intrinsic-factor and Achlorhydria

Topics: Achlorhydria; Anemia, Pernicious; Humans; Ileal Diseases; Intestinal Absorption; Intestine, Small; Intrinsic Factor; Malabsorption Syndromes; Pancreatitis; Postgastrectomy Syndromes; Protein Binding; Transcobalamins; Vitamin B 12; Vitamin B Deficiency

Topics: Achlorhydria; Anemia, Pernicious; Animals; Binding Sites; Biological Transport; Blind Loop Syndrome; Cestode Infections; Folic Acid Deficiency; Humans; Intestinal Absorption; Intestine, Small; Intrinsic Factor; Liver; Malabsorption Syndromes; Pancreas; Postgastrectomy Syndromes; Protein Binding; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Acetylcholine; Achlorhydria; Adenoma; Anemia, Pernicious; Atrophy; Duodenal Ulcer; Endocrine System Diseases; Gastrectomy; Gastric Juice; Gastric Mucins; Gastric Mucosa; Gastrins; Gastritis; Humans; Hyperplasia; Intrinsic Factor; Stomach Ulcer; Vagus Nerve; Zollinger-Ellison Syndrome

The common but incompletely understood entity of malabsorption of food bound cobalamin is generally presumed to arise from gastritis and/or achlorhydria.. To conduct a systematic comparative examination of gastric histology and function.. Nineteen volunteers, either healthy or with low cobalamin levels, were prospectively studied without prior knowledge of their absorption or gastric status.. All subjects underwent prospective assessment of food cobalamin absorption by the egg yolk cobalamin absorption test, endoscopy, histological grading of biopsies from six gastric sites, measurement of gastric secretory function, assay for serum gastrin and antiparietal cell antibodies, and direct tests for Helicobacter pylori infection.. The six subjects with severe malabsorption (group I) had worse histological scores overall and lower acid and pepsin secretion than the eight subjects with normal absorption (group III) or the five subjects with mild malabsorption (group II). However, histological findings, and acid and pepsin secretion overlapped considerably between individual subjects in group I and group III. Two distinct subgroups of three subjects each emerged within group I. One subgroup (IA) had severe gastric atrophy and achlorhydria. The other subgroup (IB) had little atrophy and only mild hypochlorhydria; the gastric findings were indistinguishable from those in many subjects with normal absorption. Absorption improved in the two subjects in subgroup IB and in one subject in group II who received antibiotics, along with evidence of clearing of H pylori. None of the subjects in group IA responded to antibiotics.. Food cobalamin malabsorption arises in at least two different gastric settings, one of which involves neither gastric atrophy nor achlorhydria. Malabsorption can respond to antibiotics, but only in some patients. Food cobalamin malabsorption is not always synonymous with atrophic gastritis and achlorhydria, and hypochlorhydria does not always guarantee food cobalamin malabsorption.

Topics: Achlorhydria; Adult; Aged; Aged, 80 and over; Biopsy; Case-Control Studies; Female; Gastric Mucosa; Gastrins; Gastritis, Atrophic; Gastroscopy; Helicobacter pylori; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Parietal Cells, Gastric; Prospective Studies; Schilling Test; Vitamin B 12 Deficiency

Ten cases of pernicious anaemia seen over a 15-year period (1973-1988) in a Lagos hospital are presented. Their ages ranged from 34 to 67 with a mean of 53.6 years. Females outnumbered males 6 to 4. Complications seen include gastric carcinoma, myelopathy, peripheral neuropathy, skin hyperpigmentation, hair depigmentation and diarrhoea. Reluctance to consider the diagnosis owing to firmly held notions of its rarity and a penchant for empirically treating chronic anaemias with all available haematinics and blood transfusion are probably contributory to its underdiagnosis. The fact that seven of the patients presented were seen in the last three years and three of them in the last one year raises the possibility of an increasing incidence of pernicious anaemia in Africans. The disease may be much less rare in Africans than once believed, and medical education should emphasize its existence and advocate greater care in the management of chronic anaemias.

