intrinsic-factor and Diphyllobothriasis

This review focusses on research performed by the author and coworkers. The absorption, turnover and excretion of cobalamin and the pathogenesis of cobalamin deficiency states are described and the laboratory tests used to diagnose these states are discussed. Topics dealt with in detail include: overall turnover, daily need, enterohepatic circulation and excretion of cobalamin and other corrins . The soluble proteins mediating cobalamin transport and their cellular receptors are described and their nomenclature, isolation, structure and mode of action, the role of calcium in the membrane transport, the evolution of these systems and the analogies with transport systems for other substrates are discussed together with deficiency states, especially fish tapeworm anemia and familial selective vitamin B12 malabsorption with proteinuria. Folate deficiency is a relatively rare cause of megaloblastic anemia in Scandinavia but common in North America and explanations for this difference are suggested. The methods of assaying cobalamin in serum and plasma and the performance of radiovitamin B12 absorption tests are critically evaluated. The measurement of intrinsic factor in gastric juice, serum, amniotic fluid and urine is described.

Topics: Anemia, Megaloblastic; Anemia, Pernicious; Biological Transport; Corrinoids; Diet; Diphyllobothriasis; Endocytosis; Erythrocyte Indices; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Membrane Transport Proteins; Metabolic Clearance Rate; Receptors, Cell Surface; Receptors, Peptide; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Absorption; Aged; Anemia, Pernicious; Animals; Biological Transport; Chemical Phenomena; Chemistry; Child; Diphyllobothriasis; Food Analysis; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Nutritional Requirements; Stomach; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency; Zollinger-Ellison Syndrome

Topics: Anemia, Macrocytic; Anemia, Pernicious; Child; Child, Preschool; Diphyllobothriasis; Female; Folic Acid Deficiency; Humans; Infant; Infant Nutrition Disorders; Infant, Newborn; Intrinsic Factor; Kwashiorkor; Malabsorption Syndromes; Male; Proteinuria; Thiamine; Transferases; Vitamin B 12 Deficiency

Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Blood Cell Count; Diagnosis, Differential; Diphyllobothriasis; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency