interleukin-8 has been researched along with Long-QT-Syndrome* in 1 studies
1 other study(ies) available for interleukin-8 and Long-QT-Syndrome
| Article | Year |
|---|---|
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.
Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. We identified low-nanomolar inhibitors of PKC-beta with good to excellent selectivity vs other PKC isozymes and GSK-3beta. In a cell-based functional assay, 8f and 8i effectively blocked IL-8 release induced by PKC-betaII (IC(50) = 20-25 nM). In cardiovascular safety assessment, representative lead compounds bound to the hERG channel with high affinity, potently inhibited ion current in a patch-clamp experiment, and caused a dose-dependent increase of QT(c) in guinea pigs. Topics: Animals; Cell Line; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guinea Pigs; Humans; Indazoles; Indoles; Interleukin-8; Isoenzymes; Long QT Syndrome; Maleimides; Models, Molecular; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase C beta; Structure-Activity Relationship | 2005 |