Page last updated: 2024-10-19

inositol and Preterm Birth

inositol has been researched along with Preterm Birth in 12 studies

Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
inositol : Any cyclohexane-1,2,3,4,5,6-hexol.
1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.
muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.

Research Excerpts

ExcerptRelevanceReference
" Inclusion criteria were randomized controlled trials (RCTs) that enrolled overweight and obese pregnant women and used myo-inositol supplementation."9.41The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Systematic Review and Meta-Analysis. ( Corpuz, H; Factor, PA, 2023)
"Evidence from seven studies shows that antenatal dietary supplementation with myo-inositol during pregnancy may reduce the incidence of gestational diabetes, hypertensive disorders of pregnancy and preterm birth."5.41Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. ( Alsweiler, J; Crawford, TJ; Crowther, CA; Lin, L; Motuhifonua, SK, 2023)
" Inclusion criteria were randomized controlled trials (RCTs) that enrolled overweight and obese pregnant women and used myo-inositol supplementation."5.41The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Systematic Review and Meta-Analysis. ( Corpuz, H; Factor, PA, 2023)
"Myo-inositol treatment in early pregnancy is associated with a reduction in the rate of gestational diabetes mellitus and in the risk of preterm birth and macrosomia in women who are at risk for gestational diabetes mellitus."3.88Clinical and metabolic outcomes in pregnant women at risk for gestational diabetes mellitus supplemented with myo-inositol: a secondary analysis from 3 RCTs. ( Alibrandi, A; Corrado, F; D'Anna, R; Di Benedetto, A; Facchinetti, F; Pintaudi, B; Santamaria, A, 2018)
"Although gestational diabetes mellitus (GDM) has several short- and long-term adverse effects on the mother and the offspring, no medicine is generally prescribed to prevent GDM."3.01Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Ács, N; Greff, D; Hegyi, P; Horváth, EM; Nyirády, P; Park, S; Szinte, J; Váncsa, S; Váradi, A; Várbíró, S, 2023)
"A total of 26 prematurely born intrauterine growth restriction infants (birthweight <10th centile for gestational age), 22 prematurely born but adequate for gestational age controls, and 26 term adequate-for-gestational-age infants underwent brain magnetic resonance imaging and magnetic resonance spectroscopy at 1 year of age during natural sleep, on a 3 Tesla scanner."1.46Brain metabolite alterations in infants born preterm with intrauterine growth restriction: association with structural changes and neurodevelopmental outcome. ( Bargalló, N; Cruz-Lemini, M; Eixarch, E; Gratacós, E; Muñoz-Moreno, E; Sanz-Cortés, M; Simões, RV, 2017)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (41.67)24.3611
2020's7 (58.33)2.80

Authors

AuthorsStudies
Sharma, N1
Watkins, OC1
Chu, AHY1
Cutfield, W2
Godfrey, KM2
Yong, HEJ1
Chan, SY2
Liu, Q1
Liu, Z1
Guarnotta, V1
Cuva, G1
Imbergamo, MP1
Giordano, C1
Motuhifonua, SK1
Lin, L1
Alsweiler, J1
Crawford, TJ1
Crowther, CA1
Greff, D1
Váncsa, S1
Váradi, A1
Szinte, J1
Park, S1
Hegyi, P1
Nyirády, P1
Ács, N1
Horváth, EM1
Várbíró, S1
Factor, PA1
Corpuz, H1
Barton, SJ1
El-Heis, S1
Kenealy, T1
Nield, H1
Baker, PN1
Chong, YS1
Zhang, H1
Lv, Y1
Li, Z1
Sun, L1
Guo, W1
Santamaria, A1
Alibrandi, A1
Di Benedetto, A1
Pintaudi, B1
Corrado, F1
Facchinetti, F1
D'Anna, R1
Vitagliano, A1
Saccone, G1
Cosmi, E1
Visentin, S1
Dessole, F1
Ambrosini, G1
Berghella, V1
Moles, L1
Manzano, S1
Fernández, L1
Montilla, A1
Corzo, N1
Ares, S1
Rodríguez, JM1
Espinosa-Martos, I1
Simões, RV1
Muñoz-Moreno, E1
Cruz-Lemini, M1
Eixarch, E1
Bargalló, N1
Sanz-Cortés, M1
Gratacós, E1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Myoinositol on Serum Asprosin Levels in Pregnant Women[NCT05943158]40 participants (Actual)Interventional2021-06-01Completed
Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health - Child Health and Well-being Follow Up Study[NCT05934422]510 participants (Anticipated)Interventional2023-06-16Enrolling by invitation
"Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health (NiPPeR)"[NCT02509988]1,729 participants (Actual)Interventional2015-07-31Completed
Myoinositol Supplementation, Insulin Resistance and Fetal Sonographic Parameters in Gestational Diabetes, Diet Treated: a Prospective, Randomized, Placebo-controlled Study[NCT03763669]120 participants (Actual)Interventional2018-11-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for inositol and Preterm Birth

