intrinsic-factor and Diabetes-Mellitus--Type-1

To determine the prevalence of pernicious anaemia in patients with Type 1 diabetes mellitus and autoimmune thyroid disease.. A randomly selected asymptomatic group of 63 patients with Type 1 diabetes who also had autoimmune thyroid disease was studied. Blood samples were taken and assayed for serum B12. Those subjects with serum B12 concentrations below the reference range had a further blood sample taken for determination of intrinsic factor antibody.. One patient had been diagnosed previously to have pernicious anaemia. Three patients had low serum B12 concentration and positive intrinsic factor antibody, confirming the diagnosis of pernicious anaemia. The prevalence of pernicious anaemia in this population with Type 1 diabetes and concomitant autoimmune thyroid disease was 6.3%. In female patients the prevalence of pernicious anaemia was 8.5%.. Patients who have both Type 1 diabetes mellitus and autoimmune thyroid disease are at risk of developing pernicious anaemia.

Topics: Aged; Aged, 80 and over; Anemia, Pernicious; Autoantibodies; Diabetes Mellitus, Type 1; Female; Folic Acid; Graves Disease; Humans; Hypothyroidism; Intrinsic Factor; Middle Aged; Prevalence; Vitamin B 12

Topics: ABO Blood-Group System; Administration, Oral; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Hydroxocobalamin; Insulin; Intrinsic Factor; Iodide Peroxidase; Purpura, Thrombocytopenic, Idiopathic; Thyroglobulin

We report a case of a 15-year-old black boy who developed juvenile-onset pernicious anemia in association with insulin-dependent diabetes mellitus. He had both intrinsic factor and parietal cell antibodies in addition to anti-islet cell surface antibodies. The existence of pernicious anemia and diabetes mellitus in such a young child makes this an unusual case.

Topics: Adolescent; Anemia, Pernicious; Diabetes Mellitus, Type 1; Humans; Intrinsic Factor; Male

Topics: Adult; Aged; Anemia, Pernicious; Antibodies; Autoimmune Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 1; Female; Humans; Insulin Antibodies; Intrinsic Factor; Male; Middle Aged; Schilling Test