interleukin-8 and Hyperventilation

Topics: Asthma; Asthma, Exercise-Induced; Bronchi; Chemotactic Factors; Humans; Hyperventilation; Interleukin-8; Neutrophils; Physical Exertion; Sports; Vagus Nerve

Topics: Air; Asthma; Bronchial Spasm; Chemotactic Factors; Cold Temperature; Humans; Hyperventilation; Interleukin-8; Physical Exertion

Elevated levels of the mast-cell-associated serum neutrophil chemotactic factor (NCF) and an increase in blood basophil counts were observed in 6 atopic asthmatics during exercise-induced asthma (EIA). These changes were not found when the same degree of airways obstruction was elicited in the same subjects by isocapnic hyperventilation (ISH) with cold air. The NCF was unlikely to be related to the basophilia alone, because asthmatics without EIA who underwent the same exercise task, produced a similar basophilia but significantly less NCF. These findings suggest that mast-cell-associated (as opposed to basophil-associated) mediators of hypersensitivity are detectable in the bloodstream during the bronchoconstriction induced by exercise, but not by ISH.

Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Basophils; Chemotactic Factors; Cold Temperature; Female; Humans; Hyperventilation; Interleukin-8; Leukocyte Count; Male; Mast Cells; Physical Exertion

Neutrophil chemotactic factor (NCF) is a slightly acidic macromolecule which is released into the circulation of asthmatic individuals following an exercise task. Its appearance was basophil-independent, accompanied the development of airflow obstruction and its release could be inhibited by administration of disodium cromoglycate. There was no elaboration of NCF after isocapnic hyperventilation with cold air, although the same asthmatics produced NCF following treadmill exercise. Finally, NCF was also released during exercise-induced late asthmatic reactions, as in antigen-induced late responses.

Topics: Asthma; Asthma, Exercise-Induced; Basophils; Chemotactic Factors; Humans; Hyperventilation; Interleukin-8; Respiratory Function Tests

Topics: Anaphylaxis; Animals; Asthma, Exercise-Induced; Chemotactic Factors; Forced Expiratory Volume; Guinea Pigs; Histamine Release; Humans; Hyperventilation; Interleukin-8; Mast Cells; Molecular Weight