intrinsic-factor has been researched along with Anemia--Macrocytic* in 86 studies
11 review(s) available for intrinsic-factor and Anemia--Macrocytic
Article | Year |
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Isotopes in megaloblastic anaemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Isotope Labeling; Protein Binding; Radioimmunoassay; Transcobalamins; Vitamin B 12 | 1977 |
Megaloblastic anaemia and disorders affecting utilisation of vitamin B12 and folate in childhood.
Topics: Adolescent; Adult; Anemia, Hemolytic; Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Biological Transport; Bone Marrow; Bone Marrow Cells; Child; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Homocystinuria; Humans; Infant; Intrinsic Factor; Malabsorption Syndromes; Male; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Orotic Acid; Phenylketonurias; Tetrahydrofolate Dehydrogenase; Transcobalamins; Vitamin B 12 | 1976 |
Metabolic approach to the diagnosis of megaloblastic anemias.
Topics: Alcoholism; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Diagnosis, Differential; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Pyrimidine Nucleotides; Thymine Nucleotides; Uracil Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
Vitamin B 12 and folate metabolism.
Topics: Anemia, Macrocytic; Bile; Binding Sites; Feces; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intrinsic Factor; Protein Binding; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Vitamin B 12 and tropical sprue.
Topics: Anemia, Macrocytic; Animals; Body Weight; Folic Acid; Humans; Ileum; Intestinal Absorption; Intrinsic Factor; Liver; Receptors, Drug; Schilling Test; Sprue, Tropical; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
The significance of gastric antibodies.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Antigens; Autoantibodies; Biopsy; Chronic Disease; Cytoplasm; Digestive System; Female; Fluorescent Antibody Technique; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Immunologic Deficiency Syndromes; Intrinsic Factor; Lipoproteins; Microsomes; Schilling Test; Stomach; Vitamin B 12 | 1971 |
[Physiologic action of vitamin B12].
Topics: Anemia, Macrocytic; Anemia, Pernicious; Coenzymes; Humans; Intestinal Absorption; Intrinsic Factor; Vitamin B 12; Vitamin B 12 Deficiency | 1971 |
[Megaloblastic anemias in childhood].
Topics: Anemia, Macrocytic; Anemia, Pernicious; Child; Child, Preschool; Diphyllobothriasis; Female; Folic Acid Deficiency; Humans; Infant; Infant Nutrition Disorders; Infant, Newborn; Intrinsic Factor; Kwashiorkor; Malabsorption Syndromes; Male; Proteinuria; Thiamine; Transferases; Vitamin B 12 Deficiency | 1970 |
The haematological management of patients following partial gastrectomy.
Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Female; Folic Acid Deficiency; Gastrectomy; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Vitamin B 12 Deficiency | 1968 |
Selective malabsorption of vitamin B12.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Child, Preschool; Gastric Mucosa; Humans; Ileum; Infant; Infant, Newborn; Intestinal Mucosa; Intrinsic Factor; Kidney; Malabsorption Syndromes; Proteinuria; Urogenital Abnormalities; Vitamin B 12 | 1968 |
[On the problem of the resorption disorders after stomach and intestine operations].
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Carbohydrate Metabolism; Dumping Syndrome; Gastroenterostomy; Hematopoiesis; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Malabsorption Syndromes; Methods; Postgastrectomy Syndromes; Protein-Losing Enteropathies; Vitamin B 12 | 1966 |
1 trial(s) available for intrinsic-factor and Anemia--Macrocytic
Article | Year |
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The haemopoietic factors associated with megaloblastosis.
Topics: Anemia, Macrocytic; Female; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Pregnancy; Vitamin B 12 | 1969 |
74 other study(ies) available for intrinsic-factor and Anemia--Macrocytic
Article | Year |
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Association of acquired thrombotic thrombocytopaenic purpura in a patient with pernicious anaemia.
