inositol has been researched along with Seizures in 26 studies
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 2014, we first described novel autoantibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1-IgG/anti-Sj) in patients with autoimmune cerebellar ataxia (ACA) in this journal." | 9.22 | Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. ( Bräuninger, S; Chung, HY; Geis, C; Haas, J; Jarius, S; Komorowski, L; Roth, C; Wildemann, B, 2022) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 8.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 7.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 6.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "The effects of seizures on brain lipid metabolism and some recent studies from our laboratory are described in this chapter." | 6.37 | The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy. ( Bazan, NG; Birkle, DL; Reddy, TS; Tang, W, 1986) |
| "Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available." | 5.51 | Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis. ( Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lepsveridze, E; Lortkipanidze, T; Margvelani, G; Solomonia, R; Tsverava, L, 2019) |
| "This was surprising since seizures induced by acute lithium plus DOI were less severe than those after acute lithium plus pilocarpine, but myo-inositol was more effective in blocking the latter." | 5.29 | Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats. ( Jope, RS; Williams, MB, 1995) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 5.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| "In 2014, we first described novel autoantibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1-IgG/anti-Sj) in patients with autoimmune cerebellar ataxia (ACA) in this journal." | 5.22 | Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. ( Bräuninger, S; Chung, HY; Geis, C; Haas, J; Jarius, S; Komorowski, L; Roth, C; Wildemann, B, 2022) |
| " Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures." | 4.31 | Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures. ( Antonowski, T; Juranek, J; Podlasz, P; Wiśniewski, K; Wojtkiewicz, J, 2023) |
| "Compared to nonpregnant women, women with normal pregnancy and preeclampsia had lower levels of the cerebral osmolytes, myo-inositol, choline and creatine (P = 0." | 3.88 | Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study. ( Bergman, L; Larsson, A; Nelander, M; Sundström-Poromaa, I; Weis, J; Wikström, AK; Wikström, J, 2018) |
| "We studied the effect of myo-inositol on pentylenetetrazole and kainic acid-induced seizures in rats." | 3.74 | Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats. ( Bolkvadze, T; Kigyradze, T; Kiladze, M; Kuchiashvili, N; Nozadze, M; Pkhakadze, V; Solomonia, R; Zhvania, M, 2007) |
| " They behaved similarly to lithium-treated animals in the model of pilocarpine seizures and in the Porsolt forced swimming test model of depression." | 3.74 | Homozygote inositol transporter knockout mice show a lithium-like phenotype. ( Agam, G; Belmaker, RH; Berry, GT; Bersudsky, Y; Shaldubina, A, 2008) |
| " To test this hypothesis, the present study evaluates the effects of two inositol uptake inhibitors, the carbohydrate L-fucose and the cyclodepsipeptide nordidemnin, in a behavioral model of pilocarpine-induced seizures known to be enhanced by lithium." | 3.70 | Augmentation of lithium's behavioral effect by inositol uptake inhibitors. ( Belmaker, RH; Einat, H; Itkin, O; Kofman, O; Lewitan, RJ, 1998) |
| " It had previously been shown that pilocarpine causes a limbic seizure syndrome in lithium treated rats, and that these lithium-pilocarpine seizures are reversible by intracerebroventricular inositol administration to rats." | 3.69 | High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium. ( Agam, G; Belmaker, RH; Bersudsky, Y; Kofman, O; Shapiro, Y, 1994) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 3.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "Thus, the Li-pilocarpine seizure model may, despite its lack of face validity, be a biochemical marker for a model of mania treatment in animals." | 2.44 | Lithium-pilocarpine seizures as a model for lithium action in mania. ( Belmaker, RH; Bersudsky, Y, 2007) |
| "The effects of seizures on brain lipid metabolism and some recent studies from our laboratory are described in this chapter." | 2.37 | The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy. ( Bazan, NG; Birkle, DL; Reddy, TS; Tang, W, 1986) |
