interleukin-8 and Polyneuropathies

interleukin-8 has been researched along with Polyneuropathies* in 2 studies

Other Studies

2 other study(ies) available for interleukin-8 and Polyneuropathies

Article	Year
IL-8 as a potential biomarker in Guillain-Barre Syndrome. European cytokine network, 2019, Dec-01, Volume: 30, Issue:4 This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8 levels in GBS compared to the other groups (p < 0.05). IL-8 could be considered a potential biomarker to differentiate GBS from CIDP. This distinction could be relevant in terms of therapeutic decisions and functional prognosis. Topics: Adult; Aged; Biomarkers; Diagnosis, Differential; Female; Guillain-Barre Syndrome; Humans; Interleukin-8; Male; Middle Aged; Migraine Disorders; Pilot Projects; Polyneuropathies; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Retrospective Studies; Tumor Necrosis Factor-alpha	2019
Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy. Muscle & nerve, 2019, Volume: 59, Issue:6 Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides.. To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and 113 controls.. Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy.. Median IL-6 and IL-10 serum concentrations differ between patients with anti-MAG neuropathy and other patients with IgM-PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune-mediated disease mechanisms. Muscle Nerve 59:694-698, 2019. Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; B-Lymphocytes; Cytokines; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoglobulin M; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-2; Interleukin-4; Interleukin-6; Interleukin-8; Male; Middle Aged; Myelin-Associated Glycoprotein; Paraproteinemias; Polyneuropathies; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Tumor Necrosis Factor-alpha	2019

Article

Year

IL-8 as a potential biomarker in Guillain-Barre Syndrome.

European cytokine network, 2019, Dec-01, Volume: 30, Issue:4

This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8 levels in GBS compared to the other groups (p < 0.05). IL-8 could be considered a potential biomarker to differentiate GBS from CIDP. This distinction could be relevant in terms of therapeutic decisions and functional prognosis.

Topics: Adult; Aged; Biomarkers; Diagnosis, Differential; Female; Guillain-Barre Syndrome; Humans; Interleukin-8; Male; Middle Aged; Migraine Disorders; Pilot Projects; Polyneuropathies; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Retrospective Studies; Tumor Necrosis Factor-alpha

2019

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy.

Muscle & nerve, 2019, Volume: 59, Issue:6

Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides.. To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and 113 controls.. Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy.. Median IL-6 and IL-10 serum concentrations differ between patients with anti-MAG neuropathy and other patients with IgM-PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune-mediated disease mechanisms. Muscle Nerve 59:694-698, 2019.

Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; B-Lymphocytes; Cytokines; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoglobulin M; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-2; Interleukin-4; Interleukin-6; Interleukin-8; Male; Middle Aged; Myelin-Associated Glycoprotein; Paraproteinemias; Polyneuropathies; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Tumor Necrosis Factor-alpha

2019