intrinsic-factor and Anemia--Macrocytic

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Isotope Labeling; Protein Binding; Radioimmunoassay; Transcobalamins; Vitamin B 12

Topics: Adolescent; Adult; Anemia, Hemolytic; Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Biological Transport; Bone Marrow; Bone Marrow Cells; Child; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Homocystinuria; Humans; Infant; Intrinsic Factor; Malabsorption Syndromes; Male; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Orotic Acid; Phenylketonurias; Tetrahydrofolate Dehydrogenase; Transcobalamins; Vitamin B 12

Topics: Alcoholism; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Diagnosis, Differential; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Pyrimidine Nucleotides; Thymine Nucleotides; Uracil Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Bile; Binding Sites; Feces; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intrinsic Factor; Protein Binding; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Animals; Body Weight; Folic Acid; Humans; Ileum; Intestinal Absorption; Intrinsic Factor; Liver; Receptors, Drug; Schilling Test; Sprue, Tropical; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Pernicious; Antigens; Autoantibodies; Biopsy; Chronic Disease; Cytoplasm; Digestive System; Female; Fluorescent Antibody Technique; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Immunologic Deficiency Syndromes; Intrinsic Factor; Lipoproteins; Microsomes; Schilling Test; Stomach; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Pernicious; Coenzymes; Humans; Intestinal Absorption; Intrinsic Factor; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Pernicious; Child; Child, Preschool; Diphyllobothriasis; Female; Folic Acid Deficiency; Humans; Infant; Infant Nutrition Disorders; Infant, Newborn; Intrinsic Factor; Kwashiorkor; Malabsorption Syndromes; Male; Proteinuria; Thiamine; Transferases; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Female; Folic Acid Deficiency; Gastrectomy; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Pernicious; Child, Preschool; Gastric Mucosa; Humans; Ileum; Infant; Infant, Newborn; Intestinal Mucosa; Intrinsic Factor; Kidney; Malabsorption Syndromes; Proteinuria; Urogenital Abnormalities; Vitamin B 12

Topics: Anemia, Hypochromic; Anemia, Macrocytic; Carbohydrate Metabolism; Dumping Syndrome; Gastroenterostomy; Hematopoiesis; Humans; Intestinal Absorption; Intrinsic Factor; Iron; Malabsorption Syndromes; Methods; Postgastrectomy Syndromes; Protein-Losing Enteropathies; Vitamin B 12

Topics: Anemia, Macrocytic; Female; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Pregnancy; Vitamin B 12

Pernicious anaemia is an autoimmune disease caused by intrinsic factor antibody; it leads to vitamin B12 deficiency and is marked by ineffective erythropoiesis. Haematological features reveal macrocytosis, hyperchromasia and hypersegmented neutrophils. Schistocytes are typically seen in microangiopathy, such as in thrombotic thrombocytopaenic purpura (TTP)/haemolytic uraemic syndrome or disseminated intravascular haemolysis (DIC). We report a case of a patient with severe anaemia who presented to the emergency room. Peripheral smear revealed macrocytosis, hypersegmented neutrophils and marked schistocytosis. The patient also had high reticulocyte count with high serum lactate dehydrogenase, elevated D-dimer, low fibrinogen and low haptoglobin. Vitamin B12 level came back low and the presence of intrinsic factor antibody confirmed pernicious anaemia. ADAMTS13 level was noted to be mildly reduced, which raised the suspicion of the association of acquired TTP with pernicious anaemia. Acquired TTP is another autoimmune disorder and its association with pernicious anaemia needs further evaluation.