Pernicious anaemia is an autoimmune disease caused by intrinsic factor antibody; it leads to vitamin B12 deficiency and is marked by ineffective erythropoiesis. Haematological features reveal macrocytosis, hyperchromasia and hypersegmented neutrophils. Schistocytes are typically seen in microangiopathy, such as in thrombotic thrombocytopaenic purpura (TTP)/haemolytic uraemic syndrome or disseminated intravascular haemolysis (DIC). We report a case of a patient with severe anaemia who presented to the emergency room. Peripheral smear revealed macrocytosis, hypersegmented neutrophils and marked schistocytosis. The patient also had high reticulocyte count with high serum lactate dehydrogenase, elevated D-dimer, low fibrinogen and low haptoglobin. Vitamin B12 level came back low and the presence of intrinsic factor antibody confirmed pernicious anaemia. ADAMTS13 level was noted to be mildly reduced, which raised the suspicion of the association of acquired TTP with pernicious anaemia. Acquired TTP is another autoimmune disorder and its association with pernicious anaemia needs further evaluation. Topics: ADAM Proteins; ADAMTS13 Protein; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Erythrocyte Count; Erythrocytes, Abnormal; Erythropoiesis; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Haptoglobins; Hemolytic-Uremic Syndrome; Humans; Intrinsic Factor; L-Lactate Dehydrogenase; Neutrophils; Purpura, Thrombotic Thrombocytopenic; Vitamin B 12 | 2015 |
Pernicious anemia (PA) subsequent to insulin-dependent diabetes mellitus and idiopathic thrombocytopenic purpura, and effects of oral cobalamin on PA.
Topics: ABO Blood-Group System; Administration, Oral; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Hydroxocobalamin; Insulin; Intrinsic Factor; Iodide Peroxidase; Purpura, Thrombocytopenic, Idiopathic; Thyroglobulin | 1999 |
[Postgastrectomy megaloblastic anemia--possible participation of anti-intrinsic factor antibody in its pathogenesis--report of a case].
A case of 78-year old man with megaloblastic anemia occurring 20 years after partial gastrectomy is reported. Since about 2 years earlier he had an episode of convulsion, and he had been on anti-convulsants (diphenylhydantion, phenobarbital) until admission. Physical examination revealed a pale lean man with polyneuropathy and mental impairment. Laboratory findings revealed WBC 3100/microliters, RBC 187 X 10(4)/microliters, HB 7.9 g/dl, MCV 124.4 microns3, MCH 42.7 micrograms, platelet counts 15.7 X 10(4)/microliters, serum vitamin B12 (VB12) 380 pg/ml, and serum folic acid 5.1 ng/ml. Serum autoantibodies to intrinsic factor (IF) and parietal cells were positive. Bone marrow examination revealed erythroid hyperplasia and megaloblastic changes. Schilling test revealed impaired absorption of VB12 with or without IF, but X-ray study of the small bowels was unremarkable. Treatment with intramuscular cyanocobalamin resulted in a rapid clinical improvement. A repeat Schilling test after 4 months of therapy showed a normal VB12 absorption in the presence of IF. These findings suggest that VB12 malabsorption of the 1st Schilling test was due to intestinal dysfunction caused by the VB12 deficiency state itself, and the improvement of VB12 absorption with IF after therapy suggests a pathogenesis similar to pernicious anemia in this patient. Topics: Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Gastrectomy; Humans; Intrinsic Factor; Male; Postoperative Complications; Schilling Test; Vitamin B 12 | 1990 |
[Congenital intrinsic factor deficiency. Apropos of 3 cases in a sibship].
Three familial cases of congenital intrinsic factor deficiency are reported: the stress is put on the interest of gastric investigations and especially of the quantity of intrinsic factor in the gastric juice when investigating megaloblastic anemia due to vitamin B12 deficiency. The study of the level of intrinsic factor in the gastric juice is proposed as a test for identifying carriers. Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Child, Preschool; Female; Gastric Juice; Genetic Carrier Screening; Humans; Infant; Intrinsic Factor; Vitamin B 12 Deficiency | 1988 |
Laboratory diagnosis of megaloblastic anaemia: current methods assessed by external quality assurance trials.
The results of an Interregional quality assurance scheme for tests in the diagnosis of megaloblastic anaemia were reviewed to assess the methods used. Serum folate assays showed great variation between methods, partly due to limitations in assessment by external quality assurance. Red cell folate assays yielded widely different results and much imprecision due both to the differences in preparation of the haemolysate and to the problems inherent in radioassay of a mixture of folate compounds. Intrinsic factor antibody tests showed appreciable variation in sensitivity. There was considerable inconsistency in the detection of polymorph nuclear hypersegmentation. Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Erythrocytes; Folic Acid; Humans; Intrinsic Factor; Laboratories; Methods; Neutrophils; Quality Control; Vitamin B 12 | 1987 |
Anemia and abnormal upper gastrointestinal study in a 15-year-old adolescent.
Topics: Adolescent; Anemia, Macrocytic; Follow-Up Studies; Humans; Intestinal Absorption; Intrinsic Factor; Lymphangiectasis, Intestinal; Malabsorption Syndromes; Male; Protein-Losing Enteropathies; Proteinuria; Vitamin B 12; Vitamin B 12 Deficiency | 1987 |
Lymphocyte subpopulations in patients with hydroxocobalamin responsive megaloblastic anaemia.
