interleukin-8 and Atrial-Fibrillation

The role of circulating inflammatory factors in atrial fibrillation (AF) occurrence and recurrence remains inconclusive.. We conducted a meta-analysis of observational studies evaluating the association of inflammatory factors with AF risk, postoperative AF (POAF) occurrence after coronary artery bypass grafting (CABG) surgery, and AF recurrence after electrical cardioversion (EC) or catheter ablation.. Increased C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α were significantly associated with AF risk (standardized mean difference [SMD] [95% confidence interval (CI)]: 0.95 [0.72-1.18], 0.89 [0.64-1.15] and 2.20 [1.17-3.23], respectively). In subgroup analysis, CRP was significantly associated with persistent and permanent AF risk, but not with paroxysmal AF. Increased preoperative CRP and IL-6 were associated with greater risk of post-CABG AF (SMD [95% CI]: 0.28 [0.02-0.54] and 1.03 [0.03-2.04], respectively). Consistent significant associations between CRP and AF recurrence were found in both patient subgroups who underwent EC (SMD, 0.56; 95% CI, 0.36-0.76) and ablation (SMD, 0.48; 95% CI, 0.11-0.86). IL-6 was significantly associated with AF recurrence after ablation (SMD, 0.55; 95% CI, 0.25-0.85), but not with the recurrence after EC (SMD, 0.85; 95% CI, -0.26-1.95).. Increased circulating inflammatory factors, such as CRP and IL-6, are associated with greater AF risk in general population and patients who underwent CABG, as well as with AF recurrence after EC or ablation. Future research is warranted to elucidate the roles of other inflammatory markers, such as white blood cell, IL-8, and transforming growth factor-β1, in occurrence and recurrence of well-established different clinical subtypes of AF.

Topics: Atrial Fibrillation; Biomarkers; C-Reactive Protein; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Observational Studies as Topic; Recurrence; Tumor Necrosis Factor-alpha

Catheter ablation (CA) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation (AF). However, AF recurrence after CA remains a relevant clinical issue. We tested the effects of an oral antioxidant treatment (alpha lipoic acid [ALA]) on AF recurrence post-CA. Patients with paroxysmal AF have been enrolled in a randomized, prospective, double-blind, controlled placebo trial. After CA, patients have been randomly assigned to receive ALA oral supplementation (ALA group) or placebo (control group) and evaluated at baseline and after a 12-month follow-up: 73 patients completed the 12-month follow-up (ALA: 33 and control: 40). No significant difference has been detected between the 2 groups at baseline. Strikingly, 1 year after CA, ALA therapy significantly reduced serum markers of inflammation. However, there was no significant difference in AF recurrence events at follow-up comparing ALA with placebo group. Multivariate analysis revealed that the only independent prognostic risk factor for AF recurrence after CA is age. In conclusion, ALA therapy reduces serum levels of common markers of inflammation in ablated patients. Nevertheless, ALA does not prevent AF recurrence after an ablative treatment.

Topics: Aged; Antioxidants; Atrial Fibrillation; Biomarkers; Blood Glucose; C-Reactive Protein; Catheter Ablation; Cholesterol, HDL; Cholesterol, LDL; Cytokines; Double-Blind Method; Female; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Peroxynitrous Acid; Postoperative Care; Recurrence; Thioctic Acid; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine

The interplay of oxidative stress, proinflammatory microparticles, and proinflammatory cytokines in recurrent arrhythmias is unknown in elderly patients with coronary restenosis and reocclusions after coronary stenting.. This research sought to investigate the potential diagnostic and therapeutic targets for recurrent arrhythmias in patients with coronary restenosis and reocclusions after coronary stenting.. We examined whether oxidative stress, proinflammatory microparticles, and proinflammatory cytokines could have effects that lead to recurrent arrhythmias in elderly patients with coronary restenosis and reocclusions. We measured the levels of malondialdehyde (MDA), CD31 + endothelial microparticle (CD31 EMP), CD62E + endothelial microparticle (CD62E + EMP), high-sensitivity C-reactive protein (hs-CRP), interleukin- 1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), as well as oxidized low-density lipoprotein (OX-LDL), and assessed the effects of relationship between oxidative stress, proinflammatory microparticles, and proinflammatory cytokines on recurrent atrial and ventricular arrhythmias in elderly patients with coronary restenosis and reocclusions after coronary stenting.. The levels of CD31 + EMP, CD62E + EMP, MDA, hs-CRP, IL-1β, IL-6, IL-8, TNF-α and OX-LDL were found to be increased significantly in coronary restenosis + recurrent atrial arrhythmia group compared to without coronary restenosis and coronary restenosis + without recurrent atrial arrhythmia groups, respectively (P < 0.001). Patients in the coronary reocclusion + recurrent ventricular arrhythmia group also exhibited significantly increased levels of CD31 + EMP, CD62E + EMP, MDA, hs-CRP, IL-1β, IL-6, IL-8, TNF-α and OXLDL compared to without coronary reocclusion and coronary reocclusion + without recurrent ventricular arrhythmia groups, respectively (P < 0.001).. Proinflammatory microparticles, proinflammatory cytokines, and oxidative stress might act as potential targets for recurrent arrhythmias in patients with coronary restenosis and reocclusions after coronary stenting.

