intrinsic-factor and Glomerulonephritis

This article reviews the mediation systems participating or potentially participating in inflammatory disease, especially in immunologic injury of the glomerulus. Mediator systems are separated into 3 mechanisms: the first involves complement and neutrophils; the second involves systems unrelated to neutrophils and complement components from C3 to C9; and the third involves blood monocytes. Major emphasis is given to an analysis of factors that potentially participate in the second mechanism. These include humoral factors such as the coagulation system and Hageman factor systems and cellular factor such as platelets or cells resident in the glomerulus. Studies on a role of vasoactive amines are presented. The importance of separating neutrophil-dependent and -independent mechanisms in these studies is emphasized. A review of current knowledge of the biochemical mechanisms involved in the Hageman factor system is presented because of the potential role of these components in the development of inflammation.

Topics: Animals; Basement Membrane; Complement System Proteins; Factor XII; Fibrin; Fibrinogen; Glomerulonephritis; Immune Complex Diseases; Inflammation; Intrinsic Factor; Kidney Glomerulus; Nephritis; Rabbits; Rats

In a cross-sectional study adjusting for age, gender, and catchment area, the prevalence of thyroid antibodies was assessed in 51 consecutive subjects with biopsy-proven glomerulonephritis and in 112 control subjects admitted for extracorporeal shock-wave lithotripsy treatment for renal stones. Women with glomerulonephritis had both a significantly greater prevalence of thyroid peroxidase antibodies (odds ratio 3.85, 95% confidence interval 1.04-14.3) and an increased prevalence of elevated serum TSH values (P = 0.007). No such difference was found in men. The prevalence of thyroglobulin antibodies did not differ between the groups. It is suggested that the possibility of an autoimmune thyroid disease should be taken into consideration in patients with glomerulonephritis, particularly in women.

Topics: Adult; Aged; Autoantibodies; Female; Glomerulonephritis; Humans; Intrinsic Factor; Iodide Peroxidase; Male; Middle Aged; Thyrotropin

Topics: Anemia, Pernicious; Animals; Antibody Formation; Antigen-Antibody Reactions; Autoantibodies; Autoimmune Diseases; Basement Membrane; Complement System Proteins; Erythrocytes; gamma-Globulins; Glomerulonephritis; Guinea Pigs; Humans; Hyperthyroidism; Intrinsic Factor; Iodine Isotopes; Long-Acting Thyroid Stimulator; Myasthenia Gravis; Organ Specificity; Thyrotropin; Vitamin B 12

Topics: Agammaglobulinemia; Anemia, Hemolytic, Autoimmune; Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Coombs Test; gamma-Globulins; Glomerulonephritis; Graft vs Host Disease; Humans; Intrinsic Factor; Rheumatoid Factor; Thyroglobulin; Thyroiditis, Autoimmune; Uveitis