Page last updated: 2024-10-19

inositol and Uremia

inositol has been researched along with Uremia in 30 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

Research Excerpts

ExcerptRelevanceReference
"It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia."7.71Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. ( Decaux, G; Schroöeder, B; Silver, S; Soupart, A; Sterns, R, 2002)
"It was recently demonstrated that renal failure and exogenous urea prevent myelinolysis induced by rapid correction of experimental hyponatremia."3.71Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. ( Decaux, G; Schroöeder, B; Silver, S; Soupart, A; Sterns, R, 2002)
"To determine whether so-called uraemic toxins exhibit direct toxic effects on Schwann cells, the latter were cultured in a monolayer with the addition of uraemic toxins."1.28Myoinositol inhibits proliferation of cultured Schwann cells: evidence for neurotoxicity of myoinositol. ( Maeda, K; Mitsuma, T; Niwa, T; Sobue, G, 1989)
"Inositol was quantified by the internal standard method."1.27Measurement of inositol in uremic serum by selected ion monitoring. ( Inouye, M; Mio, T; Sumino, K, 1988)
"In a series of patients with chronic renal failure managed conservatively, the rise in the plasma-myo-inositol (myoinositol) concentration has been found to be related to depression of sural-nerve conduction velocity."1.26Plasma-myoinositol concentrations in uraemic neuropathy. ( Reznek, RH; Salway, JG; Thomas, PK, 1977)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199024 (80.00)18.7374
1990's3 (10.00)18.2507
2000's2 (6.67)29.6817
2010's1 (3.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ferrer, MD1
Ketteler, M1
Tur, F1
Tur, E1
Isern, B1
Salcedo, C1
Joubert, PH1
Behets, GJ1
Neven, E1
D'Haese, PC1
Perelló, J1
Rysz, J1
Bartnicki, P2
Błaszczak, R1
Kujawski, K1
Ciałkowska-Rysz, A1
Olszewski, R1
Markuszewski, L1
Fürst, P2
Alvestrand, A1
Bergström, J2
Savazzi, GM1
Buzio, C1
Migone, L1
Navarro, J1
Contreras, P1
Touraine, JL1
Freyria, AM1
Later, R1
Traeger, J1
Niwa, T4
Yamamoto, N1
Maeda, K3
Yamada, K2
Ohki, T2
Mori, M1
Dewald, L1
Sone, J1
Miyazaki, T1
Kajita, M1
Zbróg, Z1
Baj, Z1
Tchórzewski, H1
Luciak, M1
De Kimpe, J1
Cornelis, R1
Vanholder, R1
Soupart, A1
Silver, S1
Schroöeder, B1
Sterns, R1
Decaux, G1
Reznek, RH1
Salway, JG1
Thomas, PK1
Blumberg, A1
Esslen, E1
Bürgi, W1
Trznadel, K2
Kidawa, Z1
Walasek, L1
Lutz, W2
Bultitude, FW1
Newham, SJ1
Servo, C1
Pitkänen, E2
Sobue, G1
Mitsuma, T1
Asada, H1
Saito, A1
Inouye, M1
Mio, T1
Sumino, K1
Onishi, S1
Kawasaki, T1
Hamada, K1
Mujais, SK1
Wills, MR1
Clements, RS1
DeJesus, PV1
Winegrad, AI1
Melmed, S1
Bank, H1
Lewin, LM2
Szeinberg, A1
Lepkifker, E1
Aloia, JF1
Friis, T1
Hahnemann, S1
Weeke, E1

Reviews

6 reviews available for inositol and Uremia

ArticleYear
Recent advances in the pathogenesis and nutritional treatment of chronic uremia.
    Zeitschrift fur Ernahrungswissenschaft, 1982, Volume: 21, Issue:3

    Topics: Amino Acids; Amino Acids, Essential; Arteriosclerosis; Choline; Chronic Disease; Cyclic AMP; Dietary

1982
Lights and shadows on the pathogenesis of uremic polyneuropathy.
    Clinical nephrology, 1982, Volume: 18, Issue:5

    Topics: Calcium; Glucose; Guanidines; Humans; Inositol; Neurotoxins; Nutrition Disorders; Peripheral Nervous