Topics: Aged; Atrial Fibrillation; C-Reactive Protein; Coronary Restenosis; Cytokines; Humans; Interleukin-6; Interleukin-8; Prognosis; Tumor Necrosis Factor-alpha

A total of 81 patients with coronary artery disease (CAD) who underwent coronary artery bypass graft (CABG) were enrolled in the study. Patients were divided into 2 groups: Group 1 - without postoperative atrial fibrillation (POAF) (59 patients, 74,6 % men, mean age 65,8±4 years), Group 2 - with early new-onset AF after CABG (22 patients, 90,9 % men, mean age of 67,7±5,4 years). Interleukin (IL)-6, IL-8, IL-10, C-reactive protein (CRP), fibrinogen, superoxide dismutase (SOD), troponin I were studied. During the observation period AF occurred in 27,2 % cases, an average of 4,9±3,8 days after surgery. In the postoperative period were significantly higher in group 2 left atrium (LA) (43,9±3,4 vs. 37,6±3,9 mm, p<0,001), IL-6 (72,7±60,8 vs. 38,0±34,6 pg/ml, p=0,04), IL-8 (11,9±6,0 vs. 7,7±5,4 pg/ml, p=0,01), SOD (2 462,0±2 029,3 vs. 1 515,0±1 292,9 units/g, p=0,04) when compared with group 1. The multivariate analysis showed that the odds ratio for AF development in postoperative period for LA more than 39 mm was 2,1 (95 % CI 1,2-3,8, p=0,0004), IL-6 levels more than 65,18 pg/ml - 1,4 (95 % CI 1,1-2,7, p=0,009), IL-8 levels more than 9,67 pg/ml - 1,2 (95 % CI 1,1-3,7, p=0,009), SOD more than 2948 units/g -1,1 (95 % CI 1,01-2,9, p=0,04). Our study showed that left atrium dimension, high interleukin-6, interleukin-8 and superoxide dismutase levels play an important role in development of atrial fibrillation in early postoperative period after coronary bypass graft surgery.. Обследован 81 пациент с ИБС, последовательно поступивший для проведения операции коронарного шунтирования (КШ). Больные были распределены на две группы: 1-я — 59 пациентов (74,6 % мужчин) без послеоперационной фибрилляции предсердий (ПОФП), средний возраст 65,8±4 года, 2-я — 22 пациента (90,9 % мужчин) с ПОФП, средний возраст 67,7±5,4 года. IL-6, IL-8, IL-10, С-РБ, фибриноген, СОД, количественный тропонин I оценивали при поступлении и после операции на 3,8±1,4 сут. За период наблюдения ПОФП возникла у 27,2 % больных, в среднем на 4,9±3,8 сут после КШ. В послеоперационном периоде достоверно выше во 2 й группе оказался размер левого предсердия (ЛП) — 43,9±3,4 против 37,6±3,9 мм (р<0,001), концентрация IL-6 — 72,7±60,8 против 38,0±34,6 пг/мл (р=0,04), уровень IL-8 — 11,9±6,0 против 7,7±5,4 пг/мл (р=0,01), уровень СОД — 2 462,0±2029,3 против 1515,0±1292,9 ед./г, (р=0,04) при сравнении с 1-й группой. После многофакторного анализа отношение шансов развития ПОФП для ЛП более 39 мм составило 2,1 (95 % ДИ, 1,2–3,8, р=0,0004), для послеоперационного уровня IL-6 более 65,18 пг/мл — 1,4 (95 % ДИ, 1,1–2,7, р=0,009), для послеоперационного уровня IL-8 более 9,67 пг/мл — 1,2 (95 % ДИ, 1,1–3,7, р=0,009), для СОД более 2 948 ед./г — 1,1 (95 % ДИ, 1,01–2,9, р=0,04).Таким образом, значимое влияние на возникновение фибрилляции предсердий в раннем послеоперационном периоде после КШ оказывал размер левого предсердия, повышенная концентрация IL-6, IL-8 и СОД.