| "Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS)." | 1.72 | Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats. ( Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L, 2022) |
| "Epilepsy is one of the most widespread neurological diseases characterized by spontaneous recurrent seizures." | 1.51 | Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo. ( Bilanishvili, IG; Gamkrelidze, GN; Kandashvili, M; Kokaia, M; Lordkipanidze, T; Nanobashvili, ZI; Solomonia, RO, 2019) |
| "Epilepsy is one of the most devastating neurological diseases and despite significant efforts there is no cure available." | 1.51 | Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis. ( Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lepsveridze, E; Lortkipanidze, T; Margvelani, G; Solomonia, R; Tsverava, L, 2019) |
| "These 2 patients presented with seizures." | 1.46 | Magnetic Resonance Spectroscopy Findings in Patients with Dural Arteriovenous Fistulas: Three Case Reports. ( Fujita, A; Hosoda, K; Kohmura, E; Kohta, M; Nagashima, H; Sasayama, T; Tanaka, J; Tanaka, K, 2017) |
| "This was surprising since seizures induced by acute lithium plus DOI were less severe than those after acute lithium plus pilocarpine, but myo-inositol was more effective in blocking the latter." | 1.29 | Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats. ( Jope, RS; Williams, MB, 1995) |
| "Inositol-4-phosphate was stable in the young rats but increased in the frontal cortex and the hippocampus in the old rats." | 1.29 | Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats. ( Hirvonen, MR; Paljärvi, L; Savolainen, KM, 1993) |
| "Myo-inositol is an important precursor in cellular second-messenger synthesis." | 1.29 | The effect of peripheral inositol injection on rat motor activity models of depression. ( Alpert, C; Belmaker, RH; Bersudsky, Y; Kofman, O; Vinnitsky, I, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 7 (26.92) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Kandashvili, M | 3 |
| Gamkrelidze, G | 2 |
| Tsverava, L | 2 |
| Lordkipanidze, T | 2 |
| Lepsveridze, E | 3 |
| Lagani, V | 1 |
| Burjanadze, M | 1 |
| Dashniani, M | 1 |
| Kokaia, M | 3 |
| Solomonia, R | 4 |
| Jarius, S | 1 |
| Bräuninger, S | 1 |
| Chung, HY | 1 |
| Geis, C | 1 |
| Haas, J | 1 |
| Komorowski, L | 1 |
| Wildemann, B | 1 |
| Roth, C | 1 |
| Gamkrelidze, GN | 1 |
| Nanobashvili, ZI | 1 |
| Bilanishvili, IG | 1 |
| Solomonia, RO | 1 |
| Alonso-Castro, AJ | 1 |
| Alba-Betancourt, C | 1 |
| Rocha-González, E | 1 |
| Ruiz-Arredondo, A | 1 |
| Zapata-Morales, JR | 1 |
| Gasca-Martínez, D | 1 |
| Pérez-Gutiérrez, S | 1 |
| Nagashima, H | 1 |
| Fujita, A | 1 |
| Tanaka, J | 1 |
| Kohta, M | 1 |
| Sasayama, T | 1 |
| Tanaka, K | 1 |
| Hosoda, K | 1 |
| Kohmura, E | 1 |
| Nelander, M | 1 |
| Wikström, AK | 1 |
| Weis, J | 1 |
| Bergman, L | 1 |
| Larsson, A | 1 |
| Sundström-Poromaa, I | 1 |
| Wikström, J | 1 |
| Margvelani, G | 1 |
| Lortkipanidze, T | 1 |
| Nozadze, M | 2 |
| Mikautadze, E | 1 |
| Mikeladze, E | 1 |
| Kuchiashvili, N | 2 |
| Kiguradze, T | 1 |
| Kikvidze, M | 1 |
| Akhtari, M | 1 |
| Bragin, A | 1 |
| Moats, R | 1 |
| Frew, A | 1 |
| Mandelkern, M | 1 |
| Belmaker, RH | 8 |
| Bersudsky, Y | 6 |
| Bolkvadze, T | 1 |
| Kiladze, M | 1 |
| Zhvania, M | 1 |
| Kigyradze, T | 1 |
| Pkhakadze, V | 1 |
| Shaldubina, A | 1 |
| Agam, G | 3 |
| Berry, GT | 1 |
| Honchar, MP | 1 |
| Olney, JW | 1 |
| Sherman, WR | 2 |
| Williams, MB | 1 |
| Jope, RS | 1 |
| Shapiro, Y | 2 |
| Kofman, O | 6 |
| Katz, V | 1 |
| Kaplan, Z | 1 |
| Hirvonen, MR | 1 |
| Paljärvi, L | 1 |
| Savolainen, KM | 1 |
| Vinnitsky, I | 1 |
| Alpert, C | 1 |
| Patishi, Y | 1 |
| Einat, H | 1 |
| Itkin, O | 1 |
| Lewitan, RJ | 1 |
| Rodriguez de Turco, EB | 1 |
| Tang, W | 2 |
| Topham, MK | 1 |
| Sakane, F | 1 |
| Marcheselli, VL | 1 |
| Chen, C | 1 |
| Taketomi, A | 1 |
| Prescott, SM | 1 |
| Bazan, NG | 2 |
| Birkle, DL | 1 |
| Reddy, TS | 1 |
| Miyamoto, K | 1 |
| Taguchi, F | 1 |
| Imazawa, M | 1 |
| Schacht, J | 1 |
| Agranoff, BW | 1 |
| Wiśniewski, K | 1 |
| Antonowski, T | 1 |
| Juranek, J | 1 |
| Podlasz, P | 1 |
| Wojtkiewicz, J | 1 |
3 reviews available for inositol and Seizures
| Article | Year |
|---|---|
Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature.
