interleukin-8 and Ear-Diseases

Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km

Topics: Adolescent; Air Pollutants; Cell Adhesion; Cell Line; Child; Child, Preschool; Ear Diseases; Epithelial Cells; Haemophilus influenzae; Humans; Indigenous Peoples; Infant; Infant, Newborn; Interleukin-8; Odds Ratio; Particulate Matter; Respiratory Tract Diseases; Western Australia

The authors investigated the anti-inflammatory actions of ketoprofen using a battery of tests: in the rat paw oedema test induced by five different inciters, in the capillary permeability test, and in measuring the interleukin-8 (IL-8) production and superoxide dismutase (SOD) activity. The findings in these studies show that ketoprofen inhibits rat paw oedema, suppresses capillary permeability, reduces IL-8 production and increases SOD activity in the acetic-acid-induced inflammatory state. These results would seem to provide a clear rationale for exploring the usefulness of ketoprofen in the treatment of acute and chronic inflammatory diseases.

Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Bradykinin; Capillary Permeability; Carrageenan; Coloring Agents; Disease Models, Animal; Ear Diseases; Edema; Enzyme-Linked Immunosorbent Assay; Hindlimb; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Interleukin-8; Ketoprofen; Male; Mice; Rats; Rats, Wistar; Superoxide Dismutase; Xylenes