Topics: ADAM Proteins; ADAMTS13 Protein; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Erythrocyte Count; Erythrocytes, Abnormal; Erythropoiesis; Female; Fibrin Fibrinogen Degradation Products; Fibrinogen; Haptoglobins; Hemolytic-Uremic Syndrome; Humans; Intrinsic Factor; L-Lactate Dehydrogenase; Neutrophils; Purpura, Thrombotic Thrombocytopenic; Vitamin B 12

Topics: ABO Blood-Group System; Administration, Oral; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Diabetes Mellitus, Type 1; Female; Glutamate Decarboxylase; Humans; Hydroxocobalamin; Insulin; Intrinsic Factor; Iodide Peroxidase; Purpura, Thrombocytopenic, Idiopathic; Thyroglobulin

A case of 78-year old man with megaloblastic anemia occurring 20 years after partial gastrectomy is reported. Since about 2 years earlier he had an episode of convulsion, and he had been on anti-convulsants (diphenylhydantion, phenobarbital) until admission. Physical examination revealed a pale lean man with polyneuropathy and mental impairment. Laboratory findings revealed WBC 3100/microliters, RBC 187 X 10(4)/microliters, HB 7.9 g/dl, MCV 124.4 microns3, MCH 42.7 micrograms, platelet counts 15.7 X 10(4)/microliters, serum vitamin B12 (VB12) 380 pg/ml, and serum folic acid 5.1 ng/ml. Serum autoantibodies to intrinsic factor (IF) and parietal cells were positive. Bone marrow examination revealed erythroid hyperplasia and megaloblastic changes. Schilling test revealed impaired absorption of VB12 with or without IF, but X-ray study of the small bowels was unremarkable. Treatment with intramuscular cyanocobalamin resulted in a rapid clinical improvement. A repeat Schilling test after 4 months of therapy showed a normal VB12 absorption in the presence of IF. These findings suggest that VB12 malabsorption of the 1st Schilling test was due to intestinal dysfunction caused by the VB12 deficiency state itself, and the improvement of VB12 absorption with IF after therapy suggests a pathogenesis similar to pernicious anemia in this patient.

Topics: Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Gastrectomy; Humans; Intrinsic Factor; Male; Postoperative Complications; Schilling Test; Vitamin B 12

Three familial cases of congenital intrinsic factor deficiency are reported: the stress is put on the interest of gastric investigations and especially of the quantity of intrinsic factor in the gastric juice when investigating megaloblastic anemia due to vitamin B12 deficiency. The study of the level of intrinsic factor in the gastric juice is proposed as a test for identifying carriers.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Child, Preschool; Female; Gastric Juice; Genetic Carrier Screening; Humans; Infant; Intrinsic Factor; Vitamin B 12 Deficiency

The results of an Interregional quality assurance scheme for tests in the diagnosis of megaloblastic anaemia were reviewed to assess the methods used. Serum folate assays showed great variation between methods, partly due to limitations in assessment by external quality assurance. Red cell folate assays yielded widely different results and much imprecision due both to the differences in preparation of the haemolysate and to the problems inherent in radioassay of a mixture of folate compounds. Intrinsic factor antibody tests showed appreciable variation in sensitivity. There was considerable inconsistency in the detection of polymorph nuclear hypersegmentation.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Erythrocytes; Folic Acid; Humans; Intrinsic Factor; Laboratories; Methods; Neutrophils; Quality Control; Vitamin B 12

Topics: Adolescent; Anemia, Macrocytic; Follow-Up Studies; Humans; Intestinal Absorption; Intrinsic Factor; Lymphangiectasis, Intestinal; Malabsorption Syndromes; Male; Protein-Losing Enteropathies; Proteinuria; Vitamin B 12; Vitamin B 12 Deficiency

Lymphocyte subpopulations and intrinsic factor and gastric parietal cell antibodies have been measured in 23 patients with megaloblastic anaemia who responded to treatment with hydroxocobalamin. The ratio of helper (OKT4) to suppressor (OKT8) lymphocytes was significantly increased in patients with intrinsic factor antibody compared with those who lacked the antibody. No such correlation was found for gastric parietal cell antibody. Alterations in the lymphocyte helper to suppressor (OKT4:OKT8) ratio may be associated with pernicious anaemia.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies, Monoclonal; Autoantibodies; Humans; Hydroxocobalamin; Intrinsic Factor; Leukocyte Count; Lymphocytes; Parietal Cells, Gastric; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory

