interleukin-8 and Enteropathy-Associated-T-Cell-Lymphoma

Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.. We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL).. In both active CD and RCDI-II elevated levels of the proinflammatory IL-8, IL-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups.. A series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.

Topics: Adult; Aged; Biomarkers; Celiac Disease; CTLA-4 Antigen; Cytokines; Diet, Gluten-Free; Enteropathy-Associated T-Cell Lymphoma; Granzymes; Histocompatibility Antigens Class I; Humans; Interleukin-17; Interleukin-2 Receptor alpha Subunit; Interleukin-22; Interleukin-6; Interleukin-8; Interleukins; Middle Aged; Retrospective Studies; ROC Curve; Severity of Illness Index; Statistics, Nonparametric; Tumor Necrosis Factor Receptor Superfamily, Member 7; Young Adult