instenon and Cerebrovascular-Disorders

Topics: Aged; Benzamides; Brain; Central Nervous System Stimulants; Cerebrovascular Disorders; Combined Modality Therapy; Drug Combinations; Electromagnetic Phenomena; Female; Hexobendine; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Severity of Illness Index; Theophylline

Topics: Adult; Age Factors; Aged; Benzamides; Blood Coagulation Tests; Central Nervous System Stimulants; Cerebrovascular Disorders; Drug Combinations; Fibrinogen; Hemostasis; Hexobendine; Humans; Middle Aged; Neuroprotective Agents; Nootropic Agents; Piracetam; Platelet Aggregation; Theophylline

Effectiveness of Instenon (Alkaloid Pharm. Co.), the preparation, containing hexobendin, hydroxytheophyllin, etamivan was investigated in treatment of patients with acute cerebrovascular disorders. Instenon was applied in acute phase of ischemic stroke both in form of ampules and dragee as well as for intravenous injections too. Marked positive influence of Instenon was observed on motor, sensory, autonomic and psychic functions. Instenon in form of ampules had advantage compared to dragee form in terms of faster positive alterations onset. Application of Instenon in form of ampules was more effective in patients with disorders of consciousness while usage of drug in the form of dragee was more effective in patients with cerebrovascular disorders in vertebro-basilar system. The drug hadn't significant influence on systemic arterial pressure either after single injection or long-termed treatment; the mild hypotensive effect was observed after therapeutical session. The drug was well tolerated by patients in both forms and hadn't any side effects. There were no negative consequences of Instenon interaction with other preparations. The conclusion was made about possibility of application of Instenon for the treatment of ischemic stroke.

Topics: Acute Disease; Benzamides; Central Nervous System Stimulants; Cerebrovascular Disorders; Drug Combinations; Drug Evaluation; Hexobendine; Humans; Neurologic Examination; Remission Induction; Theophylline; Time Factors

Topics: Acute Disease; Benzamides; Central Nervous System Stimulants; Cerebrovascular Disorders; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Electroencephalography; Heme; Hexobendine; Humans; Remission Induction; Theophylline

The distribution of the parameter of asymmetry of the wave fronts in EEG on the convexital surface of the cortex during instenon administration is significantly changed in time and becomes normal after 3 hours of observation. This may point to an improvement of the functional state of the brain under the influence of the drug. The most distinct positive dynamics in such conditions were marked in patients with general brain symptoms and transient disorders in the vertebro-basillar system. A transition of desynchronized EEG to hypersynchronized with a subsequent normalization of the structure is apparently conditioned by the central influence of the preparation on the synchronizing areas of the brain reticular formation.

Topics: Basilar Artery; Benzamides; Benzoates; Cerebral Arteries; Cerebrovascular Disorders; Drug Combinations; Electroencephalography; Hexobendine; Humans; Theophylline; Vasodilator Agents; Vertebral Artery