interleukin-8 and Mandibular-Fractures

The primary objective of this study was to verify the effects of bacteriocin in treatment of postoperative infection of mandibular fracture in vivo.. Eighty-two mice were inoculated intravenously with staphylococcal suspensions. Bacterial cultures were obtained from implants. Blood samples were collected at 1, 2, 4, 6, and 8 hours after the injection of bacteriocins.. Bacteriocins have significant inhibitory effects on Staphylococcus aureus (P < 0.05) and there are significant differences interleukin (IL)-8 and IL-10 in serum (P < 0.05).. Bacteriocin isolated from L plantarum may be one of promising ways to control postoperative infection of mandibular fracture in vivo.

Topics: Animals; Anti-Bacterial Agents; Bacteriocins; Interleukin-10; Interleukin-8; Lactobacillus plantarum; Mandibular Fractures; Mandibular Prosthesis; Mandibular Prosthesis Implantation; Mice; Models, Anatomic; Prosthesis-Related Infections; Staphylococcus aureus; Treatment Outcome

There is little information concerning the incidence of alveolar bone loss in estrogen-deficient women. Ovariectomized sheep are valid models for study of the effects of estrogen deficiency on bone metabolism. The objective of this study was to compare alveolar bone loss in control (C) and ovariectomized sheep (OVX) at 3 and 12 months following surgery. OVX animals had decreased serum levels of 17-beta-estradiol and increased serum levels of osteocalcin, IL-6, and urinary levels of deoxypyridinoline which, taken together, suggest development of osteoporosis. The mean probing depths and percentage of sites with pocket depths 4 to 6 mm and > 6 mm were significantly greater in OVX than C at each time period and in OVX were significantly greater at 12 months that at 3 months. Gingival tissue interleukin-6 (IL-6) levels (but not the number of IL-6(+) cells) were elevated adjacent to deep periodontal pockets; however, there was no significant elevation of levels of the proinflammatory cytokines IL-1 beta and IL-8 within gingiva. Taken together, the data suggest a systemic contribution for progression of periodontal disease associated with estrogen deficiency. This may involve upregulation of systemic IL-6 synthesis and transfer to gingiva in serum, resulting in enhanced IL-6 accumulation within the gingival tissues or reduced bone density allowing for a greater amount of alveolar bone loss.

Topics: Alveolar Bone Loss; Amino Acids; Animals; Biomarkers; Bone and Bones; Bone Density; Disease Models, Animal; Disease Progression; Estradiol; Estrogens; Female; Follow-Up Studies; Gingiva; Interleukin-1; Interleukin-6; Interleukin-8; Mandible; Mandibular Fractures; Osteocalcin; Osteoporosis; Ovariectomy; Ovary; Periodontal Pocket; Radiography; Sheep; Stress, Mechanical; Up-Regulation