Topics: Achlorhydria; Adult; Aged; Anemia, Pernicious; Autoantibodies; Autoimmune Diseases; Bone Marrow; Diagnosis, Differential; Fatigue; Female; Humans; Hydroxocobalamin; Incidence; Intrinsic Factor; Male; Middle Aged; Nigeria; Peripheral Nervous System Diseases; Pigmentation Disorders; Psychophysiologic Disorders; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency

The effect of 60 mg oral omeprazole daily for 9 days on intrinsic factor and gastric acid secretion was studied in eight healthy volunteers. Gastric secretion studies were performed during saline and 0.1 M HCl perfusion before and after omeprazole administration. During dosing with omeprazole, basal gastric acid output diminished by 94%, and pentagastrin-stimulated acid output by 97%. Basal, peak and steady-state stimulated intrinsic factor output were unaffected by omeprazole. It is concluded that high oral doses of omeprazole suppress gastric acid secretion to very low levels but they do not affect intrinsic factor secretion. Intrinsic factor secretion was also unaffected by profound hypochlorhydria.

Topics: Achlorhydria; Gastric Acid; Humans; Intrinsic Factor; Male; Omeprazole; Pentagastrin; Perfusion; Phenolsulfonphthalein

The megaloblastic anaemia observed in patients with chronic atrophic gastritis is usually due to malabsorption of vitamin B12. In some cases, the absence of intrinsic factor supports the diagnosis of pernicious anaemia but other factors, the importance of which varies from case to case, are also involved. They include proliferation of bacteria in the lumen of the gut, intestinal cell abnormalities resulting from lack of vitamin B12 and low hydrochloric acid output with subsequent reduction in the release of vitamin B12 from foodstuffs. With regard to treatment, it would seem justified to combine oral broad-spectrum antibiotics with parenteral administration of vitamin B12.

Topics: Achlorhydria; Aged; Anemia, Megaloblastic; Female; Gastritis; Gastritis, Atrophic; Humans; Intestine, Small; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Vitamin B 12 Deficiency

Three hundred and one first-degree relatives (series) of 73 gastric carcinoma patients and 358 control relatives (controls) of 73 computer-matched probands from a general population were studied by direct-vision gastric biopsy and functional and immunological examinations. The controls were representative of the series with respect to age, sex, birth and dwelling place, and relationship of the relatives. Series and controls behaved similarly as to total prevalence of gastritis, age and sex distribution of gastritis, serum gastrin level, and circulating gastric antibodies. On the other hand, the total prevalence of hyperplastic polyps, atrophic gastritis of the body and antrum, severe atrophic gastritis of the body, intestinal metaplasia, epithelial atypia, and achlorhydria was significantly higher in the series than in the controls. In subjects below 50 years of age the prevalence of severe atrophic gastritis of the body, intestinal metaplasia, and epithelial atypia was also significantly higher in the series. In addition, the mean age of the subjects with atrophic gastritis, intestinal metaplasia, epithelial atypia, and achlorhydria was lower in the series than in controls; however, significant differences were found only in female subjects with epithelial atypia and atrophic gastritis of the body. The results suggest that the prevalence of signs often considered premalignant is significantly higher in carcinoma relatives than in controls and that these signs show a trend to occur at an earlier age in carcinoma relatives. This could explain the significantly higher than expected death rate from gastric carcinoma in close relatives with this disease, found in the present and in other series.

Topics: ABO Blood-Group System; Achlorhydria; Adolescent; Adult; Age Factors; Antibodies; Endoscopy; Epithelium; Female; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Intestines; Intrinsic Factor; Male; Metaplasia; Middle Aged; Stomach Neoplasms

Topics: Achlorhydria; Aged; Anemia, Pernicious; Atrophy; Chronic Disease; Female; Gastritis; Humans; Intestine, Small; Intrinsic Factor; Malabsorption Syndromes; Pepsin A

Topics: Achlorhydria; Anemia, Pernicious; Humans; Intrinsic Factor

Topics: Achlorhydria; Anemia, Pernicious; Atrophy; Fasting; Gastrins; Gastritis; Humans; Intrinsic Factor; Radioimmunoassay

Topics: Achlorhydria; Adult; Aged; Anemia, Pernicious; Atrophy; Autoantibodies; Autoimmune Diseases; Female; Follow-Up Studies; Gastritis; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Schilling Test; Time Factors; Vitamin B 12

