intrinsic-factor and Crohn-Disease

Topics: Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Celiac Disease; Colitis, Ulcerative; Crohn Disease; Fluorescent Antibody Technique; Gastritis; Gastrointestinal Diseases; Glutens; Humans; Hypersensitivity; Immunoglobulin G; Intrinsic Factor; Vitamin B 12

Topics: Antibodies; Antibodies, Anti-Idiotypic; Celiac Disease; Crohn Disease; Gastroenteritis; Gastrointestinal Diseases; Hepatitis; Humans; Hypersensitivity; Immunoglobulin G; Intestinal Diseases, Parasitic; Intrinsic Factor; Liver Diseases; Lymphocytes; Microscopy, Electron; Pancreatic Diseases; Virus Diseases

Topics: Anemia, Pernicious; Celiac Disease; Crohn Disease; Glomerular Filtration Rate; Humans; Intrinsic Factor; Schilling Test; Vitamin B 12

Topics: Anemia, Pernicious; Autoimmune Diseases; Child; Colitis, Ulcerative; Crohn Disease; Dermatomyositis; Digestive System Diseases; Hepatitis; Humans; Intrinsic Factor; Lupus Erythematosus, Systemic; Scleroderma, Systemic

A patient with granulomatous gastritis is described. Two years after the presentation of his gastric disease he developed pernicious anemia. Lack of intrinsic factor production secondary to Crohn's disease of the stomach is felt to be the cause of his Vitamin B12 malabsorption.

Topics: Adult; Anemia, Pernicious; Crohn Disease; Gastritis; Humans; Intrinsic Factor; Male; Vitamin B 12

Cellular immunity to hog intrinsic factor was detected by a modified agarose-leukocyte migration test in 18 patients with pernicious amemia. Lymphocytes from 17 out of 18 patients with pernicious anemia gave positive responses to a concentrate of hog intrinsic factor; the intrinsic factor present in 1 mg. of this concentrate bound 128 ng. of vatamin B12. Six patients with atrophic gastritis, 7 with regional enteritis, and 9 out of 10 healthy adults did not respond to this preparation. No correlation existed between the presence of serum autoantibodies to intrinsic factor and in vitro lymphocyte responsiveness to intrinsic factor. The results demonstrate that cellular immunity to intrinsic factor concentrates is present in the majority of patients with pernicious anemia.

Topics: Adult; Aged; Anemia, Pernicious; Antibodies; Cell Migration Inhibition; Crohn Disease; Female; Fluorescent Antibody Technique; Gastritis; Humans; Immunity, Cellular; Intrinsic Factor; Lymphocytes; Male; Middle Aged

Topics: Anemia; Anemia, Hypochromic; Anemia, Pernicious; Anemia, Sideroblastic; Blind Loop Syndrome; Crohn Disease; Diverticulitis; Folic Acid Deficiency; Gastritis; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Intrinsic Factor; Malabsorption Syndromes; Vitamin B 12 Deficiency; Whipple Disease

Topics: Administration, Oral; Anemia, Pernicious; Cobalt Isotopes; Crohn Disease; Female; Humans; Intestinal Absorption; Intrinsic Factor; Kidney Diseases; Malabsorption Syndromes; Male; Methods; Schilling Test; Time Factors; Vitamin B 12

Topics: Anemia, Pernicious; Antibodies; Calcium; Centrifugation; Cobalt Isotopes; Crohn Disease; Edetic Acid; Gastric Juice; Humans; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Intrinsic Factor; Jejunum; Magnesium; Saliva; Tissue Extracts; Vitamin B 12

Topics: Adolescent; Adult; Aged; Child; Crohn Disease; Dietary Fats; Female; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Vitamin B 12; Xylose