interleukin-8 and Essential-Tremor

Essential tremor (ET) is one of the most common movement disorders. The clinical heterogeneity of ET has been studied for many years, however, there are practically no comprehensive studies dedicated to the assessment of biochemical and electrophysiological parameters associated with the severity of motor and non-motor disorders present in patients with ET and taking into account their heterogeneity.. The objective of this report is to differentiate subgroups of essential tremor using cluster analysis of clinical, biochemical and electrophysiological parameters.. The study enrolled 90 patients with ET. Clustering was perform on the demographic data, scores of scales FTMS, ADL, MoCA, Beka, surface electromyographic data, levels of serum IL-1β, IL-6, IL-8, IL-10, TNFα, uric acid, ceruloplasmin, MDA.. Based on the analysis of the severity of motor manifestations, the psychoemotional state, the adaptive potential of patients and the biochemical aspects of the pathogenesis, three relatively homogeneous clusters of ET were identified.. Revealing the heterogeneity of essential tremor allows to expand understanding the pathogenesis of disease.

Topics: Ceruloplasmin; Cluster Analysis; Essential Tremor; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Tumor Necrosis Factor-alpha; Uric Acid

In recent years, there has been discussion that essential tremor (ET) might be a neurodegenerative disease. Indicators of inflammation are considered as possible biomarkers of neurodegeneration. In this connection, the aim of our study was to identify the relationship between serum inflammation markers and clinical features in ET, including the severity of tremor, cognitive decline, depression.. The serum interleukin-1β (IL-1β), IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) levels were measured in 90 ET patients and 90 healthy control people of the corresponding age and gender. Fahn-Tolosa-Marin scale was used for the severity of the tremor. Cognitive function was assessed using the MoCA. Affective symptoms were measured by the Beck Depression Inventory.. Our findings demonstrate that neuroinflammation makes a certain contribution to the development of ET.

Topics: Biomarkers; Essential Tremor; Humans; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Interleukin-8; Neurodegenerative Diseases; Tremor; Tumor Necrosis Factor-alpha