The first case of megaloblastic anemia due to selective malabsorption of vitamin B(12) and vitamin B(12)-intrinsic factor is described in an otherwise normal female adult, in whom pernicious anemia had previously been diagnosed.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Ileum; Intrinsic Factor; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Diagnosis, Differential; Female; Humans; Infant; Intrinsic Factor

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Deoxyuridine; Erythrocyte Indices; Folic Acid; Humans; Intrinsic Factor; Reagent Kits, Diagnostic; Schilling Test; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Gastrectomy; Humans; Intrinsic Factor; Nutrition Disorders

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Bone Marrow Cells; DNA; Ferritins; Folic Acid Deficiency; Intestinal Mucosa; Intrinsic Factor; Iron; Myelin Sheath; Schilling Test; Vitamin B 12 Deficiency

Two cases of intrinsic factor deficiency with normal hydrochloric acid production are presented. Both patients had markedly reduced intrinsic factor secretion and substantial titers of type I (blocking) intrinsic factor antibodies. No parietal cell antibodies were recognized by immunofluorescence in either case. Three hypotheses are offered to explain these findings: (a) These patients have congenital intrinsic factor deficiency that remained in the preanemic phase until adulthood; (b) they have pernicious anemia detected at a stage before gastric mucosal atrophy and achlorhydria have occurred; or (c) they represent cases of a new syndrome characterized by isolated intrinsic factor deficiency.

Topics: Anemia, Macrocytic; Female; Gastric Acid; Gastric Mucosa; Humans; Intrinsic Factor; Male; Middle Aged

A specific gastritis was induced in BALC/c (+/?) mice by thymectomy within 3 days after birth (25 to 45 per cent) or in BALB/c (nu/nu) mice by the injection of spleen cells (10(7)) from neonatally thymectomized mice (70 per cent). Normal peripheral lymphoid cells, irrespective of the sex and dose, were generally ineffective in inducing gastritis in nude mice, while thymus cells were partially effective (30 per cent). The induced gastritis was characterized by a loss of chief and parietal cells and by varying degrees of lymphoid cell infiltration along thickened muscularis mucosa. The fundic mucosa was replaced by mucous necklike immature cells, and there was a rise of pH of the gastric juice. Argyrophilic endocrine cells escaped the inflammation and increased in number. The gastritis induced in nude mice was generally more severe and was often followed by severe macrocytic anemia. Megaloblast-like large immature erythroid cells were numerous in the spleens of affected mice. Antiparietal cell antibodies (IgG) were always demonstrated by an indirect immunofluorescence test in the sera of gastritis-developing mice, but were absent in sera of normal or untreated conventional nude mice. These findings suggest a new animal model of pernicious anemia in man.

Topics: Anemia, Macrocytic; Animals; Animals, Newborn; Autoimmune Diseases; Disease Models, Animal; Female; Gastric Mucosa; Gastritis; Immunoglobulin G; Immunoglobulin M; Intrinsic Factor; Male; Mice; Mice, Nude; Spleen; Thymectomy

Myasthenia gravis (MG) is an autoimmune disease often associated with other autoimmune disorders. A case history of MG with a coexisting atypical megaloblastic anaemia with vitamin B12 deficiency and anti Intrinsic Factor (IF) antibodies, led to a study of humoral and cellular immunity to IF in 81 MG patients. Within this series, 3 other patients had a disturbed humoral and cellular immunity to IF. These 3 patients presented no other features of pernicious anaemia. The possible origins and significance of the anti IF antibodies in MG patients are discussed.

Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Antibody Formation; Child; Female; Humans; Immunity, Cellular; Immunologic Techniques; Intrinsic Factor; Male; Middle Aged; Myasthenia Gravis; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Diagnosis, Differential; FIGLU Test; Gastric Juice; Gastritis; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Intrinsic Factor; Prognosis; Vitamin B 12

Topics: Anemia, Macrocytic; Child; Female; Humans; Intrinsic Factor; Vitamin B 12

In most cases megaloblastic anaemias are the sequel of a deficiency of vitamin B12, more infrequently of a deficiency of folic acid of different etiology. Oriented to frequency and anamnesis the diagnostics follows the leading symptoms of pernicious anaemia (straw colour, glossitis, achlorhydria) and on the basis of special findings in the peripheral blood (hyperchromacia, megalocytosis, much decreased number of reticulocytes, increased iron and bilirubin level) it leads to the proved suspicion of a megaloblastic anaemia. This suspicion is ascertained by the investigation of the bone-marrow, with the help of aimed investigations the anaemia is further clarified differential-diagnostically. An unclear anaemia should not be treated ex juvantibus with vitamin B12 and/or folic acid. The therapy, always taking into consideration a possible basic disease, is carried out by parenteral application of vitamin B12, possibly in form of hydroxocobalamine or by folic acid. In persisting disturbance of the resorption of vitamin B12 on account of the threatening complication of a funicular spinal disease the long-term therapy must never be interrupted, unless in normal haematological findings.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Diagnosis, Differential; Humans; Intrinsic Factor; Vitamin B 12; Vitamin B 12 Deficiency

The diagnostic interest of a search for anti-intrinsic factor antibodies is emphasized from the authors research on more than 200 patients or controls. Antibodies of type I, so-called blocking antibodies, were detected in 66% of cases where the diagnosis of pernicious anemia was made. Type II, so-called precipitating antibodies, were found in 47% of patients with antibodies of type I and only in the latter. Certain etiological factors, already noted in the world literature, were found, in particular the link with the female sex and with blood group A. The specificity of these antibodies is very great and false positives are exceptional. We did not find them in any of the 104 controls. They were observed, however, in 5 of the 56 patients where the diagnosis of pernicious anemia was not definite, but it is likely that, in these 5 cases, pernicious anemia existed with some other disease. Our study also showed the limits of other methods of investigation of this disease; hypovitaminimia B12 is often corrected by treatment without proper inductions and B12 malabsorption on the Schilling test may not be corrected by the addition of intrinsic factor.

Topics: Anemia, Macrocytic; Anemia, Pernicious; Antibody Specificity; Autoantibodies; Autoimmune Diseases; Blood Group Antigens; Diagnosis, Differential; False Positive Reactions; Female; Gastric Juice; Hematologic Diseases; Humans; Immunodiffusion; Intrinsic Factor; Male; Precipitins; Radioimmunoassay; Schilling Test; Sex Factors; Vitamin B 12

Because virtually all cases of vitamin B12 deficiency seen in this country are due to malabsorption, the availability of radioactive vitamin B12 for direct measurement of absorption of this essential nutrient has proved to be of great clinical value. These tests are useful not only in demonstrating vitamin B12 malabsorption but also often in defining the pathophysiological mechanism responsible for this abnormality. The urinary excretion test of Schilling remains the most useful test for vitamin B12 absorption. Minor precautions and modifications in technique make the test results more reliable and easier to interpret. The 8-hr plasma test for vitamin B12 absorption can no longer be considered acceptable. Some patients with vitamin B12 malabsorption have results in the normal range when studied by this method. Serum vitamin B12 assays utilizing radioactive vitamin B12 and the isotope dilution principle are not widely used and are useful screening tests. Low normal or borderline results observed in patients with clinical evidence suggestive of vitamin B12 deficiency should be interpreted with caution or confirmed by radioactive vitamin B12 absorption studies. Radioactive vitamin B12 can also be used for rapid, reliable assay of gastric intrinsic factor, antibody to intrinsic factor and unsaturated vitamin B12 serum. Methods using radioactive folate compounds for similar in vivo and in vitro studies are not yet applicable for routine use in nuclear medicine laboratories.

