insulin--despentapeptide(b26-b30)- and Hypoglycemia

insulin--despentapeptide(b26-b30)- has been researched along with Hypoglycemia* in 1 studies

Other Studies

1 other study(ies) available for insulin--despentapeptide(b26-b30)- and Hypoglycemia

ArticleYear
In vivo metabolic activity of des-(B26-B30)-insulin-B25-amide and related analogues in the rat.
    Diabetes research and clinical practice, 1990, Volume: 9, Issue:3

    Metabolic potency of des-(B26-B30)-insulin-B25-amide, [TyrB25]des- (B26-B30)-insulin-B25-amide and [HisB25]des-(B26-B30)-insulin-B25-amide was studied in anaesthetized rats. Compared to insulin, full potency for des-(B26-B30)-insulin-B25-amide and an enhanced potency for both substituted analogues has been described previously on rat adipocytes in vitro. Hypoglycaemic effects following i.v. injection of all of these analogues were almost identical to those of native insulin with a half-maximal effective dose of approximately 3 nmol.kg-1. Stimulation of glucose metabolism during euglycaemic hyperinsulin-/analogueaemic clamp studies was indistinguishable from that of the native hormone with a maximal stimulation of approximately 19 mg.kg-1.min-1 and half-maximal effective hormone concentrations of approximately 1 pmol.ml-1. Analogue action on individual peripheral tissues estimated by the uptake of 2-deoxyglucose as well as stimulation of lipogenesis in epididymal fat was not different to that of insulin. These data demonstrate that C-terminal amidation of des-(B26-B30)-insulin results in a shortened molecule with full in vivo metabolic potency. When substituting phenylalanine in position B25 by tyrosine or histidine, the insulin-identical potency is preserved.

    Topics: Adipose Tissue; Animals; Carbon Radioisotopes; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Hypoglycemia; Insulin; Lipid Metabolism; Male; Muscles; Rats; Rats, Inbred Strains; Tritium

1990