Topics: Aged; Atrial Fibrillation; Coronary Artery Bypass; Coronary Artery Disease; Female; Heart Atria; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Middle Aged; Organ Size; Postoperative Complications; Prospective Studies; Risk Factors; Russia; Superoxide Dismutase

Although regular physical exercise clearly reduces cardiovascular morbidity risk, long-term endurance sports practice has been recognized as a risk factor for atrial fibrillation (AF). However, the mechanisms how endurance sports can lead to AF are not yet clear. The aim of our present study was to investigate the influence of long-term endurance training on vagal tone, atrial size, and inflammatory profile in professional elite soccer players.. A total of 25 professional major league soccer players (mean age 24±4 years) and 20 sedentary controls (mean age 26±3 years) were included in the study and consecutively examined. All subjects underwent a sports cardiology check-up with physical examination, electrocardiography, echocardiography, exercise testing on a bicycle ergometer, and laboratory analysis [standard laboratory and cytokine profile: interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-8, IL-10].. Athletes were divided into two groups according to presence or absence of an early repolarization (ER) pattern, defined as a ST-segment elevation at the J-point (STE) ≥0.1mm in 2 leads. Athletes with an ER pattern showed significantly lower heart rate and an increased E/e' ratio compared to athletes without an ER pattern. STE significantly correlated with E/e' ratio as well as with left atrial (LA) volume. The pro-inflammatory cytokines IL-6, IL-8, TNF-α as well as the anti-inflammatory cytokine IL-10 were significantly elevated in all soccer players. However, athletes with an ER pattern had significantly higher IL-6 plasma levels than athletes without ER pattern. Furthermore, athletes with "high" level IL-6 had significantly larger LA volumes than players with "low" level IL-6.. Athletes with an ER pattern had significantly higher E/e' ratios, reflecting higher atrial filling pressures, higher LA volume, and higher IL-6 plasma levels. All these factors may contribute to atrial remodeling over time and thus increase the risk of AF in long-term endurance sports.

Topics: Adult; Athletes; Atrial Fibrillation; Atrial Function; Atrial Remodeling; Case-Control Studies; Echocardiography; Electrocardiography; Exercise Test; Heart Atria; Heart Conduction System; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Interleukins; Male; Physical Endurance; Risk Factors; Soccer; Tumor Necrosis Factor-alpha; Young Adult

Outcomes and risk factors associated with new-onset atrial fibrillation (AF) during acute respiratory distress syndrome (ARDS) are unclear. We investigated mortality and risk factors associated with new-onset AF during ARDS.. We obtained data from the ARDS Network Albuterol for Treatment of Acute Lung Injury trial, which prospectively identified new-onset AF among patients with ARDS as an adverse event. We determined Acute Physiology and Chronic Health Evaluation III-adjusted associations between new-onset AF and 90-day mortality. We also examined associations between new-onset AF and markers of inflammation (interleukin 6 and interleukin 8), myocardial injury (troponin I), autonomic activation (epinephrine), and atrial stretch (central venous pressure) as well as other clinical characteristics.. Of 282 patients (mean age, 51.6 years; 45% women; 77% white) enrolled in Albuterol for Treatment of Acute Lung Injury, 28 (10%) developed new-onset AF during the study. We did not identify associations between new-onset AF and baseline central venous pressure, plasma levels of troponin I, epinephrine, interleukin 6, or interleukin 8. New-onset AF during ARDS was associated with increased 90-day mortality (new-onset AF, 43% vs no new-onset AF, 19%; Acute Physiology and Chronic Health Evaluation-adjusted odds ratio, 3.09 [95% confidence interval, 1.24-7.72]; P = .02).. New-onset AF during ARDS is associated with increased mortality; however, its mechanisms require further study.

Topics: Aged; Albuterol; Atrial Fibrillation; Biomarkers; Bronchodilator Agents; Female; Hospital Mortality; Humans; Interleukin-6; Interleukin-8; Male; Middle Aged; Odds Ratio; Prognosis; Prospective Studies; Respiratory Distress Syndrome; Risk Factors

Atrial fibrillation (AF) might be associated with an inflammatory activation and reduced left ventricular (LV) function. Less is known with regard to newly introduced markers of LV dysfunction such as carbohydrate antigen-125 (CA-125) in subjects with AF. The aim of this study was therefore to assess possible associations between AF, inflammatory markers and CA-125.. Forty-eight consecutive patients with AF and 58 control patients in sinus rhythm were enrolled in this study. Patients with acute heart failure, chronic inflammatory or neoplastic disease were excluded from the study. Circulating levels of hs-C-reactive protein (CRP), interleukin-8 (IL-8), IL-6, soluble IL-2 receptor (sIL-2r), TNF-α and CA-125 were assessed; all patients underwent clinical examination with NYHA class assessment and echocardiography. Patients with AF were characterised by higher levels of IL-8 (180 ± 266 vs. 39 ± 43 pg/mL, P < 0·001), sIL-2r (987 ± 1045 vs. 680 ± 336 U/mL, P < 0·05) and TNF-α (26 ± 25 vs. 9 ± 4 pg/mL, P < 0·001). Patients with AF duration < 6 months had higher levels of CRP (54 ± 73 vs. 12 ± 14 mg/dL, P < 0·05) and IL-8 (251 ± 225 vs. 99 ± 123 pg/mL, P < 0·05) when compared with AF duration > 6 months. CA-125 levels were not statistically different if comparing subjects with AF with controls and AF > 6 months with AF < 6 months. Among patients with AF, CA-125 levels were significantly related to NYHA class, (r = 0·33, P < 0·05) as well as IL-6 levels (r = 0·31, P < 0·05). Results remained statistically significant even after multivariable correction for age, gender and LV ejection fraction.. AF is characterised by an inflammatory activation. Impaired functional class in AF subjects might be associated with increased CA-125 levels and higher inflammatory markers.