Lymphocyte subpopulations and intrinsic factor and gastric parietal cell antibodies have been measured in 23 patients with megaloblastic anaemia who responded to treatment with hydroxocobalamin. The ratio of helper (OKT4) to suppressor (OKT8) lymphocytes was significantly increased in patients with intrinsic factor antibody compared with those who lacked the antibody. No such correlation was found for gastric parietal cell antibody. Alterations in the lymphocyte helper to suppressor (OKT4:OKT8) ratio may be associated with pernicious anaemia. Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies, Monoclonal; Autoantibodies; Humans; Hydroxocobalamin; Intrinsic Factor; Leukocyte Count; Lymphocytes; Parietal Cells, Gastric; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 1985 |
Selective malabsorption of vitamin B12 and vitamin B12-intrinsic factor with megaloblastic anemia in an adult.
The first case of megaloblastic anemia due to selective malabsorption of vitamin B(12) and vitamin B(12)-intrinsic factor is described in an otherwise normal female adult, in whom pernicious anemia had previously been diagnosed. Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Ileum; Intrinsic Factor; Vitamin B 12 | 1985 |
[Congenital deficiency of intrinsic factor].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Diagnosis, Differential; Female; Humans; Infant; Intrinsic Factor | 1984 |
Status of laboratory testing in the diagnosis of megaloblastic anemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Deoxyuridine; Erythrocyte Indices; Folic Acid; Humans; Intrinsic Factor; Reagent Kits, Diagnostic; Schilling Test; Vitamin B 12 | 1983 |
Gastric bypass and megaloblastic anemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Gastrectomy; Humans; Intrinsic Factor; Nutrition Disorders | 1982 |
[Megaloblastic anemia].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Bone Marrow Cells; DNA; Ferritins; Folic Acid Deficiency; Intestinal Mucosa; Intrinsic Factor; Iron; Myelin Sheath; Schilling Test; Vitamin B 12 Deficiency | 1981 |
Intrinsic factor deficiency in adults with normal hydrochloric acid production.
Two cases of intrinsic factor deficiency with normal hydrochloric acid production are presented. Both patients had markedly reduced intrinsic factor secretion and substantial titers of type I (blocking) intrinsic factor antibodies. No parietal cell antibodies were recognized by immunofluorescence in either case. Three hypotheses are offered to explain these findings: (a) These patients have congenital intrinsic factor deficiency that remained in the preanemic phase until adulthood; (b) they have pernicious anemia detected at a stage before gastric mucosal atrophy and achlorhydria have occurred; or (c) they represent cases of a new syndrome characterized by isolated intrinsic factor deficiency. Topics: Anemia, Macrocytic; Female; Gastric Acid; Gastric Mucosa; Humans; Intrinsic Factor; Male; Middle Aged | 1981 |
Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice.
A specific gastritis was induced in BALC/c (+/?) mice by thymectomy within 3 days after birth (25 to 45 per cent) or in BALB/c (nu/nu) mice by the injection of spleen cells (10(7)) from neonatally thymectomized mice (70 per cent). Normal peripheral lymphoid cells, irrespective of the sex and dose, were generally ineffective in inducing gastritis in nude mice, while thymus cells were partially effective (30 per cent). The induced gastritis was characterized by a loss of chief and parietal cells and by varying degrees of lymphoid cell infiltration along thickened muscularis mucosa. The fundic mucosa was replaced by mucous necklike immature cells, and there was a rise of pH of the gastric juice. Argyrophilic endocrine cells escaped the inflammation and increased in number. The gastritis induced in nude mice was generally more severe and was often followed by severe macrocytic anemia. Megaloblast-like large immature erythroid cells were numerous in the spleens of affected mice. Antiparietal cell antibodies (IgG) were always demonstrated by an indirect immunofluorescence test in the sera of gastritis-developing mice, but were absent in sera of normal or untreated conventional nude mice. These findings suggest a new animal model of pernicious anemia in man. Topics: Anemia, Macrocytic; Animals; Animals, Newborn; Autoimmune Diseases; Disease Models, Animal; Female; Gastric Mucosa; Gastritis; Immunoglobulin G; Immunoglobulin M; Intrinsic Factor; Male; Mice; Mice, Nude; Spleen; Thymectomy | 1980 |
Humoral and cellular immunity to intrinsic factor in myasthenia gravis.
