine; Humans; Hyperthyroidism; Hypothyroidism; Intrinsic Factor; Male; Middle Aged; Schilling Test; Stimulation, Chemical

Topics: Adult; Anemia, Pernicious; Asian People; Atrophy; Autoantibodies; Female; Gastritis; Hong Kong; Humans; Hyperthyroidism; Intestinal Absorption; Intrinsic Factor; Male; Middle Aged; Stomach; Vitamin B 12

Topics: Anemia, Pernicious; Antibodies; Antigen-Antibody Reactions; Autoantibodies; Fluorescent Antibody Technique; Gastric Mucosa; Gastritis; Humans; Hyperthyroidism; Hypothyroidism; Intrinsic Factor; Lupus Erythematosus, Systemic

Topics: Adolescent; Adult; Aged; Anemia, Pernicious; Antibodies; Female; Fluorescent Antibody Technique; Gastric Mucosa; Humans; Hyperthyroidism; Intrinsic Factor; Iodine Isotopes; Male; Middle Aged; Vitamin B 12

Topics: Adrenal Glands; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Female; Fluorescent Antibody Technique; Goiter; Humans; Hyperthyroidism; Intrinsic Factor; Male; Middle Aged; Pancreas; Stomach; Thyroid Gland; Thyroid Neoplasms

Topics: Adult; Anemia, Pernicious; Female; Gastritis; Humans; Hyperthyroidism; India; Intrinsic Factor; Thyroid Function Tests; Vitamin B 12

Topics: Adult; Anemia, Hypochromic; Anemia, Pernicious; Antigen-Antibody Reactions; Australia; Autoantibodies; Blood Donors; Complement Fixation Tests; Diabetes Mellitus; Female; Gastric Mucosa; Gastritis; Humans; Hyperthyroidism; India; Intrinsic Factor; Male; Middle Aged; North America; United Kingdom

Topics: Adult; Anemia, Hypochromic; Anemia, Pernicious; Antibodies; Australia; Diabetes Mellitus; Female; Humans; Hyperthyroidism; India; Intrinsic Factor; Male; Middle Aged; North America

Topics: Aged; Anemia, Pernicious; Antibodies; Female; Humans; Hyperthyroidism; Intrinsic Factor; Iodine Isotopes; Male; Middle Aged; Serologic Tests

Topics: Anemia, Pernicious; Antibodies; Complement Fixation Tests; Fluorescent Antibody Technique; Genetics, Medical; Humans; Hyperthyroidism; Intrinsic Factor; Stomach; Thyroid Gland; Thyrotoxicosis