1982
Are 'middle molecules' responsible for toxic phenomena in chronic renal failure?
    Nephron, 1982, Volume: 32, Issue:4

    Topics: Anemia; Animals; Humans; Immunity, Cellular; Inositol; Kidney Failure, Chronic; Neurotoxins; Parathy

1982
[Biochemical and clinical aspects of myoinositol].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1976, Oct-25, Volume: 31, Issue:43

    Topics: Animals; Biological Transport, Active; Cell Membrane; Diabetes Mellitus; Fatty Liver; Guinea Pigs; H

1976
Uremic toxins, and their effect on intermediary metabolism.
    Clinical chemistry, 1985, Volume: 31, Issue:1

    Topics: Aluminum; Animals; Creatinine; Dimethylamines; Enzyme Inhibitors; Guanidines; Humans; Inositol; Meta

1985
The blessings of zinc.
    Food and cosmetics toxicology, 1972, Volume: 10, Issue:4

    Topics: Animals; Calcium; Cattle; Child; Deficiency Diseases; Diet; Female; Glycine max; Growth; Humans; Ino

1972

Other Studies

24 other studies available for inositol and Uremia

ArticleYear
Characterization of SNF472 pharmacokinetics and efficacy in uremic and non-uremic rats models of cardiovascular calcification.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Animals; Calcinosis; Cardiovascular Diseases; Cholecalciferol; Disease Models, Animal; Disease Progr

2018
[Anti-inflammatory action of myoinositol in renal insufficiency].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2006, Volume: 20, Issue:116

    Topics: Adult; Dinoprostone; Female; Humans; In Vitro Techniques; Inositol; Leukocytes, Mononuclear; Leukotr

2006
Gas chromatographic--mass spectrometric analysis of polyols in urine and serum of uremic patients. Identification of new deoxyalditols and inositol isomers.
    Journal of chromatography, 1983, Oct-14, Volume: 277

    Topics: Deoxy Sugars; Gas Chromatography-Mass Spectrometry; Humans; Inositol; Isomerism; Sugar Alcohols; Ure

1983
Quantification of serum 1,5-anhydroglucitol in uremic and diabetic patients by liquid chromatography/mass spectrometry.
    Clinical chemistry, 1994, Volume: 40, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Chromatography, Liquid; Deoxyglucose; Diabetes Mellitus; Female; Fru

1994
Myoinositol may be a factor in uremic immune deficiency.
    Clinical nephrology, 1997, Volume: 47, Issue:3

    Topics: Adult; CD3 Complex; CD4 Antigens; CD8 Antigens; Female; HLA-DR Antigens; Humans; In Vitro Techniques

1997
In vitro methylation of arsenite by rabbit liver cytosol: effect of metal ions, metal chelating agents, methyltransferase inhibitors and uremic toxins.
    Drug and chemical toxicology, 1999, Volume: 22, Issue:4

    Topics: Animals; Arsenites; Cresols; Cytosol; Edetic Acid; Enzyme Inhibitors; Homocysteine; Hypoxanthine; In

1999
Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:6

    Topics: Animals; Body Water; Brain; Chronic Disease; Hyponatremia; Inositol; Male; Mercuric Chloride; Potass

2002
Plasma-myoinositol concentrations in uraemic neuropathy.
    Lancet (London, England), 1977, Mar-26, Volume: 1, Issue:8013

    Topics: Action Potentials; Humans; Inositol; Kidney Failure, Chronic; Motor Neurons; Muscles; Neural Conduct

1977
Uremic toxins.
    Kidney international. Supplement, 1978, Issue:8

    Topics: Animals; Choline; Cyclic AMP; Humans; Inositol; Kidney; Polyamines; Renal Dialysis; Ribonucleases; U

1978
Myoinositol--a uremic neurotoxin?
    Nephron, 1978, Volume: 21, Issue:4

    Topics: Adult; Blood Urea Nitrogen; Creatinine; Electroencephalography; Female; Humans; Inositol; Male; Midd

