interleukin-8 and Abdominal-Abscess

The aim: To assess of pro-inflammatory IL-8 and anti-inflammatory IL-10 serum concentration in patients with T2DM with intraabdominal postoperative abscesses in perioperative period.. Materials and methods: The 48 participants, aged 40 - 75 years, among them 24 males and 24 females. All patients were divided into groups: group 1 - 12 patients with T2DM and intra-abdominal postoperative abscesses, group 2 - 12 patients without T2DM but with intra-abdominal postoperative abscesses and 24 healthy individuals. The level of IL-8and IL-10 serum was determined on the day before surgery, on the 2-3rd and 5-7th day after surgery in patients with type 2 diabetes and intra-abdominal postoperative abscesses.. Results and conclusions: The trajectories of the level of interleukins in patients with type 2 Diabetes mellitus were different from the trajectories of their level in patients without diabetes, which indicates a special immune response to nosocomial infection and surgical trauma. The mechanism of changes in serum levels of IL-8 and IL-10 in patients with type 2 Diabetes mellitus and postoperative intra-abdominal abscesses should be further studied in future studies on the specific causative agent of nosocomial infection and the cytokine response to it.

Topics: Abdominal Abscess; Abscess; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Interleukin-10; Interleukin-8; Male; Middle Aged