Topics: Achlorhydria; Adolescent; Adult; Age Factors; Anemia, Pernicious; Autoantibodies; Gastric Acidity Determination; Humans; Immunoglobulin A; Immunologic Deficiency Syndromes; Intrinsic Factor; Male; Middle Aged; Oral Manifestations; Pedigree; Schilling Test; Vitamin B 12

Topics: Achlorhydria; Anemia, Pernicious; Celiac Disease; Child; Eye Manifestations; Gastric Mucosa; Glossitis; Growth Disorders; Humans; Injections, Intramuscular; Intestinal Mucosa; Intrinsic Factor; Male; Neurologic Manifestations; Paresthesia; Skin Diseases; Skin Manifestations; Vitamin B 12; Vitiligo

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Erythrocyte Count; Folic Acid; Histamine; Humans; Intrinsic Factor; Malabsorption Syndromes; Middle Aged; Pentagastrin; Reticulocytes; Schilling Test; South Africa; Stimulation, Chemical; Syndrome; Tetracycline; Vitamin B 12

Topics: Achlorhydria; Adolescent; Agammaglobulinemia; Anemia, Pernicious; Antibody Formation; Biopsy; Cell Migration Inhibition; Diseases in Twins; DNA; Female; Gastric Mucosa; Humans; Immunoglobulin A; Immunoglobulin G; Intrinsic Factor; Lymph Nodes; Lymphocytes; Pylorus; Skin Tests; Thymidine; Tritium

Topics: Achlorhydria; Atrophy; Autoantibodies; Biopsy; Duodenal Ulcer; Duodenum; Follow-Up Studies; Gastrectomy; Gastric Mucosa; Gastritis; Humans; Intrinsic Factor; Iron; Postoperative Complications; Stomach

Topics: Achlorhydria; Anemia, Pernicious; Antibodies; Biopsy; Cobalt Isotopes; Complement Fixation Tests; Deficiency Diseases; Fats; Feces; Female; Folic Acid; Gastric Juice; Gastric Mucosa; Gastritis; Humans; India; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Male; Middle Aged; Vitamin B 12; Xylose

Topics: Achlorhydria; Adolescent; Adult; Age Factors; Aged; Anemia, Pernicious; Antibodies; Autoantibodies; Autoimmune Diseases; Child, Preschool; Cobalt Isotopes; Female; Gastric Juice; Gastric Mucosa; Histamine; Humans; Hydrogen-Ion Concentration; Intrinsic Factor; Male; Middle Aged; Schilling Test; Sex Factors; Vitamin B 12; Vitiligo

Topics: Achlorhydria; Adult; Age Factors; Aged; Biopsy; Blood Glucose; Dermatitis Herpetiformis; Feces; Female; Gastric Juice; Gastric Mucosa; Humans; Intrinsic Factor; Lipids; Male; Middle Aged; Sulfonamides

Topics: Achlorhydria; Adult; Aged; Anemia, Pernicious; Female; Humans; Intrinsic Factor; Male; Middle Aged; Smoking; Stomach Neoplasms; Vitamin B 12 Deficiency

Topics: Achlorhydria; Anemia, Macrocytic; Anemia, Pernicious; Autoantibodies; Cobalt Isotopes; Folic Acid Deficiency; Gastric Juice; Humans; Intrinsic Factor; Radioimmunoassay; Vitamin B 12

Topics: Achlorhydria; Anemia, Hypochromic; Anemia, Pernicious; Animals; Female; Gastric Juice; Gastric Mucosa; Hemoglobinometry; Hydrochloric Acid; Immune Sera; Intestinal Absorption; Intrinsic Factor; Iron; Iron Isotopes; Liver; Radiation Effects; Rats; Stomach

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Antibodies; Cestode Infections; Cobalt Isotopes; Female; Gastric Juice; Humans; Intrinsic Factor; Male; Methods; Middle Aged; Schilling Test; Vitamin B 12

Topics: Achlorhydria; Anemia, Pernicious; Cobalt Isotopes; Diagnosis, Differential; Gastric Juice; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Radiometry; Succinates; Vitamin B 12

Topics: Achlorhydria; Adolescent; Adult; Aged; Anemia, Pernicious; Biopsy; Chronic Disease; Female; Gastric Juice; Gastric Mucosa; Gastritis; Histamine; Humans; Intrinsic Factor; Male; Middle Aged; Stomach