1978
[A comparison of the efficiency of eliminating middle-weight molecules and myoinositol from plasma during hemoperfusion and hemodialysis in cases of chronic uremia].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1978, Feb-13, Volume: 33, Issue:7

    Topics: Chronic Disease; Hemoperfusion; Humans; Inositol; Renal Dialysis; Toxins, Biological; Uremia

1978
Identification of some abnormal metabolites in plasma from uremic subjects.
    Clinical chemistry, 1975, Volume: 21, Issue:9

    Topics: Autoanalysis; Chromatography, Gas; Chromatography, Gel; Chronic Disease; Erythritol; Glycerol; Human

1975
Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients.
    Diabetologia, 1975, Volume: 11, Issue:6

    Topics: Aged; Blood Glucose; Creatinine; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Ethers, Cy

1975
Myoinositol inhibits proliferation of cultured Schwann cells: evidence for neurotoxicity of myoinositol.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1989, Volume: 4, Issue:7

    Topics: Animals; Cell Division; Cells, Cultured; DNA; Inositol; Nervous System Diseases; Rats; Schwann Cells

1989
Profiling of organic acids and polyols in nerves of uraemic and non-uraemic patients.
    Journal of chromatography, 1986, Apr-25, Volume: 377

    Topics: Acids; Alcohols; Cauda Equina; Gas Chromatography-Mass Spectrometry; Humans; Inositol; Peripheral Ne

1986
Measurement of inositol in uremic serum by selected ion monitoring.
    Japanese journal of medicine, 1988, Volume: 27, Issue:1

    Topics: Adult; Benzene Derivatives; Boron Compounds; Boronic Acids; Female; Gas Chromatography-Mass Spectrom

1988
Experimental studies on pathogenesis and progression of uremic neuropathy in rats. II. Is plasma myoinositol a uremic neurotoxin?
    Bulletin of the Osaka Medical School, 1986, Volume: 32, Issue:2

    Topics: Animals; Disease Models, Animal; Inositol; Kidney Failure, Chronic; Male; Nervous System Diseases; N

1986
Renal metabolic absence.
    The International journal of artificial organs, 1987, Volume: 10, Issue:1

    Topics: Citrates; Erythropoietin; Gluconeogenesis; Homeostasis; Humans; Inositol; Kidney; Lactates; Mevaloni

1987
Raised plasma-myoinositol levels in uraemia and experimental neuropathy.
    Lancet (London, England), 1973, May-26, Volume: 1, Issue:7813

    Topics: Administration, Oral; Animals; Blood Urea Nitrogen; Chromatography, Gas; Evoked Potentials; Fasting;

1973
Clinical significance of increased serum myoinositol levels.
    Israel journal of medical sciences, 1974, Volume: 10, Issue:12

    Topics: Adolescent; Adult; Alkalies; Blood Urea Nitrogen; Chromatography, Paper; Humans; Inositol; Kidney Di

1974
Gas chromatography measurement of myo-inositol in human blood, cerebrospinal fluid and seminal fluid.
    Clinica chimica acta; international journal of clinical chemistry, 1973, May-30, Volume: 45, Issue:4

    Topics: Adult; Aged; Child, Preschool; Chromatography, Gas; Chromatography, Ion Exchange; Creatine Kinase; D

1973
Monosaccharides and polyols in diabetes mellitus and uremia.
    The Journal of laboratory and clinical medicine, 1973, Volume: 82, Issue:5

    Topics: Adult; Aged; Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Female; Fructose; Humans; Inosit

1973
The serum polyol pattern and the urinary polyol excretion in diabetic and in uremic patients.
    Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 38, Issue:1

    Topics: Acetobacter; Biological Assay; Borohydrides; Chromatography, Gas; Chromatography, Paper; Diabetes Me

1972
Serum calcium and serum phsophorus in uraemia during administration of osdium phytate and aluminium hydroxide.
    Acta medica Scandinavica, 1968, Volume: 183, Issue:6

    Topics: Aluminum; Bone and Bones; Calcium; Humans; Hydroxides; Hypocalcemia; Hypoparathyroidism; Inositol; K

1968