Topics: Aged; Atrial Fibrillation; Biomarkers; C-Reactive Protein; CA-125 Antigen; Case-Control Studies; Cytokines; Female; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Multivariate Analysis; Receptors, Interleukin-2; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left

Topics: Atrial Fibrillation; Biomarkers; C-Reactive Protein; Humans; Inflammation; Interleukin-6; Interleukin-8

Elevated levels of C-reactive protein and other inflammatory markers have been reported in some patients with atrial fibrillation (AF). Whether this finding is related to AF per se or to other conditions remains unclear. In addition, the source of inflammatory markers is unknown. Therefore, in the present study, we sought to assess the extent and the source of inflammation in patients with AF and no other concomitant heart or inflammatory conditions.. The study group consisted of 29 patients referred for radiofrequency catheter ablation: 10 patients with paroxysmal AF, 8 patients with permanent AF, and 10 control patients with Wolf-Parkinson-White (WPW) syndrome and no evidence of AF (mean age 54 +/- 11 vs. 57 +/- 13 vs. 43 +/- 16). No patient had structural heart diseases or inflammatory conditions. High-sensitive C-reactive protein, interleukin-6 (IL-6), and interleukin-8 (IL-8) were assessed in blood samples from the femoral vein, right atrium, coronary sinus, and the left and right upper pulmonary veins. All samples were collected before ablation. Compared with controls and patients with paroxysmal AF, patients with permanent AF had higher plasma levels of IL-8 in the samples from the femoral vein, right atrium, and coronary sinus, but not in the samples from the pulmonary veins (median values in the femoral vein: 2.58 vs. 2.97 vs. 4.66 pg/mL, P = 0.003; right atrium: 2.30 vs. 3.06 vs. 3.93 pg/mL, P = 0.013; coronary sinus: 2.85 vs. 3.15 vs. 4.07, P = 0.016). A high-degree correlation existed between the IL-8 levels in these samples (correlation coefficient between 0.929 and 0.976, P < 0.05). No differences in the C-reactive protein and IL-6 levels were noted between the three groups of patients.. The normal levels of C-reactive protein and IL-6, along with the elevated levels of IL-8 in patients with permanent AF but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF. The elevated IL-8 levels in the peripheral blood, right atrium, and coronary sinus but not in the pulmonary veins suggest a possible source of inflammation in the systemic circulation.

Topics: Adult; Aged; Atrial Fibrillation; Biomarkers; Blood Circulation; C-Reactive Protein; Case-Control Studies; Female; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Middle Aged; Pilot Projects; Regression Analysis; Time Factors; Wolff-Parkinson-White Syndrome

Atrial fibrillation (AF) is the most frequently encountered postoperative arrhythmic complication after coronary artery bypass graft (CABG). There is increasing evidence to support the influence of inflammation in the pathogenesis of AF. The aim of the present study was to investigate the relation of postoperative new AF and systemic inflammatory changes after CABG.. A total of 113 CABG patients were recruited in the present study. Holter data from 24-hour electrocardiography were collected from 1 day before the operation to postoperative day 2 (POD2). AF was registered as positive if any AF event occurred. Serum cytokine, including interleukin (IL)-6, IL-8, and IL-10 were analyzed before and after surgery.. The overall incidences of postoperative AF and sustained AF were 36.3% and 31.9%, respectively. Patients with postoperative AF had longer respiratory treatment, intensive care unit treatment, and inotropic medication periods. Similar concentrations of serum IL-6 were found after surgery in patients with and without AF. The concentrations of serum IL-8 was significantly higher at 2 hours and on POD1 and POD2 in patients with postoperative AF. The concentration of serum IL-10 was significantly higher on POD1 in patients with postoperative AF.. Postoperative AF in CABG patients is associated with a more complicated postoperative outcome. Higher concentrations of serum IL-8 in CABG patients with postoperative AF suggested that an influence of inflammation in the pathogenesis postoperative AF after open heart surgery.

Topics: Aged; Atrial Fibrillation; Cardiopulmonary Bypass; Cohort Studies; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Inflammation; Interleukin-10; Interleukin-8; Male; Middle Aged; Risk Factors