interleukin-8 and Meibomian-Gland-Dysfunction

This study compared the changes in tear inflammatory cytokine levels after intense pulsed light (IPL) combined with meibomian gland expression (MGX) (IPL group) and instant warm compresses combined with MGX (physiotherapy group) as treatments for meibomian gland dysfunction (MGD)-related dry eye disease (DED) to explore their similarities and differences in therapeutic mechanisms.. At the last measurement, a significant decrease was observed in all tear cytokines for both IPL and physiotherapy groups compared with baseline. The IPL group showed greater reductions in IL-6, IL-6R, IL-1β, IL-13, and CCL11/Eotaxin than the physiotherapy group. TNF-α, CXCL8/IL-8, CXCL10/IP-10, IL-10, EGF, IL-1β, IFN-γ, and Lipocalin-2/NGAL levels continued to decrease with treatment time. Important interactions were found in the changes of IL-6 and IL-13 levels, where the levels first decreased and then slightly increased in the physiotherapy group after treatment, while they continued to decrease in the IPL group.. The mechanisms of IPL and physiotherapy in treating MGD-related DED were both associated with reducing inflammation, and the superiority of IPL could be attributed to its better inhibitory effect on inflammatory cytokines like IL-6. In addition, several cytokines were on a downward trend during treatment, suggesting that the vicious cycle of DED was suppressed.

Topics: Chemokine CXCL10; Cytokines; Dry Eye Syndromes; Epidermal Growth Factor; Fas Ligand Protein; Humans; Interleukin-10; Interleukin-12; Interleukin-13; Interleukin-17; Interleukin-6; Interleukin-8; Lactoferrin; Lipocalin-2; Matrix Metalloproteinase 9; Meibomian Gland Dysfunction; Meibomian Glands; Tumor Necrosis Factor-alpha

Topics: Chemokine CXCL10; Cytokines; Dry Eye Syndromes; Humans; Interleukin-8; Meibomian Gland Dysfunction; Meibomian Glands

We aim to assess the effects of different air pollutants on meibomian gland dysfunction (MGD). As a prospective multicenter study, 864 patients were recruited from four different regions (i.e., coal, oil, steel, and living). The oil region had a significantly lower temperature and higher O

Topics: Air Pollution; Coal; Cytokines; Eyelid Diseases; Humans; Interleukin-6; Interleukin-8; Meibomian Gland Dysfunction; Prospective Studies; Steel; Tears; Vascular Endothelial Growth Factor A

This study is aimed at investigating the difference of meibum chemokines in MGD subjects with different degrees of MGD and the correlations of meibum chemokines with ocular surface parameters.. Twenty MGD subjects (MQ score > 8) and twenty MGD subjects (MQ score ≤ 8) were enrolled to examine ocular surface parameters, including meibomian gland function (MGE, MQ meibograde, and lid margin), tear stability (NIKBUT, FBUT, and LLT), tear secretion (SIT and TMH), OSDI questionnaire, and CFS. These subjects also obtained meibum samples, and then meibum chemokines (MIG, IFN-. MIG, IP-10, and MCP-1 were found clearly elevated in MGD subjects with higher MQ score than that in MGD subjects with low MQ score (MIG:. Chemokines in meibum were significantly evaluated in MGD subjects suffering from severe meibomian gland quality. These findings indicate that chemokines play roles in the pathogenesis of MGD, and molecules targeted by chemokines may develop as novel agents for MGD therapy, perhaps through inhibiting inflammation in meibomian glands and microvascular in the eyelid margin.

Topics: Chemokine CXCL10; Cytokines; Humans; Interleukin-8; Meibomian Gland Dysfunction; Tears