intrinsic-factor and Diabetes-Mellitus

Topics: Diabetes Mellitus; Female; Humans; Intrinsic Factor; Obesity; Polycystic Ovary Syndrome; Risk Factors

In a survey of 46 randomly selected diabetic patients on biguanide therapy, 30% had malabsorption of vitamin B12. Withdrawal of the drug resulted in normal absorption in only half of those with malabsorption. In most patients with persistent malabsorption, the results of absorption tests with exogenous intrinsic factor suggested the diagnosis of coincidental intrinsic factor deficiency. Further considerations, however, led to the concept that biguanides can induce malabsorption by two different mechanisms. One of these is temporary and unrelated to intrinsic factor secretion and the other is permanent and mediated by depression of intrinsic factor secretion.

Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12

Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.

Topics: Agammaglobulinemia; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Cell Migration Inhibition; Diabetes Mellitus; Female; Gastritis; Hematocrit; Humans; Hyperthyroidism; Hypothyroidism; Immunity, Cellular; Intestinal Absorption; Intrinsic Factor; Leukocytes; Lymphocyte Activation; Male; Vitamin B 12

Topics: Adolescent; Adult; Aged; Antibodies; Antibodies, Antinuclear; Child; Cytoplasm; Diabetes Mellitus; Ethnicity; Female; Gastric Mucosa; Greece; Humans; Intrinsic Factor; Male; Middle Aged; Thyroid Gland

Topics: Addison Disease; Adolescent; Adult; Antibodies, Anti-Idiotypic; Autoimmune Diseases; Candidiasis; Diabetes Mellitus; Female; Follicle Stimulating Hormone; Gastritis; Humans; Hypoparathyroidism; Hypopituitarism; Intrinsic Factor; Luteinizing Hormone; Myxedema; Ovarian Diseases; Syndrome; Thyroiditis, Autoimmune

Topics: Adult; Aged; Antibodies; Cobalt Isotopes; Diabetes Mellitus; Female; Gastric Acidity Determination; Gastric Juice; Humans; Hydrogen-Ion Concentration; Intrinsic Factor; Male; Middle Aged; Pentagastrin; Radioimmunoassay

Topics: Adult; Aged; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 1; Female; Humans; Insulin Antibodies; Intrinsic Factor; Male; Middle Aged; Schilling Test

Topics: Adult; Aged; Anemia, Hypochromic; Autoantibodies; Diabetes Mellitus; Female; Humans; Intrinsic Factor; Japan; Male; Middle Aged; Nuclear Warfare; Radiation Injuries; Stomach; Thyroid Diseases

Topics: Adult; Blood Glucose; Cobalt Isotopes; Diabetes Mellitus; Diabetic Neuropathies; Gastric Mucosa; Humans; Insulin; Intrinsic Factor; Male; Pentagastrin

Vitamin-B(12) malabsorption has been found in 21 (30%) of 71 diabetic patients taking long-term metformin therapy in addition to dietary management. The patients with evidence of B(12) malabsorption had significantly lower haemoglobin levels (and significantly higher serum folic acid levels) than those with normal B(12) absorption. Steatorrhoea was found in only one patient. Stopping metformin therapy resulted in reversion of B(12) absorption to normal in most patients examined. Four patients with B(12) malabsorption were found to have pathologically low serum B(12) levels. The causes and implications of these findings are discussed and it is concluded that all patients on long-term metformin therapy should have annual serum B(12) estimations.

Topics: Aged; Cobalt Isotopes; Diabetes Mellitus; Dietary Fats; Folic Acid; Hemoglobinometry; Humans; Ileum; Intestinal Absorption; Intrinsic Factor; Lipid Metabolism; Malabsorption Syndromes; Metformin; Middle Aged; Radiography; Vitamin B 12

Topics: Adolescent; Adult; Age Factors; Aged; Anemia, Pernicious; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Bone Marrow Examination; Child; Cobalt Isotopes; Cytoplasm; Diabetes Complications; Diabetes Mellitus; Diet Therapy; Female; Fluorescent Antibody Technique; Gastric Juice; Gastric Mucosa; Humans; Insulin; Intrinsic Factor; Male; Middle Aged; Organ Specificity; Radioimmunoassay; Schilling Test; Sex Factors; Staining and Labeling; Stomach; Thyroglobulin; Thyroid Gland; Vitamin B 12

Topics: Adult; Antibodies; Biopsy; Diabetes Mellitus; Duodenal Ulcer; Fluorescent Antibody Technique; Gastritis; Gastrointestinal Diseases; Humans; Intrinsic Factor; Middle Aged; Stomach; Stomach Neoplasms; Stomach Ulcer

Topics: Biguanides; Cobalt Isotopes; Diabetes Mellitus; Diarrhea; Humans; Intestinal Absorption; Intrinsic Factor; Obesity; Schilling Test; Vitamin B 12

Topics: Adult; Aged; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Diabetes Complications; Diabetes Mellitus; Female; Humans; Intrinsic Factor; Middle Aged; Thyroid Gland

Topics: Addison Disease; Adrenal Glands; Adult; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Cytoplasm; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypothyroidism; Intrinsic Factor; Middle Aged; Stomach; Thyroid Gland

Topics: Adult; Aged; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Diabetes Complications; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Gastric Mucosa; Gastritis; Humans; Insulin; Intestinal Absorption; Intrinsic Factor; Male; Middle Aged; Schilling Test; Vitamin B 12

Topics: Achlorhydria; Aged; Anemia, Pernicious; Animals; Antigen-Antibody Reactions; Atrophy; Biopsy; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Immune Sera; Intrinsic Factor; Male; Middle Aged; Prednisolone; Rats; Regeneration; Reticulocytes; Schilling Test; Stomach; Stomach Diseases; Thyroiditis, Autoimmune; Vitamin B 12

Topics: Adult; Antibodies; Complement Fixation Tests; Diabetes Mellitus; Female; Humans; India; Intrinsic Factor; Male; Middle Aged

Topics: Adult; Anemia, Hypochromic; Anemia, Pernicious; Antigen-Antibody Reactions; Australia; Autoantibodies; Blood Donors; Complement Fixation Tests; Diabetes Mellitus; Female; Gastric Mucosa; Gastritis; Humans; Hyperthyroidism; India; Intrinsic Factor; Male; Middle Aged; North America; United Kingdom

Topics: Adult; Anemia, Hypochromic; Anemia, Pernicious; Antibodies; Australia; Diabetes Mellitus; Female; Humans; Hyperthyroidism; India; Intrinsic Factor; Male; Middle Aged; North America

Topics: Adult; Aged; Antibodies; Autoimmune Diseases; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Humans; Intrinsic Factor; Male; Middle Aged; Schilling Test; Stomach

Topics: Anemia, Hypochromic; Anemia, Pernicious; Antibodies; Antigen-Antibody Reactions; Cobalt Isotopes; Complement Fixation Tests; Diabetes Mellitus; Fluorescent Antibody Technique; Gastric Mucosa; Humans; Intrinsic Factor; Vitamin B 12

Topics: Anemia, Pernicious; Calcium; Celiac Disease; Diabetes Complications; Diabetes Mellitus; Humans; Hypocalcemia; Intrinsic Factor; Medical Records