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Cobalt Radioisotopes; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intrinsic Factor; Radioimmunoassay; Radioisotope Dilution Technique; Schilling Test; Tritium; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Gastrectomy; Humans; Ileum; Intrinsic Factor; Malabsorption Syndromes; Metabolism, Inborn Errors; Schilling Test; Time Factors; Vitamin B 12

Topics: Afferent Loop Syndrome; Anemia, Macrocytic; Diarrhea; Dumping Syndrome; Folic Acid Deficiency; Gastrectomy; Gastric Juice; Gastrins; Humans; Intestinal Absorption; Intrinsic Factor; Mucus; Osteoporosis; Postgastrectomy Syndromes; Stomach Neoplasms; Vitamin B 12 Deficiency; Vomiting

Topics: Administration, Oral; Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Intrinsic Factor; Peutz-Jeghers Syndrome; Tetracycline; Vitamin B 12 Deficiency

Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Diagnosis, Differential; Female; Humans; Intestinal Absorption; Intrinsic Factor; Male; Middle Aged; Schilling Test; Vitamin B 12

Topics: Adolescent; Adult; Agammaglobulinemia; Anemia, Macrocytic; Anemia, Megaloblastic; Antibody Formation; Chronic Disease; Female; Gastric Juice; Humans; Immunoglobulin A; Immunoglobulin G; Immunologic Deficiency Syndromes; Intrinsic Factor; Malabsorption Syndromes; Male; Proteinuria; Syndrome; Vitamin B 12 Deficiency

Topics: Adolescent; Anemia, Macrocytic; Anemia, Pernicious; Chronic Disease; Consanguinity; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Recurrence; Vitamin B 12 Deficiency

Two siblings with megaloblastic anemia responsive to parenteral vitamin B(12) were studied to elucidate the cause of the B(12) deficiency. Gastric juice from both contained acid and functional intrinsic factor. Serum contained transcobalamin II and lacked antibodies to intrinsic factor. Schilling tests showed vitamin B(12) malabsorption uncorrected by hog intrinsic factor or pancreatic extract. Other parameters of small intestinal function were normal. Proteinuria was initially present in both but cleared in one following treatment with B(12). These patients with "familial selective vitamin B(12) malabsorption" are the first reported from Canada. Only 37 cases have been reported in the world literature to date.

Topics: Anemia, Macrocytic; Child; Child, Preschool; Cobalt Radioisotopes; Female; Follow-Up Studies; Gastric Juice; Humans; Intestinal Absorption; Intrinsic Factor; Male; Schilling Test; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Africa; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Diagnosis, Differential; Humans; Intrinsic Factor

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Erythrocyte Count; Folic Acid; Histamine; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; Pentagastrin; Reticulocytes; Schilling Test; South Africa; Stimulation, Chemical; Syndrome; Tetracycline; Vitamin B 12

Topics: Anemia, Macrocytic; Cell Nucleus; Child; Female; Humans; Intrinsic Factor; Pigmentation Disorders; Skin; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adolescent; Adult; Age Factors; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Black or African American; Black People; Diagnosis, Differential; Ethnicity; Folic Acid; Gastric Juice; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; South Africa; Syndrome; Tetracycline; Vitamin B 12

Topics: Anemia, Macrocytic; Cobalt Isotopes; Feces; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Vitamin B 12

Topics: Anemia, Macrocytic; Female; Fetus; Glycoproteins; Humans; Ileum; Intrinsic Factor; Malabsorption Syndromes; Pregnancy; Protein Binding; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Bone Marrow Examination; Diagnosis, Differential; Female; Gastric Mucosa; Humans; Intrinsic Factor; Schilling Test; Syndrome

Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Cobalt Isotopes; Female; Humans; Injections, Intramuscular; Intrinsic Factor; Male; Methods; Middle Aged; Schilling Test; Scintillation Counting; Vitamin B 12

Topics: Adolescent; Anemia, Macrocytic; Humans; Immunologic Deficiency Syndromes; Intrinsic Factor; Malabsorption Syndromes; Male; Proteinuria; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adolescent; Anemia, Macrocytic; Anemia, Pernicious; Antigens; Chromatography; Chromatography, Gel; Cobalt Isotopes; Gastric Juice; Humans; Intestinal Mucosa; Intrinsic Factor; Isoelectric Focusing; Malabsorption Syndromes; Male; Vitamin B 12