ArticleYear
    Nutrition research reviews, 2023, Volume: 36, Issue:1

    Topics: Diabetes, Gestational; Female; Fetal Membranes, Premature Rupture; Humans; Infant, Newborn; Inositol

2023
The efficacy of myo-inositol supplementation to reduce the incidence of gestational diabetes: a meta-analysis.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2022, Volume: 38, Issue:6

    Topics: Diabetes, Gestational; Dietary Supplements; Female; Glucose; Humans; Incidence; Infant, Newborn; Ino

2022
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.
    The Cochrane database of systematic reviews, 2023, 02-15, Volume: 2

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dietary Supplements; Female; Humans; Hypert

2023
Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Nutrients, 2023, Sep-30, Volume: 15, Issue:19

    Topics: Diabetes, Gestational; Female; Humans; Hypertension, Pregnancy-Induced; Hypoglycemia; Infant, Newbor

2023
The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Systematic Review and Meta-Analysis.
    Journal of the ASEAN Federation of Endocrine Societies, 2023, Volume: 38, Issue:2

    Topics: Diabetes, Gestational; Dietary Supplements; Female; Humans; Hypertension, Pregnancy-Induced; Infant,

2023
The efficacy of myo-inositol supplementation to prevent gestational diabetes onset: a meta-analysis of randomized controlled trials.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, Volume: 32, Issue:13

    Topics: Adult; Diabetes, Gestational; Female; Gestational Age; Humans; Inositol; Pregnancy; Premature Birth;

2019
Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials.
    Archives of gynecology and obstetrics, 2019, Volume: 299, Issue:1

    Topics: Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Infant, Newborn; Inositol; Insulin; Odd

2019

Trials

1 trial available for inositol and Preterm Birth

ArticleYear
    Diabetes care, 2021, Volume: 44, Issue:5

    Topics: Dietary Supplements; Double-Blind Method; Female; Humans; Infant, Newborn; Inositol; Micronutrients;

2021
    Diabetes care, 2021, Volume: 44, Issue:5

    Topics: Dietary Supplements; Double-Blind Method; Female; Humans; Infant, Newborn; Inositol; Micronutrients;

2021
    Diabetes care, 2021, Volume: 44, Issue:5

    Topics: Dietary Supplements; Double-Blind Method; Female; Humans; Infant, Newborn; Inositol; Micronutrients;

2021
    Diabetes care, 2021, Volume: 44, Issue:5

    Topics: Dietary Supplements; Double-Blind Method; Female; Humans; Infant, Newborn; Inositol; Micronutrients;

2021

Other Studies

4 other studies available for inositol and Preterm Birth

ArticleYear
Myoinositol supplementation in the treatment of gestational diabetes mellitus: effects on glycaemic control and maternal-foetal outcomes.
    BMC pregnancy and childbirth, 2022, Jun-26, Volume: 22, Issue:1

    Topics: Blood Glucose; Diabetes, Gestational; Dietary Supplements; Female; Glycemic Control; Humans; Infant,

2022
Clinical and metabolic outcomes in pregnant women at risk for gestational diabetes mellitus supplemented with myo-inositol: a secondary analysis from 3 RCTs.
    American journal of obstetrics and gynecology, 2018, Volume: 219, Issue:3

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dietary Supplements; Female; Fetal Growth R

2018
Bacteriological, biochemical, and immunological properties of colostrum and mature milk from mothers of extremely preterm infants.
    Journal of pediatric gastroenterology and nutrition, 2015, Volume: 60, Issue:1

    Topics: Adult; Bacterial Load; Chemokines; Colostrum; Cytokines; Female; Glucose; Gram-Negative Bacteria; Gr

2015
Brain metabolite alterations in infants born preterm with intrauterine growth restriction: association with structural changes and neurodevelopmental outcome.
    American journal of obstetrics and gynecology, 2017, Volume: 216, Issue:1

    Topics: Adaptation, Psychological; Anisotropy; Aspartic Acid; Brain; Child, Preschool; Choline; Cognition; C

2017