Myasthenia gravis (MG) is an autoimmune disease often associated with other autoimmune disorders. A case history of MG with a coexisting atypical megaloblastic anaemia with vitamin B12 deficiency and anti Intrinsic Factor (IF) antibodies, led to a study of humoral and cellular immunity to IF in 81 MG patients. Within this series, 3 other patients had a disturbed humoral and cellular immunity to IF. These 3 patients presented no other features of pernicious anaemia. The possible origins and significance of the anti IF antibodies in MG patients are discussed. Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Antibody Formation; Child; Female; Humans; Immunity, Cellular; Immunologic Techniques; Intrinsic Factor; Male; Middle Aged; Myasthenia Gravis; Vitamin B 12 Deficiency | 1979 |
[Pernicious anemia].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Diagnosis, Differential; FIGLU Test; Gastric Juice; Gastritis; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Intrinsic Factor; Prognosis; Vitamin B 12 | 1979 |
[A case of congenital deficiency of intrinsic factor (author's transl)].
Topics: Anemia, Macrocytic; Child; Female; Humans; Intrinsic Factor; Vitamin B 12 | 1979 |
[Diagnosis and therapy of megaloblastic anemias].
In most cases megaloblastic anaemias are the sequel of a deficiency of vitamin B12, more infrequently of a deficiency of folic acid of different etiology. Oriented to frequency and anamnesis the diagnostics follows the leading symptoms of pernicious anaemia (straw colour, glossitis, achlorhydria) and on the basis of special findings in the peripheral blood (hyperchromacia, megalocytosis, much decreased number of reticulocytes, increased iron and bilirubin level) it leads to the proved suspicion of a megaloblastic anaemia. This suspicion is ascertained by the investigation of the bone-marrow, with the help of aimed investigations the anaemia is further clarified differential-diagnostically. An unclear anaemia should not be treated ex juvantibus with vitamin B12 and/or folic acid. The therapy, always taking into consideration a possible basic disease, is carried out by parenteral application of vitamin B12, possibly in form of hydroxocobalamine or by folic acid. In persisting disturbance of the resorption of vitamin B12 on account of the threatening complication of a funicular spinal disease the long-term therapy must never be interrupted, unless in normal haematological findings. Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Diagnosis, Differential; Humans; Intrinsic Factor; Vitamin B 12; Vitamin B 12 Deficiency | 1977 |
[Search for anti-intrinsic factor antibodies in the diagnosis of Biermer's anemia].
The diagnostic interest of a search for anti-intrinsic factor antibodies is emphasized from the authors research on more than 200 patients or controls. Antibodies of type I, so-called blocking antibodies, were detected in 66% of cases where the diagnosis of pernicious anemia was made. Type II, so-called precipitating antibodies, were found in 47% of patients with antibodies of type I and only in the latter. Certain etiological factors, already noted in the world literature, were found, in particular the link with the female sex and with blood group A. The specificity of these antibodies is very great and false positives are exceptional. We did not find them in any of the 104 controls. They were observed, however, in 5 of the 56 patients where the diagnosis of pernicious anemia was not definite, but it is likely that, in these 5 cases, pernicious anemia existed with some other disease. Our study also showed the limits of other methods of investigation of this disease; hypovitaminimia B12 is often corrected by treatment without proper inductions and B12 malabsorption on the Schilling test may not be corrected by the addition of intrinsic factor. Topics: Anemia, Macrocytic; Anemia, Pernicious; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Blood Group Antigens; Diagnosis, Differential; False Positive Reactions; Female; Gastric Juice; Hematologic Diseases; Humans; Immunodiffusion; Intrinsic Factor; Male; Precipitins; Radioimmunoassay; Schilling Test; Sex Factors; Vitamin B 12 | 1975 |
Use of radioisotope techniques in the clinical evaluation of patients with megaloblastic anemia.
Because virtually all cases of vitamin B12 deficiency seen in this country are due to malabsorption, the availability of radioactive vitamin B12 for direct measurement of absorption of this essential nutrient has proved to be of great clinical value. These tests are useful not only in demonstrating vitamin B12 malabsorption but also often in defining the pathophysiological mechanism responsible for this abnormality. The urinary excretion test of Schilling remains the most useful test for vitamin B12 absorption. Minor precautions and modifications in technique make the test results more reliable and easier to interpret. The 8-hr plasma test for vitamin B12 absorption can no longer be considered acceptable. Some patients with vitamin B12 malabsorption have results in the normal range when studied by this method. Serum vitamin B12 assays utilizing radioactive vitamin B12 and the isotope dilution principle are not widely used and are useful screening tests. Low normal or borderline results observed in patients with clinical evidence suggestive of vitamin B12 deficiency should be interpreted with caution or confirmed by radioactive vitamin B12 absorption studies. Radioactive vitamin B12 can also be used for rapid, reliable assay of gastric intrinsic factor, antibody to intrinsic factor and unsaturated vitamin B12 serum. Methods using radioactive folate compounds for similar in vivo and in vitro studies are not yet applicable for routine use in nuclear medicine laboratories. Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Cobalt Radioisotopes; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intrinsic Factor; Radioimmunoassay; Radioisotope Dilution Technique; Schilling Test; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
"B12 shots". Flip side.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Gastrectomy; Humans; Ileum; Intrinsic Factor; Malabsorption Syndromes; Metabolism, Inborn Errors; Schilling Test; Time Factors; Vitamin B 12 | 1975 |
Cancer of the gastrointestinal tract. Late effects of gastrectomy.
