interleukin-8 and Narcolepsy

Narcolepsy is a sleep disorder characterized by a loss of hypocretin neurons in the hypothalamus. Inflammation is proposed as a mechanism for neurodegeneration in narcolepsy. Numerous studies have investigated peripheral cytokine measures in narcoleptic patients, though the results are not conclusive. The current systematic review and meta-analysis aims to address the question of how do serum/plasma cytokine levels change in narcolepsy.. A systematic search of the literature to July 2019, was conducted to identify studies that measured cytokine levels in patients with narcolepsy, compared with those in controls without narcolepsy.. Twelve studies were included in the meta-analysis: ten for interleukin (IL)-6, five for IL-8, three for IL-10, and ten for tumor necrosis factor alpha (TNF-α). Compared with controls, patients with narcolepsy had higher plasma levels of IL-6 (95% CI [0.22, 3.74]; P = 0.03) and TNF-α (95% CI [0.53, 4.18]; P = 0.01), while did not significantly differ in plasma IL-8 (95% CI [-1.64, 2.08]; P = 0.82) and IL-10 (95% CI [-1.29, 0.72]; P = 0.57) as well as serum IL-6 (95% CI [-1.48, 0.32], P = 0.21) and TNF-α (95% CI [-3.14, 0.19], P = 0.08) and CSF IL-8 (95% CI [-1.16, 0.41]; P = 0.35) levels. Patients with narcolepsy exhibited lower CSF IL-6 (95% CI [-0.66, 0.06]; P = 0.02) levels comparing with controls.. Patients with narcolepsy had elevated plasma levels of IL-6 and TNF-α and lower levels of CSF IL-6 than non-narcoleptic controls. Our results support the role of inflammation in the pathophysiology of narcolepsy. However, plasma levels of IL-8 and IL-10, serum levels of IL-6 and TNF-α and CSF IL-8 did not significantly differ between patients and controls.

Topics: Cytokines; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Narcolepsy; Tumor Necrosis Factor-alpha

Parasomnias in children manifest by unwanted behavior and various clinical picture. These disorders are associated with different sleep phases (REM, NREM) and sometimes threaten safety of children's sleep. They require differentiation with epileptic seizures because about 30% of epileptic seizures is associated with sleep. Some cytokines serum concentration changes were observed in sleep disturbances.. The search for peripheral markers of paroxysmal sleep disorders in children, which would be more simple method for differentiating between parasomnias and epileptic seizures.. The study included 21 hospitalized children (17 with epilepsy and 4 with parasomnias) at the age range from 2 months to 14 years. Their 2,5-hour sleep was recorded with videoelectroencephalography. Blood samples were taken two times (before sleep and up to 30 minutes after seizure occurrence or after 2,5-hour registration without seizure). Cytokine concentration (IL-6 and IL-8) was determined in these samples. Statistical analysis of the obtained results was performed.. The arithmetic means of both cytokine concentrations did not differ significantly between both examined groups of children, before and after videoEEG performance. Statistically significant differences of mean cytokine concentrations were also not found in children from both groups, between samples after sleep registration and before videoEEG. Comparison of the arithmetic means of IL-6 and IL-8 concentrations after calculating all values before videoEEG and after sleep registration was also performed in children with epilepsy and parasomnias altogether. Similarly, these values did not differ significantly. Comparison of the means of all concentrations of both cytokines between groups of children with epilepsy and parasomnias was performed and also did not differ significantly.. IL-6 as well as IL-8 concentrations can not have practical use in diagnostics of children's paroxysmal sleep disorders because they do not differentiate basic types of these disorders such as epilepsy and parasomnias.

Topics: Adolescent; Biomarkers; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans; Infant; Interleukin-6; Interleukin-8; Male; Narcolepsy