Topics: Achlorhydria; Anemia, Pernicious; Duodenal Ulcer; Female; Gastric Juice; Gastric Mucosa; Histamine; Humans; Intrinsic Factor; Male; Radioimmunoassay; Stimulation, Chemical; Stomach; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer

Topics: Achlorhydria; Adult; Agammaglobulinemia; Anemia, Pernicious; Antibodies; Arthritis, Rheumatoid; Atrophy; Autoimmune Diseases; Colitis, Ulcerative; Diarrhea; Female; Fluorescent Antibody Technique; gamma-Globulins; Gastric Mucosa; Gastritis; Giardiasis; Humans; Hypersensitivity; Hypersensitivity, Delayed; Infections; Intrinsic Factor; Male; Middle Aged; Vitamin B 12

Topics: Achlorhydria; Aged; Anemia, Pernicious; Antibody Formation; Autoantibodies; Female; Fluorescent Antibody Technique; Gastric Acidity Determination; Gastric Juice; Histamine Release; Humans; Intrinsic Factor; Male; Middle Aged; Schilling Test; Stomach Neoplasms; Vitamin B 12

Topics: Absorption; Achlorhydria; Anemia, Pernicious; Cobalt Isotopes; Diagnosis, Differential; Diet; Fasting; Gastrectomy; Humans; Intrinsic Factor; Malabsorption Syndromes; Methods; Radionuclide Imaging; Stomach; Vitamin B 12

Topics: Achlorhydria; Adult; Anemia, Pernicious; Female; Gastric Acidity Determination; Gastric Juice; Histamine; Humans; Hyperthyroidism; Hypothyroidism; Intrinsic Factor; Male; Middle Aged; Schilling Test; Stimulation, Chemical

Topics: Achlorhydria; Anemia, Pernicious; Gastric Juice; Humans; Intrinsic Factor

Topics: Achlorhydria; Anemia, Pernicious; Gastric Juice; Gastrins; Gastritis; Histamine; Humans; Intrinsic Factor; Radioimmunoassay; Schilling Test; Vitamin B 12

Topics: Achlorhydria; Adult; Age Factors; Aged; Anemia, Hypochromic; Anemia, Pernicious; Autoantibodies; Female; Fluorescent Antibody Technique; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Humans; Intrinsic Factor; Male; Middle Aged; Pepsin A; Rheumatoid Factor; Sex Factors; Thyroid Gland; Vitamin B 12

Topics: Achlorhydria; Anemia, Pernicious; Autoimmune Diseases; Gastritis; History, 19th Century; History, 20th Century; Intrinsic Factor; Prednisolone; Thyroid Diseases; Thyroiditis, Autoimmune; Vitamin B 12

Topics: Achlorhydria; Aged; Anemia, Pernicious; Animals; Antigen-Antibody Reactions; Atrophy; Biopsy; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Immune Sera; Intrinsic Factor; Male; Middle Aged; Prednisolone; Rats; Regeneration; Reticulocytes; Schilling Test; Stomach; Stomach Diseases; Thyroiditis, Autoimmune; Vitamin B 12

Topics: Achlorhydria; Adult; Aged; Anemia, Macrocytic; Anemia, Pernicious; Black People; Cobalt Isotopes; Female; Folic Acid Deficiency; Humans; Intrinsic Factor; Male; Middle Aged; Radiometry; Vitamin B 12; Vitamin B 12 Deficiency; White People

Topics: Achlorhydria; Adult; Aged; Anemia, Pernicious; Animals; Cattle; Cobalt Isotopes; Digestion; Female; Gastrectomy; Humans; In Vitro Techniques; Intestinal Absorption; Intrinsic Factor; Liver; Liver Extracts; Male; Middle Aged; Peptides; Rats; Swine; Vitamin B 12

Topics: Achlorhydria; Anemia, Macrocytic; Gastrins; Histamine; Humans; Intestinal Absorption; Intrinsic Factor; Malabsorption Syndromes; Radioimmunoassay; Stimulation, Chemical; Time Factors; Vitamin B 12

Topics: Achlorhydria; Adult; Anemia, Pernicious; Diagnosis, Differential; Gastric Juice; Gastritis; Histamine; Humans; Intrinsic Factor; Schilling Test; Vitamin B 12