Topics: Afferent Loop Syndrome; Anemia, Macrocytic; Diarrhea; Dumping Syndrome; Folic Acid Deficiency; Gastrectomy; Gastric Juice; Gastrins; Humans; Intestinal Absorption; Intrinsic Factor; Mucus; Osteoporosis; Postgastrectomy Syndromes; Stomach Neoplasms; Vitamin B 12 Deficiency; Vomiting | 1974 |
[Peutz-Jeghers syndrome with malabsorption of vitamin B 12].
Topics: Administration, Oral; Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Intrinsic Factor; Peutz-Jeghers Syndrome; Tetracycline; Vitamin B 12 Deficiency | 1974 |
[Pernicious anemia. Patients with misleading Schilling and absence of macrocytic anemia].
Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Diagnosis, Differential; Female; Humans; Intestinal Absorption; Intrinsic Factor; Male; Middle Aged; Schilling Test; Vitamin B 12 | 1974 |
[Selective malabsorption of vitamin B12, proteinuria and hypogammaglobulinaemia -- a genetic defect (author's transl)].
Topics: Adolescent; Adult; Agammaglobulinemia; Anemia, Macrocytic; Anemia, Megaloblastic; Antibody Formation; Chronic Disease; Female; Gastric Juice; Humans; Immunoglobulin A; Immunoglobulin G; Immunologic Deficiency Syndromes; Intrinsic Factor; Malabsorption Syndromes; Male; Proteinuria; Syndrome; Vitamin B 12 Deficiency | 1974 |
[Juvenile pernicious anemia in a 17-year-old boy. Congenital defficiency of Hoffbrand type 1 intrinsic factor].
Topics: Adolescent; Anemia, Macrocytic; Anemia, Pernicious; Chronic Disease; Consanguinity; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Recurrence; Vitamin B 12 Deficiency | 1974 |
Selective vitamin B12 malabsorption in two siblings.
Two siblings with megaloblastic anemia responsive to parenteral vitamin B(12) were studied to elucidate the cause of the B(12) deficiency. Gastric juice from both contained acid and functional intrinsic factor. Serum contained transcobalamin II and lacked antibodies to intrinsic factor. Schilling tests showed vitamin B(12) malabsorption uncorrected by hog intrinsic factor or pancreatic extract. Other parameters of small intestinal function were normal. Proteinuria was initially present in both but cleared in one following treatment with B(12). These patients with "familial selective vitamin B(12) malabsorption" are the first reported from Canada. Only 37 cases have been reported in the world literature to date. Topics: Anemia, Macrocytic; Child; Child, Preschool; Cobalt Radioisotopes; Female; Follow-Up Studies; Gastric Juice; Humans; Intestinal Absorption; Intrinsic Factor; Male; Schilling Test; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Editorial: Megaloblastic anaemia in Africans, resembling pernicious anaemia.
Topics: Africa; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Diagnosis, Differential; Humans; Intrinsic Factor | 1974 |
Megaloblastic anaemia, achlorhydria, low intrinsic factor, and intrinsic-factor antibodies in the absence of pernicious anaemia.
Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Erythrocyte Count; Folic Acid; Histamine; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; Pentagastrin; Reticulocytes; Schilling Test; South Africa; Stimulation, Chemical; Syndrome; Tetracycline; Vitamin B 12 | 1973 |
Epidermal changes in vitamin B 12 deficiency.
Topics: Anemia, Macrocytic; Cell Nucleus; Child; Female; Humans; Intrinsic Factor; Pigmentation Disorders; Skin; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
Pernicious anaemia-like syndromes in the non-white population of Natal.
Topics: Adolescent; Adult; Age Factors; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Black or African American; Black People; Diagnosis, Differential; Ethnicity; Folic Acid; Gastric Juice; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; South Africa; Syndrome; Tetracycline; Vitamin B 12 | 1973 |
Simultaneous measurement of free and intrinsic factor (IF) bound vitamin B12 (B12) absorption; absolute quantitation with incomplete stool collection and rapid relative measurement using plasma B12 (IF): B12 absorption ratio.
