interleukin-8 and Meningeal-Neoplasms

To compare gene expression profiles between atypical meningiomas and normal meninges from the National Center of Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database to identify key genes and pathways.. The microarray datasets GSE43290 and GSE16581 were downloaded from Gene Expression Omnibus (GEO) database to explore the key genes involved in meningioma formation and reocurrence. Additionally, the relationship between the key genes identified and clinical factors, including age, survival, and recurrence, was assessed. To investigate the the biological functions of the key genes, the gene ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathways enrichment analyses were performed. Finally, the differences in immune infiltration between atypical meningiomas and healthy tissues were assessed.. A total of 286 hub genes were identified, which were enriched in leukocyte migration, collagen-containing extracellular matrix, signaling receptor activator activity, and receptor-ligand activity. The differentially expressed genes(DEGs) were mainly enriched in the IL-17 signaling pathway and focal adhesion. Among these hub genes, two overlapping genes, including CXCL8 and CXCL2, were selected as key genes which were correlated with tumor survival and recurrence. These two genes were enriched in mediating chemokine and cytokine responses, especially neutrophil and granulocyte responses, and influenced the immune cells infiltrated in the tumor tissue, thereby, influencing prognosis.. The implications of this study excavated the key genes in atypical meningiomas which could help us understand the molecular mechanisms and provide the candidate therapeutic targets.

Topics: Chemokine CXCL2; Computational Biology; Gene Expression Profiling; Gene Ontology; Humans; Interleukin-8; Meningeal Neoplasms; Meningioma

Topics: Animals; Dog Diseases; Dogs; Female; Interleukin-6; Interleukin-8; Male; Meningeal Neoplasms; Meningioma; Neoplasm Grading

Median survival of patients with leptomeningeal metastases (LM) is 4 to 6 months, with a few long-term survivors. Current prognostic factors for survival have limited value. The authors measured the CSF levels of nine inflammatory proteins in 57 patients with LM and determined their prognostic value. High interleukin (IL)-8 CSF levels predicted short-term survival independently. The data indicate that IL-8 CSF levels may serve as a prognosticator in patients with LM, but prospective validation is needed.

Topics: Adult; Aged; Arachnoid; Female; Humans; Immunoassay; Interleukin-8; Male; Meningeal Neoplasms; Middle Aged; Pia Mater; Predictive Value of Tests; Prognosis; Sex Factors; Survival Analysis; Survivors