Topics: Achlorhydria; Aged; Anemia, Pernicious; Blood Cell Count; Bone Marrow Examination; Diagnosis, Differential; Humans; Intrinsic Factor; Male; Schilling Test

Topics: Achlorhydria; Adult; Anemia, Pernicious; Antibodies; Female; gamma-Globulins; Gastric Juice; Gastric Mucosa; Humans; Immunoassay; Infant, Newborn; Infant, Newborn, Diseases; Intrinsic Factor; Maternal-Fetal Exchange; Pregnancy

Topics: Achlorhydria; Anemia, Hypochromic; Anemia, Pernicious; Gastric Mucosa; Gastrins; Humans; Intrinsic Factor; Peptic Ulcer; Peptides; Pylorus; Secretory Rate; Skin Tests; Vagotomy

Topics: Achlorhydria; Aged; Anemia, Macrocytic; Antibodies; Chemical Precipitation; Cobalt Isotopes; Electrophoresis; Gastric Juice; Humans; In Vitro Techniques; Intestinal Absorption; Intrinsic Factor; Jejunum; Male; Vitamin B 12

Topics: Achlorhydria; Anemia, Pernicious; Antibodies; Blood; Carotenoids; Humans; In Vitro Techniques; Intrinsic Factor; Malabsorption Syndromes; Schilling Test; Vitamin A; Vitamin B 12; Vitamin B 12 Deficiency; Xylose

Topics: Achlorhydria; Adolescent; Adult; Anemia, Pernicious; Antibodies; Biopsy; Blood; Child; Child, Preschool; Female; Gastric Juice; Gastritis; Humans; Hydrochloric Acid; In Vitro Techniques; Infant; Intrinsic Factor; Male; Stomach Diseases; Vitamin B 12

Topics: Achlorhydria; Anemia, Pernicious; Cobalt Isotopes; Gastric Juice; Humans; Immunoassay; Immunochemistry; In Vitro Techniques; Intrinsic Factor; Vitamin B 12

Topics: Achlorhydria; Anemia; Anemia, Pernicious; Animals; Cobalt Isotopes; Electrophoresis; Gastrectomy; Gastric Juice; Gastric Mucosa; Guinea Pigs; Histamine; In Vitro Techniques; Intestinal Mucosa; Intrinsic Factor; Pathology; Peptic Ulcer; Rats; Research; Saliva; Stomach Neoplasms; Urine; Vagus Nerve; Vitamin B 12

Topics: Achlorhydria; Anemia; Anemia, Pernicious; Blood; Carbachol; Gastric Juice; Gastritis; Gastritis, Atrophic; Geriatrics; Histamine; Humans; Hydrochloric Acid; Intrinsic Factor; Pathology; Pharmacology; Vitamin B 12

Topics: Achlorhydria; Anemia; Anemia, Pernicious; Atrophy; Chemical Phenomena; Chemistry; Erythropoiesis; Gastric Juice; Gastric Mucosa; Gastritis; Gastrointestinal Hormones; Humans; Intrinsic Factor; Metabolism; Peptic Ulcer; Pharmacology; Physiology; Vitamin B 12

Topics: Achlorhydria; Anemia, Pernicious; Duodenum; Gastric Fistula; Gastric Juice; Humans; Intrinsic Factor; Neoplasms; Polyps; Stomach Neoplasms

Topics: Achlorhydria; Gastric Juice; Gastritis; Gastritis, Atrophic; Intrinsic Factor

Topics: Achlorhydria; Anemia; Anemia, Pernicious; Corrinoids; Gastrectomy; Gastric Juice; Hematinics; Humans; Intrinsic Factor; Radioactivity; Stomach; Urine; Vitamin B 12

Topics: Achlorhydria; Administration, Oral; Anemia; Anemia, Pernicious; Corrinoids; Gastric Juice; Hematinics; Humans; Intrinsic Factor; Vitamin B 12

Topics: Achlorhydria; Anemia; Anemia, Pernicious; Duodenum; Humans; Intrinsic Factor

Topics: Achlorhydria; Anemia; Anemia, Pernicious; Humans; Intrinsic Factor; Thymus Plant