Topics: Anemia, Macrocytic; Cobalt Isotopes; Feces; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Vitamin B 12 | 1973 |
Editorial: Congenital disorders of vitamin B12 transport and their contribution to concepts.
Topics: Anemia, Macrocytic; Female; Fetus; Glycoproteins; Humans; Ileum; Intrinsic Factor; Malabsorption Syndromes; Pregnancy; Protein Binding; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
[Juvenile pernicious anaemia (author's transl)].
Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Bone Marrow Examination; Diagnosis, Differential; Female; Gastric Mucosa; Humans; Intrinsic Factor; Schilling Test; Syndrome | 1973 |
An evaluation of the double isotope test in the diagnosis of pernicious anaemia.
Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Cobalt Isotopes; Female; Humans; Injections, Intramuscular; Intrinsic Factor; Male; Methods; Middle Aged; Schilling Test; Scintillation Counting; Vitamin B 12 | 1972 |
[Megaloblastic anemia in selective disorder of vitamin B12 resorption with proteinuria and antibody deficiency syndrome--a genetic defect].
Topics: Adolescent; Anemia, Macrocytic; Humans; Immunologic Deficiency Syndromes; Intrinsic Factor; Malabsorption Syndromes; Male; Proteinuria; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Vitamin B 12 malabsorption due to a biologically inert intrinsic factor.
Topics: Adolescent; Anemia, Macrocytic; Anemia, Pernicious; Antigens; Chromatography; Chromatography, Gel; Cobalt Isotopes; Gastric Juice; Humans; Intestinal Mucosa; Intrinsic Factor; Isoelectric Focusing; Malabsorption Syndromes; Male; Vitamin B 12 | 1972 |
[Antibodies against intrinsic factor in oral treatment of pernicious anemia with highly purified hog intrinsic factor-vitamin B 12 complex].
Topics: Administration, Oral; Anemia, Macrocytic; Anemia, Pernicious; Animals; Antibodies; Antibody Specificity; Erythrocyte Count; Gastrectomy; Hematocrit; Humans; Intrinsic Factor; Swine; Vitamin B 12 | 1972 |
Juvenile pernicious anaemia.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Child, Preschool; Female; Growth Disorders; Humans; Intrinsic Factor; Vitamin B 12 | 1972 |
[Biermer's anemia, chronic thyroiditis and polydysplasic bullous epidermolysis. Immunologic and genetic considerations].
Topics: Adult; Anemia, Macrocytic; Autoantibodies; Epidermolysis Bullosa; Female; Fluorescent Antibody Technique; Humans; Intrinsic Factor; Keratins; Skin; Thyroiditis | 1971 |
Megaloblastic anaemia in children due to isolated vitamin B 12 malabsorption.
Topics: Adolescent; Anemia, Macrocytic; Bone Marrow Examination; Female; Gastric Juice; Humans; Hydrochloric Acid; Infant; Intrinsic Factor; Kidney Function Tests; Malabsorption Syndromes; Male; Proteinuria; Schilling Test; Vitamin B 12 | 1971 |
Autoantibodies to intrinsic factor: their determination and clinical usefulness.
Topics: Achlorhydria; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Cobalt Isotopes; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Radioimmunoassay; Vitamin B 12 | 1971 |
[Congenital deficiency of intrinsic factor].
Topics: Anemia, Macrocytic; Child; Heart Defects, Congenital; Humans; Intrinsic Factor; Male; Metabolism, Inborn Errors; Schilling Test; Vitamin B Complex | 1971 |
Response of dietary vitamin-B12 deficiency to physiological oral doses of cyanocobalamin.
Topics: Adolescent; Anemia, Macrocytic; Anemia, Pernicious; Diet; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Male; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
The diagnostic use of radioactive isotopes in haematology.
Topics: Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Anemia, Macrocytic; Antibodies; Cell Survival; Cobalt Isotopes; Diagnosis, Differential; Erythrocytes; Feces; Female; Folic Acid; Gastric Juice; Hematologic Diseases; Hemorrhage; Humans; Intrinsic Factor; Iron; Iron Isotopes; Plasma Volume; Radioimmunoassay; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Schilling Test; Spleen; Vitamin B 12; Whole-Body Counting | 1970 |
Intrinsic factor in tapeworm anaemia.
Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Cestode Infections; Cobalt Isotopes; Female; Gastric Juice; Humans; Intrinsic Factor; Male; Methods; Middle Aged; Schilling Test; Vitamin B 12 | 1970 |
Recent advances in the nutritional anemias.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Anticonvulsants; Ascorbic Acid Deficiency; Contraceptives, Oral; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Nutritional Requirements; Schilling Test; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
[Schilling test and measurement of the level of gastric intrinsic factor in Biermer's anemias. Comparative study].
Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Child, Preschool; Diagnosis, Differential; Female; Gastric Juice; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Vitamin B 12 Deficiency | 1970 |
Vitamin B 12, intrinsic factor and immunological reactions in megaloblastic anaemia.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Antibody Formation; Autoantibodies; Autoimmune Diseases; Cell Migration Inhibition; Gastric Juice; Humans; Intestinal Absorption; Intrinsic Factor; Nutritional Requirements; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
[Familial forms of megaloblastic anemias].
Topics: Anemia, Macrocytic; Folic Acid Deficiency; Humans; Intellectual Disability; Intestinal Absorption; Intrinsic Factor; Metabolism, Inborn Errors; Orotic Acid; Transferases; Vitamin B 12 Deficiency | 1970 |
Studies on human gastric intrinsic factor. II. In vitr assay of human gastric juice and purified human intrinsic factor for intrinsic factor activity.
Topics: Absorption; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Animals; Biological Assay; Centrifugation; Cobalt Isotopes; Dialysis; Gastrectomy; Gastric Juice; Guinea Pigs; Heating; Histamine; Humans; In Vitro Techniques; Intestinal Mucosa; Intrinsic Factor; Male; Middle Aged; Pepsin A; Proteins; Vitamin B 12 | 1969 |
Vitamin B12 absorption test.
Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Cobalt Isotopes; Female; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Vitamin B 12 | 1969 |
Effect of vitamin B12 and folic acid deficiency on small intestinal absorption.
Three patients are described, and they provide further evidence that deficiency of folic acid and vitamin B(12) may sometimes affect small intestinal function. Malabsorption of both xylose and vitamin B(12) returned to normal in one patient after treatment of a megaloblastic anaemia due to dietary deficiency of folic acid. Impaired absorption of vitamin B(12) was corrected by vitamin B(12) therapy in the other two patients. The initial cause of the vitamin B(12) deficiency in one patient was not apparent, but she was taking Gynovlar 21, which may have been an aetiological factor. In the third patient the small intestinal defect was secondary to pernicious anaemia, and in a group of 98 other patients with pernicious anaemia intrinsic factor did not improve vitamin B(12) absorption in six, and only partially corrected absorption in 30. The significance of these observations is discussed. Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Contraceptives, Oral; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestine, Small; Intrinsic Factor; Malabsorption Syndromes; Vitamin B 12; Vitamin B 12 Deficiency; Xylose | 1969 |
Immunologic approaches to malabsorption of vitamin B12.
Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Blood Cell Count; Diagnosis, Differential; Diphyllobothriasis; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1969 |
[Multiplicity and significance of autoantibodies in the megaloblastic anemias].
Topics: Adrenal Glands; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Female; Fluorescent Antibody Technique; Goiter; Humans; Hyperthyroidism; Intrinsic Factor; Male; Middle Aged; Pancreas; Stomach; Thyroid Gland; Thyroid Neoplasms | 1968 |
Application of whole-body gamma spectrometry to vitamin B12 absorption.
Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Black People; Cobalt Isotopes; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Male; Middle Aged; Radiometry; Vitamin B 12; Vitamin B 12 Deficiency; White People | 1968 |
Congenital pernicious anemia: effects on growth, brain, and absorption of B12.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Body Height; Body Weight; Chromosome Aberrations; Chromosome Disorders; Diet Therapy; Female; Genes, Recessive; Growth; Humans; Infant; Infant, Newborn; Intellectual Disability; Intelligence Tests; Intrinsic Factor; Male; Vitamin B 12; Vitamin B 12 Deficiency | 1968 |
Vitamin B12 absorption correlated witthe gastric secretion of intrinsic factor as determined by radioimmunoassay following stimulation with histamine or pentagastrin.
Topics: Achlorhydria; Anemia, Macrocytic; Gastrins; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Radioimmunoassay; Stimulation, Chemical; Time Factors; Vitamin B 12 | 1968 |
[Primary megaloblastic anemia caused by isolated absence of intrinsic factor; probable Biermer's disease].
Topics: Anemia, Macrocytic; Anemia, Pernicious; Child; Child, Preschool; Female; Humans; Intrinsic Factor | 1967 |
Absorption of vitamin B12 in patients with anaemia after Polya partial gastrectomy.
Topics: Aged; Anemia, Macrocytic; Anemia, Pernicious; Cobalt Isotopes; Female; Gastrectomy; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Male; Middle Aged; Radiometry; Vitamin B 12; Vitamin B 12 Deficiency | 1967 |
[Megaloblastic anemia as result of selective vitamin B 12 malabsorption. Imerslund-Gräsbeck syndrome].
