intrinsic-factor and Asthma

For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.

Topics: Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Asthma; Disease Progression; Humans; Immunity, Innate; Intrinsic Factor; Omalizumab

Topics: Antigens; Asthma; Gastric Juice; Humans; Intrinsic Factor; Medical Records; Occupational Diseases

Topics: Asthma; Humans; Intrinsic Factor