interleukin-8 and Language-Disorders

We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.

Topics: Adolescent; Case-Control Studies; Chemokine CCL2; Chemokine CCL3; Child; Child, Preschool; Cognition Disorders; Cytokines; Electroencephalography; Female; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Inflammation; Interleukin-10; Interleukin-1alpha; Interleukin-6; Interleukin-8; Intramolecular Oxidoreductases; Language Disorders; Macrophage Migration-Inhibitory Factors; Male; Methylprednisolone; Neuropsychological Tests; Prednisolone; Sleep Wake Disorders; Status Epilepticus; Syndrome; Treatment Outcome