Topics: Adolescent; Anemia, Macrocytic; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Vitamin B 12 Deficiency | 1966 |
Occurrence in gastric juice of antibody to a complex of intrinsic factor and vitamin B12.
Topics: Achlorhydria; Aged; Anemia, Macrocytic; Antibodies; Chemical Precipitation; Cobalt Isotopes; Electrophoresis; Gastric Juice; Humans; In Vitro Techniques; Intestinal Absorption; Intrinsic Factor; Jejunum; Male; Vitamin B 12 | 1966 |
Megaloblastic anemia in an adult vegan.
Topics: Adult; Anemia, Macrocytic; Biological Assay; Blood Transfusion; Bone Marrow; Diet, Vegetarian; Folic Acid; Histamine; Humans; Intrinsic Factor; Iron; Jejunum; Male; Vitamin B 12 | 1966 |
ASSAY OF GASTRIC INTRINSIC FACTOR IN THE DIAGNOSIS OF ADDISONIAN PERNICIOUS ANAEMIA.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Blood Chemical Analysis; Clinical Laboratory Techniques; Cobalt Isotopes; Gastrectomy; Glutamates; Hematinics; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Lactobacillus; Pharmacology; Radiometry; Vitamin B 12 | 1965 |
Vitamin B12 and iron deficiency after partial gastrectomy.
Topics: Aged; Anemia, Hypochromic; Anemia, Macrocytic; Gastrectomy; Humans; Intrinsic Factor; Iron; Male; Vitamin B 12; Vitamin B 12 Deficiency | 1965 |
STUDIES ON SECRETION OF GASTRIC INTRINSIC FACTOR IN MAN.
Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Carbachol; Celiac Disease; Cobalt Isotopes; Colonic Neoplasms; Duodenal Ulcer; Folic Acid; Folic Acid Deficiency; Gastric Acidity Determination; Gastric Juice; Histamine; Humans; Insulin; Intrinsic Factor; Male; Pharmacology; Physiology; Sprue, Tropical; Vitamin B 12 | 1964 |
MEGALOBLASTIC ANEMIA.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Celiac Disease; Deficiency Diseases; Diagnosis; Female; Folic Acid; Humans; Intrinsic Factor; Malabsorption Syndromes; Physiology; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Sprue, Tropical; Vitamin B 12 | 1964 |
EFFECT OF VITAMIN B12 THERAPY IN A PATIENT WITH FOLIC ACID DEFICIENCY.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Black People; Blood Chemical Analysis; Bone Marrow; Deficiency Diseases; Drug Therapy; Folic Acid; Folic Acid Deficiency; Gastric Juice; Gastric Mucosa; Glutamates; Hematopoiesis; Humans; Hydrochloric Acid; Intrinsic Factor; Pathology; Pharmacology; Urine; Vitamin B 12 | 1964 |
THE MEGALOBLASTIC ANAEMIAS.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Blood Cell Count; Deficiency Diseases; Drug Therapy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intrinsic Factor; Malabsorption Syndromes; Metabolism; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Vitamin B 12; Vitamin B 12 Deficiency | 1964 |
[MEGALOBLASTIC ANEMIA ATTRIBUTED TO THE DEFICIENCY OF THE INTRINSIC FACTOR AFTER PARTIAL GASTRECTOMY].
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Therapy; Gastrectomy; Humans; Intrinsic Factor; Vitamin B 12 | 1964 |
Selective malabsorption of vitamin B12 deficiency of factor (S) for absorption of vitamin B12 in succus entericus.
Topics: Anemia; Anemia, Macrocytic; Biotin; Humans; Intestines; Intrinsic Factor; Vitamin B 12; Vitamin B 12 Deficiency | 1963 |
[EXPERIENCE WITH THE URINARY EXCRETION TEST OF RADIOACTIVE VITAMIN B 12. (SCHILLING TEST)].
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Celiac Disease; Cobalt Isotopes; Humans; Intrinsic Factor; Schilling Test; Urine; Vitamin B 12 | 1963 |
[Vitamin B12 and antipernicious intrinsic factor in experimental macrocytic anemia of folic acid deficient rat].
Topics: Anemia; Anemia, Macrocytic; Animals; Folic Acid; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Rats; Vitamin B 12; Vitamin B Complex | 1954 |
Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor.
Topics: Anemia; Anemia, Macrocytic; Gastrectomy; Humans; Intrinsic Factor; Stomach; Vitamin B 12 | 1954 |