inositol and Respiratory Distress Syndrome, Newborn

inositol has been researched along with Respiratory Distress Syndrome, Newborn in 18 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.

Research

Studies (18)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Participants With Any Ophthalmologic Diagnosis

Any ophthalmologic diagnosis at 18-22 month corrected age (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Any Ophthalmologic Medical Treatment

Any ophthalmologic medical treatment at 18-22 month corrected age (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Any Ophthalmologic Surgical Treatment

Any ophthalmologic surgical treatment at 18-22 month corrected age (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Any Ophthalmologic Treatment

Any ophthalmologic treatment at 18-22 month corrected age (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Any Retinopathy of Prematurity (ROP)

Any ROP is defined as ROP of any severity that is observed at 18-22 month corrected age (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Any Retinopathy of Prematurity Through 18-22 Month Corrected Age or Death

Number of participants with any Retinopathy of Prematurity (ROP) through 18-22 month corrected age or death (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Composite Cognitive Score Less Than 70

This is measured as a score of less than 70 on the Bayley Scale of Infant and Toddler Development (BSID)-III composite cognitive score (NCT01030575)
Timeframe: 18-22 months corrected age.

Number of Participants With Composite Motor Score Less Than 70

This is measured as a scored of less than 70 on the Bayley Scale of Infant and Toddler Development (BSID)-III composite motor score. Higher scores indicate better performance. (NCT01030575)
Timeframe: 18-22 months corrected age

Number of Participants With Gross Motor Function Greater Than or Equal to 2

A Gross Motor Function Classification System (GMFCS) level of at least II (on a scale from level I to V, with I indicating normal gross motor function and higher levels indicating greater impairment). Level II is defined as Infants maintain floor sitting but may need to use their hands for support to maintain balance. Infants creep on their stomach or crawl on hands and knees with reciprocal leg movement. Infants may pull to stand and take steps holding on to furniture.) (NCT01030575)
Timeframe: 18 -22 months corrected age

Number of Participants With Moderate or Severe Cerebral Palsy

Cerebral palsy by severity category (absent/mild/moderate/severe). (NCT01030575)
Timeframe: 18-22 months corrected age.

Number of Participants With Moderate or Severe Neurodevelopmental Impairment at 18-22 Month Corrected Age

A composite outcome that measures the occurrence of neurodevelopmental impairment between birth and 18-22 months corrected age. (NCT01030575)
Timeframe: 18-22 month corrected age

Number of Participants With Moderate or Severe Neurodevelopmental Impairment at 18-22 Month Corrected Age or Death

Moderate or Severe NDI defined as occurrence of any of the following: GMFCS level II or higher (severe is level 4 or 5), Bayley III cognitive composite score < 85 (severe is <70), Bayley III motor composite score < 85 (severe is <70), unilateral blind or bilateral blind, permanent hearing loss that does not permit child to understand directions of the examiner and communicate despite amplification with cochlear implant or hearing aid (NCT01030575)
Timeframe: 8-22 months corrected age.

Number of Participants With Severe Hearing Impairment

Defined as permanent hearing loss that does not permit child to understand directions of the examiner and communicate despite amplification with cochlear implant or hearing aid. (NCT01030575)
Timeframe: 18-22 months corrected age.

Number of Participants With Severe Vision Loss

"Vision loss as diagnosed by an ophthalmologist as legally blind, and subdivided into ophthalmic origin, or not ophthalmic origin (i.e., cortical blindness is non-ophthalmic in origin and indicates that there is no retinal detachment or other abnormal fundus or ocular finding, except optic atrophy. Such cases will be considered central [neurologic] in origin.)" (NCT01030575)
Timeframe: 18-22 Months Corrected Age

Population Pharmacokinetics: Cl - Clearance

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

Population Pharmacokinetics: E - Concentration Due to Endogenous Infusion (R/Cl)

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

Population Pharmacokinetics: k - Elimination Rate (Cl/V)

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

Population Pharmacokinetics: R - Endogenous Infusion Rate

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

Population Pharmacokinetics: t1/2 - Half-Life (0.693/k)

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

Population Pharmacokinetics: V - Volume

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

SD of Residual Error (mg/l)

(NCT01030575)
Timeframe: 8-10 blood samples per infant were drawn over 10 weeks for infant safety with the full study duration represented across all infants. Samples were drawn at baseline & on days 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 28, 35, 42, 56, and 70.

Reviews

7 reviews available for inositol and Respiratory Distress Syndrome, Newborn

Trials

6 trials available for inositol and Respiratory Distress Syndrome, Newborn

Other Studies

5 other studies available for inositol and Respiratory Distress Syndrome, Newborn