interleukin-8 and Anemia--Iron-Deficiency

Iron supplementation may have adverse health effects in infants, probably through manipulation of the gut microbiome. Previous research in low-resource settings have focused primarily on anemic infants. This was a double blind, randomized, controlled trial of home fortification comparing multiple micronutrient powder (MNP) with and without iron. Six-month-old, non- or mildly anemic, predominantly-breastfed Kenyan infants in a rural malaria-endemic area were randomized to consume: (1) MNP containing 12.5 mg iron (MNP+Fe,

Topics: Anemia, Iron-Deficiency; Anthropometry; Bifidobacterium; Biomarkers; Clostridium; Double-Blind Method; Escherichia coli; Feces; Female; Gastrointestinal Microbiome; Humans; Infant; Inflammation; Interleukin-8; Iron; Kenya; Male; Micronutrients; Powders; Proteobacteria; RNA, Ribosomal, 16S; Sequence Analysis, DNA

Topics: Anemia, Iron-Deficiency; Calcium Signaling; CD18 Antigens; Cell Degranulation; Cells, Cultured; Ferrosoferric Oxide; Humans; Inflammation; Interleukin-8; Kidney Failure, Chronic; L-Selectin; Magnetic Iron Oxide Nanoparticles; Neutrophil Activation; Neutrophils; Receptors, Interleukin-8A

Helicobacter pylori infection occurs predominantly in childhood. Host immune response gene polymorphism is reported to affect the susceptibility to H pylori infection and the outcome of H pylori-related gastric cancer. Not all H pylori-infected patients, however, exhibit iron deficiency (ID). The relationship between host genetic polymorphisms and ID mediated by H pylori infection is not well understood.. Subjects (n = 644) from the general population of age 10 to 18 years were divided into 2 groups based on serology testing for anti-H pylori IgG: seropositive study group; and seronegative control group. Five single nucleotide polymorphisms (SNPs) in IL1B (rs1143627 and rs16944), IL8 (rs4073), IL10 (rs1800896), and ABO (rs505922), were genotyped and the iron status of the 2 groups was compared.. The seroprevalence rate for H pylori was 10.7% in this study. Infected subjects were significantly older and had lower serum iron levels than uninfected subjects (P = 0.0195 and 0.0059, respectively). Multivariate analysis revealed a significantly higher frequency of the T allele of rs505922 (odds ratio [OR] = 6.128; P < 0.001) and lower frequency of the T allele of rs1143627 (OR = 0.846; P = 0.014) in seropositive subjects. Among 59 seropositive subjects, the T allele frequency of rs1143627 was significantly higher in those with ID (OR = 3.156; P = 0.043), compared with those without ID.. ABO (rs505922) and IL1B (rs1143627) may affect H pylori infection susceptibility, and IL1B (rs1143627) may also influence ID risk in infected children.

Topics: ABO Blood-Group System; Adolescent; Anemia, Iron-Deficiency; Case-Control Studies; Child; Female; Genetic Predisposition to Disease; Genotype; Helicobacter Infections; Helicobacter pylori; Humans; Interleukin-10; Interleukin-1beta; Interleukin-8; Iron; Male; Polymorphism, Single Nucleotide; Seroepidemiologic Studies; Taiwan