Topics: Autoantibodies; Carrier Proteins; Cerebellar Ataxia; Encephalitis; Female; Humans; Immunoglobulin G; | 2022 |
Lithium-pilocarpine seizures as a model for lithium action in mania.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Humans; Inositol; Limbic System | 2007 |
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biomechanical Phenomena; Brain; Diglycerides; Epilepsy | 1986 |
23 other studies available for inositol and Seizures
| Article | Year |
|---|---|
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.
Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory | 2022 |
Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo.
Topics: Anticonvulsants; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Hipp | 2019 |
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Flumazenil; Hypnotics and Seda | 2019 |
Magnetic Resonance Spectroscopy Findings in Patients with Dural Arteriovenous Fistulas: Three Case Reports.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Central Nervous System Vascular Malformations; Cerebral Angi | 2017 |
Cerebral Osmolytes and Plasma Osmolality in Pregnancy and Preeclampsia: A Proton Magnetic Resonance Spectroscopy Study.
Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Cerebrovascular Circulation; Choline; Creatine; | 2018 |
Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis.
Topics: Animals; Behavior, Animal; Epilepsy; Inositol; Kainic Acid; Seizures; Time Factors | 2019 |
Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures.
Topics: Animals; Anticonvulsants; Convulsants; Inositol; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2011 |
Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI.
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Convulsants; Dextrans; Disease Models, Animal; Ele | 2012 |
Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats.
Topics: Animals; Anticonvulsants; Convulsants; Inositol; Kainic Acid; Pentylenetetrazole; Rats; Seizures | 2007 |
Homozygote inositol transporter knockout mice show a lithium-like phenotype.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Inositol; Lithium Compounds; Mice; Mice, Inb | 2008 |
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Topics: Animals; Atropine; Brain Chemistry; Chlorides; Drug Interactions; Humans; Inositol; Inositol Phospha | 1983 |
Modulation by inositol of cholinergic- and serotonergic-induced seizures in lithium-treated rats.
Topics: Amphetamines; Animals; Cholinergic Agents; Drug Synergism; Inositol; Lithium; Male; Pilocarpine; Rat | 1995 |
High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Chromatography, Gas; Glucose; Injection | 1994 |
Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Epilepsy, Tonic-Clonic; Injections, Int | 1993 |
Behavioral evidence for the existence of two pools of cellular inositol.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Hypernatremia; Hyponatremia; Inositol; | 1994 |
Sustained effects of pilocarpine-induced convulsions on brain inositol and inositol monophosphate levels and brain morphology in young and old male rats.
Topics: Aging; Animals; Brain; Inositol; Inositol Phosphates; Male; Neurons; Pilocarpine; Rats; Rats, Wistar | 1993 |
The effect of peripheral inositol injection on rat motor activity models of depression.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Depression; Disease Models, Animal; Drug Sy | 1993 |
A comparison of the ability of myo-inositol and epi-inositol to attenuate lithium-pilocarpine seizures in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Injections, Intraperitoneal; Injections, Intraventricu | 1996 |
Augmentation of lithium's behavioral effect by inositol uptake inhibitors.
Topics: Animals; Depsipeptides; Drug Synergism; Fucose; Injections, Intraventricular; Inositol; Lithium; Mal | 1998 |
Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling.
Topics: Animals; Arachidonic Acids; Base Sequence; Behavior, Animal; Diacylglycerol Kinase; DNA Primers; Fem | 2001 |
Correlation between inositide response and seizure-related substances as well as antiepileptic drugs.
Topics: Animals; Anticonvulsants; Binding Sites; Inositol; Membrane Lipids; Phenytoin; Phosphatidylinositol | 1986 |
Phospholipid labelling by ( 32 P)-orthophosphate and ( 3 H)-myo-inositol in the stimulated goldfish brain in vivo.
Topics: Animals; Brain; Cyprinidae; Electroshock; Inositol; Pentylenetetrazole; Phosphates; Phosphatidylinos | 1972 |
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures.
Topics: Animals; Anticonvulsants; Epilepsy; Larva; Pentylenetetrazole; Seizures; Zebrafish | 2023 |