Topics: Administration, Oral; Anemia, Macrocytic; Anemia, Pernicious; Animals; Antibodies; Antibody Specificity; Erythrocyte Count; Gastrectomy; Hematocrit; Humans; Intrinsic Factor; Swine; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Pernicious; Child, Preschool; Female; Growth Disorders; Humans; Intrinsic Factor; Vitamin B 12

Topics: Adult; Anemia, Macrocytic; Autoantibodies; Epidermolysis Bullosa; Female; Fluorescent Antibody Technique; Humans; Intrinsic Factor; Keratins; Skin; Thyroiditis

Topics: Adolescent; Anemia, Macrocytic; Bone Marrow Examination; Female; Gastric Juice; Humans; Hydrochloric Acid; Infant; Intrinsic Factor; Kidney Function Tests; Malabsorption Syndromes; Male; Proteinuria; Schilling Test; Vitamin B 12

Topics: Achlorhydria; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Cobalt Isotopes; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Radioimmunoassay; Vitamin B 12

Topics: Anemia, Macrocytic; Child; Heart Defects, Congenital; Humans; Intrinsic Factor; Male; Metabolism, Inborn Errors; Schilling Test; Vitamin B Complex

Topics: Adolescent; Anemia, Macrocytic; Anemia, Pernicious; Diet; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Male; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Anemia, Macrocytic; Antibodies; Cell Survival; Cobalt Isotopes; Diagnosis, Differential; Erythrocytes; Feces; Female; Folic Acid; Gastric Juice; Hematologic Diseases; Hemorrhage; Humans; Intrinsic Factor; Iron; Iron Isotopes; Plasma Volume; Radioimmunoassay; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Schilling Test; Spleen; Vitamin B 12; Whole-Body Counting

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Cestode Infections; Cobalt Isotopes; Female; Gastric Juice; Humans; Intrinsic Factor; Male; Methods; Middle Aged; Schilling Test; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Pernicious; Anticonvulsants; Ascorbic Acid Deficiency; Contraceptives, Oral; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Nutritional Requirements; Schilling Test; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Child, Preschool; Diagnosis, Differential; Female; Gastric Juice; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Anemia, Pernicious; Antibody Formation; Autoantibodies; Autoimmune Diseases; Cell Migration Inhibition; Gastric Juice; Humans; Intestinal Absorption; Intrinsic Factor; Nutritional Requirements; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia, Macrocytic; Folic Acid Deficiency; Humans; Intellectual Disability; Intestinal Absorption; Intrinsic Factor; Metabolism, Inborn Errors; Orotic Acid; Transferases; Vitamin B 12 Deficiency

Topics: Absorption; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Animals; Biological Assay; Centrifugation; Cobalt Isotopes; Dialysis; Gastrectomy; Gastric Juice; Guinea Pigs; Heating; Histamine; Humans; In Vitro Techniques; Intestinal Mucosa; Intrinsic Factor; Male; Middle Aged; Pepsin A; Proteins; Vitamin B 12

Topics: Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Cobalt Isotopes; Female; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Vitamin B 12

Three patients are described, and they provide further evidence that deficiency of folic acid and vitamin B(12) may sometimes affect small intestinal function. Malabsorption of both xylose and vitamin B(12) returned to normal in one patient after treatment of a megaloblastic anaemia due to dietary deficiency of folic acid. Impaired absorption of vitamin B(12) was corrected by vitamin B(12) therapy in the other two patients. The initial cause of the vitamin B(12) deficiency in one patient was not apparent, but she was taking Gynovlar 21, which may have been an aetiological factor. In the third patient the small intestinal defect was secondary to pernicious anaemia, and in a group of 98 other patients with pernicious anaemia intrinsic factor did not improve vitamin B(12) absorption in six, and only partially corrected absorption in 30. The significance of these observations is discussed.

Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Contraceptives, Oral; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestine, Small; Intrinsic Factor; Malabsorption Syndromes; Vitamin B 12; Vitamin B 12 Deficiency; Xylose

Topics: Adult; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Blood Cell Count; Diagnosis, Differential; Diphyllobothriasis; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adrenal Glands; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Female; Fluorescent Antibody Technique; Goiter; Humans; Hyperthyroidism; Intrinsic Factor; Male; Middle Aged; Pancreas; Stomach; Thyroid Gland; Thyroid Neoplasms

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Black People; Cobalt Isotopes; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Male; Middle Aged; Radiometry; Vitamin B 12; Vitamin B 12 Deficiency; White People

Topics: Anemia, Macrocytic; Anemia, Pernicious; Body Height; Body Weight; Chromosome Aberrations; Chromosome Disorders; Diet Therapy; Female; Genes, Recessive; Growth; Humans; Infant; Infant, Newborn; Intellectual Disability; Intelligence Tests; Intrinsic Factor; Male; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Achlorhydria; Anemia, Macrocytic; Gastrins; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Radioimmunoassay; Stimulation, Chemical; Time Factors; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Pernicious; Child; Child, Preschool; Female; Humans; Intrinsic Factor

Topics: Aged; Anemia, Macrocytic; Anemia, Pernicious; Cobalt Isotopes; Female; Gastrectomy; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Male; Middle Aged; Radiometry; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Adolescent; Anemia, Macrocytic; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Vitamin B 12 Deficiency

Topics: Achlorhydria; Aged; Anemia, Macrocytic; Antibodies; Chemical Precipitation; Cobalt Isotopes; Electrophoresis; Gastric Juice; Humans; In Vitro Techniques; Intestinal Absorption; Intrinsic Factor; Jejunum; Male; Vitamin B 12

Topics: Adult; Anemia, Macrocytic; Biological Assay; Blood Transfusion; Bone Marrow; Diet, Vegetarian; Folic Acid; Histamine; Humans; Intrinsic Factor; Iron; Jejunum; Male; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Blood Chemical Analysis; Clinical Laboratory Techniques; Cobalt Isotopes; Gastrectomy; Glutamates; Hematinics; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Lactobacillus; Pharmacology; Radiometry; Vitamin B 12

Topics: Aged; Anemia, Hypochromic; Anemia, Macrocytic; Gastrectomy; Humans; Intrinsic Factor; Iron; Male; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Carbachol; Celiac Disease; Cobalt Isotopes; Colonic Neoplasms; Duodenal Ulcer; Folic Acid; Folic Acid Deficiency; Gastric Acidity Determination; Gastric Juice; Histamine; Humans; Insulin; Intrinsic Factor; Male; Pharmacology; Physiology; Sprue, Tropical; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Pernicious; Celiac Disease; Deficiency Diseases; Diagnosis; Female; Folic Acid; Humans; Intrinsic Factor; Malabsorption Syndromes; Physiology; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Sprue, Tropical; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Black People; Blood Chemical Analysis; Bone Marrow; Deficiency Diseases; Drug Therapy; Folic Acid; Folic Acid Deficiency; Gastric Juice; Gastric Mucosa; Glutamates; Hematopoiesis; Humans; Hydrochloric Acid; Intrinsic Factor; Pathology; Pharmacology; Urine; Vitamin B 12

Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Blood Cell Count; Deficiency Diseases; Drug Therapy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intrinsic Factor; Malabsorption Syndromes; Metabolism; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Drug Therapy; Gastrectomy; Humans; Intrinsic Factor; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Biotin; Humans; Intestines; Intrinsic Factor; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Celiac Disease; Cobalt Isotopes; Humans; Intrinsic Factor; Schilling Test; Urine; Vitamin B 12

Topics: Anemia; Anemia, Macrocytic; Animals; Folic Acid; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Rats; Vitamin B 12; Vitamin B Complex

Topics: Anemia; Anemia, Macrocytic; Gastrectomy; Humans; Intrinsic Factor; Stomach; Vitamin B 12